{"id":"https://openalex.org/W2937520639","doi":"https://doi.org/10.1200/cci.18.00091","title":"Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy","display_name":"Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy","publication_year":2019,"publication_date":"2019-04-19","ids":{"openalex":"https://openalex.org/W2937520639","doi":"https://doi.org/10.1200/cci.18.00091","mag":"2937520639","pmid":"https://pubmed.ncbi.nlm.nih.gov/31002563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6873985"},"language":"en","primary_location":{"id":"doi:10.1200/cci.18.00091","doi":"https://doi.org/10.1200/cci.18.00091","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.18.00091","pdf_url":null,"source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1200/cci.18.00091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062171182","display_name":"Eileen Huh Shinn","orcid":"https://orcid.org/0000-0002-3220-7423","observed_orcids":["https://orcid.org/0000-0002-3220-7423"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eileen H. Shinn","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015262975","display_name":"Gordon Broderick","orcid":"https://orcid.org/0000-0002-3588-8252","observed_orcids":["https://orcid.org/0000-0002-3588-8252"]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon Broderick","raw_affiliation_strings":["Rochester Institute of Technology, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester Institute of Technology, Rochester, NY","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080656521","display_name":"Bryan M. Fellman","orcid":"https://orcid.org/0000-0002-1810-5762","observed_orcids":["https://orcid.org/0000-0002-1810-5762"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Fellman","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085859297","display_name":"Ainslee Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ainslee Johnson","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066397614","display_name":"Elizabeth Wieland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Wieland","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102972148","display_name":"Stacy Moulder","orcid":"https://orcid.org/0000-0001-8890-7077","observed_orcids":["https://orcid.org/0000-0001-8890-7077"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy Moulder","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001315712","display_name":"W. Fraser Symmans","orcid":"https://orcid.org/0000-0002-1526-184X","observed_orcids":["https://orcid.org/0000-0002-1526-184X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Fraser Symmans","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062171182"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":2.6677,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88215273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"3","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/medication-non-adherence","display_name":"medication non-adherence","score":0.7730000019073486},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cost-concerns","display_name":"cost concerns","score":0.41499999165534973},{"id":"https://openalex.org/keywords/emotional-distress","display_name":"emotional distress","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bone-and-joint-pain","display_name":"bone and joint pain","score":0.9800000190734863},{"id":"https://openalex.org/keywords/computer-simulation","display_name":"computer simulation","score":0.3659999966621399},{"id":"https://openalex.org/keywords/oral-hormone-therapy","display_name":"oral hormone therapy","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8869761228561401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.78995680809021},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6397252678871155},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5670052170753479},{"id":"https://openalex.org/C2779978724","wikidata":"https://www.wikidata.org/wiki/Q1436482","display_name":"Worry","level":3,"score":0.4874849319458008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46889418363571167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41488149762153625},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35692131519317627},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3493070602416992},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.2089051902294159},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12499132752418518}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019538","descriptor_name":"Health Care Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1200/cci.18.00091","doi":"https://doi.org/10.1200/cci.18.00091","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.18.00091","pdf_url":null,"source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6873985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6873985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clin Cancer Inform","raw_type":"Text"},{"id":"pmid:31002563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31002563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO clinical cancer informatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1200/cci.18.00091","doi":"https://doi.org/10.1200/cci.18.00091","is_oa":true,"landing_page_url":"https://doi.org/10.1200/cci.18.00091","pdf_url":null,"source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4345935667","display_name":"Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer","funder_award_id":"R01DE019141","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1965996707","https://openalex.org/W1966624459","https://openalex.org/W1975236199","https://openalex.org/W2005734528","https://openalex.org/W2044702943","https://openalex.org/W2051069418","https://openalex.org/W2066440464","https://openalex.org/W2068577110","https://openalex.org/W2071003201","https://openalex.org/W2094362265","https://openalex.org/W2120521807","https://openalex.org/W2151447010","https://openalex.org/W2151984197","https://openalex.org/W2154835844","https://openalex.org/W2155655370","https://openalex.org/W2157279316","https://openalex.org/W2161977537"],"related_works":["https://openalex.org/W2910535245","https://openalex.org/W4309162418","https://openalex.org/W3138703501","https://openalex.org/W3170426587","https://openalex.org/W3118554446","https://openalex.org/W2586143047","https://openalex.org/W4285042285","https://openalex.org/W4375955601","https://openalex.org/W4417107525","https://openalex.org/W4383979676"],"abstract_inverted_index":{"PURPOSE:":[0],"Nearly":[1],"40%":[2],"of":[3,19,35,40,83,93,129,140,200,215,217,248,257],"patients":[4,95,116,135],"with":[5,38,44,197],"breast":[6,46],"cancer":[7,24,47],"discontinue":[8],"their":[9,141],"adjuvant":[10,50],"oral":[11],"endocrine":[12],"treatment":[13],"(ET).":[14],"We":[15,26,66],"measured":[16],"discontinuation":[17,39,158,163,216,223],"rates":[18],"ET":[20,51,123,152,172,231],"at":[21,62,164],"a":[22,68,225],"comprehensive":[23],"center.":[25],"then":[27],"used":[28],"an":[29,59,132],"iterative":[30],"approach":[31],"to":[32,57,85,105,162],"model":[33,70],"patterns":[34,199,214],"determinants":[36],"associated":[37],"ET.":[41,169,218,258],"METHODS:":[42],"Patients":[43],"nonmetastatic":[45],"receiving":[48],"active":[49],"were":[52,110,159,189],"approached":[53],"by":[54,71],"nurse":[55],"practitioners":[56],"complete":[58],"anonymous":[60],"survey":[61],"one":[63],"time":[64,81,166],"point.":[65],"simulated":[67],"prospective":[69],"iteratively":[72],"regressing":[73],"adverse":[74,153],"effects":[75,154],"onto":[76],"adherence":[77],"status":[78],"across":[79],"windowed":[80],"periods":[82],"2":[84],"3":[86],"consecutive":[87],"years,":[88],"bootstrapping":[89],"the":[90,98,113,125,190,229,254],"smaller":[91],"group":[92],"nonadherent":[94],"and":[96,131,155,182,184,235,245],"subsampling":[97],"larger":[99],"adherent":[100],"group.":[101],"RESULTS:":[102],"From":[103],"February":[104],"April":[106],"2013,":[107],"216":[108],"participants":[109],"enrolled":[111],"in":[112,253],"study.":[114],"Forty":[115],"(18.5%)":[117],"reported":[118],"that":[119,149,210],"they":[120],"had":[121],"discontinued":[122],"during":[124,168],"first":[126],"5":[127],"years":[128,256],"ET,":[130],"additional":[133],"four":[134],"(1.9%)":[136],"missed":[137],">":[138],"20%":[139],"doses.":[142],"Using":[143],"two-sided":[144],"significance":[145],"tests,":[146],"simulations":[147],"showed":[148],"all":[150],"13":[151],"reasons":[156,194,221],"for":[157,195,222],"significantly":[160],"related":[161],"some":[165,220],"point":[167],"Worry":[170],"about":[171],"cost":[173],"(odds":[174],"ratio":[175],"[OR],":[176],"1.79),":[177],"emotional":[178],"distress":[179],"(OR,":[180,187],"1.72),":[181],"bone":[183,234],"joint":[185,236],"pain":[186],"1.69)":[188],"three":[191],"most":[192],"impactful":[193],"discontinuation,":[196],"varying":[198,213],"influence":[201,227],"over":[202,228],"time.":[203],"CONCLUSION:":[204],"These":[205],"analyses":[206],"provide":[207],"preliminary":[208],"evidence":[209],"there":[211],"are":[212],"Although":[219],"exerted":[224],"steady":[226],"6-year":[230],"trajectory":[232],"(ie,":[233],"pain),":[237],"other":[238],"reasons,":[239],"such":[240],"as":[241],"cost,":[242],"cognitive":[243],"complaints,":[244],"general":[246],"dislike":[247],"pills,":[249],"became":[250],"more":[251],"important":[252],"later":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}
