{"id":"https://openalex.org/W293391840","doi":null,"title":"Patient compliance with enteric-coated weekly fluoxetine during continuation treatment of major depressive disorder.","display_name":"Patient compliance with enteric-coated weekly fluoxetine during continuation treatment of major depressive disorder.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W293391840","mag":"293391840","pmid":"https://pubmed.ncbi.nlm.nih.gov/11206033"},"language":"en","primary_location":{"id":"pmid:11206033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11206033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038025366","display_name":"Franklin R. Schneier","orcid":"https://orcid.org/0000-0002-2938-2693","observed_orcids":["https://orcid.org/0000-0002-2938-2693"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"F R Schneier","raw_affiliation_strings":["Anxiety Disorders Clinic, New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York 10032, USA. frs1@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anxiety Disorders Clinic, New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York 10032, USA. frs1@columbia.edu","institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038025366"],"corresponding_institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":11.1378,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.98526703,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"62 Suppl 1","issue":null,"first_page":"43","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.8370000123977661},{"id":"https://openalex.org/keywords/once-weekly-dosing","display_name":"weekly dosing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/enteric-coated-formulation","display_name":"enteric-coated formulation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7870000004768372},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9490000009536743},{"id":"https://openalex.org/keywords/long-term-antidepressant-treatment","display_name":"long-term antidepressant treatment","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.6674472689628601},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.5392988324165344},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5331069231033325},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5307849645614624},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.4849093556404114},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46117058396339417},{"id":"https://openalex.org/C2778630814","wikidata":"https://www.wikidata.org/wiki/Q410954","display_name":"Monoamine oxidase inhibitor","level":4,"score":0.45642727613449097},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4316728711128235},{"id":"https://openalex.org/C2910020395","wikidata":"https://www.wikidata.org/wiki/Q175854","display_name":"Phobic disorder","level":3,"score":0.4171576499938965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33671945333480835},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.3357272148132324},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.32363784313201904},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24862471222877502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07643619179725647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010624","descriptor_name":"Phenelzine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010698","descriptor_name":"Phobic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010698","descriptor_name":"Phobic Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018849","descriptor_name":"Controlled Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020912","descriptor_name":"Moclobemide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11206033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11206033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"pmid:11599648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11599648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Clinical Trial"},{"id":"mag:293391840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11206033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981238440","https://openalex.org/W2003388617","https://openalex.org/W2111661680","https://openalex.org/W2993913797","https://openalex.org/W2062521606","https://openalex.org/W2029110247","https://openalex.org/W2205531850","https://openalex.org/W1967683669","https://openalex.org/W4299740154","https://openalex.org/W2363697694"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"once-weekly":[2,27,108,231,276],"enteric-coated":[3],"formulation":[4],"of":[5,16,52,66,71,82,85,98,102,266],"fluoxetine":[6,28,33,46,86,115,166,232],"represents":[7],"a":[8,49,79,221,275],"new,":[9],"effective":[10],"option":[11],"for":[12,48,58,89,116,202],"the":[13,25,39,99,129,280],"long-term":[14],"treatment":[15,47,163,172],"clinically":[17],"diagnosed":[18],"depression.":[19],"This":[20,176],"study":[21,69,73,100,158,205,211,268],"assessed":[22],"compliance":[23,59,154,185,203,209,218,260,273],"with":[24,31,60,128,164,173,230,237,274,279],"new":[26],"as":[29],"compared":[30,278],"once-daily":[32,112,182,238,282],"treatment.":[34],"METHOD:":[35],"Adult":[36],"patients":[37,105,148,245,252],"from":[38,187,254],"United":[40],"Kingdom":[41],"who":[42],"had":[43],"responded":[44],"to":[45,106,151,192,257],"current":[50],"episode":[51],"depression":[53],"(DSM-IV":[54],"criteria)":[55],"were":[56],"monitored":[57],"daily":[61,87,165,217,248,255],"and":[62,167,216],"weekly":[63,152,174,208,258],"dose":[64],"administration":[65],"fluoxetine.":[67,175,239],"The":[68,95,264],"consisted":[70,101],"2":[72],"phases.":[74],"Study":[75],"phase":[76,97],"I":[77,160,191],"was":[78,132,155,178,214,219,233],"baseline":[80],"assessment":[81],"20":[83],"mg":[84],"dosing":[88,130,256],"4":[90],"weeks":[91],"(N":[92],"=":[93,121,125,226],"117).":[94],"second":[96],"randomly":[103,149],"assigning":[104],"either":[107],"(90":[109],"mg/wk)":[110],"or":[111],"(20":[113],"mg/day)":[114],"3":[117],"months":[118],"(weekly,":[119],"N":[120,124],"56;":[122],"daily,":[123],"53).":[126],"Compliance":[127,229,240],"regimen":[131,277],"measured":[133],"using":[134],"an":[135],"electronic":[136],"Drug":[137],"Exposure":[138],"Monitor":[139],"(eDEM,":[140],"AARDEX":[141],"Ltd.,":[142],"Zug,":[143],"Switzerland).":[144],"RESULTS:":[145],"For":[146,181],"those":[147],"assigned":[150],"fluoxetine,":[153],"85.4%":[156],"during":[157,189,194,204,210],"period":[159,190,195,206,212],"while":[161,170],"on":[162,171,247],"then":[168],"87.5%":[169],"difference":[177,224],"not":[179,262],"significant.":[180],"dosing,":[183,259],"however,":[184,250],"declined":[186],"87.3%":[188],"79.4%":[193],"II":[196,213],"(p":[197,225],"<":[198],".001).":[199],"After":[200],"adjusting":[201],"I,":[207],"87.8%":[215],"79.0%,":[220],"statistically":[222],"significant":[223],".006).":[227],"CONCLUSION:":[228],"better":[234],"than":[235],"that":[236],"decreased":[241],"over":[242],"time":[243],"when":[244,251],"remained":[246],"dosing;":[249],"switched":[253],"did":[261],"decrease.":[263],"results":[265],"this":[267],"allay":[269],"concerns":[270],"about":[271],"inferior":[272],"conventional":[281],"regimen.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}