{"id":"https://openalex.org/W2935957448","doi":"https://doi.org/10.1155/2019/3264858","title":"The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NF\u03baB-Dependent Manner","display_name":"The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NF\u03baB-Dependent Manner","publication_year":2019,"publication_date":"2019-04-18","ids":{"openalex":"https://openalex.org/W2935957448","doi":"https://doi.org/10.1155/2019/3264858","mag":"2935957448","pmid":"https://pubmed.ncbi.nlm.nih.gov/31178956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6501210"},"language":"en","primary_location":{"id":"doi:10.1155/2019/3264858","doi":"https://doi.org/10.1155/2019/3264858","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3264858","pdf_url":"http://downloads.hindawi.com/journals/omcl/2019/3264858.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/omcl/2019/3264858.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083473276","display_name":"Valeska Helfinger","orcid":"https://orcid.org/0000-0002-7103-2144","observed_orcids":["https://orcid.org/0000-0002-7103-2144"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V. Helfinger","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084833632","display_name":"Katalin P\u00e1lfi","orcid":"https://orcid.org/0009-0002-8437-516X","observed_orcids":["https://orcid.org/0009-0002-8437-516X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Palfi","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032227105","display_name":"Andreas Weigert","orcid":"https://orcid.org/0000-0002-7529-1952","observed_orcids":["https://orcid.org/0000-0002-7529-1952"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Weigert","raw_affiliation_strings":["Institute for Biochemistry I, Goethe-University, Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7529-1952","affiliations":[{"raw_affiliation_string":"Institute for Biochemistry I, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013415164","display_name":"Katrin Schr\u00f6der","orcid":"https://orcid.org/0000-0002-3099-526X","observed_orcids":["https://orcid.org/0000-0002-3099-526X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"K. Schr\u00f6der","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3099-526X","affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013415164"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":2.981,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91881933,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.3637999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.3637999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.21549999713897705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.734000027179718},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.890999972820282},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9589999914169312},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.6890000104904175},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8029999732971191},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-marrow-derived-monocytes","display_name":"bone marrow-derived monocytes","score":0.859000027179718},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4959999918937683},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.8922072649002075},{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.8918828964233398},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.54768306016922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5227736830711365},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.47944942116737366},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4526415467262268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24288630485534668},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22842934727668762},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16298773884773254},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09949669241905212}],"mesh":[{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1155/2019/3264858","doi":"https://doi.org/10.1155/2019/3264858","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3264858","pdf_url":"http://downloads.hindawi.com/journals/omcl/2019/3264858.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5527643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6501210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6501210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6501210","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"},{"id":"pmid:31178956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31178956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8b1741d05ea64c3e9c617c2d3a067261","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8b1741d05ea64c3e9c617c2d3a067261","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)","raw_type":"article"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:50495","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hebis:30:3-504955","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2019/3264858","doi":"https://doi.org/10.1155/2019/3264858","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3264858","pdf_url":"http://downloads.hindawi.com/journals/omcl/2019/3264858.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1374194149","display_name":null,"funder_award_id":"SCHR 1241/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1462112011","display_name":null,"funder_award_id":"EXC2026","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"},{"id":"https://openalex.org/G2240698509","display_name":null,"funder_award_id":"SCHR1241/1-1","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"},{"id":"https://openalex.org/G3071976274","display_name":null,"funder_award_id":"SFB815/TP1","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"},{"id":"https://openalex.org/G3605224778","display_name":null,"funder_award_id":"SFB834/TPA2","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G3744262921","display_name":null,"funder_award_id":"SFB815/TP1","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G3853625243","display_name":"EXC 2026: CardioPulmonary Institute (CPI)","funder_award_id":"390649896","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4866575835","display_name":null,"funder_award_id":"SFB834/TPA2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G491379599","display_name":null,"funder_award_id":"SFB 815","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5477856110","display_name":null,"funder_award_id":"SFB815","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G551519423","display_name":null,"funder_award_id":"390649896","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"},{"id":"https://openalex.org/G590706412","display_name":null,"funder_award_id":"EXC 2026","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6121923423","display_name":null,"funder_award_id":"EXC 2026, Project ID: 390649896","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"},{"id":"https://openalex.org/G6419202740","display_name":null,"funder_award_id":"SFB,834","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6883002441","display_name":null,"funder_award_id":"390649896","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G7384480948","display_name":null,"funder_award_id":"SCHR1241/1-1","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G8107261377","display_name":null,"funder_award_id":"SFB815/TP1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G892208509","display_name":null,"funder_award_id":"SFB834","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G9000217389","display_name":null,"funder_award_id":"SFB834/TPA2","funder_id":"https://openalex.org/F4320331426","funder_display_name":"Cardio-Pulmonary Institute"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320331426","display_name":"Cardio-Pulmonary Institute","ror":"https://ror.org/04ckbty56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2935957448.pdf","grobid_xml":"https://content.openalex.org/works/W2935957448.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1484263832","https://openalex.org/W1525369521","https://openalex.org/W1975602384","https://openalex.org/W1987880652","https://openalex.org/W1991576776","https://openalex.org/W1994749115","https://openalex.org/W1998073026","https://openalex.org/W2019221616","https://openalex.org/W2027851837","https://openalex.org/W2036684796","https://openalex.org/W2041997633","https://openalex.org/W2044364749","https://openalex.org/W2070855360","https://openalex.org/W2081810806","https://openalex.org/W2085128107","https://openalex.org/W2100820895","https://openalex.org/W2109327697","https://openalex.org/W2122002245","https://openalex.org/W2128635872","https://openalex.org/W2140545013","https://openalex.org/W2147986625","https://openalex.org/W2150459982","https://openalex.org/W2159560463","https://openalex.org/W2196975609","https://openalex.org/W2319967189","https://openalex.org/W2499640845","https://openalex.org/W2751551260","https://openalex.org/W2777309068","https://openalex.org/W2783643850","https://openalex.org/W2783771244"],"related_works":["https://openalex.org/W2961781863","https://openalex.org/W2501174056","https://openalex.org/W985875736","https://openalex.org/W1004008661","https://openalex.org/W2109327697","https://openalex.org/W2561443930","https://openalex.org/W2102910971","https://openalex.org/W2127596141","https://openalex.org/W1576159916","https://openalex.org/W2131634572"],"abstract_inverted_index":{"The":[0],"family":[1,24],"of":[2,9,22,39,65,87,97,114,130,187,210,222,253],"NADPH":[3],"oxidases":[4],"represents":[5],"an":[6,217,237],"important":[7],"source":[8],"reactive":[10],"oxygen":[11],"species":[12],"(ROS)":[13],"within":[14],"the":[15,42,66,109,112,131,179,184,208,220,227,230],"cell.":[16],"Nox4":[17,70,93,103,144,169,205,241,244],"is":[18,41,71,75],"a":[19,84,105,200],"special":[20],"member":[21],"this":[23,140,234],"as":[25],"it":[26],"constitutively":[27],"produces":[28],"H2O2":[29],"and":[30,59,111,149,158,174,213,251],"its":[31],"loss":[32],"promotes":[33,175],"inflammation.":[34],"A":[35],"major":[36],"cellular":[37],"component":[38],"inflammation":[40],"macrophage":[43],"population,":[44],"which":[45],"can":[46],"be":[47],"divided":[48],"into":[49,133],"several":[50],"subpopulations":[51],"depending":[52],"on":[53],"their":[54],"phenotype,":[55],"with":[56,123,178],"proinflammatory":[57,211,223],"M(LPS+IFN\u03b3)":[58,134],"wound-healing":[60],"M(IL4+IL13)":[61,136,147,249],"macrophages":[62,74,82,154,225],"being":[63,181],"extremes":[64],"functional":[67],"spectrum.":[68],"Whether":[69],"expressed":[72],"in":[73,107,128,189,197,199,219,226,233,242,247,256],"discussed":[76],"controversially.":[77],"Here,":[78],"we":[79,100],"show":[80],"that":[81,102],"besides":[83],"high":[85],"level":[86,186],"Nox2":[88,157,188],"indeed":[89],"express":[90,155],"Nox4.":[91],"As":[92],"contributes":[94],"to":[95,194],"differentiation":[96],"many":[98],"cells,":[99],"hypothesize":[101],"plays":[104],"role":[106,239],"determining":[108],"polarization":[110,129,148,250],"phenotype":[113],"macrophages.":[115,167,192,243],"In":[116,139],"bone":[117],"marrow-derived":[118],"monocytes,":[119],"ex":[120,141],"vivo":[121,142],"treatment":[122],"LPS/IFN\u03b3":[124],"or":[125,135],"IL4/IL13":[126],"results":[127,246],"cells":[132],"macrophages,":[137],"respectively.":[138],"setting,":[143],"deficiency":[145,170,206,245],"reduces":[146,171],"forces":[150,207],"M(LPS+IFN\u03b3).":[151],"Nox4-/-":[152],"M(LPS+IFN\u03b3)-polarized":[153,166,191],"more":[156,160],"produce":[159],"superoxide":[161],"anions":[162],"than":[163],"wild":[164],"type":[165],"Mechanistically,":[168],"STAT6":[172],"activation":[173],"NF\u03baB":[176,254],"activity,":[177],"latter":[180],"responsible":[182],"for":[183,240],"higher":[185],"Nox4-deficient":[190],"According":[193],"those":[195],"findings,":[196],"vivo,":[198],"murine":[201],"inflammation-driven":[202],"fibrosarcoma":[203],"model,":[204],"expression":[209],"genes":[212],"cytokines,":[214],"accompanied":[215],"by":[216],"increase":[218],"number":[221],"Ly6C+":[224],"tumors.":[228],"Collectively,":[229],"data":[231],"obtained":[232],"study":[235],"suggest":[236],"anti-inflammatory":[238],"less":[248],"suppression":[252],"activity":[255],"monocytes.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-25T00:00:00"}
