{"id":"https://openalex.org/W2934480116","doi":null,"title":"eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma.","display_name":"eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2934480116","mag":"2934480116","pmid":"https://pubmed.ncbi.nlm.nih.gov/27904670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126312"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5126312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034187972","display_name":"Fei Xue","orcid":"https://orcid.org/0000-0002-8896-8192","observed_orcids":["https://orcid.org/0000-0002-8896-8192"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Xue","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanhui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhui Liu","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068593706","display_name":"Haoyuan Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyuan Chu","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101931699","display_name":"Yu Wen","orcid":"https://orcid.org/0000-0002-4413-2115","observed_orcids":["https://orcid.org/0000-0002-4413-2115"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wen","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103965525","display_name":"Lei Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Yan","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026462731","display_name":"Qiang Tang","orcid":"https://orcid.org/0000-0001-5489-3690","observed_orcids":["https://orcid.org/0000-0001-5489-3690"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Tang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112376410","display_name":"Erhui Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erhui Xiao","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024505007","display_name":"Dongyi Zhang","orcid":"https://orcid.org/0009-0000-3811-0510","observed_orcids":["https://orcid.org/0009-0000-3811-0510"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyi Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100397264","display_name":"Hongwei Zhang","orcid":"https://orcid.org/0000-0002-9971-4518","observed_orcids":["https://orcid.org/0000-0002-9971-4518"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital Zhengzhou, PR China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.411,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89442538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"11","first_page":"4670","last_page":"4681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif5a2","display_name":"EIF5A2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gc7","display_name":"GC7","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8859999775886536},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.5519999861717224},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9530327320098877},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.678122341632843},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6667337417602539},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6023126840591431},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4399715065956116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3542364835739136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3231412172317505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2575976252555847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2364613115787506},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1334170699119568},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09410250186920166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.049881428480148315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5126312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:27904670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27904670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2934480116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27904670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5126312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W303348942","https://openalex.org/W1544786964","https://openalex.org/W1967748192","https://openalex.org/W1971837077","https://openalex.org/W1980696888","https://openalex.org/W1985569200","https://openalex.org/W1994193851","https://openalex.org/W1996935355","https://openalex.org/W2001472847","https://openalex.org/W2015109149","https://openalex.org/W2020509813","https://openalex.org/W2023836157","https://openalex.org/W2041788377","https://openalex.org/W2049093430","https://openalex.org/W2077833543","https://openalex.org/W2087690112","https://openalex.org/W2102723674","https://openalex.org/W2103351853","https://openalex.org/W2116657176","https://openalex.org/W2136121728","https://openalex.org/W2155933329","https://openalex.org/W2159183306","https://openalex.org/W2163403599","https://openalex.org/W2331091476","https://openalex.org/W4245403358"],"related_works":["https://openalex.org/W2769828730","https://openalex.org/W1989911225","https://openalex.org/W2015109149","https://openalex.org/W2465841147","https://openalex.org/W1966020729","https://openalex.org/W2133129337","https://openalex.org/W1996935355","https://openalex.org/W4282982241","https://openalex.org/W2373400232","https://openalex.org/W2241609366"],"abstract_inverted_index":{"Heaptocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,173],"still":[4],"a":[5,196],"great":[6],"health":[7],"problem":[8],"around":[9],"the":[10,13,40,84,111,122,133,139,186,201],"world.":[11],"Recently,":[12],"cetuximab":[14,81,120,146,204],"has":[15,26,55],"been":[16,28],"implicated":[17],"to":[18,32,38,82,150],"have":[19],"therapeutic":[20],"values":[21],"for":[22,177],"HCC.":[23],"However,":[24],"cetuximab-resistance":[25],"also":[27,147,159],"synchronously":[29],"reported":[30],"pertaining":[31],"HCC":[33,46,63,76,88,182,207],"treatment.":[34],"This":[35],"study":[36],"aimed":[37],"evaluate":[39],"role":[41],"of":[42,105,125,136,141,188,203],"eIF5A2":[43,51,142,172],"in":[44,62,75,86,97,154,164,180],"cetuximab-treated":[45,118],"cell":[47,64,73,77,89,99,152,156,162,166,178],"proliferation,":[48],"and":[49,93,102,127,130],"whether":[50],"specific":[52,108],"inhibitor":[53,192],"GC7":[54,70,79,115,149,158,193],"any":[56],"effects":[57,113],"on":[58,205],"cetuximab-mediated":[59],"proliferation":[60,74,85,153,163,179],"inhibition":[61],"lines.":[65,78,157,167],"It":[66],"was":[67],"observed":[68],"that":[69,171,199],"significantly":[71],"inhibited":[72],"synergized":[80,148],"inhibit":[83,151],"epithelial":[87,155,165,181,206],"lines":[90,100],"HepG2,":[91],"Huh7":[92],"Hep3B,":[94],"but":[95],"not":[96],"mesenchymal":[98],"SNU387":[101],"SNU449.":[103],"Knockdown":[104],"eIF5A-2":[106],"by":[107],"siRNA":[109],"exhibited":[110],"similar":[112],"as":[114],"did.":[116],"In":[117,144],"cells,":[119],"decreased":[121],"protein":[123],"level":[124,135],"EGFR":[126],"phosphorylated":[128],"STAT3":[129],"unexpectedly":[131],"up-regulated":[132],"expression":[134],"eIF5A2,":[137],"indicating":[138],"activation":[140],"pathway.":[143],"turn,":[145],"suppressed":[160],"hypoxia-induced":[161],"These":[168],"data":[169],"suggest":[170],"an":[174],"alternative":[175],"pathway":[176],"cells":[183],"escaping":[184],"from":[185],"cytotoxicity":[187,202],"cetuximab.":[189],"The":[190],"eIF5A":[191],"might":[194],"be":[195],"potent":[197],"agent":[198],"promotes":[200],"cells.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-04-11T00:00:00"}
