{"id":"https://openalex.org/W2937597581","doi":"https://doi.org/10.1161/atvbaha.118.312128","title":"Targeted Sequencing Study to Uncover Shared Genetic Susceptibility Between Peripheral Artery Disease and Coronary Heart Disease\u2014Brief Report","display_name":"Targeted Sequencing Study to Uncover Shared Genetic Susceptibility Between Peripheral Artery Disease and Coronary Heart Disease\u2014Brief Report","publication_year":2019,"publication_date":"2019-04-11","ids":{"openalex":"https://openalex.org/W2937597581","doi":"https://doi.org/10.1161/atvbaha.118.312128","mag":"2937597581","pmid":"https://pubmed.ncbi.nlm.nih.gov/31070467","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6531315"},"language":"en","primary_location":{"id":"doi:10.1161/atvbaha.118.312128","doi":"https://doi.org/10.1161/atvbaha.118.312128","is_oa":true,"landing_page_url":"https://doi.org/10.1161/atvbaha.118.312128","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.312128","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.312128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050387718","display_name":"Maya S. Safarova","orcid":"https://orcid.org/0000-0003-3069-3752","observed_orcids":["https://orcid.org/0000-0003-3069-3752"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maya S. Safarova","raw_affiliation_strings":["From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067498089","display_name":"Xiao Fan","orcid":"https://orcid.org/0000-0002-8526-6945","observed_orcids":["https://orcid.org/0000-0002-8526-6945"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiao Fan","raw_affiliation_strings":["From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971435","display_name":"Erin E. Austin","orcid":"https://orcid.org/0000-0002-2709-8699","observed_orcids":["https://orcid.org/0000-0002-2709-8699"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin E. Austin","raw_affiliation_strings":["From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054146938","display_name":"Natalie Van Zuydam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalie van Zuydam","raw_affiliation_strings":["Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom (N.v.Z.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom (N.v.Z.)","institution_ids":["https://openalex.org/I1336263701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090329946","display_name":"Jemma C. Hopewell","orcid":"https://orcid.org/0000-0002-3870-8018","observed_orcids":["https://orcid.org/0000-0002-3870-8018"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jemma Hopewell","raw_affiliation_strings":["Nuffield Department of Population Health, Oxford, United Kingdom (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Population Health, Oxford, United Kingdom (J.H.)","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011038911","display_name":"Daniel J. Schaid","orcid":"https://orcid.org/0000-0003-1457-6433","observed_orcids":["https://orcid.org/0000-0003-1457-6433"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Schaid","raw_affiliation_strings":["Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065025844","display_name":"Iftikhar J. Kullo","orcid":"https://orcid.org/0000-0002-6524-3471","observed_orcids":["https://orcid.org/0000-0002-6524-3471"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iftikhar J. Kullo","raw_affiliation_strings":["From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN","Gonda Vascular Center (I.J.K.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cardiovascular Medicine (M.S.S., X.F., E.E.A., I.J.K.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Gonda Vascular Center (I.J.K.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050387718","https://openalex.org/A5067498089"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":1.0539,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7472817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"39","issue":"6","first_page":"1227","last_page":"1233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.48100000619888306,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8019999861717224},{"id":"https://openalex.org/keywords/shared-genetic-variants","display_name":"shared genetic variants","score":0.7839999794960022},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sh2b3","display_name":"SH2B3","score":0.9290000200271606},{"id":"https://openalex.org/keywords/turku","display_name":"Turku","score":0.7369999885559082},{"id":"https://openalex.org/keywords/zeb2","display_name":"ZEB2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ankle-brachial-index","display_name":"ankle-brachial index","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lower-extremity-revascularization","display_name":"lower extremity revascularization","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.7196967601776123},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5563670992851257},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5031928420066833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4907773435115814},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.48564302921295166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42716848850250244},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.42306995391845703},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.41895389556884766},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4185425639152527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38170719146728516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38106682896614075},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3715894818305969},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3113959729671478},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24711328744888306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2420976459980011}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058729","descriptor_name":"Peripheral Arterial Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D058729","descriptor_name":"Peripheral Arterial Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D058729","descriptor_name":"Peripheral Arterial Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/atvbaha.118.312128","doi":"https://doi.org/10.1161/atvbaha.118.312128","is_oa":true,"landing_page_url":"https://doi.org/10.1161/atvbaha.118.312128","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.312128","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:31070467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31070467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6531315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6531315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/atvbaha.118.312128","doi":"https://doi.org/10.1161/atvbaha.118.312128","is_oa":true,"landing_page_url":"https://doi.org/10.1161/atvbaha.118.312128","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.312128","source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1375804293","display_name":"EHR-based Genomic Discovery and Implementation","funder_award_id":"U01HG006379","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3840122606","display_name":"Patient-Oriented Research in Genomic Discovery and Implementation","funder_award_id":"K24HL137010","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2937597581.pdf","grobid_xml":"https://content.openalex.org/works/W2937597581.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W242743621","https://openalex.org/W1535834464","https://openalex.org/W1696693741","https://openalex.org/W1919257374","https://openalex.org/W1979421770","https://openalex.org/W1982640569","https://openalex.org/W1990204315","https://openalex.org/W2003829437","https://openalex.org/W2029182773","https://openalex.org/W2029874790","https://openalex.org/W2041300580","https://openalex.org/W2046801160","https://openalex.org/W2073487143","https://openalex.org/W2076766431","https://openalex.org/W2080695824","https://openalex.org/W2097572487","https://openalex.org/W2098146006","https://openalex.org/W2098230963","https://openalex.org/W2098460741","https://openalex.org/W2103441770","https://openalex.org/W2104304161","https://openalex.org/W2104549677","https://openalex.org/W2114560428","https://openalex.org/W2119180969","https://openalex.org/W2131094135","https://openalex.org/W2146704860","https://openalex.org/W2149147756","https://openalex.org/W2150291527","https://openalex.org/W2155766871","https://openalex.org/W2158206794","https://openalex.org/W2161633633","https://openalex.org/W2168133698","https://openalex.org/W2238851414","https://openalex.org/W2294667433","https://openalex.org/W2331834241","https://openalex.org/W2417483443","https://openalex.org/W2417793431","https://openalex.org/W2775393828"],"related_works":["https://openalex.org/W2757837292","https://openalex.org/W2029182773","https://openalex.org/W2753723653","https://openalex.org/W2075821102","https://openalex.org/W2959924472","https://openalex.org/W2146704860","https://openalex.org/W7098144502","https://openalex.org/W3202307311","https://openalex.org/W4388666128","https://openalex.org/W4391693866"],"abstract_inverted_index":{"Objective\u2014":[0],"It":[1],"is":[2],"unclear":[3],"to":[4,163,200],"what":[5],"extent":[6],"genetic":[7,119,210],"susceptibility":[8,211],"variants":[9,34,113,130,156],"are":[10,40],"shared":[11,209],"between":[12,212],"peripheral":[13],"artery":[14],"disease":[15,20],"(PAD)":[16],"and":[17,32,46,71,125,147,161,183,214],"coronary":[18],"heart":[19],"(CHD),":[21],"both":[22],"manifestations":[23],"of":[24,50,78,91,99,105,189,208],"atherosclerotic":[25],"vascular":[26],"disease.":[27],"We":[28,101],"investigated":[29],"whether":[30],"common":[31,106,155,198],"low-frequency/rare":[33,129],"in":[35,57,63,157],"loci":[36],"associated":[37,42,54,135,165,193,202],"with":[38,43,55,114,121,136,166,194,203],"CHD":[39,56,195,213],"also":[41],"PAD.":[44,100,215],"Approach":[45],"Results\u2014":[47],"Targeted":[48,187],"sequencing":[49,188],"41":[51,190],"genomic":[52,191],"regions":[53,192],"genome-wide":[58],"association":[59,104,145],"studies":[60],"was":[61],"performed":[62],"1749":[64],"PAD":[65,81,115,167],"cases":[66,82],"(65\u00b111":[67],"years,":[68,75],"61%":[69],"men)":[70,77],"1855":[72],"controls":[73,95],"(60\u00b111":[74],"56%":[76],"European":[79],"ancestry.":[80],"had":[83,96],"a":[84],"resting/postexercise":[85],"ankle-brachial":[86],"index":[87],"\u22640.9,":[88],"or":[89],"history":[90,98],"lower":[92],"extremity":[93],"revascularization;":[94],"no":[97],"tested":[102],"the":[103,174,177,206],"(defined":[107],"as":[108],"minor":[109],"allele":[110,132],"frequency":[111,133],"\u22655%)":[112],"assuming":[116],"an":[117],"additive":[118],"model":[120],"adjustment":[122],"for":[123,181],"age":[124],"sex.":[126],"To":[127],"identify":[128],"(minor":[131],"<5%)":[134],"PAD,":[137,204],"we":[138,153],"conducted":[139],"gene-level":[140],"analyses":[141],"using":[142],"sequence":[143],"kernel":[144],"test":[146],"permutation":[148],"test.":[149],"After":[150],"Bonferroni":[151],"correction,":[152],"found":[154],"SH2B3,":[158],"ABO":[159],",":[160],"ZEB2":[162],"be":[164,201],"(":[168],"P":[169],"<4.5\u00d710":[170],"\u22125":[171],").":[172],"At":[173],"gene":[175],"level,":[176],"strongest":[178],"associations":[179],"were":[180],"LPL":[182],"SH2B3":[184],".":[185],"Conclusions\u2014":[186],"revealed":[196],"several":[197],"variants/genes":[199],"highlighting":[205],"basis":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-25T00:00:00"}
