{"id":"https://openalex.org/W2931058211","doi":"https://doi.org/10.1016/j.molcel.2019.03.016","title":"Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control?","display_name":"Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control?","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2931058211","doi":"https://doi.org/10.1016/j.molcel.2019.03.016","mag":"2931058211","pmid":"https://pubmed.ncbi.nlm.nih.gov/30951651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6561724"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2019.03.016","doi":"https://doi.org/10.1016/j.molcel.2019.03.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.016","pdf_url":"http://www.cell.com/article/S1097276519302205/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1097276519302205/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063773733","display_name":"Timothy Z. Chang","orcid":"https://orcid.org/0000-0002-5620-6062","observed_orcids":["https://orcid.org/0000-0002-5620-6062"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Z. Chang","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103855331","display_name":"James Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Kuo","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087859961","display_name":"Pamela A. Silver","orcid":"https://orcid.org/0000-0002-7856-4071","observed_orcids":["https://orcid.org/0000-0002-7856-4071"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pamela A. Silver","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: pamela_silver@hms.harvard.edu","Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: pamela_silver@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087859961"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.0728,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33073784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"74","issue":"1","first_page":"5","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenine-methylation","display_name":"adenine methylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/human-cells","display_name":"human cells","score":0.5910000205039978},{"id":"https://openalex.org/keywords/epigenetic-engineering","display_name":"epigenetic engineering","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9454387426376343},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6604624390602112},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.45851632952690125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4428463876247406},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.43216636776924133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3296182453632355},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.19032150506973267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10213524103164673},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08465701341629028},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07871565222740173},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07396012544631958}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molcel.2019.03.016","doi":"https://doi.org/10.1016/j.molcel.2019.03.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.016","pdf_url":"http://www.cell.com/article/S1097276519302205/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:30951651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30951651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6561724","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6561724/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2019.03.016","doi":"https://doi.org/10.1016/j.molcel.2019.03.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.016","pdf_url":"http://www.cell.com/article/S1097276519302205/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1711182428","display_name":"A synchronized circadian clock in gut bacteria, using control theory","funder_award_id":"F32GM125108","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2931058211.pdf"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1890391421","https://openalex.org/W2059099579","https://openalex.org/W2330245166","https://openalex.org/W2415866521","https://openalex.org/W2610903912","https://openalex.org/W2617697895","https://openalex.org/W2618047787","https://openalex.org/W2902825844","https://openalex.org/W2952631944"],"related_works":["https://openalex.org/W2906683289","https://openalex.org/W2807288284","https://openalex.org/W2982780161","https://openalex.org/W2902825844","https://openalex.org/W2903838824","https://openalex.org/W7055545942","https://openalex.org/W2898698486","https://openalex.org/W2589766927","https://openalex.org/W2921694406","https://openalex.org/W2740790311"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-11T00:00:00"}