{"id":"https://openalex.org/W2932641340","doi":"https://doi.org/10.1039/9781788016452-00091","title":"Recent Advances in Anticancer Copper Compounds","display_name":"Recent Advances in Anticancer Copper Compounds","publication_year":2019,"publication_date":"2019-04-05","ids":{"openalex":"https://openalex.org/W2932641340","doi":"https://doi.org/10.1039/9781788016452-00091","mag":"2932641340"},"language":"en","primary_location":{"id":"doi:10.1039/9781788016452-00091","doi":"https://doi.org/10.1039/9781788016452-00091","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781788016452-00091","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metal-based Anticancer Agents","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4249635897","display_name":"Metal-based Anticancer Agents"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010144309","display_name":"Andrew Kellett","orcid":"https://orcid.org/0000-0002-8947-1401","observed_orcids":["https://orcid.org/0000-0002-8947-1401"]},"institutions":[{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Andrew Kellett","raw_affiliation_strings":["School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068856350","display_name":"Zara E. Molphy","orcid":"https://orcid.org/0000-0001-9717-6130","observed_orcids":["https://orcid.org/0000-0001-9717-6130"]},"institutions":[{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Zara Molphy","raw_affiliation_strings":["School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107985144","display_name":"Vickie McKee","orcid":"https://orcid.org/0000-0002-7780-5814","observed_orcids":["https://orcid.org/0000-0002-7780-5814"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["DK","IE"],"is_corresponding":false,"raw_author_name":"Vickie McKee","raw_affiliation_strings":["Department of Physics, Chemistry and Pharmacy, University of Southern Denmark Campusvej 55 5230 Odense M Denmark","School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark Campusvej 55 5230 Odense M Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023384150","display_name":"Creina Slator","orcid":"https://orcid.org/0000-0002-1778-5217","observed_orcids":["https://orcid.org/0000-0002-1778-5217"]},"institutions":[{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Creina Slator","raw_affiliation_strings":["School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie","institution_ids":["https://openalex.org/I42934936"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.0025,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.98293625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"91","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9070000052452087},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6340000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.49799999594688416},{"id":"https://openalex.org/keywords/phenanthroline-ligands","display_name":"phenanthroline ligands","score":0.7979999780654907},{"id":"https://openalex.org/keywords/bipyridine-ligands","display_name":"bipyridine ligands","score":0.9929999709129333},{"id":"https://openalex.org/keywords/copper-enzymes","display_name":"copper enzymes","score":0.6230000257492065},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6650762557983398},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6302909851074219},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.48434579372406006},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4767483174800873},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4627833962440491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44188469648361206},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4389348030090332},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43378445506095886},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4280228018760681},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.42165228724479675},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.36661720275878906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20515775680541992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08954876661300659},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1039/9781788016452-00091","doi":"https://doi.org/10.1039/9781788016452-00091","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781788016452-00091","pdf_url":null,"source":{"id":"https://openalex.org/S4306463862","display_name":"Royal Society of Chemistry eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metal-based Anticancer Agents","raw_type":"book-chapter"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/bc095e58-bcc0-4946-a800-dbb96a29f3ea","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/bc095e58-bcc0-4946-a800-dbb96a29f3ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kellett, A, Molphy, Z, McKee, V & Slator, C 2019, Recent Advances in Anticancer Copper Compounds. in A Vessieres, S M Meier-Menches & A Casini (eds), Metal-based Anticancer Agents. Royal Society of Chemistry, RSC Metallobiology, no. 14, vol. 2019-January, pp. 91-119. https://doi.org/10.1039/9781788016452-00091","raw_type":"info:eu-repo/semantics/bookPart"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1603675492","https://openalex.org/W1745634660","https://openalex.org/W1938051019","https://openalex.org/W1965948702","https://openalex.org/W1965970124","https://openalex.org/W1970713347","https://openalex.org/W1972779889","https://openalex.org/W1973832810","https://openalex.org/W1976881265","https://openalex.org/W1979867324","https://openalex.org/W1982419115","https://openalex.org/W1983198174","https://openalex.org/W1984883623","https://openalex.org/W1985201539","https://openalex.org/W1985226816","https://openalex.org/W1985251367","https://openalex.org/W1988047686","https://openalex.org/W1995810957","https://openalex.org/W2008445367","https://openalex.org/W2009183786","https://openalex.org/W2011673896","https://openalex.org/W2012190608","https://openalex.org/W2013869567","https://openalex.org/W2016040396","https://openalex.org/W2016154684","https://openalex.org/W2021388388","https://openalex.org/W2022938402","https://openalex.org/W2025234908","https://openalex.org/W2027904538","https://openalex.org/W2040527477","https://openalex.org/W2040675733","https://openalex.org/W2042468380","https://openalex.org/W2043310375","https://openalex.org/W2046900004","https://openalex.org/W2052853635","https://openalex.org/W2068119081","https://openalex.org/W2074060550","https://openalex.org/W2075385784","https://openalex.org/W2076605211","https://openalex.org/W2080493328","https://openalex.org/W2085562385","https://openalex.org/W2087312216","https://openalex.org/W2089526528","https://openalex.org/W2089731664","https://openalex.org/W2094985059","https://openalex.org/W2095761326","https://openalex.org/W2096510511","https://openalex.org/W2096806896","https://openalex.org/W2103088199","https://openalex.org/W2107682629","https://openalex.org/W2109034822","https://openalex.org/W2112046350","https://openalex.org/W2113253067","https://openalex.org/W2115003365","https://openalex.org/W2123488363","https://openalex.org/W2125145029","https://openalex.org/W2128516354","https://openalex.org/W2129774902","https://openalex.org/W2130177169","https://openalex.org/W2143817553","https://openalex.org/W2144277227","https://openalex.org/W2149587863","https://openalex.org/W2169654670","https://openalex.org/W2170534556","https://openalex.org/W2313035794","https://openalex.org/W2315542573","https://openalex.org/W2319105941","https://openalex.org/W2325082608","https://openalex.org/W2326152465","https://openalex.org/W2326876220","https://openalex.org/W2343430192","https://openalex.org/W2410993730","https://openalex.org/W2423208326","https://openalex.org/W2548865742","https://openalex.org/W2560172664","https://openalex.org/W2561236934","https://openalex.org/W2563104540","https://openalex.org/W2578282122","https://openalex.org/W2580862813","https://openalex.org/W2584407667","https://openalex.org/W2612489848","https://openalex.org/W2619242535","https://openalex.org/W2729958698","https://openalex.org/W2769433773","https://openalex.org/W2783936283","https://openalex.org/W2791048938","https://openalex.org/W2795920498","https://openalex.org/W2810658624","https://openalex.org/W2884473373","https://openalex.org/W2890458122","https://openalex.org/W2891028746","https://openalex.org/W2892254135","https://openalex.org/W2914314704","https://openalex.org/W4245397386","https://openalex.org/W4256098704"],"related_works":["https://openalex.org/W7134040142","https://openalex.org/W2624177752","https://openalex.org/W2901031043","https://openalex.org/W6964441553","https://openalex.org/W2115003365","https://openalex.org/W2129658137","https://openalex.org/W2531460510","https://openalex.org/W3174118659","https://openalex.org/W4291618610","https://openalex.org/W2514263689"],"abstract_inverted_index":{"There":[0],"have":[1,119],"been":[2],"significant":[3],"advances":[4],"in":[5],"the":[6,13,100,169],"discovery":[7],"of":[8,15,21,94,173,184],"developmental":[9],"copper":[10,165],"complexes":[11,93,166],"for":[12,29],"treatment":[14],"human":[16],"cancer.":[17],"The":[18,109],"enzyme-active":[19],"sites":[20],"several":[22,92],"copper-containing":[23],"enzymes":[24],"suggest":[25],"a":[26,138,171],"starting":[27],"point":[28],"metallodrug":[30,117],"development":[31],"and":[32,73,88,122,133,153,159],"successful":[33],"strategies":[34],"have,":[35],"so":[36],"far,":[37],"employed":[38],"phenanthroline":[39],"or":[40,55],"bipyridine":[41],"ligands":[42,58],"to":[43,84,125,164],"supply":[44],"two":[45],"pyridyl":[46],"donors":[47],"(modelling":[48],"histidine":[49],"residues)":[50],"along":[51,180],"with":[52,181],"other":[53,174],"oxygen":[54,70],"nitrogen":[56,75],"donor":[57],"that":[59,78,155],"tune":[60],"specific":[61],"properties.":[62],"Suitably":[63],"designed":[64],"copper(ii)":[65,116],"metallodrugs":[66],"can":[67],"generate":[68],"reactive":[69,74],"species":[71,76],"(ROS)":[72],"(RNS)":[77],"overwhelm":[79],"innate":[80],"cellular":[81,140],"antioxidant":[82],"defences":[83],"trigger":[85],"oxidative":[86],"damage":[87,156],"cell":[89,111,145],"death.":[90],"Recently,":[91],"this":[95],"class":[96],"were":[97],"screened":[98,167],"by":[99,149],"National":[101],"Cancer":[102],"Institute's":[103],"(NCI)":[104],"Developmental":[105],"Therapeutics":[106],"Program":[107],"(DTP).":[108],"60-cancer":[110],"line":[112],"screening":[113],"results":[114],"indicate":[115],"leads":[118],"unique":[120],"activity":[121],"alternative":[123],"mechanisms":[124],"clinically":[126],"established":[127],"anticancer":[128],"agents":[129],"such":[130],"as":[131],"cisplatin":[132],"bleomycin.":[134],"Although":[135],"DNA":[136],"is":[137,147],"valid":[139],"target,":[141],"mechanistic":[142,182],"evidence":[143],"suggests":[144],"death":[146],"triggered":[148],"metal-catalysed":[150],"pro-apoptotic":[151],"ROS":[152],"RNS":[154],"cytoplasmic,":[157],"mitochondrial,":[158],"genome":[160],"function.":[161],"In":[162],"addition":[163],"within":[168],"DTP,":[170],"number":[172],"structurally":[175],"relevant":[176],"compounds":[177],"are":[178],"described,":[179],"aspects":[183],"their":[185],"chemotherapeutic":[186],"activity.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-11T00:00:00"}