{"id":"https://openalex.org/W29364775","doi":null,"title":"Abstract 16203: Deletion of Foxp Repressors Induces Rapid-Onset Cardiomyopathy in Adult Mice","display_name":"Abstract 16203: Deletion of Foxp Repressors Induces Rapid-Onset Cardiomyopathy in Adult Mice","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W29364775","mag":"29364775"},"language":"en","primary_location":{"id":"mag:29364775","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.A16203","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084070627","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-9431-6457","observed_orcids":["https://orcid.org/0000-0002-9431-6457"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-9431-6457","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068463912","display_name":"Ann L. Chokas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann L. Chokas","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000966153","display_name":"Jeffrey Brandimarto","orcid":"https://orcid.org/0000-0002-9348-2349","observed_orcids":["https://orcid.org/0000-0002-9348-2349"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Brandimarto","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-9348-2349","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064809970","display_name":"Shanru Li","orcid":"https://orcid.org/0009-0009-7851-7468","observed_orcids":["https://orcid.org/0009-0009-7851-7468"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanru Li","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450821","display_name":"Xi Liu","orcid":"https://orcid.org/0000-0003-3142-7843","observed_orcids":["https://orcid.org/0000-0003-3142-7843"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Liu","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0003-3142-7843","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065670232","display_name":"Edward E. Morrisey","orcid":"https://orcid.org/0000-0001-5785-1939","observed_orcids":["https://orcid.org/0000-0001-5785-1939"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward E. Morrisey","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0001-5785-1939","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029333303","display_name":"Thomas P. Cappola","orcid":"https://orcid.org/0000-0002-9630-7204","observed_orcids":["https://orcid.org/0000-0002-9630-7204"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Cappola","raw_affiliation_strings":["Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-9630-7204","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.44359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.44359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2939000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp1","display_name":"FOXP1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/foxp4","display_name":"FOXP4","score":1.0},{"id":"https://openalex.org/keywords/forkhead-box-transcription-factors","display_name":"forkhead transcription factor","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.984000027179718},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.6629999876022339},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7722307443618774},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.7111998200416565},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.643240213394165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6326018571853638},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6091464161872864},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.603468656539917},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5966504812240601},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5259956121444702},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.485434353351593},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.4625034034252167},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4394177198410034},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4335038661956787},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.42247554659843445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4143914580345154},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3927454948425293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3824513554573059},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36988571286201477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27237749099731445},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24833351373672485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2301495373249054},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18601173162460327},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1342378854751587},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11511966586112976},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.10464426875114441}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:29364775","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.A16203","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G13955761","display_name":"Health-Promoting Effects of Positive Emotions","funder_award_id":"R01MH059615","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5008712400","display_name":"Affective and Genomic Mediators of Sustained Behavior Change","funder_award_id":"R01NR012899","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G5046266327","display_name":"Promoting Cancer-related Behavior Change through Positive Emotions (PQ4)","funder_award_id":"R01CA170128","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7063085986","display_name":"Nonconscious Affective and Physiological Mediators of Behavioral Decision Making","funder_award_id":"R01AT007884","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969661970","https://openalex.org/W2014543194","https://openalex.org/W2017524046","https://openalex.org/W2149500977","https://openalex.org/W2085193287","https://openalex.org/W2121169322","https://openalex.org/W2137654131","https://openalex.org/W2152504779","https://openalex.org/W2116160693","https://openalex.org/W4407114233"],"abstract_inverted_index":{"Transcriptomic":[0],"studies":[1,60],"in":[2,48,61,79,104,169],"the":[3,18,49,71,97,105],"human":[4],"and":[5,32,67,93,161],"murine":[6],"heart":[7,22,34,51,56,159],"have":[8],"demonstrated":[9],"that":[10,43,65],"forkhead":[11],"(FOX)":[12],"binding":[13],"motifs":[14],"are":[15,69,84],"enriched":[16],"within":[17],"promoters":[19],"of":[20,45,91,148,158],"regulated":[21],"failure":[23,35,160],"genes,":[24],"but":[25,153],"a":[26,162,167],"functional":[27],"link":[28],"between":[29],"FOX":[30,75],"repressors":[31],"adult":[33,50,106],"has":[36],"not":[37],"been":[38],"established.":[39],"Here":[40],"we":[41,95,132],"demonstrate":[42,64],"disruption":[44],"Foxp":[46],"signaling":[47],"is":[52],"sufficient":[53],"to":[54,86,100,125,135],"cause":[55],"failure.":[57],"Quantitative":[58],"RT-PCR":[59],"isolated":[62],"myocytes":[63],"Foxp1":[66],"Foxp4":[68],"among":[70],"most":[72],"highly":[73],"expressed":[74],"transcription":[76,88],"factors":[77,103],"(TFs)":[78],"myocytes.":[80],"As":[81],"these":[82],"TFs":[83],"known":[85],"repress":[87],"via":[89],"formation":[90],"homo-":[92],"hetero-dimers,":[94],"used":[96],"MerCreMer":[98],"system":[99],"delete":[101],"both":[102],"mouse":[107],"heart.":[108],"We":[109],"created":[110],"tamoxifen-":[111],"inducible":[112],"cardiac-specific":[113],"knockout":[114],"(KO)":[115],"mice":[116],"(alphaMHC-MerCreMer":[117],"het":[118,137],"/Foxp1":[119],"flox/flox":[120,122],"/Foxp4":[121],")":[123],"and,":[124],"account":[126],"for":[127],"potential":[128],"nonspecific":[129],"Cre-mediated":[130],"cardiotoxicity,":[131],"compared":[133],"them":[134],"alphaMHC-MerCreMer":[136],"controls.":[139],"After":[140],"treatment":[141],"with":[142],"intraperitoneal":[143],"tamoxifen":[144],"at":[145],"\u223c3":[146],"months":[147],"age,":[149],"controls":[150],"remained":[151],"normal,":[152],"KO":[154],"animals":[155],"developed":[156],"signs":[157],"profound":[163],"cardiomyopathy":[164],"characterized":[165],"by":[166],"drop":[168],"ejection":[170],"fraction":[171],"(KO":[172],"27":[173],"%":[174],"vs.":[175],"control":[176],"55%;":[177],"p":[178]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
