{"id":"https://openalex.org/W2936601462","doi":"https://doi.org/10.17235/reed.2019.5600/2018","title":"Validation of a population pharmacokinetic model of adalimumab in a cohort of patients with inflammatory bowel disease","display_name":"Validation of a population pharmacokinetic model of adalimumab in a cohort of patients with inflammatory bowel disease","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2936601462","doi":"https://doi.org/10.17235/reed.2019.5600/2018","mag":"2936601462","pmid":"https://pubmed.ncbi.nlm.nih.gov/31021170"},"language":"en","primary_location":{"id":"doi:10.17235/reed.2019.5600/2018","doi":"https://doi.org/10.17235/reed.2019.5600/2018","is_oa":false,"landing_page_url":"https://doi.org/10.17235/reed.2019.5600/2018","pdf_url":null,"source":{"id":"https://openalex.org/S33840552","display_name":"Revista Espa\u00f1ola de Enfermedades Digestivas","issn_l":"1130-0108","issn":["1130-0108","2340-4167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310322006","host_organization_name":"Ar\u00e1n Ediciones","host_organization_lineage":["https://openalex.org/P4310322006"],"host_organization_lineage_names":["Ar\u00e1n Ediciones"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Espa\u00f1ola de Enfermedades Digestivas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015768764","display_name":"Gregorio Juan Mart\u00ednez-Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gregorio J. Mart\u00ednez-Romero","raw_affiliation_strings":["Department of Pharmacy, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077755126","display_name":"A. Alvari\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Alvari\u00f1o","raw_affiliation_strings":["Laboratory Department,, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Department,, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110843977","display_name":"Esther Hinojosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Hinojosa","raw_affiliation_strings":["IBD Unit,, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit,, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109407084","display_name":"Mar\u00eda Mora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Mora","raw_affiliation_strings":["IBD Unit, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103921145","display_name":"Lorena Oltra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lorena Oltra","raw_affiliation_strings":["IBD Unit, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006341310","display_name":"Nuria Maroto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Maroto","raw_affiliation_strings":["IBD Unit, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009138858","display_name":"Isabel Ferrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Ferrer","raw_affiliation_strings":["IBD Unit, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011913306","display_name":"M.D. Hinojosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Dolores Hinojosa","raw_affiliation_strings":["IBD Unit, Hospital de Manises"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBD Unit, Hospital de Manises","institution_ids":["https://openalex.org/I4210122505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039571121","display_name":"Joaqu\u00edn Hinojosa","orcid":"https://orcid.org/0000-0002-2157-9328","observed_orcids":["https://orcid.org/0000-0002-2157-9328"]},"institutions":[{"id":"https://openalex.org/I4210122505","display_name":"Hospital de Manises","ror":"https://ror.org/0396mnx76","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122505"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaquin Ernesto Hinojosa","raw_affiliation_strings":["Servicio de Medicina Digestiva, Hospital de Manises, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Medicina Digestiva, Hospital de Manises, Espa\u00f1a","institution_ids":["https://openalex.org/I4210122505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210122505"],"apc_list":null,"apc_paid":null,"fwci":0.1821,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53706981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"111","issue":"6","first_page":"431","last_page":"436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.9279999732971191},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8529999852180481},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.8450000286102295},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.5960000157356262},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9411463737487793},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.8822498321533203},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.7283110618591309},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6631397604942322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6354133486747742},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6332485675811768},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.49732163548469543},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47800412774086},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3491289019584656},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33305293321609497},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3243306875228882},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.17235/reed.2019.5600/2018","doi":"https://doi.org/10.17235/reed.2019.5600/2018","is_oa":false,"landing_page_url":"https://doi.org/10.17235/reed.2019.5600/2018","pdf_url":null,"source":{"id":"https://openalex.org/S33840552","display_name":"Revista Espa\u00f1ola de Enfermedades Digestivas","issn_l":"1130-0108","issn":["1130-0108","2340-4167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310322006","host_organization_name":"Ar\u00e1n Ediciones","host_organization_lineage":["https://openalex.org/P4310322006"],"host_organization_lineage_names":["Ar\u00e1n Ediciones"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Espa\u00f1ola de Enfermedades Digestivas","raw_type":"journal-article"},{"id":"pmid:31021170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31021170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de enfermedades digestivas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W163800411","https://openalex.org/W850868591","https://openalex.org/W1561994144","https://openalex.org/W1575586478","https://openalex.org/W1602142879","https://openalex.org/W1940760407","https://openalex.org/W1969084658","https://openalex.org/W1984814995","https://openalex.org/W1992035731","https://openalex.org/W1994479450","https://openalex.org/W1995529175","https://openalex.org/W1996472975","https://openalex.org/W1997999969","https://openalex.org/W2000739170","https://openalex.org/W2003143162","https://openalex.org/W2003904406","https://openalex.org/W2009025779","https://openalex.org/W2022413885","https://openalex.org/W2030638161","https://openalex.org/W2034939253","https://openalex.org/W2044160586","https://openalex.org/W2065616659","https://openalex.org/W2076523377","https://openalex.org/W2085949689","https://openalex.org/W2088135039","https://openalex.org/W2092863985","https://openalex.org/W2117212747","https://openalex.org/W2118088660","https://openalex.org/W2118559127","https://openalex.org/W2131950421","https://openalex.org/W2134803931","https://openalex.org/W2147810684","https://openalex.org/W2152353173","https://openalex.org/W2153438195","https://openalex.org/W2171341132","https://openalex.org/W2290515360","https://openalex.org/W2410520654"],"related_works":["https://openalex.org/W3016351657","https://openalex.org/W4389100659","https://openalex.org/W7171725131","https://openalex.org/W3190443421","https://openalex.org/W3016770440","https://openalex.org/W3028274277","https://openalex.org/W2587400408","https://openalex.org/W2313378560","https://openalex.org/W2090475103","https://openalex.org/W4387744385"],"abstract_inverted_index":{"BACKGROUND:":[0],"therapeutic":[1,167],"monitoring":[2,169],"of":[3,20,23,28,37,44,100,127,136,176,179,185,206],"anti-TNF":[4,24],"drugs":[5],"and":[6,18,61,73,96,114,146,160,204],"anti-drug":[7],"antibody":[8],"levels":[9,77],"are":[10,195],"useful":[11],"for":[12,56,144,151,190],"clinical":[13],"decision-making,":[14],"via":[15],"the":[16,21,29,35,69,101,107,110,137,174,177,186,202,207],"rationalization":[17],"optimization":[19,175],"use":[22],"treatments.":[25],"The":[26,134,153,182],"objective":[27],"present":[30],"study":[31,66,81],"was":[32,53,62,103,139,155],"to":[33,67],"validate":[34],"model":[36,52,102,138,189],"Ternant":[38],"et":[39],"al.,":[40],"in":[41,64,192],"a":[42,125],"cohort":[43],"patients":[45,57,89,194],"with":[46,58],"inflammatory":[47],"bowel":[48],"diseases":[49],"(IBD).":[50],"This":[51],"originally":[54],"established":[55],"rheumatoid":[59],"arthritis":[60],"used":[63,82],"this":[65,80],"optimize":[68],"adalimumab":[70],"(ADA)":[71],"dose":[72],"predict":[74],"ADA":[75,92,129,191],"trough":[76],"(ATL).":[78],"METHODS:":[79],"concentration":[83,130],"data":[84],"points":[85,131],"from":[86],"30":[87],"IBD":[88,180,193],"who":[90],"received":[91],"treatment":[93,178],"between":[94,109],"2014":[95],"2015.":[97],"A":[98],"goodness-of-fit":[99],"determined":[104],"by":[105],"evaluating":[106],"relationship":[108],"observed":[111],"ATL":[112,171],"values":[113,117,122],"population":[115],"model-predicted":[116,121],"(PRED)":[118],"or":[119],"individual":[120],"(IPRED).":[123],"RESULTS:":[124],"total":[126],"51":[128],"were":[132],"analyzed.":[133],"bias":[135,203],"2.39":[140],"(95%":[141,148,157,162],"CI,":[142,149,158,163],"1.63-3.15)":[143],"PRED":[145],"0.63":[147],"0.23-1.03)":[150],"IPRED.":[152],"precision":[154,205],"3.57":[156],"2.90-4.13)":[159],"1.53":[161],"1.22-1.80),":[164],"respectively.":[165],"CONCLUSIONS:":[166],"drug":[168],"involving":[170],"may":[172],"allow":[173],"patients.":[181],"validation":[183],"results":[184],"phamacokinectic":[187],"(PK)":[188],"inadequate.":[196],"However,":[197],"additional":[198],"studies":[199],"will":[200],"strengthen":[201],"model.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-25T00:00:00"}