{"id":"https://openalex.org/W2934487545","doi":"https://doi.org/10.1002/tkm2.1215","title":"Hainosan (painongsan) suppresses the biofilm formation of Porphyromonas gingivalis and Prevotella intermedia in vitro","display_name":"Hainosan (painongsan) suppresses the biofilm formation of Porphyromonas gingivalis and Prevotella intermedia in vitro","publication_year":2019,"publication_date":"2019-04-04","ids":{"openalex":"https://openalex.org/W2934487545","doi":"https://doi.org/10.1002/tkm2.1215","mag":"2934487545"},"language":"en","primary_location":{"id":"doi:10.1002/tkm2.1215","doi":"https://doi.org/10.1002/tkm2.1215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.1215","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055354099","display_name":"Masaaki Minami","orcid":"https://orcid.org/0000-0001-7651-9077","observed_orcids":["https://orcid.org/0000-0001-7651-9077"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaaki Minami","raw_affiliation_strings":["Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7651-9077","affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084495215","display_name":"Hiroshi Takase","orcid":"https://orcid.org/0000-0003-2025-9952","observed_orcids":["https://orcid.org/0000-0003-2025-9952"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takase","raw_affiliation_strings":["Core Laboratory, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Laboratory, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084541097","display_name":"Masayo Taira","orcid":"https://orcid.org/0000-0002-4299-589X","observed_orcids":["https://orcid.org/0000-0002-4299-589X"]},"institutions":[{"id":"https://openalex.org/I4405252779","display_name":"Pharmaceutical Society of Japan","ror":"https://ror.org/01rvyj653","country_code":"JP","type":"other","lineage":["https://openalex.org/I4405252779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayo Taira","raw_affiliation_strings":["JPS Pharmaceutical Co. Ltd., Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JPS Pharmaceutical Co. Ltd., Yokohama, Japan","institution_ids":["https://openalex.org/I4405252779"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035998238","display_name":"Toshiaki Makino","orcid":"https://orcid.org/0000-0002-2524-8745","observed_orcids":["https://orcid.org/0000-0002-2524-8745"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Makino","raw_affiliation_strings":["Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055354099"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":0.9885,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7434291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"2","first_page":"79","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.949999988079071},{"id":"https://openalex.org/keywords/prevotella-intermedia","display_name":"Prevotella intermedia","score":1.0},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.847000002861023},{"id":"https://openalex.org/keywords/antibiofilm-activity","display_name":"antibiofilm activity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.7799999713897705},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hangeshashinto","display_name":"Hangeshashinto","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2776895894","wikidata":"https://www.wikidata.org/wiki/Q2022791","display_name":"Prevotella intermedia","level":4,"score":0.9914299845695496},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.9756028652191162},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8240450024604797},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7767952680587769},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6465730667114258},{"id":"https://openalex.org/C2780423288","wikidata":"https://www.wikidata.org/wiki/Q7242440","display_name":"Prevotella","level":3,"score":0.5158711671829224},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.4765254259109497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4570915102958679},{"id":"https://openalex.org/C2779626144","wikidata":"https://www.wikidata.org/wiki/Q403356","display_name":"Kampo","level":3,"score":0.4479920566082001},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.43931344151496887},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3319700360298157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2729019224643707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25177162885665894},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.1550869643688202},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07439112663269043},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/tkm2.1215","doi":"https://doi.org/10.1002/tkm2.1215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.1215","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1541294208","https://openalex.org/W1606638691","https://openalex.org/W1891787316","https://openalex.org/W1964237148","https://openalex.org/W1980837323","https://openalex.org/W1998617363","https://openalex.org/W2021838232","https://openalex.org/W2026184332","https://openalex.org/W2040014098","https://openalex.org/W2042111787","https://openalex.org/W2043302685","https://openalex.org/W2045264957","https://openalex.org/W2052215327","https://openalex.org/W2061727521","https://openalex.org/W2065651343","https://openalex.org/W2075578034","https://openalex.org/W2077145977","https://openalex.org/W2111806749","https://openalex.org/W2124578957","https://openalex.org/W2130351384","https://openalex.org/W2140779147","https://openalex.org/W2147183704","https://openalex.org/W2162347423","https://openalex.org/W2172738006","https://openalex.org/W2178494121","https://openalex.org/W2330557543","https://openalex.org/W2340070207","https://openalex.org/W2607072530","https://openalex.org/W2794856115"],"related_works":["https://openalex.org/W2944963700","https://openalex.org/W3040447235","https://openalex.org/W4319021147","https://openalex.org/W4385550730","https://openalex.org/W4206284855","https://openalex.org/W4409185518","https://openalex.org/W4377084972","https://openalex.org/W2147183704","https://openalex.org/W4406094984","https://openalex.org/W4385602933"],"abstract_inverted_index":{"ABSTRACT":[0],"Aim":[1],"Porphyromonas":[2,75,114,128,139,193],"gingivalis":[3,76,115,129,140,194],"and":[4,39,48,77,83,93,102,104,116,130,135,141,147,156,195],"Prevotella":[5,78,117,131,142,196],"intermedia":[6,143],"are":[7],"pathogenic":[8],"bacteria":[9],"that":[10],"cause":[11],"several":[12],"periodontal":[13],"diseases":[14],"such":[15,26,66],"as":[16,27,67],"periodontitis.":[17],"They":[18],"frequently":[19],"form":[20],"biofilm":[21,126,205],"to":[22,45,59],"protect":[23],"from":[24,127],"threats":[25],"antimicrobial":[28],"agents.":[29],"Hainosan":[30],"(painongsan":[31],"in":[32],"Chinese)":[33],"is":[34],"a":[35],"Japanese":[36,175],"traditional":[37,40,176],"kampo":[38,177],"Chinese":[41],"medicine":[42,178],"formula":[43,179],"used":[44],"treat":[46],"acute":[47],"chronic":[49],"purulent":[50],"disease.":[51],"The":[52,81,133],"aim":[53],"of":[54,63,70,86,113,125,137,158,166,172,192,200,203],"the":[55,61,111,123,152,159,190,201],"present":[56],"study":[57],"was":[58,88],"elucidate":[60],"mechanism":[62],"antibacterial":[64,82,164],"effects":[65,165],"anti\u2010biofilm":[68,84],"activity,":[69],"hainosan":[71],"extract":[72],"(HNS)":[73],"against":[74],"intermedia.":[79,118,132],"Methods":[80],"activity":[85],"HNS":[87,108,150,167,185],"examined":[89],"on":[90],"bacterial":[91,153,160,204],"turbidity":[92],"colony\u2010forming":[94],"unit":[95],"analysis,":[96,101],"transmission":[97],"electron":[98],"microscopy,":[99],"microplate":[100],"hydrophobicity":[103,157],"auto\u2010aggregation":[105],"analysis.":[106],"Results":[107],"significantly":[109,121,145],"suppressed":[110],"growth":[112],"It":[119],"also":[120],"inhibited":[122],"formation":[124],"size":[134],"shape":[136],"HNS\u2010treated":[138],"were":[144,168],"smaller":[146],"irregular.":[148],"Furthermore,":[149],"reduced":[151],"auto":[154],"aggregation":[155],"cell":[161],"surface.":[162],"These":[163],"greater":[169],"than":[170],"those":[171],"hangeshashinto,":[173],"another":[174],"for":[180,189],"oral":[181],"cavity":[182],"inflammation.":[183],"Conclusion":[184],"may":[186],"be":[187],"useful":[188],"treatment":[191],"intermedia\u2010induced":[197],"periodontitis":[198],"because":[199],"inhibition":[202],"formation.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-11T00:00:00"}
