{"id":"https://openalex.org/W2939994749","doi":"https://doi.org/10.3389/fphys.2019.00502","title":"Using the Xenopus Developmental Eye Regrowth System to Distinguish the Role of Developmental Versus Regenerative Mechanisms","display_name":"Using the Xenopus Developmental Eye Regrowth System to Distinguish the Role of Developmental Versus Regenerative Mechanisms","publication_year":2019,"publication_date":"2019-05-08","ids":{"openalex":"https://openalex.org/W2939994749","doi":"https://doi.org/10.3389/fphys.2019.00502","mag":"2939994749","pmid":"https://pubmed.ncbi.nlm.nih.gov/31139088","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518849"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2019.00502","doi":"https://doi.org/10.3389/fphys.2019.00502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00502/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00502/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017146790","display_name":"Cindy X. Kha","orcid":"https://orcid.org/0000-0002-6038-1875","observed_orcids":["https://orcid.org/0000-0002-6038-1875"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy X. Kha","raw_affiliation_strings":["School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111438385","display_name":"Dylan J. Guerin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan J. Guerin","raw_affiliation_strings":["School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056637728","display_name":"Kelly Ai-Sun Tseng","orcid":"https://orcid.org/0000-0001-5133-6696","observed_orcids":["https://orcid.org/0000-0001-5133-6696"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kelly Ai-Sun Tseng","raw_affiliation_strings":["School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, United States","institution_ids":["https://openalex.org/I133999245"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056637728"],"corresponding_institution_ids":["https://openalex.org/I133999245"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2082,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.76042531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"502","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.890999972820282},{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.7480000257492065},{"id":"https://openalex.org/keywords/retinal-differentiation","display_name":"retinal differentiation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/retinal-patterning","display_name":"retinal patterning","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":0.8560000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.922588586807251},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.49487870931625366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4855765700340271},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4423621892929077},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43421903252601624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24075648188591003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18097758293151855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07161781191825867}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fphys.2019.00502","doi":"https://doi.org/10.3389/fphys.2019.00502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00502/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6518849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:31139088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31139088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalscholarship.unlv.edu:sls_fac_articles-1734","doi":null,"is_oa":true,"landing_page_url":"https://digitalscholarship.unlv.edu/sls_fac_articles/453","pdf_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1734&context=sls_fac_articles","source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Sciences Faculty Publications","raw_type":"text"},{"id":"pmh:oai:oasis.library.unlv.edu:sls_fac_articles-1734","doi":null,"is_oa":true,"landing_page_url":"https://oasis.library.unlv.edu/sls_fac_articles/453","pdf_url":null,"source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Sciences Faculty Research","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6a45d5fde4134dbb9d03ab77ee5ba94f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6a45d5fde4134dbb9d03ab77ee5ba94f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2019.00502","doi":"https://doi.org/10.3389/fphys.2019.00502","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00502","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00502/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G274537482","display_name":null,"funder_award_id":"GM103440","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7912190211","display_name":"MRI: Acquisition of a high speed multiphoton laser-scanning microscope for research and training at UNLV","funder_award_id":"1726925","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000916033","display_name":"Nevada IDeA Networks of Biomedical Research Excellence (INBRE)","funder_award_id":"P20GM103440","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309566","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2939994749.pdf","grobid_xml":"https://content.openalex.org/works/W2939994749.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W74337203","https://openalex.org/W1140456161","https://openalex.org/W1492743403","https://openalex.org/W1492877023","https://openalex.org/W1516362092","https://openalex.org/W1516851780","https://openalex.org/W1527977646","https://openalex.org/W1967594819","https://openalex.org/W1970550559","https://openalex.org/W1971860633","https://openalex.org/W1986380537","https://openalex.org/W2005081876","https://openalex.org/W2005943162","https://openalex.org/W2007773129","https://openalex.org/W2010584894","https://openalex.org/W2010854221","https://openalex.org/W2024490391","https://openalex.org/W2030924655","https://openalex.org/W2045282732","https://openalex.org/W2058939075","https://openalex.org/W2061808806","https://openalex.org/W2062094940","https://openalex.org/W2062652610","https://openalex.org/W2069666205","https://openalex.org/W2073097612","https://openalex.org/W2080937698","https://openalex.org/W2086129220","https://openalex.org/W2090827770","https://openalex.org/W2121273109","https://openalex.org/W2126245868","https://openalex.org/W2158924528","https://openalex.org/W2159234350","https://openalex.org/W2167279371","https://openalex.org/W2183928429","https://openalex.org/W2184976335","https://openalex.org/W2573023629","https://openalex.org/W2575518983","https://openalex.org/W2792009934","https://openalex.org/W2888154300","https://openalex.org/W3023791708"],"related_works":["https://openalex.org/W6908939271","https://openalex.org/W6927878398","https://openalex.org/W2888154300","https://openalex.org/W2770570701","https://openalex.org/W2792009934","https://openalex.org/W2573023629","https://openalex.org/W2993084165","https://openalex.org/W2051456159","https://openalex.org/W2010584894","https://openalex.org/W1140456161"],"abstract_inverted_index":{"A":[0],"longstanding":[1],"challenge":[2],"in":[3,14,66,100,267],"regeneration":[4,57,63,99,119,140,335],"biology":[5],"is":[6,31,64,74,111,128,131,156,248],"to":[7,60,76,84,97,207,250,260,323],"understand":[8],"the":[9,67,85,107,123,169,213,226,262,296,328],"role":[10,263],"of":[11,37,69,172,212,215,264,316],"developmental":[12,38,50,81,102,314],"mechanisms":[13,39,51,266,297,330],"restoring":[15],"lost":[16],"or":[17,54],"damaged":[18],"tissues":[19],"and":[20,118,138,175,189,221,244,282,302,325],"organs.":[21],"As":[22],"these":[23,292],"body":[24],"structures":[25],"were":[26],"built":[27],"during":[28,43,56,178,185,231,246],"embryogenesis,":[29],"it":[30,46,73],"not":[32],"surprising":[33],"that":[34,145,155,184,225,236,274,295,331],"a":[35,93,101,112,152,320],"number":[36],"are":[40,332],"also":[41,132],"active":[42],"regeneration.":[44],"However,":[45],"remains":[47],"unclear":[48],"whether":[49],"act":[52],"similarly":[53],"differently":[55],"as":[58,319],"compared":[59,206],"development.":[61,209,240,253,337],"Since":[62],"studied":[65],"context":[68,103],"mature,":[70],"differentiated":[71],"tissues,":[72],"difficult":[75],"evaluate":[77],"comparative":[78],"studies":[79,272],"with":[80,235],"processes":[82],"due":[83],"latter\u2019s":[86],"highly":[87],"proliferative":[88],"environment.":[89],"We":[90,254],"have":[91],"taken":[92],"more":[94],"direct":[95],"approach":[96],"study":[98,311],"(regrowth).":[104],"Xenopus":[105,125,130,146],"laevis,":[106],"African":[108],"clawed":[109],"frog,":[110],"well-established":[113],"model":[114,135,259,315],"for":[115,122,136,238,278,289,299,334],"both":[116,279,300],"embryology":[117],"studies,":[120],"especially":[121],"eye.":[124,163],"eye":[126,154,179,208,239,252,257,280,317],"development":[127,268,281,301],"well-defined.":[129],"an":[133,160],"established":[134],"retinal":[137,173,190,227],"lens":[139],"studies.":[141],"Previously,":[142],"we":[143,167],"demonstrated":[144],"tailbud":[147],"embryo":[148],"can":[149,304],"successfully":[150],"regrow":[151],"functional":[153],"morphologically":[157],"indistinguishable":[158],"from":[159,307],"age-matched":[161],"control":[162],"In":[164],"this":[165,256,313],"study,":[166],"assessed":[168],"temporal":[170],"regulation":[171],"differentiation":[174,214,243],"patterning":[176,188,245],"restoration":[177],"regrowth.":[180,270,290],"Our":[181,310],"findings":[182],"showed":[183,273],"regrowth,":[186],"cellular":[187],"layer":[191],"formation":[192],"was":[193,200,233,276,286],"delayed":[194],"by":[195,202],"approximately":[196],"one":[197],"day":[198],"but":[199],"restored":[201],"three":[203],"days":[204],"when":[205],"An":[210],"assessment":[211],"ganglion":[216],"cells,":[217,220],"rod":[218],"photoreceptor":[219],"M\u00fcller":[222],"glia":[223],"indicated":[224],"birth":[228],"order":[229],"generated":[230],"regrowth":[232,247,258,283,303,318],"consistent":[234],"observed":[237],"Thus,":[241],"retina":[242],"similar":[249],"endogenous":[251],"used":[255],"assess":[261],"known":[265],"versus":[269,336],"Loss-of-function":[271],"Pax6":[275],"required":[277,288,298,333],"whereas":[284],"apoptosis":[285],"only":[287],"Together,":[291],"results":[293],"revealed":[294],"be":[305],"distinguished":[306],"regrowth-specific":[308],"ones.":[309],"highlights":[312],"robust":[321],"platform":[322],"systematically":[324],"efficiently":[326],"define":[327],"molecular":[329]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}
