{"id":"https://openalex.org/W2935830237","doi":"https://doi.org/10.1016/j.tiv.2019.04.011","title":"Development of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitro RhCE and BCOP test methods","display_name":"Development of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitro RhCE and BCOP test methods","publication_year":2019,"publication_date":"2019-04-11","ids":{"openalex":"https://openalex.org/W2935830237","doi":"https://doi.org/10.1016/j.tiv.2019.04.011","mag":"2935830237","pmid":"https://pubmed.ncbi.nlm.nih.gov/30981694"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2019.04.011","doi":"https://doi.org/10.1016/j.tiv.2019.04.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2019.04.011","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023026500","display_name":"Nathalie Al\u00e9p\u00e9e","orcid":"https://orcid.org/0000-0002-2181-4308","observed_orcids":["https://orcid.org/0000-0002-2181-4308"]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Al\u00e9p\u00e9e","raw_affiliation_strings":["L'Or\u00e9al Research & Innovation, Aulnay Sous Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al Research & Innovation, Aulnay Sous Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061601297","display_name":"Els Adriaens","orcid":"https://orcid.org/0000-0001-5108-5321","observed_orcids":["https://orcid.org/0000-0001-5108-5321"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. Adriaens","raw_affiliation_strings":["Adriaens Consulting, Aalter, Belgium. Electronic address: adriaens.consulting@telenet.be","Adriaens Consulting, Aalter, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adriaens Consulting, Aalter, Belgium. Electronic address: adriaens.consulting@telenet.be","institution_ids":[]},{"raw_affiliation_string":"Adriaens Consulting, Aalter, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005936159","display_name":"Takayuki Abo","orcid":"https://orcid.org/0000-0003-2414-8408","observed_orcids":["https://orcid.org/0000-0003-2414-8408"]},"institutions":[{"id":"https://openalex.org/I207623266","display_name":"Kao Corporation (Japan)","ror":"https://ror.org/016t1kc57","country_code":"JP","type":"company","lineage":["https://openalex.org/I207623266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Abo","raw_affiliation_strings":["Kao Corporation, Safety Science Research, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kao Corporation, Safety Science Research, Kanagawa, Japan","institution_ids":["https://openalex.org/I207623266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110802053","display_name":"D.M. Bagley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135004","display_name":"Colgate-Palmolive (United States)","ror":"https://ror.org/03q50jp21","country_code":"US","type":"company","lineage":["https://openalex.org/I4210135004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Bagley","raw_affiliation_strings":["Colgate-Palmolive Co., Piscataway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colgate-Palmolive Co., Piscataway, NJ, USA","institution_ids":["https://openalex.org/I4210135004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044004983","display_name":"Bertrand Desprez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117215","display_name":"Cosmetics Europe","ror":"https://ror.org/02errzw26","country_code":"BE","type":"other","lineage":["https://openalex.org/I4210117215"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"B. Desprez","raw_affiliation_strings":["Cosmetics Europe - The Personal Care Association, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmetics Europe - The Personal Care Association, Brussels, Belgium","institution_ids":["https://openalex.org/I4210117215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081649322","display_name":"Jalila Hibatallah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Hibatallah","raw_affiliation_strings":["Chanel Parfums Beaut\u00e9, Neuilly sur Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chanel Parfums Beaut\u00e9, Neuilly sur Seine, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078710727","display_name":"Karsten R\u00fcdiger Mewes","orcid":"https://orcid.org/0000-0003-3924-0792","observed_orcids":["https://orcid.org/0000-0003-3924-0792"]},"institutions":[{"id":"https://openalex.org/I71187865","display_name":"Henkel (Germany)","ror":"https://ror.org/0526cz443","country_code":"DE","type":"company","lineage":["https://openalex.org/I71187865"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Mewes","raw_affiliation_strings":["Henkel AG & Co. KGaA, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henkel AG & Co. KGaA, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I71187865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047018693","display_name":"Uwe Pfannenbecker","orcid":"https://orcid.org/0000-0002-8072-824X","observed_orcids":["https://orcid.org/0000-0002-8072-824X"]},"institutions":[{"id":"https://openalex.org/I106618798","display_name":"Beiersdorf (Germany)","ror":"https://ror.org/04aqg9s78","country_code":"DE","type":"company","lineage":["https://openalex.org/I106618798"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Pfannenbecker","raw_affiliation_strings":["Beiersdorf AG, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beiersdorf AG, Hamburg, Germany","institution_ids":["https://openalex.org/I106618798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023093661","display_name":"\u00c0lvar Sala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131047","display_name":"Kao Corporation (Spain)","ror":"https://ror.org/03826h192","country_code":"ES","type":"company","lineage":["https://openalex.org/I207623266","https://openalex.org/I4210131047"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c0. Sala","raw_affiliation_strings":["Kao Corporation, S.A., Barcelona, Spain; HP Inc., Barcelona, Spain","HP Inc., Barcelona, Spain","Kao Corporation, S.A., Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kao Corporation, S.A., Barcelona, Spain; HP Inc., Barcelona, Spain","institution_ids":["https://openalex.org/I4210131047"]},{"raw_affiliation_string":"HP Inc., Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Kao Corporation, S.A., Barcelona, Spain","institution_ids":["https://openalex.org/I4210131047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062239666","display_name":"An R. Van Rompay","orcid":"https://orcid.org/0000-0001-7636-858X","observed_orcids":["https://orcid.org/0000-0001-7636-858X"]},"institutions":[{"id":"https://openalex.org/I68522396","display_name":"Flemish Institute for Technological Research","ror":"https://ror.org/04gq0w522","country_code":"BE","type":"facility","lineage":["https://openalex.org/I68522396"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A.R. Van Rompay","raw_affiliation_strings":["VITO NV (Flemish Institute for Technological Research), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VITO NV (Flemish Institute for Technological Research), Mol, Belgium","institution_ids":["https://openalex.org/I68522396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037976364","display_name":"Sandra Verstraelen","orcid":"https://orcid.org/0000-0003-0529-8208","observed_orcids":["https://orcid.org/0000-0003-0529-8208"]},"institutions":[{"id":"https://openalex.org/I68522396","display_name":"Flemish Institute for Technological Research","ror":"https://ror.org/04gq0w522","country_code":"BE","type":"facility","lineage":["https://openalex.org/I68522396"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. Verstraelen","raw_affiliation_strings":["VITO NV (Flemish Institute for Technological Research), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VITO NV (Flemish Institute for Technological Research), Mol, Belgium","institution_ids":["https://openalex.org/I68522396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103461206","display_name":"Pauline M. McNamee","orcid":"https://orcid.org/0000-0002-3655-7287","observed_orcids":["https://orcid.org/0000-0002-3655-7287"]},"institutions":[{"id":"https://openalex.org/I4210115918","display_name":"Procter & Gamble (United Kingdom)","ror":"https://ror.org/02a8cv967","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210115918","https://openalex.org/I74680897"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. McNamee","raw_affiliation_strings":["The Procter & Gamble Company, Egham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Procter & Gamble Company, Egham, United Kingdom","institution_ids":["https://openalex.org/I4210115918"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5061601297"],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":6.7429,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.97464096,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"59","issue":null,"first_page":"100","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.621999979019165},{"id":"https://openalex.org/keywords/in-vitro-methods","display_name":"in vitro methods","score":0.5720000267028809},{"id":"https://openalex.org/keywords/rhce","display_name":"RHCE","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bottom-up-approach","display_name":"bottom-up approach","score":0.652999997138977},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cosmetics","display_name":"cosmetics","score":0.4699999988079071},{"id":"https://openalex.org/keywords/draize-eye-test","display_name":"Draize eye test","score":0.5600000023841858},{"id":"https://openalex.org/keywords/chemical-classification","display_name":"chemical classification","score":0.42800000309944153},{"id":"https://openalex.org/keywords/assay-sensitivity-and-specificity","display_name":"assay sensitivity and specificity","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2994251472","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Eye irritation","level":3,"score":0.9582661390304565},{"id":"https://openalex.org/C2779717098","wikidata":"https://www.wikidata.org/wiki/Q131207","display_name":"Cosmetics","level":2,"score":0.869744062423706},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5849323868751526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4866262376308441},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4196542203426361},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41504979133605957},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35326671600341797},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3336431384086609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2280554175376892},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11994999647140503},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11863559484481812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10799053311347961},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000826","descriptor_name":"Animal Testing Alternatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003318","descriptor_name":"Corneal Opacity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003358","descriptor_name":"Cosmetics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2019.04.011","doi":"https://doi.org/10.1016/j.tiv.2019.04.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2019.04.011","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:30981694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30981694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W11829256","https://openalex.org/W1272700117","https://openalex.org/W1983787440","https://openalex.org/W2007440314","https://openalex.org/W2009661740","https://openalex.org/W2010904703","https://openalex.org/W2032931324","https://openalex.org/W2034451386","https://openalex.org/W2063859424","https://openalex.org/W2073981243","https://openalex.org/W2077858580","https://openalex.org/W2095247301","https://openalex.org/W2154396544","https://openalex.org/W2159141432","https://openalex.org/W2174123198","https://openalex.org/W2282375668","https://openalex.org/W2298970340","https://openalex.org/W2307755049","https://openalex.org/W2312796503","https://openalex.org/W2405127917","https://openalex.org/W2524479041","https://openalex.org/W2526193113","https://openalex.org/W2539793540","https://openalex.org/W2582743722","https://openalex.org/W2618708415","https://openalex.org/W2625213653","https://openalex.org/W2725992204","https://openalex.org/W2727874871","https://openalex.org/W2733783278","https://openalex.org/W2757762157","https://openalex.org/W2791381924","https://openalex.org/W2891898845","https://openalex.org/W2915384151","https://openalex.org/W4206256483","https://openalex.org/W4233056853","https://openalex.org/W4236357078","https://openalex.org/W4242432827","https://openalex.org/W6698160565"],"related_works":["https://openalex.org/W2915384151","https://openalex.org/W4253208692","https://openalex.org/W2725992204","https://openalex.org/W3037191156","https://openalex.org/W2757762157","https://openalex.org/W4236357078","https://openalex.org/W2981759265","https://openalex.org/W4248176500","https://openalex.org/W2618708415","https://openalex.org/W6944399512"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}
