{"id":"https://openalex.org/W2935307698","doi":"https://doi.org/10.1111/aas.13366","title":"Optimal cut\u2010off for hourly lactate reduction in ICU\u2010treated patients with septic shock","display_name":"Optimal cut\u2010off for hourly lactate reduction in ICU\u2010treated patients with septic shock","publication_year":2019,"publication_date":"2019-04-02","ids":{"openalex":"https://openalex.org/W2935307698","doi":"https://doi.org/10.1111/aas.13366","mag":"2935307698","pmid":"https://pubmed.ncbi.nlm.nih.gov/30937900"},"language":"en","primary_location":{"id":"doi:10.1111/aas.13366","doi":"https://doi.org/10.1111/aas.13366","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aas.13366","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049901433","display_name":"Panuwat Promsin","orcid":"https://orcid.org/0000-0001-8922-7145","observed_orcids":["https://orcid.org/0000-0001-8922-7145"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE","TH"],"is_corresponding":true,"raw_author_name":"Panuwat Promsin","raw_affiliation_strings":["Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"],"raw_orcid":"https://orcid.org/0000-0001-8922-7145","affiliations":[{"raw_affiliation_string":"Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084263346","display_name":"Jonathan Grip","orcid":"https://orcid.org/0000-0001-9735-4160","observed_orcids":["https://orcid.org/0000-0001-9735-4160"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonathan Grip","raw_affiliation_strings":["Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9735-4160","affiliations":[{"raw_affiliation_string":"Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042028544","display_name":"\u00c5ke Norberg","orcid":"https://orcid.org/0000-0002-3776-1570","observed_orcids":["https://orcid.org/0000-0002-3776-1570"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5ke Norberg","raw_affiliation_strings":["Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3776-1570","affiliations":[{"raw_affiliation_string":"Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074556836","display_name":"Jan Wernerman","orcid":"https://orcid.org/0000-0003-1343-7773","observed_orcids":["https://orcid.org/0000-0003-1343-7773"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Wernerman","raw_affiliation_strings":["Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1343-7773","affiliations":[{"raw_affiliation_string":"Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082522987","display_name":"Olav Rooyackers","orcid":"https://orcid.org/0000-0002-3391-5448","observed_orcids":["https://orcid.org/0000-0002-3391-5448"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olav Rooyackers","raw_affiliation_strings":["Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3391-5448","affiliations":[{"raw_affiliation_string":"Division of Anaesthesia and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Perioperative Medicine and Intensive Care, B31 Karolinska University Hospital Huddinge, Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049901433"],"corresponding_institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158","https://openalex.org/I28166907"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.2968,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78966295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"63","issue":"7","first_page":"885","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":1.0},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7200000286102295},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vasopressors","display_name":"vasopressors","score":0.777999997138977},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.4090000092983246},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5770000219345093},{"id":"https://openalex.org/keywords/saps-iii","display_name":"SAPS 3","score":0.5690000057220459},{"id":"https://openalex.org/keywords/prognostic-cutoff-values","display_name":"prognostic cutoff values","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9205456376075745},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.8215363025665283},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5572872757911682},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5308172702789307},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5226540565490723},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4967356324195862},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.4847280979156494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.459033727645874},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3330262303352356},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3299879729747772},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32936057448387146},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.3152692914009094}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/aas.13366","doi":"https://doi.org/10.1111/aas.13366","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aas.13366","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:30937900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30937900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anaesthesiologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1531196479","https://openalex.org/W1973367652","https://openalex.org/W1980784335","https://openalex.org/W2016808620","https://openalex.org/W2053214870","https://openalex.org/W2057350807","https://openalex.org/W2067677232","https://openalex.org/W2068316060","https://openalex.org/W2134909543","https://openalex.org/W2151237184","https://openalex.org/W2151426785","https://openalex.org/W2152154097","https://openalex.org/W2158623850","https://openalex.org/W2164334584","https://openalex.org/W2170973852","https://openalex.org/W2198824178","https://openalex.org/W2268913206","https://openalex.org/W2280404143","https://openalex.org/W2294908710","https://openalex.org/W2312229227","https://openalex.org/W2314067895","https://openalex.org/W2322368960","https://openalex.org/W2463979167","https://openalex.org/W2516982490","https://openalex.org/W2529528719","https://openalex.org/W2532342231","https://openalex.org/W2589049887","https://openalex.org/W2617595617","https://openalex.org/W2740134957","https://openalex.org/W2763751618","https://openalex.org/W2766407462","https://openalex.org/W2799592883","https://openalex.org/W2801360758","https://openalex.org/W3016555942","https://openalex.org/W4254170669"],"related_works":["https://openalex.org/W1973367652","https://openalex.org/W2974933839","https://openalex.org/W190132753","https://openalex.org/W2160476049","https://openalex.org/W7128545992","https://openalex.org/W4402645753","https://openalex.org/W2031160744","https://openalex.org/W2463979167","https://openalex.org/W2346451074","https://openalex.org/W2054778140"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,66],"decrease":[2],"in":[3,28,57,62,241],"lactate":[4,50,80,95,102,110,151,172,194,222],"concentration":[5],"over":[6],"time":[7,26],"during":[8,23,131],"septic":[9,58,70,242],"shock":[10,59,71,243],"is":[11,31,43,52],"associated":[12,233],"with":[13,77,170,234],"favourable":[14],"outcomes.":[15],"However,":[16],"if":[17],"this":[18,36,213],"applies":[19],"to":[20,39,54,74],"hourly":[21,46,91],"intervals":[22],"the":[24,29,63,75,164,225],"initial":[25,79],"period":[27],"ICU":[30,76,122,129,230],"unknown.":[32],"The":[33,116,145],"aim":[34],"of":[35,49,68,94,109,149,183,208,221,229,238],"study":[37],"was":[38,87,97,124,143,232],"investigate":[40],"whether":[41],"there":[42],"an":[44,78,235],"early":[45],"reduction":[47,92,219],"rate":[48,93,139,220],"that":[51,190],"related":[53],"clinical":[55],"outcome":[56],"patients":[60,72,135,165],"treated":[61],"ICU.":[64],"METHODS:":[65],"cohort":[67],"adult":[69],"admitted":[73],"level":[81],">2":[82],"mmol/L":[83,159,175,196],"and":[84,152,160,176,197],"receiving":[85],"vasopressor":[86],"retrospectively":[88],"analysed.":[89],"Mean":[90],"(\u0394Lact/h)":[96],"calculated":[98],"individually":[99],"from":[100,105],"all":[101],"concentrations":[103],"measured":[104],"inclusion":[106],"until":[107],"normalization":[108],"(\u22641.5":[111],"mmol/L)":[112],"within":[113,224],"24":[114,227],"hours.":[115],"mortality":[117,156,240],"at":[118,140],"30":[119,141],"days":[120,142],"following":[121],"admission":[123],"evaluated.":[125],"RESULTS:":[126],"Among":[127],"1405":[128],"admissions":[130],"2":[132],"years,":[133],"104":[134],"were":[136,157,204],"eligible.":[137],"Mortality":[138],"34%.":[144],"optimal":[146],"cut-off":[147],"values":[148],"baseline":[150,171,193],"\u0394Lact/h":[153,177,191],"for":[154],"30-day":[155,209,239],"4":[158,174],"2.5%/h.":[161],"When":[162],"stratifying":[163],"by":[166],"these":[167],"cut-points,":[168],"those":[169],">":[173],"<":[178],"2.5%/h":[179],"had":[180],"lowest":[181],"probability":[182],"survival":[184],"(27%).":[185],"Multivariable":[186],"logistic":[187],"regression":[188],"showed":[189],"<2.5%/h,":[192],">4":[195],"high":[198],"Simplified":[199],"Acute":[200],"Physiology":[201],"Score":[202],"III":[203],"independent":[205],"risk":[206,237],"factors":[207],"mortality.":[210],"CONCLUSIONS:":[211],"In":[212],"retrospective":[214],"pilot":[215],"cohort,":[216],"a":[217],"mean":[218],"<2.5%/h":[223],"first":[226],"hours":[228],"stay":[231],"increased":[236],"patients.":[244]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-11T00:00:00"}