{"id":"https://openalex.org/W29333641","doi":null,"title":"Development of biomarkers of endocrine disrupting activity in emerging amphibian model, Silurana (Xenopus) tropicalis.","display_name":"Development of biomarkers of endocrine disrupting activity in emerging amphibian model, Silurana (Xenopus) tropicalis.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W29333641","mag":"29333641","pmid":"https://pubmed.ncbi.nlm.nih.gov/18030284"},"language":"en","primary_location":{"id":"pmid:18030284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18030284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental sciences : an international journal of environmental physiology and toxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103581318","display_name":"Minoru Takase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Takase","raw_affiliation_strings":["Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. minoru@hiroshima-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. minoru@hiroshima-u.ac.jp","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111930886","display_name":"Naoko Mitsui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoko Mitsui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376258","display_name":"Tomohiro Oka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohiro Oka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016000266","display_name":"Osamu Tooi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osamu Tooi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086144491","display_name":"Noriaki Santo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriaki Santo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055458022","display_name":"Daniel B. Pickford","orcid":"https://orcid.org/0000-0002-5778-4630","observed_orcids":["https://orcid.org/0000-0002-5778-4630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel B Pickford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005360431","display_name":"Taisen Iguchi","orcid":"https://orcid.org/0000-0002-6020-0704","observed_orcids":["https://orcid.org/0000-0002-6020-0704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taisen Iguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2313,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53885437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"6","first_page":"285","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.227400004863739,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/xenopus-tropicalis","display_name":"Xenopus tropicalis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8159999847412109},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.953000009059906},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-alpha","display_name":"thyroid hormone receptor alpha","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reporter-gene-assay","display_name":"reporter gene assay","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gonadal-sex-differentiation","display_name":"gonadal sex differentiation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tadpoles","display_name":"tadpoles","score":0.6100000143051147},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.5609999895095825},{"id":"https://openalex.org/keywords/rana-japonica","display_name":"Rana japonica","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.8839563131332397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.829544723033905},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7829610109329224},{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.7573910355567932},{"id":"https://openalex.org/C2781471917","wikidata":"https://www.wikidata.org/wiki/Q213456","display_name":"Gonad","level":2,"score":0.6923847198486328},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6364331841468811},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.6357353925704956},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.43074822425842285},{"id":"https://openalex.org/C2910670510","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenins","level":5,"score":0.41690075397491455},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40684542059898376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35765430331230164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3420131206512451},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3212682604789734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2876683473587036},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28305429220199585},{"id":"https://openalex.org/C56366318","wikidata":"https://www.wikidata.org/wiki/Q7937033","display_name":"Vitellogenesis","level":4,"score":0.1708015501499176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011898","descriptor_name":"Ranidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012733","descriptor_name":"Sex Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052244","descriptor_name":"Endocrine Disruptors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18030284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18030284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental sciences : an international journal of environmental physiology and toxicology","raw_type":"Journal Article"},{"id":"mag:29333641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18030284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1997551115","https://openalex.org/W2003109412","https://openalex.org/W2078670096","https://openalex.org/W2010994721","https://openalex.org/W2074122173","https://openalex.org/W2002119158","https://openalex.org/W2023906738","https://openalex.org/W2086377079","https://openalex.org/W2020116349","https://openalex.org/W2104935808","https://openalex.org/W2074449425","https://openalex.org/W1977563835","https://openalex.org/W2094314175","https://openalex.org/W2560616874","https://openalex.org/W4231203432","https://openalex.org/W2185597094","https://openalex.org/W1992569119","https://openalex.org/W2287426467","https://openalex.org/W2060352965","https://openalex.org/W2610978923","https://openalex.org/W2035137687"],"related_works":["https://openalex.org/W2164782161","https://openalex.org/W1973847024","https://openalex.org/W2298872891","https://openalex.org/W2115205318","https://openalex.org/W2051414725","https://openalex.org/W7096183631","https://openalex.org/W3016166198","https://openalex.org/W1988173027","https://openalex.org/W2372607447","https://openalex.org/W3080978150"],"abstract_inverted_index":{"Because":[0],"amphibians":[1,16],"show":[2],"peculiar":[3],"ecological":[4],"features":[5],"and":[6,76,114,119,165,176,234,251,289,298,311,342,369],"interesting":[7],"responses":[8],"to":[9,47,82,109,199,265,279,308,318,327,330,356],"some":[10],"hormones,":[11],"it":[12],"is":[13],"conceivable":[14],"that":[15,161,195],"are":[17,197,277],"very":[18],"useful":[19],"animals":[20],"for":[21,53,93,338],"assessing":[22,357],"the":[23,102,122,127,145,162,173,180,208,219,224,242,274,286,294,302,358,370],"toxic":[24],"effects":[25],"of":[26,35,39,78,111,116,121,136,179,296,352,360],"environmental":[27,40,94,348,361],"contaminants,":[28],"including":[29],"endocrine":[30,37,332,345],"disrupters.":[31],"To":[32],"develop":[33,83],"methods":[34],"detecting":[36],"toxicity":[38,346],"chemicals":[41],"in":[42,172,207,218,223,241,301,335,347,367],"amphibians,":[43],"we":[44,228,276,325],"have":[45],"started":[46],"assemble":[48],"a":[49,84,133,270],"biomarker":[50],"tool":[51,92],"kit":[52],"an":[54,90,353],"emerging":[55],"amphibian":[56,365],"model,":[57],"Silurana":[58],"(Xenopus)":[59],"tropicalis.":[60],"We":[61],"isolated":[62],"full-length":[63,104,287],"cDNAs":[64,105],"encoding":[65],"estrogen":[66],"receptor":[67,73],"alpha":[68,74],"(ERalpha),":[69],"ERbeta,":[70],"thyroid":[71,299],"hormone":[72],"(TRalpha),":[75],"TRbeta":[77,115],"S.":[79,128,148,181,244,303,315],"(X.)":[80,129,149,182,245,304,316],"tropicalis":[81,130,150,183,246,305,317],"reporter":[85,281],"gene":[86,282],"assay":[87,283],"system,":[88],"as":[89,152,237,269,350],"estimation":[91],"chemicals.":[95],"The":[96],"amino":[97,137],"acid":[98,138],"sequences":[99],"inferred":[100],"from":[101,260],"four":[103],"were":[106,168,216],"highly":[107],"homologous":[108],"those":[110],"ERalpha,":[112,151],"TRalpha":[113],"X.":[117,141],"laevis,":[118],"ERbeta":[120,166],"Japanese":[123],"quail.":[124],"In":[125,253,273],"particular,":[126],"ERalpha":[131,143,164],"shared":[132],"higher":[134],"similarity":[135],"sequence":[139],"with":[140],"laevis":[142],"than":[144,222],"previously":[146],"reported":[147],"determined":[153],"by":[154],"Wu":[155],"et":[156],"al.":[157],"RT-PCR":[158],"analysis":[159,250],"showed":[160],"two":[163,209],"transcripts":[167],"expressed":[169,240],"relatively":[170],"abundantly":[171],"brain,":[174],"liver,":[175],"gonad/kidney":[177,220],"complex":[178,221],"tadpole":[184,306],"after":[185],"gonadal":[186],"sex":[187],"differentiation":[188,295],"occurring":[189],"at":[190],"developmental":[191],"stages":[192],"54-59,":[193],"suggesting":[194],"they":[196],"susceptible":[198],"estrogenic":[200,309],"substances.":[201],"A":[202,231],"similar":[203],"result":[204],"was":[205,258],"obtained":[206],"TR":[210,290],"transcripts,":[211],"although":[212],"their":[213],"expression":[214],"levels":[215],"lower":[217],"other":[225],"tissues.":[226],"Moreover,":[227],"identified":[229],"vitellogenin":[230],"(Vtg":[232],"A)":[233],"Vtg":[235,257],"B":[236],"estrogen-responsive":[238],"genes":[239],"female":[243],"liver":[247],"using":[248,262,285],"macroarray":[249],"RT-PCR.":[252],"addition,":[254],"Rana":[255],"japonica":[256],"purified":[259],"serum":[261],"anion-exchange":[263],"chromatography":[264],"produce":[266,312],"anti-Vtg":[267],"antibody":[268],"protein":[271],"marker.":[272],"future,":[275],"going":[278],"construct":[280],"systems":[284],"ER":[288],"cDNAs,":[291],"analyze":[292],"histologically":[293],"gonads":[297],"glands":[300],"exposed":[307],"chemicals,":[310],"sex-reversed":[313],"male":[314],"obtain":[319],"all-male":[320],"tadpoles.":[321],"Using":[322],"these":[323],"tools,":[324],"hope":[326],"be":[328],"able":[329],"identify":[331],"disrupting":[333],"compounds":[334],"laboratory":[336],"experiments":[337],"hazard":[339],"assessment":[340],"purposes,":[341],"also":[343],"detect":[344],"samples":[349],"part":[351],"integrated":[354],"approach":[355],"impact":[359],"contaminants":[362],"on":[363],"wild":[364],"populations":[366],"Japan":[368],"UK.":[371]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}