{"id":"https://openalex.org/W2935898552","doi":"https://doi.org/10.3389/fimmu.2019.00829","title":"Antigen Extraction and B Cell Activation Enable Identification of Rare Membrane Antigen Specific Human B Cells","display_name":"Antigen Extraction and B Cell Activation Enable Identification of Rare Membrane Antigen Specific Human B Cells","publication_year":2019,"publication_date":"2019-04-16","ids":{"openalex":"https://openalex.org/W2935898552","doi":"https://doi.org/10.3389/fimmu.2019.00829","mag":"2935898552","pmid":"https://pubmed.ncbi.nlm.nih.gov/31040853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477023"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.00829","doi":"https://doi.org/10.3389/fimmu.2019.00829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00829","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00829/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00829/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maria Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria Zimmermann","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090410012","display_name":"Natalie Rose","orcid":"https://orcid.org/0000-0001-5102-4385","observed_orcids":["https://orcid.org/0000-0001-5102-4385"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Natalie Rose","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020794095","display_name":"John M. Lindner","orcid":"https://orcid.org/0000-0002-4940-5354","observed_orcids":["https://orcid.org/0000-0002-4940-5354"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"John M. Lindner","raw_affiliation_strings":["BioMed X Innovation Center, Heidelberg, Germany","Novartis Institute for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Innovation Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]},{"raw_affiliation_string":"Novartis Institute for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643036","display_name":"Hye-In Kim","orcid":"https://orcid.org/0000-0002-0314-1445","observed_orcids":["https://orcid.org/0000-0002-0314-1445"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hyein Kim","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021172421","display_name":"Ana Rita Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-7893-0158","observed_orcids":["https://orcid.org/0000-0002-7893-0158"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ana Rita Gon\u00e7alves","raw_affiliation_strings":["Laboratory of Virology, Geneva University Hospitals, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Geneva University Hospitals, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036375045","display_name":"Ilaria Callegari","orcid":"https://orcid.org/0000-0003-3361-3084","observed_orcids":["https://orcid.org/0000-0003-3361-3084"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Callegari","raw_affiliation_strings":["Neuroscience Consortium, Monza Policlinico and Pavia Mondino, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Consortium, Monza Policlinico and Pavia Mondino, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069760348","display_name":"Mohammedyaseen Syedbasha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mohammedyaseen Syedbasha","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102774964","display_name":"Lukas Kaufmann","orcid":"https://orcid.org/0000-0001-8218-7486","observed_orcids":["https://orcid.org/0000-0001-8218-7486"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Kaufmann","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053893299","display_name":"Adrian Egli","orcid":"https://orcid.org/0000-0002-3564-8603","observed_orcids":["https://orcid.org/0000-0002-3564-8603"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian Egli","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","Division of Clinical Microbiology, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Clinical Microbiology, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073096423","display_name":"Raija L.P. Lindberg","orcid":"https://orcid.org/0000-0003-3349-314X","observed_orcids":["https://orcid.org/0000-0003-3349-314X"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Raija L. P. Lindberg","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054874316","display_name":"Ludwig Kappos","orcid":"https://orcid.org/0000-0003-4175-5509","observed_orcids":["https://orcid.org/0000-0003-4175-5509"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ludwig Kappos","raw_affiliation_strings":["Departments of Medicine, Neurologic Clinic and Policlinic, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Neurologic Clinic and Policlinic, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075331092","display_name":"Elisabetta Traggiai","orcid":"https://orcid.org/0000-0002-0616-6285","observed_orcids":["https://orcid.org/0000-0002-0616-6285"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elisabetta Traggiai","raw_affiliation_strings":["Novartis Institute for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072901113","display_name":"Nicholas Sanderson","orcid":"https://orcid.org/0000-0003-1711-7275","observed_orcids":["https://orcid.org/0000-0003-1711-7275"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Nicholas S. R. Sanderson","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071466585","display_name":"Tobias J Derfuss","orcid":"https://orcid.org/0000-0001-8656-4250","observed_orcids":["https://orcid.org/0000-0001-8656-4250","https://orcid.org/0000-0001-8431-8769"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Tobias Derfuss","raw_affiliation_strings":["Department of Medicine, Neurologic Clinic and Policlinic, University Hospital and University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Neurologic Clinic and Policlinic, University Hospital and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071466585","https://openalex.org/A5072901113"],"corresponding_institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2601,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.7645941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"829","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen-extraction","display_name":"antigen extraction","score":0.824999988079071},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.984000027179718},{"id":"https://openalex.org/keywords/antigen-capture","display_name":"antigen capture","score":0.37400001287460327},{"id":"https://openalex.org/keywords/influenza-hemagglutinin","display_name":"influenza hemagglutinin","score":0.824999988079071},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"acetylcholine receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myasthenia-gravis","display_name":"myasthenia gravis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/monoclonal-antibody-production","display_name":"monoclonal antibody production","score":0.6019999980926514},{"id":"https://openalex.org/keywords/bioorthogonal-labeling","display_name":"bioorthogonal labeling","score":0.7549999952316284},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.4309999942779541},{"id":"https://openalex.org/keywords/antibody-neutralization","display_name":"antibody neutralization","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7335277199745178},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.5830157995223999},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.5467749834060669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5269924998283386},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.5022413730621338},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49595436453819275},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48274773359298706},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.476885586977005},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4612419009208679},{"id":"https://openalex.org/C2781053203","wikidata":"https://www.wikidata.org/wiki/Q1660182","display_name":"Immunomagnetic separation","level":2,"score":0.4253711700439453},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3750273883342743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34751784801483154},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32013678550720215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22885537147521973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1574416160583496},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.12261146306991577},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.1067037582397461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09105053544044495},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2019.00829","doi":"https://doi.org/10.3389/fimmu.2019.00829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00829","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00829/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:31040853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31040853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6477023","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6477023/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:unige.ch:unige:144558","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:144558","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1664-3224","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4c179b6d186f45d4ae31dab86489f891","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4c179b6d186f45d4ae31dab86489f891","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:unige.ch:aou:unige:144558","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:144558","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, vol. 10 (2019) 829","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.00829","doi":"https://doi.org/10.3389/fimmu.2019.00829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00829","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00829/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1846846128","display_name":"Identification and characterisation of autoreactive B cells in multiple sclerosis","funder_award_id":"149966","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2328874201","display_name":"B cells and antibodies in autoimmune CNS diseases","funder_award_id":"169674","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310466","display_name":"Universit\u00e4t Basel","ror":"https://ror.org/02s6k3f65"},{"id":"https://openalex.org/F4320316261","display_name":"Universit\u00e4tsspital Basel","ror":"https://ror.org/04k51q396"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320324842","display_name":"Neuromuscular Research Association Basel","ror":"https://ror.org/04b6xpy41"},{"id":"https://openalex.org/F4320325166","display_name":"Schweizerische Multiple Sklerose Gesellschaft","ror":"https://ror.org/015zgf178"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2935898552.pdf","grobid_xml":"https://content.openalex.org/works/W2935898552.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W820588856","https://openalex.org/W1666706706","https://openalex.org/W1979552897","https://openalex.org/W1983090571","https://openalex.org/W1989544708","https://openalex.org/W2019206924","https://openalex.org/W2022615852","https://openalex.org/W2023841575","https://openalex.org/W2029232806","https://openalex.org/W2039239800","https://openalex.org/W2055195337","https://openalex.org/W2061056490","https://openalex.org/W2072608359","https://openalex.org/W2072974935","https://openalex.org/W2087293737","https://openalex.org/W2088143327","https://openalex.org/W2111470622","https://openalex.org/W2118166534","https://openalex.org/W2119779320","https://openalex.org/W2122023348","https://openalex.org/W2129973151","https://openalex.org/W2144422858","https://openalex.org/W2154666710","https://openalex.org/W2155112931","https://openalex.org/W2160578795","https://openalex.org/W2166559731","https://openalex.org/W2510979876","https://openalex.org/W2560099569","https://openalex.org/W2571533957","https://openalex.org/W2734512809","https://openalex.org/W2766021298","https://openalex.org/W2769734033","https://openalex.org/W2884166686","https://openalex.org/W2915529594"],"related_works":["https://openalex.org/W2041078707","https://openalex.org/W2072765827","https://openalex.org/W6962833902","https://openalex.org/W1983295948","https://openalex.org/W2013628100","https://openalex.org/W2000176299","https://openalex.org/W1739708574","https://openalex.org/W4400737515","https://openalex.org/W2077644183","https://openalex.org/W2571533957"],"abstract_inverted_index":{"Determining":[0],"antigen":[1,53],"specificity":[2],"is":[3,163],"vital":[4],"for":[5,11,22,178],"understanding":[6],"B":[7,24,44,62,94,109,112,145,169],"cell":[8,45,63,159],"biology":[9],"and":[10,46,61,78,104,126,128,131,137,174],"producing":[12],"human":[13,119],"monoclonal":[14],"antibodies.":[15],"We":[16,65],"describe":[17],"here":[18],"a":[19,43,73,86],"powerful":[20],"method":[21,68],"identifying":[23],"cells":[25,95,100,113,146,170],"that":[26],"recognize":[27],"membrane":[28,56,76,88,180],"antigens":[29],"expressed":[30,121],"on":[31,36,158],"cells.":[32,110],"The":[33,90,161],"technique":[34,91],"depends":[35],"two":[37],"characteristics":[38],"of":[39,52,57],"the":[40,55,58,67,156],"interaction":[41],"between":[42],"an":[47],"antigen-expressing":[48],"cell:":[49],"antigen-receptor-mediated":[50],"extraction":[51],"from":[54,117,143,148],"target":[59],"cell,":[60],"activation.":[64],"developed":[66],"using":[69,81],"influenza":[70],"hemagglutinin":[71],"as":[72,85],"model":[74,87],"viral":[75,139],"antigen,":[77,103],"tested":[79],"it":[80],"acetylcholine":[82],"receptor":[83,157],"(AChR)":[84],"autoantigen.":[89],"involves":[92],"co-culturing":[93],"with":[96,150],"adherent,":[97],"bioorthogonally":[98],"labeled":[99],"expressing":[101],"GFP-tagged":[102],"sorting":[105],"GFP-capturing,":[106],"newly":[107],"activated":[108],"Hemagglutinin-specific":[111],"isolated":[114],"this":[115],"way":[116],"vaccinated":[118],"donors":[120],"elevated":[122],"CD20,":[123],"CD27,":[124],"CD71,":[125],"CD11c,":[127],"reduced":[129],"CD21,":[130],"their":[132],"secreted":[133],"antibodies":[134],"blocked":[135],"hemagglutination":[136],"neutralized":[138],"infection.":[140],"Antibodies":[141],"cloned":[142],"AChR-capturing":[144],"derived":[147],"patients":[149],"myasthenia":[151],"gravis":[152],"bound":[153],"specifically":[154],"to":[155,166],"membrane.":[160],"approach":[162],"sensitive":[164],"enough":[165],"detect":[167],"antigen-specific":[168],"at":[171],"steady":[172],"state,":[173],"can":[175],"be":[176],"adapted":[177],"any":[179],"antigen.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-25T00:00:00"}
