{"id":"https://openalex.org/W2932287678","doi":"https://doi.org/10.1016/j.molcel.2019.02.003","title":"A Combined Approach Reveals a Regulatory Mechanism Coupling Src\u2019s Kinase Activity, Localization, and Phosphotransferase-Independent Functions","display_name":"A Combined Approach Reveals a Regulatory Mechanism Coupling Src\u2019s Kinase Activity, Localization, and Phosphotransferase-Independent Functions","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2932287678","doi":"https://doi.org/10.1016/j.molcel.2019.02.003","mag":"2932287678","pmid":"https://pubmed.ncbi.nlm.nih.gov/30956043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6474823"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2019.02.003","doi":"https://doi.org/10.1016/j.molcel.2019.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.molcel.2019.02.003","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069659767","display_name":"Ethan Ahler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Ahler","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060345055","display_name":"Ames C. Register","orcid":"https://orcid.org/0000-0002-6167-9980","observed_orcids":["https://orcid.org/0000-0002-6167-9980"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ames C. Register","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sujata Chakraborty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata Chakraborty","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003432548","display_name":"Linglan Fang","orcid":"https://orcid.org/0000-0003-2637-090X","observed_orcids":["https://orcid.org/0000-0003-2637-090X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linglan Fang","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068023412","display_name":"Emily M. Dieter","orcid":"https://orcid.org/0009-0004-2294-9775","observed_orcids":["https://orcid.org/0009-0004-2294-9775"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily M. Dieter","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010823685","display_name":"Katherine A. Sitko","orcid":"https://orcid.org/0009-0008-5810-9590","observed_orcids":["https://orcid.org/0009-0008-5810-9590"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Sitko","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109464298","display_name":"Rama Subba Rao Vidadala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama Subba Rao Vidadala","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015955848","display_name":"Bridget M. Trevillian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridget M. Trevillian","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041899935","display_name":"Martin G. Golkowski","orcid":"https://orcid.org/0000-0002-0996-1655","observed_orcids":["https://orcid.org/0000-0002-0996-1655"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Golkowski","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059568807","display_name":"Hannah Gelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Gelman","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082282727","display_name":"Jason J. Stephany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason J. Stephany","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001173365","display_name":"Alan F. Rubin","orcid":"https://orcid.org/0000-0003-1474-605X","observed_orcids":["https://orcid.org/0000-0003-1474-605X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alan F. Rubin","raw_affiliation_strings":["Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, Unversity of Melbourne, Melbourne, VIC, Australia; Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","Department of Medical Biology, Unversity of Melbourne, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, Unversity of Melbourne, Melbourne, VIC, Australia; Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976","https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Department of Medical Biology, Unversity of Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011941300","display_name":"Ethan A. Merritt","orcid":"https://orcid.org/0000-0003-1498-244X","observed_orcids":["https://orcid.org/0000-0003-1498-244X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan A. Merritt","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000189657","display_name":"Douglas M. Fowler","orcid":"https://orcid.org/0000-0001-7614-1713","observed_orcids":["https://orcid.org/0000-0001-7614-1713"]},"institutions":[{"id":"https://openalex.org/I109736498","display_name":"Canadian Institute for Advanced Research","ror":"https://ror.org/01sdtdd95","country_code":"CA","type":"facility","lineage":["https://openalex.org/I109736498"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Douglas M. Fowler","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Genetic Networks Program, CIFAR, Toronto, ON, Canada. Electronic address: dfowler@uw.edu","Department of Bioengineering, University of Washington, Seattle, WA 98195, USA","Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","Genetic Networks Program, CIFAR, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Genetic Networks Program, CIFAR, Toronto, ON, Canada. Electronic address: dfowler@uw.edu","institution_ids":["https://openalex.org/I109736498","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Genetic Networks Program, CIFAR, Toronto, ON, Canada","institution_ids":["https://openalex.org/I109736498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054397869","display_name":"Dustin J. Maly","orcid":"https://orcid.org/0000-0003-0094-0177","observed_orcids":["https://orcid.org/0000-0003-0094-0177"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dustin J. Maly","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: djmaly@uw.edu","Department of Biochemistry, University of Washington, Seattle, WA 98195, USA","Department of Chemistry, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: djmaly@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000189657","https://openalex.org/A5054397869"],"corresponding_institution_ids":["https://openalex.org/I109736498","https://openalex.org/I201448701"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.1242,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.88350893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"74","issue":"2","first_page":"393","last_page":"408.e20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.6759999990463257},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/kinase-conformation","display_name":"kinase conformation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/membrane-association","display_name":"membrane association","score":0.6869999766349792},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6019999980926514},{"id":"https://openalex.org/keywords/saturation-mutagenesis","display_name":"saturation mutagenesis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemical-genetics","display_name":"chemical genetics","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7968447804450989},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5999814867973328},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5871633291244507},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5847054123878479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5819308161735535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45601892471313477},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.4488341510295868},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4448120594024658},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3897828757762909},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2797810435295105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1492183804512024}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molcel.2019.02.003","doi":"https://doi.org/10.1016/j.molcel.2019.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:30956043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30956043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6474823","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6474823/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2019.02.003","doi":"https://doi.org/10.1016/j.molcel.2019.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1254732888","display_name":"Bioinformatics for medical \u201comics\u201d","funder_award_id":"1054618","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1306473456","display_name":"Large-Scale Methods for Assessing the Consequences of Mutations in Proteins","funder_award_id":"R01GM109110","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000888121","display_name":"New Molecular Probes For Protein Kinases","funder_award_id":"R01GM086858","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309949","display_name":"Canadian Institute for Advanced Research","ror":"https://ror.org/01sdtdd95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1604402321","https://openalex.org/W1928233886","https://openalex.org/W1964396270","https://openalex.org/W1973883065","https://openalex.org/W1980907312","https://openalex.org/W1981825167","https://openalex.org/W1981978621","https://openalex.org/W1982853447","https://openalex.org/W1986656413","https://openalex.org/W1991285913","https://openalex.org/W1991683855","https://openalex.org/W1999417865","https://openalex.org/W2003229373","https://openalex.org/W2003625237","https://openalex.org/W2016966302","https://openalex.org/W2023075172","https://openalex.org/W2023569481","https://openalex.org/W2030205108","https://openalex.org/W2038591876","https://openalex.org/W2043879728","https://openalex.org/W2054906811","https://openalex.org/W2060544488","https://openalex.org/W2060588922","https://openalex.org/W2062574001","https://openalex.org/W2072035559","https://openalex.org/W2078672252","https://openalex.org/W2083248905","https://openalex.org/W2090282739","https://openalex.org/W2094173028","https://openalex.org/W2095036253","https://openalex.org/W2095492902","https://openalex.org/W2097356092","https://openalex.org/W2107996465","https://openalex.org/W2110776558","https://openalex.org/W2127528783","https://openalex.org/W2129202771","https://openalex.org/W2139362357","https://openalex.org/W2139365100","https://openalex.org/W2151887741","https://openalex.org/W2152765584","https://openalex.org/W2153977062","https://openalex.org/W2156480395","https://openalex.org/W2161531010","https://openalex.org/W2163052215","https://openalex.org/W2225583487","https://openalex.org/W2317007660","https://openalex.org/W2415861058","https://openalex.org/W2418152327","https://openalex.org/W2577398872","https://openalex.org/W2616575720","https://openalex.org/W2622566370","https://openalex.org/W2744336424","https://openalex.org/W2752501139","https://openalex.org/W2792662161","https://openalex.org/W2896982772","https://openalex.org/W2949706399"],"related_works":["https://openalex.org/W4383710050","https://openalex.org/W7135871379","https://openalex.org/W2130304871","https://openalex.org/W1966892912","https://openalex.org/W1993417814","https://openalex.org/W1521881285","https://openalex.org/W2773375980","https://openalex.org/W2023075172","https://openalex.org/W2473186428","https://openalex.org/W1971160595"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-11T00:00:00"}