{"id":"https://openalex.org/W2931743436","doi":"https://doi.org/10.1371/journal.pone.0214250","title":"Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy","display_name":"Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy","publication_year":2019,"publication_date":"2019-03-28","ids":{"openalex":"https://openalex.org/W2931743436","doi":"https://doi.org/10.1371/journal.pone.0214250","mag":"2931743436","pmid":"https://pubmed.ncbi.nlm.nih.gov/30921410"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0214250","doi":"https://doi.org/10.1371/journal.pone.0214250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0214250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0214250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0214250&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028723649","display_name":"Amanda H. Kahn-Kirby","orcid":"https://orcid.org/0000-0002-8878-0413","observed_orcids":["https://orcid.org/0000-0002-8878-0413"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amanda H. Kahn-Kirby","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8878-0413","affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061039488","display_name":"Akiko Amagata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Amagata","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087904752","display_name":"C\u00e9line I. Maeder","orcid":"https://orcid.org/0000-0002-0789-1294","observed_orcids":["https://orcid.org/0000-0002-0789-1294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celine I. Maeder","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003153129","display_name":"Janet J. Mei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet J. Mei","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017935216","display_name":"Steve Sideris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Sideris","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084278583","display_name":"Yuko Kosaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Kosaka","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Hinman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Hinman","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107870402","display_name":"Stephanie A. Malone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie A. Malone","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046476675","display_name":"Joel J. Bruegger","orcid":"https://orcid.org/0009-0009-7199-4528","observed_orcids":["https://orcid.org/0009-0009-7199-4528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel J. Bruegger","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049669069","display_name":"Leslie Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie Wang","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060971778","display_name":"Virna Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virna Kim","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048414926","display_name":"William D. Shrader","orcid":"https://orcid.org/0000-0002-5713-7636","observed_orcids":["https://orcid.org/0000-0002-5713-7636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William D. Shrader","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103579606","display_name":"Kevin G. Hoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin G. Hoff","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109029215","display_name":"Joey C. Latham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joey C. Latham","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075711252","display_name":"Euan Angus Ashley","orcid":"https://orcid.org/0000-0001-9418-9577","observed_orcids":["https://orcid.org/0000-0001-9418-9577"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Euan A. Ashley","raw_affiliation_strings":["Stanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053510600","display_name":"Matthew Thomas Wheeler","orcid":"https://orcid.org/0000-0001-8721-3022","observed_orcids":["https://orcid.org/0000-0001-8721-3022"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew T. Wheeler","raw_affiliation_strings":["Stanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059742070","display_name":"Enrico Bertini","orcid":"https://orcid.org/0000-0001-9276-4590","observed_orcids":["https://orcid.org/0000-0001-9276-4590"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Bertini","raw_affiliation_strings":["Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029377107","display_name":"Rosalba Carrozzo","orcid":"https://orcid.org/0000-0002-3327-4054","observed_orcids":["https://orcid.org/0000-0002-3327-4054"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosalba Carrozzo","raw_affiliation_strings":["Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087472564","display_name":"Diego Martinelli","orcid":"https://orcid.org/0000-0002-9324-2871","observed_orcids":["https://orcid.org/0000-0002-9324-2871"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Martinelli","raw_affiliation_strings":["Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Ges\u00f9 Children's Research Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087777712","display_name":"Carlo Dionisi\u2010Vici","orcid":"https://orcid.org/0000-0002-0007-3379","observed_orcids":["https://orcid.org/0000-0002-0007-3379"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Dionisi-Vici","raw_affiliation_strings":["Clinical Division and Research Unit of Metabolic Diseases, Bambino Ges\u00f9 Children's Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division and Research Unit of Metabolic Diseases, Bambino Ges\u00f9 Children's Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036670808","display_name":"Kimberly A. Chapman","orcid":"https://orcid.org/0000-0002-5471-9083","observed_orcids":["https://orcid.org/0000-0002-5471-9083"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly A. Chapman","raw_affiliation_strings":["Children's National Rare Disease Institute, Children's National Health System, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's National Rare Disease Institute, Children's National Health System, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008356363","display_name":"Gregory M. Enns","orcid":"https://orcid.org/0000-0001-9968-0840","observed_orcids":["https://orcid.org/0000-0001-9968-0840"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Enns","raw_affiliation_strings":["Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082442398","display_name":"William Allen Gahl","orcid":"https://orcid.org/0000-0002-2494-6752","observed_orcids":["https://orcid.org/0000-0002-2494-6752"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Gahl","raw_affiliation_strings":["NIH Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075661027","display_name":"Lynne A. Wolfe","orcid":"https://orcid.org/0000-0001-7628-5741","observed_orcids":["https://orcid.org/0000-0001-7628-5741"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne Wolfe","raw_affiliation_strings":["NIH Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIH Undiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040980763","display_name":"Russell P. Saneto","orcid":"https://orcid.org/0000-0002-7250-2347","observed_orcids":["https://orcid.org/0000-0002-7250-2347"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell P. Saneto","raw_affiliation_strings":["Division of Pediatric Neurology, Department of Neurology, Neuroscience Institute, Seattle Children's Hospital, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Neurology, Department of Neurology, Neuroscience Institute, Seattle Children's Hospital, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053802883","display_name":"Simon C. Johnson","orcid":"https://orcid.org/0000-0002-1942-3674","observed_orcids":["https://orcid.org/0000-0002-1942-3674"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon C. Johnson","raw_affiliation_strings":["Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","Department of Neurology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Department of Neurology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011426512","display_name":"Jeffrey K. Trimmer","orcid":"https://orcid.org/0009-0009-6467-3574","observed_orcids":["https://orcid.org/0009-0009-6467-3574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey K. Trimmer","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103406622","display_name":"Matthew B. Klein","orcid":"https://orcid.org/0000-0002-8697-1769","observed_orcids":["https://orcid.org/0000-0002-8697-1769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew B. Klein","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043296636","display_name":"Charles R. Holst","orcid":"https://orcid.org/0000-0001-8010-1677","observed_orcids":["https://orcid.org/0000-0001-8010-1677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles R. Holst","raw_affiliation_strings":["BioElectron Technology Corporation, Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioElectron Technology Corporation, Mountain View, California, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5028723649"],"corresponding_institution_ids":[],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":6.3092,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.97166318,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"e0214250","last_page":"e0214250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.8230000138282776},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/15-hydroxyeicosatetraenoic-acid","display_name":"15-hydroxyeicosatetraenoic acid","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.902999997138977},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.925000011920929},{"id":"https://openalex.org/keywords/rsl3","display_name":"RSL3","score":0.6190000176429749},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.38499999046325684},{"id":"https://openalex.org/keywords/anticonvulsant-therapy","display_name":"anticonvulsant therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pediatric-neurodegenerative-disorder","display_name":"pediatric neurodegenerative disorder","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.7679550647735596},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6765230894088745},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48793384432792664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48692357540130615},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.4461181163787842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4227057099342346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33741992712020874},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.23829442262649536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21169424057006836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1647975742816925},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.14444229006767273},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0214250","doi":"https://doi.org/10.1371/journal.pone.0214250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0214250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0214250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:30921410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30921410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5443216","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6438538","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6438538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6438538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8d6a4743a7c54e47b90913a261c70803","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d6a4743a7c54e47b90913a261c70803","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 3, p e0214250 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7913084","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Targeting_ferroptosis_A_novel_therapeutic_strategy_for_the_treatment_of_mitochondrial_disease-related_epilepsy/7913084","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/426554","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/426554","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0214250","doi":"https://doi.org/10.1371/journal.pone.0214250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0214250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0214250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1759665073","display_name":null,"funder_award_id":"K99 GM126147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G400208886","display_name":"The role of mTOR in mitochondrial encephalopathy","funder_award_id":"1k99gm126147-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320319071","display_name":"Moderna","ror":"https://ror.org/01xm4wg91"},{"id":"https://openalex.org/F4320327470","display_name":"Swedish Orphan Biovitrum","ror":"https://ror.org/04asvbz37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333587","display_name":"Sanofi Genzyme","ror":null},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2931743436.pdf","grobid_xml":"https://content.openalex.org/works/W2931743436.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W881626459","https://openalex.org/W1493931678","https://openalex.org/W1958394803","https://openalex.org/W1964545403","https://openalex.org/W1964914272","https://openalex.org/W1980004854","https://openalex.org/W1981221705","https://openalex.org/W1983103988","https://openalex.org/W1993706836","https://openalex.org/W1995642261","https://openalex.org/W1996533374","https://openalex.org/W1997183854","https://openalex.org/W2000415736","https://openalex.org/W2002289370","https://openalex.org/W2002490399","https://openalex.org/W2005535410","https://openalex.org/W2007794772","https://openalex.org/W2009894419","https://openalex.org/W2016211613","https://openalex.org/W2025464337","https://openalex.org/W2026083984","https://openalex.org/W2035898183","https://openalex.org/W2036098732","https://openalex.org/W2036216403","https://openalex.org/W2036963968","https://openalex.org/W2050394095","https://openalex.org/W2070066327","https://openalex.org/W2076307611","https://openalex.org/W2082233250","https://openalex.org/W2085600787","https://openalex.org/W2089541130","https://openalex.org/W2089609935","https://openalex.org/W2091536100","https://openalex.org/W2092105468","https://openalex.org/W2114138419","https://openalex.org/W2126799109","https://openalex.org/W2135363908","https://openalex.org/W2143099403","https://openalex.org/W2152011937","https://openalex.org/W2157374284","https://openalex.org/W2158228504","https://openalex.org/W2159800234","https://openalex.org/W2167879855","https://openalex.org/W2171864779","https://openalex.org/W2239667419","https://openalex.org/W2263417796","https://openalex.org/W2314788017","https://openalex.org/W2322300924","https://openalex.org/W2399192198","https://openalex.org/W2466526161","https://openalex.org/W2526660394","https://openalex.org/W2535886134","https://openalex.org/W2549188196","https://openalex.org/W2550324626","https://openalex.org/W2584596997","https://openalex.org/W2602903584","https://openalex.org/W2736059261","https://openalex.org/W2753909435","https://openalex.org/W2759112714","https://openalex.org/W2761782504","https://openalex.org/W2762087180","https://openalex.org/W2778262854","https://openalex.org/W2781675540","https://openalex.org/W2786707817","https://openalex.org/W2794662094","https://openalex.org/W2800366218","https://openalex.org/W2801814378","https://openalex.org/W2802800214","https://openalex.org/W2803141971","https://openalex.org/W2804102163","https://openalex.org/W2805138955","https://openalex.org/W2883153061","https://openalex.org/W2885747263","https://openalex.org/W2908942899","https://openalex.org/W2950923091"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2980161056","https://openalex.org/W2508296626","https://openalex.org/W4315864849","https://openalex.org/W2147418323","https://openalex.org/W2007897359","https://openalex.org/W2014443941","https://openalex.org/W2011686138","https://openalex.org/W3135650082","https://openalex.org/W2301670026"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitochondrial":[1],"disease":[2,220],"is":[3,20,41,83],"a":[4,21,42,73,101,185,229,255],"family":[5],"of":[6,17,24,32,45,58,65,76,89,141,147,187,252],"genetic":[7],"disorders":[8],"characterized":[9],"by":[10,61,85,176,228],"defects":[11],"in":[12,28,72,124,213,232],"the":[13,29,66,87,127,138,145,179,237,248],"generation":[14],"and":[15,27,47,56,93,121,143,159,191,197,202,236,260],"regulation":[16],"energy.":[18],"Epilepsy":[19],"common":[22],"symptom":[23],"mitochondrial":[25,128,153,165,262],"disease,":[26],"vast":[30],"majority":[31],"cases,":[33],"refractory":[34],"to":[35,105,117,136,150],"commonly":[36],"used":[37],"antiepileptic":[38],"drugs.":[39],"Ferroptosis":[40,173],"recently-described":[43],"form":[44],"iron-":[46],"lipid-dependent":[48],"regulated":[49,84],"cell":[50,200],"death":[51],"associated":[52,122,223,265],"with":[53,126,164,178,222,264],"glutathione":[54,90,189],"depletion":[55,190],"production":[57],"lipid":[59,204,234],"peroxides":[60],"lipoxygenase":[62],"enzymes.":[63],"Activation":[64],"ferroptosis":[67,82,212],"pathway":[68],"has":[69],"been":[70],"implicated":[71],"growing":[74],"number":[75],"disorders,":[77],"including":[78,199],"epilepsy.":[79,224,266],"Given":[80],"that":[81],"balancing":[86],"activities":[88],"peroxidase-4":[91],"(GPX4)":[92],"15-lipoxygenase":[94],"(15-LO),":[95],"targeting":[96,148],"these":[97],"enzymes":[98],"may":[99],"provide":[100],"rational":[102],"therapeutic":[103,110,256],"strategy":[104],"modulate":[106],"seizure.":[107],"The":[108],"clinical-stage":[109],"vatiquinone":[111],"(EPI-743,":[112],"\u03b1-tocotrienol":[113],"quinone)":[114],"was":[115,174,195,226],"reported":[116],"reduce":[118],"seizure":[119],"frequency":[120],"morbidity":[123],"children":[125],"disorder":[129],"pontocerebellar":[130],"hypoplasia":[131],"type":[132],"6.":[133],"We":[134],"sought":[135],"elucidate":[137],"molecular":[139],"mechanism":[140],"EPI-743":[142,194,209,253],"explore":[144],"potential":[146],"15-LO":[149,239],"treat":[151],"additional":[152],"disease-associated":[154,166],"epilepsies.":[155],"METHODS:":[156],"Primary":[157],"fibroblasts":[158],"B-lymphocytes":[160],"derived":[161],"from":[162],"patients":[163],"epilepsy":[167],"were":[168,206],"cultured":[169],"under":[170],"standardized":[171],"conditions.":[172],"induced":[175],"treatment":[177],"irreversible":[180],"GPX4":[181],"inhibitor":[182],"RSL3":[183],"or":[184],"combination":[186],"pharmacological":[188],"excess":[192],"iron.":[193],"co-administered":[196],"endpoints,":[198],"viability":[201],"15-LO-dependent":[203],"oxidation,":[205],"measured.":[207],"RESULTS:":[208],"potently":[210],"prevented":[211],"patient":[214],"cells":[215],"representing":[216],"five":[217],"distinct":[218],"pediatric":[219],"syndromes":[221],"Cytoprotection":[225],"preceded":[227],"dose-dependent":[230],"decrease":[231],"general":[233],"oxidation":[235],"specific":[238],"product":[240],"15-hydroxyeicosatetraenoic":[241],"acid":[242],"(15-HETE).":[243],"CONCLUSIONS:":[244],"These":[245],"findings":[246],"support":[247],"continued":[249],"clinical":[250],"evaluation":[251],"as":[254],"agent":[257],"for":[258],"PCH6":[259],"other":[261],"diseases":[263]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}