{"id":"https://openalex.org/W2931752016","doi":"https://doi.org/10.1021/acsmedchemlett.9b00071","title":"Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer\u2019s Disease","display_name":"Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer\u2019s Disease","publication_year":2019,"publication_date":"2019-03-29","ids":{"openalex":"https://openalex.org/W2931752016","doi":"https://doi.org/10.1021/acsmedchemlett.9b00071","mag":"2931752016","pmid":"https://pubmed.ncbi.nlm.nih.gov/30996816"},"language":"en","primary_location":{"id":"doi:10.1021/acsmedchemlett.9b00071","doi":"https://doi.org/10.1021/acsmedchemlett.9b00071","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.9b00071","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466821","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075804512","display_name":"Luiz Ant\u00f4nio Soares Romeiro","orcid":"https://orcid.org/0000-0001-5679-0820","observed_orcids":["https://orcid.org/0000-0001-5679-0820"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]},{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Luiz Antonio Soares Romeiro","raw_affiliation_strings":["Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","LADETER, Catholic University of Brasilia, QS 07, Lote 01,\rEPCT, \u00c1guas Claras, 71966-700 Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]},{"raw_affiliation_string":"LADETER, Catholic University of Brasilia, QS 07, Lote 01,\rEPCT, \u00c1guas Claras, 71966-700 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000518140","display_name":"J\u00e9ssica Larissa da Costa Nunes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J\u00e9ssica Larissa da Costa Nunes","raw_affiliation_strings":["Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024343666","display_name":"Camila de Oliveira Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila de Oliveira Miranda","raw_affiliation_strings":["Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038645983","display_name":"Gabriella Sim\u00f5es Heyn Roth Cardoso","orcid":"https://orcid.org/0000-0001-7120-1086","observed_orcids":["https://orcid.org/0000-0001-7120-1086"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriella Sim\u00f5es Heyn Roth Cardoso","raw_affiliation_strings":["Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001849471","display_name":"Andressa Souza de Oliveira","orcid":"https://orcid.org/0000-0001-5508-1184","observed_orcids":["https://orcid.org/0000-0001-5508-1184"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andressa Souza de Oliveira","raw_affiliation_strings":["Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health Sciences Faculty, University of Bras\u00edlia, Campus Universit\u00e1rio\rDarcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054083521","display_name":"Annachiara Gandini","orcid":"https://orcid.org/0000-0002-2888-9636","observed_orcids":["https://orcid.org/0000-0002-2888-9636"]},"institutions":[{"id":"https://openalex.org/I138549579","display_name":"Scuola Internazionale Superiore di Studi Avanzati","ror":"https://ror.org/004fze387","country_code":"IT","type":"education","lineage":["https://openalex.org/I138549579"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annachiara Gandini","raw_affiliation_strings":["Department of Neuroscience, Laboratory of Prion Biology, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, I-34136 Trieste, Italy","Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2888-9636","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Laboratory of Prion Biology, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, I-34136 Trieste, Italy","institution_ids":["https://openalex.org/I138549579"]},{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041457152","display_name":"Tereza Kobrlov\u00e1","orcid":"https://orcid.org/0000-0002-4445-0287","observed_orcids":["https://orcid.org/0000-0002-4445-0287"]},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210137570"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Tereza Kobrlova","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, 500 00 Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, 500 00 Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011323357","display_name":"Ond\u0159ej Soukup","orcid":"https://orcid.org/0000-0001-6376-8701","observed_orcids":["https://orcid.org/0000-0001-6376-8701"]},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210137570"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ondrej Soukup","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, 500 00 Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, 500 00 Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michele Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Rossi","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003943852","display_name":"Johanna Senger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Senger","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg im Breisgau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg im Breisgau, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016266091","display_name":"Manfred Jung","orcid":"https://orcid.org/0000-0002-6361-7716","observed_orcids":["https://orcid.org/0000-0002-6361-7716"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Jung","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg im Breisgau, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6361-7716","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg im Breisgau, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031707065","display_name":"Silvia I. Gervasoni","orcid":"https://orcid.org/0000-0002-5731-3396","observed_orcids":["https://orcid.org/0000-0002-5731-3396"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Gervasoni","raw_affiliation_strings":["Department of Pharmaceutical Science, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028843194","display_name":"Giulio Vistoli","orcid":"https://orcid.org/0000-0002-3939-5172","observed_orcids":["https://orcid.org/0000-0002-3939-5172"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Vistoli","raw_affiliation_strings":["Department of Pharmaceutical Science, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3939-5172","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085277820","display_name":"Sabrina Petralla","orcid":"https://orcid.org/0000-0003-4009-5676","observed_orcids":["https://orcid.org/0000-0003-4009-5676"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Petralla","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002660712","display_name":"Francesca Massenzio","orcid":"https://orcid.org/0000-0002-5189-7546","observed_orcids":["https://orcid.org/0000-0002-5189-7546"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Massenzio","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090475908","display_name":"Barbara Monti","orcid":"https://orcid.org/0000-0003-0330-482X","observed_orcids":["https://orcid.org/0000-0003-0330-482X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Monti","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069833831","display_name":"Mar\u00eda Laura Bolognesi","orcid":"https://orcid.org/0000-0002-1289-5361","observed_orcids":["https://orcid.org/0000-0002-1289-5361"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Laura Bolognesi","raw_affiliation_strings":["Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1289-5361","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5069833831","https://openalex.org/A5075804512"],"corresponding_institution_ids":["https://openalex.org/I150729083","https://openalex.org/I24871856","https://openalex.org/I9360294"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9317,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.71668679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"671","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.1632000058889389,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cashew-nut-shell-liquid","display_name":"cashew nut shell liquid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/agri-food-waste-valorization","display_name":"agri-food waste valorization","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pro-inflammatory-phenotype","display_name":"pro-inflammatory phenotype","score":0.578000009059906},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.7701051235198975},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5638372302055359},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5628221035003662},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.48348909616470337},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4481750726699829},{"id":"https://openalex.org/C3020017016","wikidata":"https://www.wikidata.org/wiki/Q34007","display_name":"Cashew nut","level":2,"score":0.4358539283275604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3947691023349762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3763918876647949},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.3473299741744995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2506744861602783},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15020474791526794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1294199526309967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11796808242797852},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.08998674154281616},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.08934816718101501},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1021/acsmedchemlett.9b00071","doi":"https://doi.org/10.1021/acsmedchemlett.9b00071","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.9b00071","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:30996816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30996816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS medicinal chemistry letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6466821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},{"id":"pmh:oai:cris.unibo.it:11585/700009","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/700009","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.7270/q2bp068p","doi":"https://doi.org/10.7270/q2bp068p","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2bp068p","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6466821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6466821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.7811999917030334,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1751440291","display_name":null,"funder_award_id":"Ju 295/13-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2261748492","display_name":null,"funder_award_id":"401864/2013-8","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5145690062","display_name":null,"funder_award_id":"SV/FVZ201708","funder_id":"https://openalex.org/F4320321798","funder_display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6436822930","display_name":null,"funder_award_id":"UHHK, 00179906","funder_id":"https://openalex.org/F4320321798","funder_display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6892136719","display_name":null,"funder_award_id":"RFO2016","funder_id":"https://openalex.org/F4320323553","funder_display_name":"Universit\u00e0 di Bologna"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321798","display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","ror":"https://ror.org/00y6khe77"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1993676790","https://openalex.org/W1995678544","https://openalex.org/W2010105460","https://openalex.org/W2021098795","https://openalex.org/W2044000724","https://openalex.org/W2063078660","https://openalex.org/W2077978004","https://openalex.org/W2090054406","https://openalex.org/W2116381732","https://openalex.org/W2129635356","https://openalex.org/W2132351720","https://openalex.org/W2146249493","https://openalex.org/W2146824244","https://openalex.org/W2157020351","https://openalex.org/W2167710782","https://openalex.org/W2206696478","https://openalex.org/W2407468727","https://openalex.org/W2491494855","https://openalex.org/W2584086915","https://openalex.org/W2615166509","https://openalex.org/W2622437567","https://openalex.org/W2728558285","https://openalex.org/W2735906958","https://openalex.org/W2738387465","https://openalex.org/W2745028397","https://openalex.org/W2793294925","https://openalex.org/W2799566889","https://openalex.org/W2892417862","https://openalex.org/W2911866882","https://openalex.org/W2918066696"],"related_works":["https://openalex.org/W3151757475","https://openalex.org/W1483077634","https://openalex.org/W2145470144","https://openalex.org/W4200528065","https://openalex.org/W3023264035","https://openalex.org/W1513102126","https://openalex.org/W2345149559","https://openalex.org/W2516856182","https://openalex.org/W2184344430","https://openalex.org/W1974692834"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"represents":[3],"a":[4,74,83],"global":[5],"problem,":[6],"with":[7,82],"an":[8,63],"estimation":[9],"of":[10,13,26,38,120,132,141],"the":[11,24,43,52,110,118,130,139],"majority":[12],"dementia":[14],"patients":[15],"in":[16,33],"low-":[17],"and":[18,71,96,107,134],"middle-income":[19],"countries":[20],"by":[21],"2050.":[22],"Thus,":[23],"development":[25,131],"sustainable":[27,135],"drugs":[28],"has":[29],"attracted":[30],"much":[31],"attention":[32],"recent":[34],"years.":[35],"In":[36],"light":[37],"this,":[39],"taking":[40],"inspiration":[41],"from":[42,57],"HDAC":[44,54,75],"inhibitor":[45],"vorinostat":[46],"(":[47],"1":[48,91],"),":[49],"we":[50],"develop":[51],"first":[53],"inhibitors":[55],"derived":[56],"cashew":[58],"nut":[59],"shell":[60],"liquid":[61],"(CNSL),":[62],"inexpensive":[64,121],"agro-food":[65],"waste":[66,123],"material.":[67],"CNSL":[68],"derivatives":[69],"8":[70],"9":[72,88,98],"display":[73],"inhibitory":[76],"profile":[77],"similar":[78],"to":[79,90,101,108],"1,":[80],"together":[81],"more":[84],"promising":[85],"safety":[86],"for":[87,129,138],"compared":[89],".":[92],"Moreover,":[93],"both":[94],"compounds":[95],"particularly":[97],"were":[99],"able":[100],"effectively":[102],"modulate":[103],"glial":[104],"cell-induced":[105],"inflammation":[106],"revert":[109],"pro-inflammatory":[111],"phenotype.":[112],"All":[113],"these":[114],"results":[115],"demonstrate":[116],"that":[117],"use":[119],"food":[122],"materials":[124],"could":[125],"be":[126],"successfully":[127],"applied":[128],"accessible":[133],"drug":[136],"candidates":[137],"treatment":[140],"AD.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2019-04-11T00:00:00"}