{"id":"https://openalex.org/W292969287","doi":"https://doi.org/10.1054/bjoc.2000.1423","title":"Inhibition of transcription factor nuclear factor-\u03baB by a mutant inhibitor-\u03baB\u03b1 attenuates resistance of human head and neck squamous cell carcinoma to TNF-\u03b1 caspase-mediated cell death","display_name":"Inhibition of transcription factor nuclear factor-\u03baB by a mutant inhibitor-\u03baB\u03b1 attenuates resistance of human head and neck squamous cell carcinoma to TNF-\u03b1 caspase-mediated cell death","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W292969287","doi":"https://doi.org/10.1054/bjoc.2000.1423","mag":"292969287","pmid":"https://pubmed.ncbi.nlm.nih.gov/11044363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2408789"},"language":"en","primary_location":{"id":"doi:10.1054/bjoc.2000.1423","doi":"https://doi.org/10.1054/bjoc.2000.1423","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1423","pdf_url":"https://www.nature.com/articles/6691423.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6691423.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113656154","display_name":"Dianne C. Duffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D C Duffey","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064345717","display_name":"C C Bancroft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C V Crowl-Bancroft","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090072911","display_name":"Z Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Chen","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067074708","display_name":"Frank G. Ondrey","orcid":"https://orcid.org/0000-0002-4951-9335","observed_orcids":["https://orcid.org/0000-0002-4951-9335"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F G Ondrey","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076938231","display_name":"M Nejad-Sattari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Nejad-Sattari","raw_affiliation_strings":["Howard Hughes Medical Institute, Bethesda, MD, USA","Howard Hughes Medical Institute, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Bethesda, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101884311","display_name":"Gang Dong","orcid":"https://orcid.org/0000-0001-8428-0668","observed_orcids":["https://orcid.org/0000-0001-8428-0668","https://orcid.org/0000-0003-2722-3098"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Dong","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067960602","display_name":"Carter Van Waes","orcid":"https://orcid.org/0000-0002-9599-5113","observed_orcids":["https://orcid.org/0000-0002-9599-5113"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Van Waes","raw_affiliation_strings":["Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]},{"raw_affiliation_string":"Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.0687,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.73786408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"83","issue":"10","first_page":"1367","last_page":"1374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tnf-alpha-resistance","display_name":"TNF-alpha resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/caspase-mediated-cell-death","display_name":"caspase-mediated cell death","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/constitutive-nf-kappab-activation","display_name":"constitutive NF-\u03baB activation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.47099998593330383},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/caspase-inhibitors","display_name":"caspase inhibitors","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6492088437080383},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6348221302032471},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6143341064453125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5832705497741699},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5795026421546936},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5570865273475647},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5504933595657349},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5103606581687927},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4935828447341919},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.49300143122673035},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4826672375202179},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.433494508266449},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4232533872127533},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.41943708062171936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1880093216896057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11189678311347961},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05806058645248413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05805402994155884},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.057079702615737915},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1054/bjoc.2000.1423","doi":"https://doi.org/10.1054/bjoc.2000.1423","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1423","pdf_url":"https://www.nature.com/articles/6691423.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2408789","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2408789","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:11044363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11044363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1054/bjoc.2000.1423","doi":"https://doi.org/10.1054/bjoc.2000.1423","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2000.1423","pdf_url":"https://www.nature.com/articles/6691423.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1479001176","display_name":"NF-kappaB in pathogenesis and therapy of head and neck cancer","funder_award_id":"Z01DC000016","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G7970543208","display_name":null,"funder_award_id":"ZO1-DC-00016","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W292969287.pdf","grobid_xml":"https://content.openalex.org/works/W292969287.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W95988660","https://openalex.org/W1488153046","https://openalex.org/W1492606093","https://openalex.org/W1497061219","https://openalex.org/W1497680781","https://openalex.org/W1500705682","https://openalex.org/W1502665310","https://openalex.org/W1517251498","https://openalex.org/W1578639156","https://openalex.org/W1825703274","https://openalex.org/W1832527043","https://openalex.org/W1863698700","https://openalex.org/W1888783223","https://openalex.org/W1915074145","https://openalex.org/W1979596837","https://openalex.org/W1983014391","https://openalex.org/W1983398917","https://openalex.org/W1989508434","https://openalex.org/W2002568132","https://openalex.org/W2003514161","https://openalex.org/W2024789741","https://openalex.org/W2025504025","https://openalex.org/W2053626724","https://openalex.org/W2057123987","https://openalex.org/W2057271298","https://openalex.org/W2064629331","https://openalex.org/W2065257477","https://openalex.org/W2067527807","https://openalex.org/W2070853191","https://openalex.org/W2073296110","https://openalex.org/W2076584185","https://openalex.org/W2076741139","https://openalex.org/W2082575834","https://openalex.org/W2083726090","https://openalex.org/W2083735475","https://openalex.org/W2086941505","https://openalex.org/W2087689701","https://openalex.org/W2090685205","https://openalex.org/W2091444924","https://openalex.org/W2091695331","https://openalex.org/W2095333484","https://openalex.org/W2103953729","https://openalex.org/W2114839218","https://openalex.org/W2119264408","https://openalex.org/W2121863127","https://openalex.org/W2127650036","https://openalex.org/W2132915524","https://openalex.org/W2133726754","https://openalex.org/W2147760686","https://openalex.org/W2148839497","https://openalex.org/W2148860368","https://openalex.org/W2150571795","https://openalex.org/W2151677238","https://openalex.org/W2152190150","https://openalex.org/W2161360807","https://openalex.org/W2171865516","https://openalex.org/W2171914962","https://openalex.org/W2172010722","https://openalex.org/W2288040354","https://openalex.org/W2395896744","https://openalex.org/W2405343802","https://openalex.org/W2462772841","https://openalex.org/W2991669885"],"related_works":["https://openalex.org/W2127650036","https://openalex.org/W2039395669","https://openalex.org/W4403335956","https://openalex.org/W4365453951","https://openalex.org/W2135339893","https://openalex.org/W2101423153","https://openalex.org/W862993277","https://openalex.org/W2318014438","https://openalex.org/W2992857549","https://openalex.org/W2143999201"],"abstract_inverted_index":{"Tumour":[0],"necrosis":[1],"factor-alpha":[2],"(TNF-alpha)":[3],"is":[4,82,136],"a":[5,16,95,142],"cytokine":[6],"that":[7,80,88,231,262,264,279],"can":[8],"induce":[9],"cell":[10,39,44,55,227],"death":[11,58,247],"of":[12,19,32,90,94,99,107,123,130,141,160,175,197,204,217,240,270,281,291,294,296,300,310,319],"different":[13],"cancers":[14],"via":[15],"cellular":[17],"cascade":[18],"proteases,":[20],"the":[21,113,118,292,308],"caspases.":[22],"However,":[23],"TNF-alpha":[24,61,119,176,183,232,286,303],"has":[25],"been":[26],"detected":[27],"in":[28,85,110,133,177,298,307],"tumour":[29,43],"and":[30,36,42,62,87,105,121,129,152,191,194,254,267,278,316],"serum":[31],"patients":[33],"with":[34,125,238,242],"head":[35],"neck":[37],"squamous":[38],"carcinoma":[40],"(HNSCC),":[41],"lines":[45,149,186],"derived":[46],"from":[47],"this":[48],"environment":[49],"often":[50],"exhibit":[51,157,265],"resistance":[52,299],"to":[53,156,164,168,173,222,276,285,302],"TNF-alpha-induced":[54,223],"death.":[56],"Cell":[57,246],"mediated":[59],"by":[60,67,71,92,138,171,201,207,250,257],"caspases":[63],"may":[64,304],"be":[65,165,305],"inhibited":[66,137],"cytoprotective":[68],"genes":[69],"regulated":[70],"transcription":[72,271],"factor":[73,272],"nuclear":[74,202],"factor-kappaB":[75],"(NF-kappaB).":[76],"We":[77,260],"recently":[78],"showed":[79],"NF-kappaB":[81,91,135,198,205,273,282,297],"constitutively":[83,126],"activated":[84],"HNSCC,":[86],"inhibition":[89,170,235,280],"expression":[93,140],"nondegradable":[96],"mutant":[97,145],"inhibitor":[98,216],"NF-kappaB,":[100,128,161,218],"IkappaBalphaM,":[101],"markedly":[102],"decreased":[103],"survival":[104],"growth":[106,169,224,234],"HNSCC":[108,124,131,185,263,284,301],"cells":[109,132,211,241],"vivo.":[111],"In":[112],"present":[114],"study,":[115],"we":[116],"examined":[117],"sensitivity":[120],"response":[122],"active":[127],"which":[134,212],"stable":[139],"dominant":[143],"negative":[144],"inhibitor,":[146],"IkappaBalphaM.":[147],"Human":[148],"UM-SCC-9,":[150],"11B":[151],"38,":[153],"previously":[154],"shown":[155],"constitutive":[158,193,266],"activation":[159,196,269,295],"were":[162,220],"found":[163],"highly":[166],"resistant":[167,184,275],"up":[172],"10(4)U/ml":[174],"5":[178],"day":[179],"MTT":[180],"assay.":[181],"These":[182],"expressed":[187,214],"TNF":[188],"receptor":[189],"I,":[190],"exhibited":[192],"TNF-alpha-inducible":[195,268],"as":[199],"demonstrated":[200,249],"localization":[203],"p65":[206],"immunohistochemistry.":[208],"UM-SCC-9":[209],"I11":[210],"stably":[213],"an":[215],"IkappaBalpham,":[219],"susceptible":[221],"inhibition.":[225],"DNA":[226,244],"cycle":[228],"analysis":[229],"revealed":[230],"induced":[233],"was":[236,248,255],"associated":[237],"accumulation":[239],"sub-G0/G1":[243],"content.":[245],"trypan":[251],"blue":[252],"staining,":[253],"blocked":[256],"caspase":[258],"inhibitor.":[259],"conclude":[261],"are":[274],"TNF-alpha,":[277],"sensitizes":[283],"caspase-mediated":[287],"cytotoxicity.":[288],"The":[289],"demonstration":[290],"role":[293],"helpful":[306],"identification":[309],"potential":[311],"targets":[312],"for":[313],"pharmacological,":[314],"molecular":[315],"immune":[317],"therapy":[318],"HNSCC.":[320]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}