{"id":"https://openalex.org/W2938200898","doi":"https://doi.org/10.21037/jtd.2019.03.60","title":"The role of RASSF proteins in modulating RAS driven lung tumors in vivo","display_name":"The role of RASSF proteins in modulating RAS driven lung tumors in vivo","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2938200898","doi":"https://doi.org/10.21037/jtd.2019.03.60","mag":"2938200898","pmid":"https://pubmed.ncbi.nlm.nih.gov/31245154","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6560612"},"language":"en","primary_location":{"id":"doi:10.21037/jtd.2019.03.60","doi":"https://doi.org/10.21037/jtd.2019.03.60","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd.2019.03.60","pdf_url":"https://jtd.amegroups.com/article/viewFile/28143/pdf","source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jtd.amegroups.com/article/viewFile/28143/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097130535","display_name":"Katherine Hobbing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Hobbing","raw_affiliation_strings":["Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102968455","display_name":"Marianne Schmidt","orcid":"https://orcid.org/0000-0003-0382-2694","observed_orcids":["https://orcid.org/0000-0003-0382-2694"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lee Schmidt","raw_affiliation_strings":["Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065550697","display_name":"Howard Donninger","orcid":"https://orcid.org/0000-0002-8589-1660","observed_orcids":["https://orcid.org/0000-0002-8589-1660"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Donninger","raw_affiliation_strings":["Department of Medicine, University of Louisville, Louisville, KY, USA","Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":null,"display_name":"Geoffrey J. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey J. Clark","raw_affiliation_strings":["Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, 2Department of Medicine, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.0827,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37303395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"11","issue":"S9","first_page":"S1436","last_page":"S1437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6660000085830688},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5580000281333923},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7399927377700806},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7095030546188354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.637921154499054},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5522013306617737},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4316681921482086},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37399035692214966},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33194974064826965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25396254658699036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18345800042152405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13318338990211487},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10395637154579163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07796293497085571}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/jtd.2019.03.60","doi":"https://doi.org/10.21037/jtd.2019.03.60","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd.2019.03.60","pdf_url":"https://jtd.amegroups.com/article/viewFile/28143/pdf","source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5560512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6560612","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6560612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6560612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Thorac Dis","raw_type":"Text"},{"id":"pmid:31245154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31245154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jtd.2019.03.60","doi":"https://doi.org/10.21037/jtd.2019.03.60","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd.2019.03.60","pdf_url":"https://jtd.amegroups.com/article/viewFile/28143/pdf","source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3562549009","display_name":"The role of the Ras effector Nore1a in tumor suppression","funder_award_id":"R01CA133171","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000895881","display_name":"UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM","funder_award_id":"T32ES011564","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2938200898.pdf","grobid_xml":"https://content.openalex.org/works/W2938200898.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1933277054","https://openalex.org/W1964646880","https://openalex.org/W2021099124","https://openalex.org/W2049186397","https://openalex.org/W2052333525","https://openalex.org/W2073597741","https://openalex.org/W2151606345","https://openalex.org/W2409603723","https://openalex.org/W2802958691"],"related_works":["https://openalex.org/W2802958691","https://openalex.org/W1953337176","https://openalex.org/W2742708044","https://openalex.org/W2558255316","https://openalex.org/W2069058550","https://openalex.org/W4367608159","https://openalex.org/W7100829492","https://openalex.org/W7213676305","https://openalex.org/W2139193008","https://openalex.org/W2341457363"],"abstract_inverted_index":{"Sir,":[0],"the":[1,8,32],"recent":[2],"editorial":[3],"of":[4],"our":[5,25],"article":[6],"describing":[7],"first":[9],"animal":[10],"model":[11],"for":[12],"KRAS-driven":[13],"lung":[14],"tumors":[15],"in":[16],"a":[17],"RASSF1A-deficient":[18],"background":[19],"(1)":[20],"succinctly":[21],"and":[22,36],"accurately":[23],"describes":[24],"work.":[26],"I":[27],"would":[28],"like":[29],"to":[30,34,37],"take":[31],"opportunity":[33],"elaborate":[35],"describe":[38],"some":[39],"additional":[40],"pertinent":[41],"experiments.":[42]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-04-25T00:00:00"}