{"id":"https://openalex.org/W2932838414","doi":"https://doi.org/10.1101/599050","title":"Homeostasis in the Central Dogma of Molecular Biology: the importance of mRNA instability","display_name":"Homeostasis in the Central Dogma of Molecular Biology: the importance of mRNA instability","publication_year":2019,"publication_date":"2019-04-05","ids":{"openalex":"https://openalex.org/W2932838414","doi":"https://doi.org/10.1101/599050","mag":"2932838414"},"language":"en","primary_location":{"id":"doi:10.1101/599050","doi":"https://doi.org/10.1101/599050","is_oa":true,"landing_page_url":"https://doi.org/10.1101/599050","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/23/599050.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/23/599050.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034235006","display_name":"Jos\u00e9 Enrique P\u00e9rez-Ort\u00edn","orcid":"https://orcid.org/0000-0002-1992-513X","observed_orcids":["https://orcid.org/0000-0002-1992-513X"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 E. P\u00e9rez-Ort\u00edn","raw_affiliation_strings":["E.R.I. Biotecmed, Universitat de Val\u00e8ncia, C/ Dr. Moliner 50, E-46100 Burjassot. Spain"],"raw_orcid":"https://orcid.org/0000-0002-1992-513X","affiliations":[{"raw_affiliation_string":"E.R.I. Biotecmed, Universitat de Val\u00e8ncia, C/ Dr. Moliner 50, E-46100 Burjassot. Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vicente Tordera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Tordera","raw_affiliation_strings":["E.R.I. Biotecmed, Universitat de Val\u00e8ncia, C/ Dr. Moliner 50, E-46100 Burjassot. Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E.R.I. Biotecmed, Universitat de Val\u00e8ncia, C/ Dr. Moliner 50, E-46100 Burjassot. Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048374141","display_name":"Sebasti\u00e1n Ch\u00e1vez","orcid":"https://orcid.org/0000-0002-8064-4839","observed_orcids":["https://orcid.org/0000-0002-8064-4839"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sebasti\u00e1n Ch\u00e1vez","raw_affiliation_strings":["Instituto de Biomedicina de Sevilla. Universidad de Sevilla-CSIC-Hospital Universitario Virgen del Roc\u00edo. Campus Hospital Universitario Virgen del Roc\u00edo. Avda. Manuel Siurot, s/n. E-41013, Seville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla. Universidad de Sevilla-CSIC-Hospital Universitario Virgen del Roc\u00edo. Campus Hospital Universitario Virgen del Roc\u00edo. Avda. Manuel Siurot, s/n. E-41013, Seville","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034235006"],"corresponding_institution_ids":["https://openalex.org/I16097986"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.20640000700950623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.382999986410141},{"id":"https://openalex.org/keywords/central-dogma","display_name":"central dogma","score":0.578000009059906},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/response-capacity","display_name":"response capacity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.46000000834465027},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7860000133514404},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9990000128746033},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9919999837875366},{"id":"https://openalex.org/keywords/human-cells","display_name":"human cells","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.9646000266075134},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.6771000027656555},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6733999848365784},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5968000292778015},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5602999925613403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5601000189781189},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42239999771118164},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4043000042438507},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4007999897003174},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3637999892234802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3418999910354614},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.32829999923706055},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2775992057","wikidata":"https://www.wikidata.org/wiki/Q16956568","display_name":"Translational efficiency","level":5,"score":0.3061000108718872},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.30399999022483826},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2761000096797943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/599050","doi":"https://doi.org/10.1101/599050","is_oa":true,"landing_page_url":"https://doi.org/10.1101/599050","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/23/599050.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/599050","doi":"https://doi.org/10.1101/599050","is_oa":true,"landing_page_url":"https://doi.org/10.1101/599050","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/23/599050.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G645376606","display_name":null,"funder_award_id":"BFU2016\u201077728\u2010C3\u20103\u2010P","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7474285604","display_name":null,"funder_award_id":"BFU2016-77728-C3-1-P","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2932838414.pdf","grobid_xml":"https://content.openalex.org/works/W2932838414.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1581546115","https://openalex.org/W1606142774","https://openalex.org/W1768187423","https://openalex.org/W1883779479","https://openalex.org/W1971284016","https://openalex.org/W1972066788","https://openalex.org/W1972399884","https://openalex.org/W1984704432","https://openalex.org/W1985217551","https://openalex.org/W1992927069","https://openalex.org/W1993009001","https://openalex.org/W2008555978","https://openalex.org/W2011503994","https://openalex.org/W2013321787","https://openalex.org/W2018003897","https://openalex.org/W2019377841","https://openalex.org/W2022393880","https://openalex.org/W2036573675","https://openalex.org/W2037768790","https://openalex.org/W2043391289","https://openalex.org/W2043831708","https://openalex.org/W2044662818","https://openalex.org/W2044692345","https://openalex.org/W2048454307","https://openalex.org/W2049883153","https://openalex.org/W2059551822","https://openalex.org/W2064153840","https://openalex.org/W2064334669","https://openalex.org/W2077052198","https://openalex.org/W2115585439","https://openalex.org/W2124495107","https://openalex.org/W2128551987","https://openalex.org/W2129178024","https://openalex.org/W2132617512","https://openalex.org/W2134259738","https://openalex.org/W2140937954","https://openalex.org/W2141803727","https://openalex.org/W2150561721","https://openalex.org/W2150698842","https://openalex.org/W2167264963","https://openalex.org/W2168765510","https://openalex.org/W2174022806","https://openalex.org/W2196842638","https://openalex.org/W2218660561","https://openalex.org/W2219121760","https://openalex.org/W2258657513","https://openalex.org/W2306996931","https://openalex.org/W2608001333","https://openalex.org/W2737102646","https://openalex.org/W2766368962","https://openalex.org/W2770351359","https://openalex.org/W2785199982","https://openalex.org/W2785428883","https://openalex.org/W2909620196","https://openalex.org/W2911928150","https://openalex.org/W2953251842","https://openalex.org/W3044219031","https://openalex.org/W6622161800","https://openalex.org/W7100804310"],"related_works":["https://openalex.org/W2306996931","https://openalex.org/W2952594353","https://openalex.org/W2950430276","https://openalex.org/W2196842638","https://openalex.org/W2418051327","https://openalex.org/W2279866531","https://openalex.org/W2338974397","https://openalex.org/W4322216960","https://openalex.org/W3095839623","https://openalex.org/W3006243445"],"abstract_inverted_index":{"Abstract":[0,199],"Cell":[1],"survival":[2],"requires":[3],"the":[4,17,41,52,61,104,129,134,142,150,154,168,174,191],"control":[5],"of":[6,55,131,157,161,171,177],"biomolecule":[7],"concentration,":[8],"i.e.":[9],"biomolecules":[10],"should":[11],"approach":[12],"homeostasis.":[13],"With":[14],"information-carrying":[15],"macromolecules,":[16],"particular":[18,53],"concentration":[19],"variation":[20],"ranges":[21],"depend":[22],"on":[23],"each":[24],"type:":[25],"DNA":[26],"is":[27,94,123,146],"not":[28,116,147],"buffered,":[29],"but":[30,115,145],"mRNA":[31,56,92,172],"and":[32,43,58,85,107,133,180],"protein":[33],"concentrations":[34],"are":[35],"homeostatically":[36],"controlled,":[37],"which":[38],"leads":[39],"to":[40,125],"ribostasis":[42,57,93],"proteostasis":[44,59],"concepts.":[45],"In":[46],"recent":[47],"years,":[48],"we":[49,68],"have":[50],"studied":[51],"features":[54],"in":[60,173],"model":[62,79],"organism":[63],"S.":[64,83],"cerevisiae":[65],".":[66],"Here":[67],"extend":[69],"this":[70,122],"study":[71],"by":[72],"comparing":[73],"published":[74],"data":[75],"from":[76],"three":[77],"other":[78],"organisms:":[80],"E.":[81],"coli,":[82],"pombe":[84],"cultured":[86],"human":[87],"cells.":[88],"We":[89,119,165],"describe":[90],"how":[91],"less":[95],"strict":[96],"than":[97,188],"proteostasis.":[98],"A":[99],"constant":[100],"ratio":[101],"appears":[102],"between":[103,128],"average":[105],"decay":[106],"dilution":[108],"rates":[109],"during":[110],"cell":[111],"growth":[112],"for":[113,117,190,195],"mRNA,":[114],"proteins.":[118],"postulate":[120],"that":[121,160,167],"due":[124],"a":[126],"trade-off":[127],"cost":[130],"synthesis":[132],"response":[135],"capacity.":[136],"This":[137],"compromise":[138],"takes":[139],"place":[140],"at":[141,149],"transcription":[143],"level,":[144],"possible":[148],"translation":[151],"level":[152],"as":[153],"high":[155],"stability":[156],"proteins,":[158],"versus":[159],"mRNAs,":[162],"precludes":[163],"it.":[164],"hypothesize":[166],"middle-place":[169],"role":[170],"Central":[175],"Dogma":[176],"Molecular":[178],"Biology":[179],"its":[181],"chemical":[182],"instability":[183],"make":[184],"it":[185],"more":[186],"suitable":[187],"proteins":[189],"fast":[192],"changes":[193],"needed":[194],"gene":[196],"regulation.":[197],"Graphical":[198]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2019-04-11T00:00:00"}