{"id":"https://openalex.org/W2932883479","doi":null,"title":"Post-prandial serum concentrations of Trimethylamine-N-oxide in overweight and obese adults with low and high systemic inflammation","display_name":"Post-prandial serum concentrations of Trimethylamine-N-oxide in overweight and obese adults with low and high systemic inflammation","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2932883479","mag":"2932883479"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.montana.edu:1/15111","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/15111","pdf_url":"https://scholarworks.montana.edu/bitstreams/ea97d24f-1c2d-45e7-869b-859c172b8b46/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.montana.edu/bitstreams/ea97d24f-1c2d-45e7-869b-859c172b8b46/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113865213","display_name":"Stephanie Michelle Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephanie Michelle Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113865213"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.3984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.3984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.08309999853372574,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.8669999837875366},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9399999976158142},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2780924926","wikidata":"https://www.wikidata.org/wiki/Q419802","display_name":"Trimethylamine N-oxide","level":3,"score":0.9023677706718445},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.788375973701477},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.783397912979126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6079825758934021},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5574712753295898},{"id":"https://openalex.org/C2776149385","wikidata":"https://www.wikidata.org/wiki/Q423953","display_name":"Trimethylamine","level":2,"score":0.5490725636482239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5299103260040283},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5241867899894714},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5073348879814148},{"id":"https://openalex.org/C2909688399","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Post-prandial","level":3,"score":0.4216134548187256},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.22015705704689026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20850834250450134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08479589223861694}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.montana.edu:1/15111","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/15111","pdf_url":"https://scholarworks.montana.edu/bitstreams/ea97d24f-1c2d-45e7-869b-859c172b8b46/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2932883479","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/15111","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.montana.edu:1/15111","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/15111","pdf_url":"https://scholarworks.montana.edu/bitstreams/ea97d24f-1c2d-45e7-869b-859c172b8b46/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311310","display_name":"Montana State University","ror":"https://ror.org/02w0trx84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2932883479.pdf","grobid_xml":"https://content.openalex.org/works/W2932883479.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W180144476","https://openalex.org/W260994251","https://openalex.org/W1903768306","https://openalex.org/W1977220675","https://openalex.org/W1989780776","https://openalex.org/W2012561030","https://openalex.org/W2014663082","https://openalex.org/W2042398122","https://openalex.org/W2044638285","https://openalex.org/W2046208657","https://openalex.org/W2046971089","https://openalex.org/W2054916011","https://openalex.org/W2061853512","https://openalex.org/W2064119981","https://openalex.org/W2078511984","https://openalex.org/W2078599166","https://openalex.org/W2090296913","https://openalex.org/W2094278898","https://openalex.org/W2115944543","https://openalex.org/W2117121624","https://openalex.org/W2117613892","https://openalex.org/W2135568455","https://openalex.org/W2138411980","https://openalex.org/W2143104968","https://openalex.org/W2145050940","https://openalex.org/W2145185485","https://openalex.org/W2150350691","https://openalex.org/W2152289100","https://openalex.org/W2152527784","https://openalex.org/W2153439971","https://openalex.org/W2154380413","https://openalex.org/W2155965977","https://openalex.org/W2156141764","https://openalex.org/W2163604084","https://openalex.org/W2167062509","https://openalex.org/W2207436601","https://openalex.org/W2232990799","https://openalex.org/W2288501492","https://openalex.org/W2465423486","https://openalex.org/W2468622561","https://openalex.org/W2552933452","https://openalex.org/W2617058021","https://openalex.org/W2734440527","https://openalex.org/W2770392750","https://openalex.org/W2785877333","https://openalex.org/W2789463949","https://openalex.org/W2809401897","https://openalex.org/W2888466427"],"related_works":["https://openalex.org/W2807395849","https://openalex.org/W2153439971","https://openalex.org/W4282827932","https://openalex.org/W1965021718","https://openalex.org/W4317538916","https://openalex.org/W3195854882","https://openalex.org/W2786915159","https://openalex.org/W2911691845","https://openalex.org/W3016402963","https://openalex.org/W2231380317"],"abstract_inverted_index":{"Purpose:":[0],"Elevated":[1],"trimethylamine-N-oxide":[2],"(TMAO)":[3],"levels":[4,110],"have":[5],"been":[6],"implicated":[7],"in":[8,24,53,70,101,190],"the":[9,20,39,71,125,138,172,186,191],"development":[10],"of":[11,15,41,81,111,124,147],"atherosclerosis.":[12],"The":[13],"impact":[14],"a":[16,54,156,213],"high-fat":[17,55],"meal":[18,56,75,173],"on":[19,167],"post-prandial":[21],"TMAO":[22,42,99,120,140,170,193,201,210],"response":[23,141,194],"healthy":[25],"overweight":[26,46],"and":[27,47,50,68,77,88,161,164],"obese":[28,48],"adults":[29],"was":[30,95,128,142,174,185],"explored,":[31],"accounting":[32,114],"for":[33,79,115],"additional":[34],"variables":[35],"that":[36,117,137],"may":[37,118],"affect":[38],"rate":[40,151],"conversion.":[43],"Methods:":[44],"Forty":[45],"men":[49],"women":[51],"participated":[52],"challenge":[57,216],"containing":[58],"50":[59],"g":[60],"fat.":[61],"Blood":[62],"samples":[63],"were":[64,217],"collected":[65],"at":[66],"fasting":[67,225],"hourly":[69],"4":[72],"hours":[73],"after":[74,171],"ingestion":[76],"tested":[78],"concentrations":[80,211],"TMAO,":[82],"liver":[83],"enzymes,":[84],"lipids,":[85],"creatinine,":[86],"insulin,":[87],"inflammatory":[89],"markers.":[90],"An":[91],"initial":[92,126],"mixed-effects":[93],"model":[94,127],"constructed":[96],"to":[97],"analyze":[98],"changes":[100],"participants":[102],"who":[103],"classified":[104],"as":[105],"having":[106],"low":[107],"or":[108],"high":[109,214],"systemic":[112],"inflammation":[113,162,178,226],"factors":[116],"influence":[119],"concentrations.":[121],"Backward":[122],"refinement":[123,135],"performed":[129],"based":[130],"off":[131],"p-values.":[132],"Results:":[133],"Model":[134],"found":[136],"log":[139,192,200],"best":[143],"explained":[144],"by":[145,220,224],"inclusion":[146],"estimated":[148],"glomerular":[149],"filtration":[150],"(eGFR),":[152],"insulin":[153],"over":[154],"time,":[155],"linear":[157],"interaction":[158],"between":[159,177],"time":[160],"phenotype,":[163],"random":[165],"effects":[166],"subject.":[168],"Log":[169],"not":[175,223],"different":[176],"phenotypes":[179],"(p":[180,195],"=":[181,196],"0.33).":[182],"Estimated":[183],"GFR":[184],"most":[187],"important":[188],"determinant":[189],"0.03),":[197],"with":[198,203],"lower":[199],"observed":[202],"higher":[204],"eGFR":[205],"values.":[206],"In":[207],"conclusion,":[208],"serum":[209],"during":[212],"fat-meal":[215],"strongly":[218],"determined":[219],"eGFR,":[221],"but":[222],"status.":[227]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2019-04-11T00:00:00"}