{"id":"https://openalex.org/W2936810344","doi":"https://doi.org/10.1242/dev.166173","title":"Biologically inspired approaches to enhance human organoid complexity","display_name":"Biologically inspired approaches to enhance human organoid complexity","publication_year":2019,"publication_date":"2019-04-15","ids":{"openalex":"https://openalex.org/W2936810344","doi":"https://doi.org/10.1242/dev.166173","mag":"2936810344","pmid":"https://pubmed.ncbi.nlm.nih.gov/30992275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503984"},"language":"en","primary_location":{"id":"doi:10.1242/dev.166173","doi":"https://doi.org/10.1242/dev.166173","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.166173","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1242/dev.166173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077361437","display_name":"Emily M. Holloway","orcid":"https://orcid.org/0000-0001-9893-1265","observed_orcids":["https://orcid.org/0000-0001-9893-1265"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily M. Holloway","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035759204","display_name":"Meghan M. Capeling","orcid":"https://orcid.org/0000-0003-0310-123X","observed_orcids":["https://orcid.org/0000-0003-0310-123X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan M. Capeling","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040983764","display_name":"Jason R. Spence","orcid":"https://orcid.org/0000-0001-7869-3992","observed_orcids":["https://orcid.org/0000-0001-7869-3992"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason R. Spence","raw_affiliation_strings":["Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA","Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0001-7869-3992","affiliations":[{"raw_affiliation_string":"Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040983764"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":1.2521,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.75139147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"146","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4065000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-organoids","display_name":"human organoids","score":0.9599999785423279},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.7879999876022339},{"id":"https://openalex.org/keywords/organoid-transplantation","display_name":"organoid transplantation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/organ-regeneration","display_name":"organ regeneration","score":0.7120000123977661},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/organoid-models","display_name":"organoid models","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.973556637763977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9223654866218567},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4825372099876404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3336276710033417}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1242/dev.166173","doi":"https://doi.org/10.1242/dev.166173","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.166173","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6103356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503984","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6503984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503984","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:30992275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30992275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:146/8/dev166173","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/146/8/dev166173","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1242/dev.166173","doi":"https://doi.org/10.1242/dev.166173","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.166173","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1026775581","display_name":"Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center","funder_award_id":"U24DK085532","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1323858849","display_name":"University of Michigan Center for Gastrointestinal Research","funder_award_id":"P30DK034933","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3545555290","display_name":"Engineered human intestinal organoids: a modular system to model enteric disease","funder_award_id":"U19AI116482","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G36165910","display_name":"Control of progenitor cell maintenance and differentiation in the developing lung","funder_award_id":"R01HL119215","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4569188361","display_name":"Cellular Biotechnology Training Program (CBTP)","funder_award_id":"T32GM008353","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6007009154","display_name":null,"funder_award_id":"NIDDK DK094775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8395882484","display_name":"Intestinal Stem Cell Consortium Coordinating Center","funder_award_id":"U01DK085532","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8458705906","display_name":"Niche support of human intestinal stem cells","funder_award_id":"U01DK103141","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000872646","display_name":"Training in Basic and Translational Digestive Sciences","funder_award_id":"T32DK094775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000919722","display_name":"Cellular Biotechnology Training Program (CBTP) - Years 31-35","funder_award_id":"T32GM145304","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1409384233","https://openalex.org/W1483496013","https://openalex.org/W1496521029","https://openalex.org/W1601582416","https://openalex.org/W1802574002","https://openalex.org/W1910612799","https://openalex.org/W1931882100","https://openalex.org/W1979504798","https://openalex.org/W1980247655","https://openalex.org/W1981367331","https://openalex.org/W1985842788","https://openalex.org/W1987392926","https://openalex.org/W1987775184","https://openalex.org/W1996955003","https://openalex.org/W1999914688","https://openalex.org/W2000151960","https://openalex.org/W2002513358","https://openalex.org/W2017060663","https://openalex.org/W2018286352","https://openalex.org/W2020493895","https://openalex.org/W2020755558","https://openalex.org/W2025167083","https://openalex.org/W2030780423","https://openalex.org/W2031522785","https://openalex.org/W2034745491","https://openalex.org/W2045067641","https://openalex.org/W2052969143","https://openalex.org/W2054186703","https://openalex.org/W2055001415","https://openalex.org/W2060697891","https://openalex.org/W2073947789","https://openalex.org/W2074314696","https://openalex.org/W2078023729","https://openalex.org/W2078788648","https://openalex.org/W2081128785","https://openalex.org/W2082055798","https://openalex.org/W2085652695","https://openalex.org/W2085844606","https://openalex.org/W2086943348","https://openalex.org/W2089676626","https://openalex.org/W2093065606","https://openalex.org/W2116228354","https://openalex.org/W2119429325","https://openalex.org/W2120863421","https://openalex.org/W2122292170","https://openalex.org/W2125806967","https://openalex.org/W2130744572","https://openalex.org/W2132771789","https://openalex.org/W2136607014","https://openalex.org/W2138977668","https://openalex.org/W2139884694","https://openalex.org/W2143196592","https://openalex.org/W2143296478","https://openalex.org/W2151829259","https://openalex.org/W2152161931","https://openalex.org/W2155942576","https://openalex.org/W2156862506","https://openalex.org/W2160473148","https://openalex.org/W2162807448","https://openalex.org/W2164512616","https://openalex.org/W2166643977","https://openalex.org/W2170095671","https://openalex.org/W2176166968","https://openalex.org/W2193652497","https://openalex.org/W2195294260","https://openalex.org/W2209535620","https://openalex.org/W2261291226","https://openalex.org/W2264853099","https://openalex.org/W2280945597","https://openalex.org/W2307185071","https://openalex.org/W2311770845","https://openalex.org/W2327959547","https://openalex.org/W2341041396","https://openalex.org/W2345969966","https://openalex.org/W2416457568","https://openalex.org/W2490424988","https://openalex.org/W2508798274","https://openalex.org/W2509256481","https://openalex.org/W2510564348","https://openalex.org/W2520533178","https://openalex.org/W2525538087","https://openalex.org/W2527207446","https://openalex.org/W2528543174","https://openalex.org/W2531835077","https://openalex.org/W2549963625","https://openalex.org/W2552754421","https://openalex.org/W2566591223","https://openalex.org/W2567981910","https://openalex.org/W2568145394","https://openalex.org/W2580419078","https://openalex.org/W2587737921","https://openalex.org/W2592257382","https://openalex.org/W2593638094","https://openalex.org/W2593844681","https://openalex.org/W2597311576","https://openalex.org/W2598108133","https://openalex.org/W2598899113","https://openalex.org/W2599036809","https://openalex.org/W2603154743","https://openalex.org/W2605401453","https://openalex.org/W2609587333","https://openalex.org/W2609844460","https://openalex.org/W2610506730","https://openalex.org/W2610726090","https://openalex.org/W2612519453","https://openalex.org/W2617770907","https://openalex.org/W2620344213","https://openalex.org/W2620385663","https://openalex.org/W2626990934","https://openalex.org/W2645361946","https://openalex.org/W2706066070","https://openalex.org/W2732316774","https://openalex.org/W2741800270","https://openalex.org/W2744251510","https://openalex.org/W2761945803","https://openalex.org/W2766670989","https://openalex.org/W2766832099","https://openalex.org/W2766959028","https://openalex.org/W2769542972","https://openalex.org/W2769549586","https://openalex.org/W2769550043","https://openalex.org/W2772609750","https://openalex.org/W2772832977","https://openalex.org/W2773293509","https://openalex.org/W2780908039","https://openalex.org/W2788159447","https://openalex.org/W2791909710","https://openalex.org/W2792073521","https://openalex.org/W2792476159","https://openalex.org/W2792969305","https://openalex.org/W2793065417","https://openalex.org/W2793367223","https://openalex.org/W2793938961","https://openalex.org/W2799736418","https://openalex.org/W2802943395","https://openalex.org/W2803499747","https://openalex.org/W2803752338","https://openalex.org/W2805176058","https://openalex.org/W2805924527","https://openalex.org/W2809107133","https://openalex.org/W2809282651","https://openalex.org/W2885650843","https://openalex.org/W2885781100","https://openalex.org/W2886103315","https://openalex.org/W2890016264","https://openalex.org/W2890540126","https://openalex.org/W2890597376","https://openalex.org/W2892348456","https://openalex.org/W2894232765","https://openalex.org/W2896481903","https://openalex.org/W2903148550","https://openalex.org/W2904950674","https://openalex.org/W2905447079","https://openalex.org/W2909592500","https://openalex.org/W2916592801","https://openalex.org/W2949559283","https://openalex.org/W2949559557","https://openalex.org/W2953029274","https://openalex.org/W4213108508"],"related_works":["https://openalex.org/W7160875589","https://openalex.org/W7163923907","https://openalex.org/W3117494630","https://openalex.org/W2943279078","https://openalex.org/W4407903597","https://openalex.org/W4298086646","https://openalex.org/W4251173059","https://openalex.org/W3080246658","https://openalex.org/W3040646360","https://openalex.org/W4406949326"],"abstract_inverted_index":{"organ-like":[0],"model":[1],"systems.":[2,94],"Human":[3],"organoids,":[4],"which":[5],"are":[6],"derived":[7],"from":[8],"human":[9,15,26,63,75,103],"pluripotent":[10],"stem":[11,28],"cells":[12],"or":[13],"primary":[14],"donor":[16],"tissue,":[17],"have":[18],"been":[19],"used":[20],"to":[21,49,101,109],"address":[22],"fundamental":[23],"questions":[24],"about":[25],"development,":[27],"cell":[29],"biology":[30,64],"and":[31,45,65,79,107,118],"organ":[32,104],"regeneration.":[33],"Focus":[34],"has":[35,58,66],"now":[36],"shifted":[37],"towards":[38],"implementation":[39],"of":[40,74],"organoids":[41],"for":[42,88,92],"biological":[43],"discovery":[44],"advancing":[46],"existing":[47],"systems":[48],"more":[50,113],"faithfully":[51],"recapitulate":[52],"the":[53,71,81],"native":[54],"organ.":[55],"This":[56],"work":[57,84],"highlighted":[59],"significant":[60],"unknowns":[61],"in":[62,80],"invigorated":[67],"new":[68],"exploration":[69],"into":[70],"cellular":[72,105],"makeup":[73],"organs":[76],"during":[77],"development":[78],"adult":[82],"-":[83],"that":[85],"is":[86],"crucial":[87],"providing":[89],"appropriate":[90],"benchmarks":[91],"organoid":[93,111],"In":[95],"this":[96],"Review,":[97],"we":[98],"discuss":[99],"efforts":[100],"characterize":[102],"complexity":[106],"attempts":[108],"make":[110],"models":[112],"realistic":[114],"through":[115],"co-culture,":[116],"transplantation":[117],"bioengineering":[119],"approaches.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-25T00:00:00"}
