{"id":"https://openalex.org/W2937536041","doi":null,"title":"An\u00e1lise de citocinas no soro de pacientes com c\u00e2ncer g\u00e1strico","display_name":"An\u00e1lise de citocinas no soro de pacientes com c\u00e2ncer g\u00e1strico","publication_year":2017,"publication_date":"2017-08-16","ids":{"openalex":"https://openalex.org/W2937536041","mag":"2937536041"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:2593061","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFPA","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040344015","display_name":"Pedro Ant\u00f4nio Mufarrej Hage","orcid":"https://orcid.org/0009-0003-3103-975X","observed_orcids":["https://orcid.org/0009-0003-3103-975X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pedro Ant\u00f4nio Mufarrej Hage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040344015"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7699999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.9129999876022339},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/diffuse-type-gastric-cancer","display_name":"diffuse-type gastric cancer","score":0.765999972820282},{"id":"https://openalex.org/keywords/intestinal-type-gastric-cancer","display_name":"intestinal-type gastric cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7820000052452087},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9750000238418579},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6190000176429749},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.6740000247955322},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.703000009059906},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5429999828338623},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5907365083694458},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5088432431221008},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.43853840231895447},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42658448219299316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2424437403678894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23135992884635925},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20619559288024902}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:2593061","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFPA","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.ufpa.br:2011/10379","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379>.","pdf_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1 CD-ROM","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2937536041","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.ufpa.br/jspui/bitstream/2011/10379/1/Tese_AnaliseCitocinasSoro.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306497531","display_name":"1 CD-ROM","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"1 CD-ROM","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2593061","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufpa.br/jspui/handle/2011/10379","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFPA","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2937536041.pdf","grobid_xml":"https://content.openalex.org/works/W2937536041.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2004851435","https://openalex.org/W2043406057","https://openalex.org/W2549497115"],"related_works":["https://openalex.org/W4200567486","https://openalex.org/W7120530397","https://openalex.org/W1544164369","https://openalex.org/W6920456573","https://openalex.org/W7120479496","https://openalex.org/W4205380407","https://openalex.org/W2913953164","https://openalex.org/W2037016927","https://openalex.org/W3112741342","https://openalex.org/W4410473990"],"abstract_inverted_index":{"Apesar":[0],"da":[1,43,185,206],"redu\u00e7\u00e3o":[2],"na":[3],"incid\u00eancia":[4],"mundial":[5],"do":[6,72,117,196,293],"c\u00e2ncer":[7,20,252,287],"g\u00e1strico,":[8,253,288],"essa":[9],"neoplasia":[10],"continua":[11],"sendo":[12],"a":[13,92,98,204,214,227,244,255,299],"segunda":[14],"maior":[15,301],"causa":[16],"de":[17,31,36,57,64,76,81,94,102,124,133,156,173,187,221,234,257,286,311,317,330],"morte":[18],"por":[19],"no":[21,100,171,193,239,323],"mundo.":[22],"O":[23,61],"diagn\u00f3stico":[24,69],"tardio":[25],"ocorre,":[26],"principalmente,":[27],"devido":[28],"\u00e0":[29,34],"aus\u00eancia":[30],"sintomas":[32,37],"ou":[33],"presen\u00e7a":[35],"n\u00e3o":[38],"espec\u00edficos":[39],"nos":[40],"est\u00e1gios":[41],"iniciais":[42],"doen\u00e7a.":[44],"Nesse":[45],"caso,":[46],"poucas":[47],"op\u00e7\u00f5es":[48],"terap\u00eauticas":[49],"eficientes":[50],"est\u00e3o":[51],"dispon\u00edveis,":[52],"resultando":[53],"em":[54,199,210,304],"altas":[55],"taxas":[56],"morbidade":[58],"e":[59,74,108,130,149,169,191,218,237,247,281,289,321],"mortalidade.":[60],"estudo":[62],"cont\u00ednuo":[63],"novas":[65],"estrat\u00e9gias":[66],"para":[67,112,122],"o":[68,114,127,131,291],"precoce,":[70],"defini\u00e7\u00e3o":[71],"progn\u00f3stico":[73,331],"identifica\u00e7\u00e3o":[75],"novos":[77],"m\u00e9todos":[78],"terap\u00eauticos":[79],"\u00e9":[80],"grande":[82],"interesse":[83],"nesse":[84],"tipo":[85,197,294,307],"neopl\u00e1sico.":[86],"No":[87],"presente":[88],"estudo,":[89],"foi":[90,126,152,182,241,259],"realizada":[91],"quantifica\u00e7\u00e3o":[93,123],"prote\u00ednas":[95,125],"inflamat\u00f3rias":[96],"candidatas":[97],"biomarcadores":[99,134,285,329],"soro":[101,172,324],"19":[103],"pacientes":[104,146,174,250,333],"com":[105,147,175,213,243,251,262,334],"adenocarcinoma":[106,148,194,292],"g\u00e1strico":[107,195],"13":[109],"indiv\u00edduos":[110],"saud\u00e1veis":[111],"constituirem":[113],"grupo":[115,150],"controle":[116],"experimento.":[118],"A":[119,232,309],"metodologia":[120],"utilizada":[121],"sistema":[128],"MAGPIX":[129],"painel":[132],"Bio-Plex":[135],"Pro":[136],"Human":[137],"Pro-Cytokine,":[138],"Chemokine":[139],"and":[140],"Growth":[141],"Factors.":[142],"Na":[143],"compara\u00e7\u00e3o":[144],"entre":[145],"controle,":[151],"observado":[153,183],"n\u00edveis":[154,316],"elevados":[155,315],"IL-1\u03b2,IL-1RA,":[157],"IL-2,":[158],"IL-6,":[159],"IL-8,":[160,273],"IL-10,":[161,274,318],"IL12,":[162],"IL-15,":[163,276],"G-CSF,":[164,235,277,319],"GM-CSF,":[165],"IFN-\u03b3,":[166],"MIP1\u03b1,":[167,279],"RANTES":[168,280],"VEGF":[170,238,282,322],"adenocarcinoma.":[176],"Em":[177],"rela\u00e7\u00e3o":[178,200,305],"as":[179,268],"caracter\u00edsticas":[180],"clinicopatologicas,":[181],"aumento":[184],"express\u00e3o":[186,207],"IL-5,":[188],"IL-7,":[189],"IL-10":[190,258],"IL-17A":[192],"difuso":[198,295],"ao":[201,306],"intestinal.":[202,308],"Adicionalmente,":[203],"associa\u00e7\u00e3o":[205],"das":[208],"citocinas":[209,269],"tumores":[211],"g\u00e1stricos":[212],"sobrevida":[215,219,312],"global":[216],"(OS)":[217],"livre":[220],"reca\u00edda":[222],"(PFS)":[223],"foram":[224],"realizadas":[225],"usando":[226],"KM":[228],"Plotter":[229],"Online":[230],"Tool.":[231],"superexpress\u00e3o":[233,256],"GM-CSF":[236,320],"tumor":[240],"associado":[242],"menor":[245],"OS":[246],"PFS":[248],"dos":[249,332],"entretanto":[254],"associada":[260],"apenas":[261],"PFS.":[263],"Assim,":[264],"podemos":[265],"concluir":[266],"que":[267,290,314],"IL-1\u03b2,":[270],"IL-1RA,":[271],"IL-2,IL-6,":[272],"IL-12,":[275],"GM-CSF,IFN-\u03b3,":[278],"s\u00e3o":[283],"potenciais":[284],"pode":[296],"est\u00e1":[297],"relacionados":[298],"uma":[300],"resposta":[302],"inflamat\u00f3ria":[303],"an\u00e1lise":[310],"sugere":[313],"possam":[325],"ser":[326],"utilizados":[327],"como":[328],"c\u00e2ncerg\u00e1strico.":[335]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}