{"id":"https://openalex.org/W2939638420","doi":"https://doi.org/10.1111/exd.13943","title":"Particulate matter induces pro\u2010inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammaging","display_name":"Particulate matter induces pro\u2010inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammaging","publication_year":2019,"publication_date":"2019-04-19","ids":{"openalex":"https://openalex.org/W2939638420","doi":"https://doi.org/10.1111/exd.13943","mag":"2939638420","pmid":"https://pubmed.ncbi.nlm.nih.gov/31001893"},"language":"en","primary_location":{"id":"doi:10.1111/exd.13943","doi":"https://doi.org/10.1111/exd.13943","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.13943","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100416215","display_name":"Minjeong Kim","orcid":"https://orcid.org/0000-0002-0524-9281","observed_orcids":["https://orcid.org/0000-0002-0524-9281"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"MinJeong Kim","raw_affiliation_strings":["Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0524-9281","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775566","display_name":"Ju Hee Kim","orcid":"https://orcid.org/0000-0001-5031-3740","observed_orcids":["https://orcid.org/0000-0001-5031-3740"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Hee Kim","raw_affiliation_strings":["Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-5031-3740","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071679046","display_name":"Guk Jin Jeong","orcid":"https://orcid.org/0000-0002-2379-0370","observed_orcids":["https://orcid.org/0000-0002-2379-0370"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Guk Jin Jeong","raw_affiliation_strings":["Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2379-0370","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018285744","display_name":"Kui Young Park","orcid":"https://orcid.org/0000-0001-5965-1754","observed_orcids":["https://orcid.org/0000-0001-5965-1754"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kui Young Park","raw_affiliation_strings":["Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-5965-1754","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711001","display_name":"Mi\u2010Kyung Lee","orcid":"https://orcid.org/0000-0003-1824-476X","observed_orcids":["https://orcid.org/0000-0003-1824-476X"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi\u2010Kyung Lee","raw_affiliation_strings":["Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1824-476X","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008162398","display_name":"Seong Jun Seo","orcid":"https://orcid.org/0000-0003-2915-839X","observed_orcids":["https://orcid.org/0000-0003-2915-839X"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seong Jun Seo","raw_affiliation_strings":["Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2915-839X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008162398","https://openalex.org/A5018285744"],"corresponding_institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I67900169"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":8.5719,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.98382384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"28","issue":"7","first_page":"809","last_page":"815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.9980000257492065},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.7210000157356262},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.7590000033378601},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.824999988079071},{"id":"https://openalex.org/keywords/p38-mapk-phosphorylation","display_name":"p38 MAPK phosphorylation","score":0.859000027179718},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.8389999866485596},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":1.0},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9409999847412109},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.777999997138977},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9550884962081909},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.763314962387085},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6583420038223267},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5412582159042358},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5299715995788574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5000076293945312},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4775215685367584},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.44202086329460144},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4376169443130493},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27943986654281616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2721579074859619},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2555812895298004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.188624769449234},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0756790041923523}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053582","descriptor_name":"Interleukin-1alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/exd.13943","doi":"https://doi.org/10.1111/exd.13943","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.13943","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:31001893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31001893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6384089723","display_name":null,"funder_award_id":"2017R1C1B1007523","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W138539255","https://openalex.org/W765401283","https://openalex.org/W879479010","https://openalex.org/W1587130504","https://openalex.org/W1963886920","https://openalex.org/W1977093178","https://openalex.org/W1989696800","https://openalex.org/W1993047865","https://openalex.org/W2016316911","https://openalex.org/W2047285521","https://openalex.org/W2060387658","https://openalex.org/W2068365575","https://openalex.org/W2087476152","https://openalex.org/W2115914792","https://openalex.org/W2124118506","https://openalex.org/W2129155846","https://openalex.org/W2143493476","https://openalex.org/W2158046173","https://openalex.org/W2159193579","https://openalex.org/W2214999925","https://openalex.org/W2345672003","https://openalex.org/W2438455430","https://openalex.org/W2587414694","https://openalex.org/W2592323922","https://openalex.org/W2800501827","https://openalex.org/W4292189154"],"related_works":["https://openalex.org/W4404342033","https://openalex.org/W3015076813","https://openalex.org/W4400768601","https://openalex.org/W4366183266","https://openalex.org/W2800501827","https://openalex.org/W2914621503","https://openalex.org/W4406406775","https://openalex.org/W4412516075","https://openalex.org/W4404972401","https://openalex.org/W2904006811"],"abstract_inverted_index":{"Particulate":[0],"matter":[1],"(PM)":[2],"is":[3,19],"known":[4],"to":[5,21,44,117],"have":[6,14],"harmful":[7],"effects":[8],"on":[9,52],"human":[10,62],"health.":[11],"Epidemiological":[12],"studies":[13],"suggested":[15],"that":[16,183],"PM":[17,33],"exposure":[18],"related":[20],"skin":[22,26,35,56,186],"diseases":[23],"and":[24,55,65,71,79,98,126,132,138,167,175,192],"extrinsic":[25],"ageing.":[27],"However,":[28],"the":[29,46,122,130,155,163,171],"mechanisms":[30],"by":[31,113],"which":[32,74],"affects":[34],"are":[36],"unclear.":[37],"The":[38,107],"aim":[39],"of":[40,48,50,61,92,95,109,136,157,173],"this":[41],"study":[42],"was":[43,115],"investigate":[45],"mechanism":[47],"action":[49],"PMs":[51,114,153,184],"epidermal":[53,196],"inflammation":[54],"ageing":[57,187],"using":[58],"a":[59],"co-culture":[60],"keratinocytes":[63,161],"(HaCaT)":[64],"fibroblasts":[66],"(HDF).":[67],"SRM":[68],"1648a":[69],"(pmA)":[70],"1649b":[72],"(pmB),":[73],"mainly":[75],"comprise":[76],"heavy":[77],"metals":[78],"polycyclic":[80],"aromatic":[81],"hydrocarbons,":[82],"respectively,":[83],"were":[84,101,140],"used":[85],"as":[86],"reference":[87],"PMs.":[88],"Cytotoxic":[89],"effects,":[90],"activation":[91,191],"AhR,":[93],"phosphorylation":[94,108],"p38":[96,110,164,189],"kinase":[97],"ROS":[99],"generation":[100],"examined":[102],"in":[103,124,143,160,177,195],"PM-treated":[104,148],"HaCaT":[105,149],"cells.":[106,150,179],"MAPK":[111,165,190],"induced":[112],"shown":[116],"be":[118],"critically":[119],"important":[120],"for":[121],"increases":[123],"IL-1\u03b1":[125],"IL-1\u03b2":[127],"expression.":[128],"Moreover,":[129],"mRNA":[131],"protein":[133],"expression":[134,156,172],"levels":[135],"MMP1":[137,174],"COX2":[139,176],"markedly":[141],"increased":[142],"HDF":[144,178],"cells":[145],"co-cultured":[146],"with":[147],"In":[151],"conclusion,":[152],"induce":[154],"pro-inflammatory":[158],"cytokines":[159],"via":[162,188],"pathway,":[166],"these":[168],"interleukins":[169],"increase":[170],"These":[180],"results":[181],"suggest":[182],"trigger":[185],"interleukin":[193],"secretion":[194],"keratinocytes.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}