{"id":"https://openalex.org/W2934688564","doi":"https://doi.org/10.1124/dmd.119.086637","title":"Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity","display_name":"Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity","publication_year":2019,"publication_date":"2019-03-28","ids":{"openalex":"https://openalex.org/W2934688564","doi":"https://doi.org/10.1124/dmd.119.086637","mag":"2934688564","pmid":"https://pubmed.ncbi.nlm.nih.gov/30918015","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6505377"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.119.086637","doi":"https://doi.org/10.1124/dmd.119.086637","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.119.086637","pdf_url":"https://dmd.aspetjournals.org/content/dmd/47/6/574.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://dmd.aspetjournals.org/content/dmd/47/6/574.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100459045","display_name":"Yujie Chen","orcid":"https://orcid.org/0000-0003-0666-5874","observed_orcids":["https://orcid.org/0000-0003-0666-5874"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yu-Jie Chen","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409851","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0001-5106-1397","observed_orcids":["https://orcid.org/0000-0001-5106-1397"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping-Ping Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ping-Ping Zhu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112123704","display_name":"Tan Xian-wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xian-Wen Tan","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044305129","display_name":"Qiu-Hong Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qiu-Hong Lin","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100688152","display_name":"Wenxia Wang","orcid":"https://orcid.org/0000-0003-4681-8783","observed_orcids":["https://orcid.org/0000-0003-4681-8783","https://orcid.org/0000-0003-0007-3333"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wen-Xia Wang","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shan-Shan Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shan-Shan Yin","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086845885","display_name":"Ling-Zhi Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ling-Zhi Gao","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036071031","display_name":"Mingming Su","orcid":"https://orcid.org/0000-0002-9996-9094","observed_orcids":["https://orcid.org/0000-0002-9996-9094"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ming-Ming Su","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077854313","display_name":"Changxiao Liu","orcid":"https://orcid.org/0000-0003-3034-2522","observed_orcids":["https://orcid.org/0000-0003-3034-2522"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chang-Xiao Liu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062029066","display_name":"Liang Xu","orcid":"https://orcid.org/0000-0003-0384-9547","observed_orcids":["https://orcid.org/0000-0003-0384-9547"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Liang Xu","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wei Jia","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023772959","display_name":"Irina F. Sevrioukova","orcid":"https://orcid.org/0000-0002-4498-6057","observed_orcids":["https://orcid.org/0000-0002-4498-6057"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Irina F. Sevrioukova","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) sevrioui@uci.edu","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) sevrioui@uci.edu","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080461662","display_name":"Ke Lan","orcid":"https://orcid.org/0000-0002-9237-9219","observed_orcids":["https://orcid.org/0000-0002-9237-9219"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]},{"id":"https://openalex.org/I4391767783","display_name":"State Key Laboratory of Pharmacokinetics and Drug Delivery Technology","ror":"https://ror.org/04g1mec21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ke Lan","raw_affiliation_strings":["Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) lanwoco@scu.edu.cn","Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)"],"raw_orcid":"https://orcid.org/0000-0002-9237-9219","affiliations":[{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.); Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.) lanwoco@scu.edu.cn","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I24185976","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, People's Republic of China (S.-S.Y., K.L.)","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California (I.F.S.)","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China (Y.-J.C., J.Z., P.-P.Z., X.-W.T., Q.-H.L., W.W., S.-S.Y., L.-Z.G., L.X., K.L.)","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.)","institution_ids":["https://openalex.org/I4390039246"]},{"raw_affiliation_string":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China (C.-X.L.)","institution_ids":["https://openalex.org/I4210105139","https://openalex.org/I4391767783"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.0177,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93378447,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"47","issue":"6","first_page":"574","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deoxycholate","display_name":"deoxycholate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cyp3a7","display_name":"CYP3A7","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stereoselective-oxidation","display_name":"stereoselective oxidation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.6480000019073486},{"id":"https://openalex.org/keywords/secondary-bile-acids","display_name":"secondary bile acids","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hill-kinetics","display_name":"Hill kinetics","score":0.7450000047683716},{"id":"https://openalex.org/keywords/critical-micelle-concentration","display_name":"critical micelle concentration","score":0.8080000281333923},{"id":"https://openalex.org/keywords/testosterone-6beta-hydroxylation","display_name":"testosterone 6beta-hydroxylation","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C11824378","wikidata":"https://www.wikidata.org/wiki/Q5014970","display_name":"CYP3A","level":4,"score":0.8517217040061951},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8046554923057556},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.7976791858673096},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7049412727355957},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.6600854992866516},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6195782423019409},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.6174207329750061},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5679637789726257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.496737539768219},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.1106700599193573}],"mesh":[{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1124/dmd.119.086637","doi":"https://doi.org/10.1124/dmd.119.086637","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.119.086637","pdf_url":"https://dmd.aspetjournals.org/content/dmd/47/6/574.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6505377","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6505377","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metab Dispos","raw_type":"Text"},{"id":"pmid:30918015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30918015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1124/dmd.119.086637","doi":"https://doi.org/10.1124/dmd.119.086637","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.119.086637","pdf_url":"https://dmd.aspetjournals.org/content/dmd/47/6/574.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000907736","display_name":"Toxicological importance of CYP3A4 catalysis and inhibition","funder_award_id":"R01ES025767","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2934688564.pdf","grobid_xml":"https://content.openalex.org/works/W2934688564.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1532212858","https://openalex.org/W1581885355","https://openalex.org/W1951469402","https://openalex.org/W1965859062","https://openalex.org/W1985137868","https://openalex.org/W1992475241","https://openalex.org/W1996041024","https://openalex.org/W2005289090","https://openalex.org/W2026250153","https://openalex.org/W2030181584","https://openalex.org/W2034424913","https://openalex.org/W2041685866","https://openalex.org/W2043455776","https://openalex.org/W2052406081","https://openalex.org/W2056096245","https://openalex.org/W2058215178","https://openalex.org/W2071273298","https://openalex.org/W2076336531","https://openalex.org/W2086874119","https://openalex.org/W2095046636","https://openalex.org/W2096580672","https://openalex.org/W2106515170","https://openalex.org/W2111668019","https://openalex.org/W2116418471","https://openalex.org/W2123326503","https://openalex.org/W2135285043","https://openalex.org/W2136904160","https://openalex.org/W2137472574","https://openalex.org/W2155268095","https://openalex.org/W2165811356","https://openalex.org/W2295763822","https://openalex.org/W2316224242","https://openalex.org/W2322012164","https://openalex.org/W2622674337","https://openalex.org/W2727103189","https://openalex.org/W2764310005","https://openalex.org/W2766401019","https://openalex.org/W2774699186","https://openalex.org/W2808494948","https://openalex.org/W2908014754","https://openalex.org/W4406976184"],"related_works":["https://openalex.org/W2908014754","https://openalex.org/W3134384301","https://openalex.org/W4389132952","https://openalex.org/W2467485523","https://openalex.org/W3011147288","https://openalex.org/W7211952116","https://openalex.org/W2082196885","https://openalex.org/W2764310005","https://openalex.org/W1980300504","https://openalex.org/W2043209699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-11T00:00:00"}
