{"id":"https://openalex.org/W2937210909","doi":"https://doi.org/10.1080/00397911.2019.1587775","title":"De novo consecutive chemo/regioselective IBX mediated oxidation of andrographolide and its derivatives","display_name":"De novo consecutive chemo/regioselective IBX mediated oxidation of andrographolide and its derivatives","publication_year":2019,"publication_date":"2019-04-16","ids":{"openalex":"https://openalex.org/W2937210909","doi":"https://doi.org/10.1080/00397911.2019.1587775","mag":"2937210909"},"language":"en","primary_location":{"id":"doi:10.1080/00397911.2019.1587775","doi":"https://doi.org/10.1080/00397911.2019.1587775","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00397911.2019.1587775","pdf_url":null,"source":{"id":"https://openalex.org/S114976158","display_name":"Synthetic Communications","issn_l":"0039-7911","issn":["0039-7911","1532-2432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023932007","display_name":"Sudhakar Mokenapelli","orcid":"https://orcid.org/0000-0001-9575-4830","observed_orcids":["https://orcid.org/0000-0001-9575-4830"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudhakar Mokenapelli","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040752583","display_name":"Madhu Gutam","orcid":"https://orcid.org/0000-0003-2963-566X","observed_orcids":["https://orcid.org/0000-0003-2963-566X"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhu Gutam","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053059154","display_name":"Ramana Govu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramana Govu","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063142104","display_name":"Vijay Kumar Pasala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijay Kumar Pasala","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109464580","display_name":"Jayaprakash Rao Yerrabelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jayaprakash Rao Yerrabelly","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103181396","display_name":"Prasad Rao Chitneni","orcid":"https://orcid.org/0000-0003-0062-9856","observed_orcids":["https://orcid.org/0000-0003-0062-9856"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Prasad Rao Chitneni","raw_affiliation_strings":["Natural Products Laboratory, Department of Chemistry, Osmania University","Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India"],"raw_orcid":"https://orcid.org/0000-0003-0062-9856","affiliations":[{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University","institution_ids":["https://openalex.org/I8975392"]},{"raw_affiliation_string":"Natural Products Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana State, India","institution_ids":["https://openalex.org/I8975392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103181396"],"corresponding_institution_ids":["https://openalex.org/I8975392"],"apc_list":null,"apc_paid":null,"fwci":0.6645,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70313534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"10","first_page":"1241","last_page":"1251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ibx-oxidation","display_name":"IBX oxidation","score":0.796999990940094},{"id":"https://openalex.org/keywords/regioselective-oxidation","display_name":"regioselective oxidation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chemoselective-oxidation","display_name":"chemoselective oxidation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/labdane-diterpenes","display_name":"labdane diterpenes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/andrographis-paniculata","display_name":"Andrographis paniculata","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2781357234","wikidata":"https://www.wikidata.org/wiki/Q4759444","display_name":"Andrographolide","level":2,"score":0.9955692887306213},{"id":"https://openalex.org/C2777970627","wikidata":"https://www.wikidata.org/wiki/Q1551608","display_name":"Andrographis paniculata","level":3,"score":0.9337000846862793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9201423525810242},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.8063058853149414},{"id":"https://openalex.org/C2778594897","wikidata":"https://www.wikidata.org/wiki/Q8214660","display_name":"Labdane","level":3,"score":0.6456522345542908},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.5977248549461365},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4603962302207947},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3904551863670349},{"id":"https://openalex.org/C2776710815","wikidata":"https://www.wikidata.org/wiki/Q59447","display_name":"Diterpene","level":2,"score":0.38842546939849854},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1534443199634552},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/00397911.2019.1587775","doi":"https://doi.org/10.1080/00397911.2019.1587775","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00397911.2019.1587775","pdf_url":null,"source":{"id":"https://openalex.org/S114976158","display_name":"Synthetic Communications","issn_l":"0039-7911","issn":["0039-7911","1532-2432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1499946374","https://openalex.org/W1551309927","https://openalex.org/W1963813223","https://openalex.org/W1966907522","https://openalex.org/W1967492443","https://openalex.org/W1968165784","https://openalex.org/W1970356319","https://openalex.org/W1973751723","https://openalex.org/W1986413411","https://openalex.org/W1992480863","https://openalex.org/W2004263474","https://openalex.org/W2015001994","https://openalex.org/W2015747821","https://openalex.org/W2035420565","https://openalex.org/W2038018133","https://openalex.org/W2042002595","https://openalex.org/W2052671216","https://openalex.org/W2056323898","https://openalex.org/W2057140242","https://openalex.org/W2057575288","https://openalex.org/W2057743317","https://openalex.org/W2070057708","https://openalex.org/W2073727079","https://openalex.org/W2081225089","https://openalex.org/W2091536194","https://openalex.org/W2102498134","https://openalex.org/W2109426473","https://openalex.org/W2133043485","https://openalex.org/W2150545191","https://openalex.org/W2153272646","https://openalex.org/W2161340765","https://openalex.org/W2340717611","https://openalex.org/W2749634635","https://openalex.org/W2950744081"],"related_works":["https://openalex.org/W2951252743","https://openalex.org/W2153272646","https://openalex.org/W2738503293","https://openalex.org/W6921157734","https://openalex.org/W4255894078","https://openalex.org/W2106620057","https://openalex.org/W2952667457","https://openalex.org/W2953118706","https://openalex.org/W2120286158","https://openalex.org/W2951211093"],"abstract_inverted_index":{"A":[0],"new":[1],"IBX":[2],"mediated":[3],"protocol":[4,26],"for":[5,45],"regio/chemoselective":[6],"oxidation":[7,47],"of":[8,24,48,67,74],"andrographolide":[9,28,52],"(1),":[10],"a":[11],"labdane":[12],"diterpenoid":[13],"isolated":[14],"from":[15],"Andrographis":[16],"paniculata,":[17],"is":[18],"developed.":[19],"After":[20],"the":[21,40,46],"initial":[22],"success":[23],"this":[25],"with":[27,71],"(1)":[29],"to":[30,69],"provide":[31],"19-dehydroandrographolide":[32],"(5)":[33],"or":[34],"3,19-didehydroandrographolide":[35],"(6)":[36],"as":[37],"major":[38],"products,":[39],"procedure":[41],"was":[42,62,81],"further":[43],"applied":[44],"hydroxyl":[49],"functionality":[50],"in":[51,76,85,89],"derivatives,":[53],"namely":[54],"2,":[55],"3,":[56],"14,":[57],"and":[58,79],"16.":[59],"The":[60],"process":[61],"equally":[63],"suitable":[64],"on":[65],"scales":[66],"milligram":[68],"gram":[70],"ease.":[72],"Deprotection":[73],"C-19-OTBDMS":[75],"compounds":[77],"15":[78],"18":[80],"achieved":[82],"using":[83],"TBDMS-Cl":[84],"acetonitrile-water":[86],"(8:2)":[87],"system":[88],"good":[90],"yields.":[91]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-25T00:00:00"}