{"id":"https://openalex.org/W2932398043","doi":"https://doi.org/10.5505/ejm.2019.82713","title":"Overexpression of Insulin Receptor Substrate 1 (IRS1) Promotes Radioresistance in A172 Glioblastoma Cell Line","display_name":"Overexpression of Insulin Receptor Substrate 1 (IRS1) Promotes Radioresistance in A172 Glioblastoma Cell Line","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2932398043","doi":"https://doi.org/10.5505/ejm.2019.82713","mag":"2932398043"},"language":"en","primary_location":{"id":"doi:10.5505/ejm.2019.82713","doi":"https://doi.org/10.5505/ejm.2019.82713","is_oa":true,"landing_page_url":"https://doi.org/10.5505/ejm.2019.82713","pdf_url":"https://doi.org/10.5505/ejm.2019.82713","source":{"id":"https://openalex.org/S2765070564","display_name":"Eastern Journal Of Medicine","issn_l":"1301-0883","issn":["1301-0883","1309-3886"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eastern Journal Of Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2932398043"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5505/ejm.2019.82713","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020962529","display_name":"G\u00f6khan G\u00f6rgi\u015fen","orcid":"https://orcid.org/0000-0001-6040-7863","observed_orcids":["https://orcid.org/0000-0001-6040-7863"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gokhan Gorgisen","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Van Yuzu ncu Yil University, Van /Turkey","Van Yuzuncu Yil University , Faculty of Medicine , Department of Medical Biology , Van , Turkey","Van Yuzuncu Yil University, Faculty of Medicine, Department of Biophysics, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Van Yuzu ncu Yil University, Van /Turkey","institution_ids":["https://openalex.org/I118567650"]},{"raw_affiliation_string":"Van Yuzuncu Yil University , Faculty of Medicine , Department of Medical Biology , Van , Turkey","institution_ids":["https://openalex.org/I118567650"]},{"raw_affiliation_string":"Van Yuzuncu Yil University, Faculty of Medicine, Department of Biophysics, Van, Turkey","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126194205","display_name":"Tahir \u00c7ak\u0131r","orcid":"https://orcid.org/0000-0003-0080-6605","observed_orcids":["https://orcid.org/0000-0003-0080-6605"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tahir \u00c7ak\u0131r","raw_affiliation_strings":["Van Yuzuncu Yil University , Faculty of Medicine , Department of Biophysics , Van , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Yuzuncu Yil University , Faculty of Medicine , Department of Biophysics , Van , Turkey","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078220177","display_name":"Can Ate\u015f","orcid":"https://orcid.org/0000-0003-2286-4398","observed_orcids":["https://orcid.org/0000-0003-2286-4398"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"can ate\u015f","raw_affiliation_strings":["Van Yuzuncu Yil University, Faculty of Medicine, Department of Biostatistics, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Yuzuncu Yil University, Faculty of Medicine, Department of Biostatistics, Van, Turkey","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044387270","display_name":"\u0130smail Musab G\u00fcla\u00e7ar","orcid":"https://orcid.org/0000-0002-9431-5585","observed_orcids":["https://orcid.org/0000-0002-9431-5585"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ismail Musab GULACAR","raw_affiliation_strings":["Van Yuzuncu Yil University, Faculty of Medicine, Department of Medical Biology, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Yuzuncu Yil University, Faculty of Medicine, Department of Medical Biology, Van, Turkey","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5127395229","display_name":"Zafer Yaren","orcid":"https://orcid.org/0000-0002-3833-1900","observed_orcids":["https://orcid.org/0000-0002-3833-1900"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zafer Yaren","raw_affiliation_strings":["Van Yuzuncu Yil University, Faculty of Medicine, Department of Medical Biology, Van, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Yuzuncu Yil University, Faculty of Medicine, Department of Medical Biology, Van, Turkey","institution_ids":["https://openalex.org/I118567650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020962529"],"corresponding_institution_ids":["https://openalex.org/I118567650"],"apc_list":null,"apc_paid":null,"fwci":0.3253,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57762087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"24","issue":"2","first_page":"204","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8320000171661377},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/a172-cells","display_name":"A172 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.621999979019165},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.9380000233650208},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.652999997138977},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.7839999794960022},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.9406688213348389},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.8477751016616821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8240605592727661},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.683545708656311},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.497454434633255},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.46770402789115906},{"id":"https://openalex.org/C197902417","wikidata":"https://www.wikidata.org/wiki/Q18033191","display_name":"IRS2","level":5,"score":0.43878403306007385},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.41203218698501587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3549152612686157},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.24800807237625122},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1283545196056366},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.05668112635612488},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5505/ejm.2019.82713","doi":"https://doi.org/10.5505/ejm.2019.82713","is_oa":true,"landing_page_url":"https://doi.org/10.5505/ejm.2019.82713","pdf_url":"https://doi.org/10.5505/ejm.2019.82713","source":{"id":"https://openalex.org/S2765070564","display_name":"Eastern Journal Of Medicine","issn_l":"1301-0883","issn":["1301-0883","1309-3886"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eastern Journal Of Medicine","raw_type":"journal-article"},{"id":"pmh:4d3b3564-4f79-434a-b412-c9070b8051cb","doi":null,"is_oa":true,"landing_page_url":"https://avesis.yyu.edu.tr/publication/details/4d3b3564-4f79-434a-b412-c9070b8051cb/oai","pdf_url":"https://avesis.yyu.edu.tr/publication/details/4d3b3564-4f79-434a-b412-c9070b8051cb/oai/document.pdf","source":{"id":"https://openalex.org/S7407055328","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University Academic Data Management System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5505/ejm.2019.82713","doi":"https://doi.org/10.5505/ejm.2019.82713","is_oa":true,"landing_page_url":"https://doi.org/10.5505/ejm.2019.82713","pdf_url":"https://doi.org/10.5505/ejm.2019.82713","source":{"id":"https://openalex.org/S2765070564","display_name":"Eastern Journal Of Medicine","issn_l":"1301-0883","issn":["1301-0883","1309-3886"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eastern Journal Of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2932398043.pdf","grobid_xml":"https://content.openalex.org/works/W2932398043.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W298582129","https://openalex.org/W1593462525","https://openalex.org/W1785947665","https://openalex.org/W1824970382","https://openalex.org/W1836718508","https://openalex.org/W1848388033","https://openalex.org/W1972624341","https://openalex.org/W2016759829","https://openalex.org/W2027032514","https://openalex.org/W2031633606","https://openalex.org/W2037332721","https://openalex.org/W2057048253","https://openalex.org/W2089171551","https://openalex.org/W2096913544","https://openalex.org/W2099412193","https://openalex.org/W2101989193","https://openalex.org/W2107979516","https://openalex.org/W2108157289","https://openalex.org/W2110938265","https://openalex.org/W2121209739","https://openalex.org/W2166934199","https://openalex.org/W2318035377","https://openalex.org/W2589233140","https://openalex.org/W2738721070","https://openalex.org/W2749412384","https://openalex.org/W2772187857","https://openalex.org/W2772814183","https://openalex.org/W2802832662","https://openalex.org/W2893863200","https://openalex.org/W2900254393","https://openalex.org/W2988297928","https://openalex.org/W6643289025"],"related_works":["https://openalex.org/W3020213890","https://openalex.org/W4403320743","https://openalex.org/W7116276672","https://openalex.org/W612948789","https://openalex.org/W793274644","https://openalex.org/W4409086206","https://openalex.org/W2082163147","https://openalex.org/W2897474496","https://openalex.org/W4378903977","https://openalex.org/W2070179329"],"abstract_inverted_index":{"Insulin":[0],"receptor":[1],"substrate":[2],"1":[3],"(IRS1)":[4],"is":[5,54,75],"the":[6,55,79,140],"main":[7],"adaptor":[8],"molecule":[9],"in":[10,42,61,69,142,158],"insulin":[11,13],"and":[12,23,63,84,111,116,125,157],"like":[14],"growth":[15],"factor":[16],"signaling.Increased":[17],"level":[18],"of":[19,21,86,132,139,166],"expression":[20,83],"IRS1":[22,82,96,133],"IGF-1R":[24],"proteins":[25],"are":[26,49],"associated":[27],"with":[28,92,109],"many":[29],"human":[30,95],"malignancies.They":[31],"also":[32],"induced":[33],"resistance":[34],"to":[35,77],"therapeutic":[36],"approaches":[37],"such":[38],"as":[39],"chemo-and":[40],"radiotherapy":[41,64],"cancer":[43],"treatment":[44],"however":[45],"their":[46,117],"molecular":[47,155],"mechanisms":[48],"still":[50],"unclear.Glioblastoma":[51],"Multiforme":[52],"(GBM)":[53],"most":[56],"common":[57],"primary":[58],"brain":[59],"tumor":[60],"adults":[62],"has":[65],"a":[66,135,146,163],"pivotal":[67],"role":[68],"its":[70],"treatment.In":[71],"this":[72,148],"study,":[73],"it":[74],"aimed":[76],"determine":[78],"relationship":[80],"between":[81],"radiosensitivity":[85,167],"GBM":[87,143],"cells.Therefore,":[88],"A172":[89,105],"cells":[90,106],"transfected":[91],"pcDNA3.1":[93],"-HA-tagged":[94],"gene.Its":[97],"overexpression":[98,131],"was":[99],"confirmed":[100,152],"by":[101,123,153],"western":[102],"blot.IRS1":[103],"overexpressed":[104],"were":[107],"irradiated":[108],"5,8":[110],"10":[112],"Gray":[113],"ionizing":[114],"radiation":[115,141],"effects":[118],"on":[119,137],"cell":[120],"viability":[121],"determined":[122],"MTT":[124],"clonogenic":[126],"assay.Our":[127],"results":[128],"showed":[129],"that":[130],"led":[134],"decrease":[136],"sensitivity":[138],"cel":[144],"ls.As":[145],"conclusion,":[147],"study":[149],"should":[150],"be":[151,162],"further":[154],"analysis":[156],"vivo":[159],"studies.IRS1":[160],"may":[161],"predictive":[164],"marker":[165],"for":[168],"GBM.":[169]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2019-04-11T00:00:00"}