{"id":"https://openalex.org/W293310820","doi":"https://doi.org/10.21236/ada519305","title":"The Role of Tumor Microenvironment on Prostate Cancer Progression","display_name":"The Role of Tumor Microenvironment on Prostate Cancer Progression","publication_year":2009,"publication_date":"2009-08-01","ids":{"openalex":"https://openalex.org/W293310820","doi":"https://doi.org/10.21236/ada519305","mag":"293310820"},"language":"en","primary_location":{"id":"doi:10.21236/ada519305","doi":"https://doi.org/10.21236/ada519305","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada519305","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060515951","display_name":"Clayton Clopton Yates","orcid":"https://orcid.org/0000-0001-5420-9852","observed_orcids":["https://orcid.org/0000-0001-5420-9852"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Clayton Yates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060515951"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.972000002861023},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/kaiso","display_name":"Kaiso","score":0.8180000185966492},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6759999990463257},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.6850000023841858},{"id":"https://openalex.org/keywords/metastasis-related-genes","display_name":"metastasis-associated genes","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7385271191596985},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6850260496139526},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5234410166740417},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4723808765411377},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4385264217853546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4155465364456177},{"id":"https://openalex.org/C3018028425","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumor heterogeneity","level":3,"score":0.41312935948371887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34887105226516724},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34267574548721313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3324909508228302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2682207226753235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada519305","doi":"https://doi.org/10.21236/ada519305","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada519305","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1601028323","https://openalex.org/W2004699369","https://openalex.org/W14378259","https://openalex.org/W2751639769","https://openalex.org/W2545169478","https://openalex.org/W1484864581","https://openalex.org/W2810608944","https://openalex.org/W4414007917","https://openalex.org/W2020323807","https://openalex.org/W3166795112"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Current":[2],"therapies":[3],"for":[4],"invasive":[5],"and":[6,13,47,83,134,142,159,167],"metastatic":[7,25],"prostate":[8],"cancer":[9,55],"are":[10],"not":[11,93,145],"curative":[12],"prolong":[14],"survival":[15],"by":[16,100],"nearly":[17],"a":[18,24,29,62,107,137],"year":[19],"even":[20],"in":[21],"patients":[22],"with":[23,162],"disease.":[26],"Metastasis":[27],"is":[28,160],"multi-step":[30],"process":[31],"wherein":[32],"tumor":[33,80,124],"cells":[34],"acquire":[35],"properties":[36],"that":[37,72,151],"enable":[38],"them":[39],"to":[40,45,114],"detach,":[41],"migrate,":[42],"gain":[43],"access":[44],"conduits,":[46],"disseminate":[48],"throughout":[49],"the":[50,57,65,73,86,95,101,155],"body.":[51],"The":[52],"dissemination":[53],"of":[54,64,89],"from":[56],"primary":[58],"carcinoma":[59],"mass":[60],"requires":[61],"loosening":[63],"cell-cell":[66],"bonds.":[67],"Previous":[68],"investigations":[69],"have":[70,92],"demonstrated":[71],"epidermal":[74],"growth":[75],"factor":[76],"receptor":[77],"(EGFR)":[78],"promotes":[79],"cell":[81,128,165],"invasiveness":[82],"metastasis.":[84,168],"However,":[85,136],"regulatory":[87],"control":[88],"metastasis":[90,143],"genes":[91,120],"explored":[94],"key":[96],"molecular":[97],"events":[98],"mediated":[99],"EGFR":[102,156,163],"induced":[103,164],"responses.":[104],"Recently,":[105],"Kaiso":[106,141,152],"biomodal":[108],"transcription":[109],"factor,":[110],"has":[111],"been":[112,146],"shown":[113],"be":[115],"associated":[116,161],"with,":[117],"many":[118],"cancer-related":[119],"which":[121],"function":[122],"as":[123,127,144],"suppressor,":[125],"such":[126],"cycle":[129],"regulator":[130],"CDKN2A":[131],"(P16),":[132],"TIMPS":[133],"E-cadherin.":[135],"direct":[138],"link":[139],"between":[140],"shown.":[147],"Therefore,":[148],"we":[149],"hypothesized":[150],"fits":[153],"into":[154],"signaling":[157],"cascade,":[158],"migration":[166]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
