{"id":"https://openalex.org/W29296376","doi":"https://doi.org/10.1007/978-1-59745-104-8_7","title":"Ossicle and Vossicle Implant Model Systems","display_name":"Ossicle and Vossicle Implant Model Systems","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W29296376","doi":"https://doi.org/10.1007/978-1-59745-104-8_7","mag":"29296376","pmid":"https://pubmed.ncbi.nlm.nih.gov/18463813"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-104-8_7","doi":"https://doi.org/10.1007/978-1-59745-104-8_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-104-8_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods In Molecular Biology\u2122","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4250141980","display_name":"Osteoporosis"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111548620","display_name":"Glenda J. Pettway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenda J. Pettway","raw_affiliation_strings":["Departments of Periodontics & Oral Medicine and Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Departments of Periodontics & Oral Medicine and Biomedical Engineering, University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Periodontics & Oral Medicine and Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Departments of Periodontics & Oral Medicine and Biomedical Engineering, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010672369","display_name":"Laurie K. McCauley","orcid":"https://orcid.org/0000-0001-9173-9123","observed_orcids":["https://orcid.org/0000-0001-9173-9123"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie K. McCauley","raw_affiliation_strings":["Departments of Periodontics & Oral Medicine and Pathology, University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Periodontics & Oral Medicine and Pathology, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":11.6193,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.97931161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"455","issue":null,"first_page":"101","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/bone-growth","display_name":"bone growth","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.6859999895095825},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6766877174377441},{"id":"https://openalex.org/C2777038747","wikidata":"https://www.wikidata.org/wiki/Q17151027","display_name":"Ossicle","level":3,"score":0.6297966241836548},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4952656328678131},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.48320329189300537},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.447065144777298},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.414128839969635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39812785387039185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3928028345108032},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3654407858848572},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34582510590553284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3175424337387085},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.24013152718544006},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.22200459241867065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21193543076515198},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17818483710289001},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016025","descriptor_name":"Bone Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020007","descriptor_name":"Implants, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-59745-104-8_7","doi":"https://doi.org/10.1007/978-1-59745-104-8_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-104-8_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods In Molecular Biology\u2122","raw_type":"book-chapter"},{"id":"pmid:18463813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18463813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2846347270","display_name":"The Biology of Prostate Cancer Skeletal Metastases","funder_award_id":"P01CA093900","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2901253349","display_name":null,"funder_award_id":"DK-53904","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G39597776","display_name":null,"funder_award_id":"CA93900","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1981043866","https://openalex.org/W1983582703","https://openalex.org/W1985009041","https://openalex.org/W1990863760","https://openalex.org/W1996656034","https://openalex.org/W2004217766","https://openalex.org/W2125788963","https://openalex.org/W2134478449"],"related_works":["https://openalex.org/W2914944674","https://openalex.org/W2371029890","https://openalex.org/W3009185135","https://openalex.org/W2547754825","https://openalex.org/W2275206530","https://openalex.org/W4304809085","https://openalex.org/W3012245794","https://openalex.org/W1951631449","https://openalex.org/W2900103134","https://openalex.org/W1963521745"],"abstract_inverted_index":{"Bone":[0],"regeneration":[1],"and":[2,11,23,33,57,69,80,86,100,117,122,147],"repair":[3],"is":[4,92,104],"a":[5,64,70,93,105],"goal":[6],"of":[7,37,46,83],"many":[8],"skeletal":[9,52],"therapies":[10],"numerous":[12],"agents":[13,22,32],"positively":[14],"or":[15,160],"negatively":[16],"impact":[17],"these":[18],"processes.":[19],"New":[20],"therapeutic":[21],"effective":[24],"model":[25,68,91,99,103],"systems":[26],"are":[27,39],"continually":[28],"sought":[29],"to":[30,77,115,135,157,176],"identify":[31],"characterize":[34],"their":[35],"mechanisms":[36],"action":[38],"in":[40,50,132,155],"constant":[41],"demand.":[42],"In":[43],"addition,":[44],"investigations":[45],"tumor":[47],"cell-bone":[48],"interaction":[49],"the":[51,101,178],"metastatic":[53],"microenvironment":[54],"require":[55],"well-defined":[56],"readily":[58],"orchestrated":[59],"models.":[60],"This":[61],"chapter":[62],"describes":[63],"novel":[65],"ectopic":[66],"ossicle":[67,90],"vossicle":[71,102],"modification":[72],"that":[73],"can":[74,129,164],"be":[75,130,166],"used":[76],"provide":[78],"focused":[79],"rapid":[81],"feedback":[82],"bone":[84,94,108],"growth":[85],"bone-cellular":[87],"interactions.":[88],"The":[89],"marrow":[95],"stromal":[96],"cell":[97,148,170],"(BMSC)-based":[98],"neonatal":[106],"vertebral":[107],"transplant":[109],"model.":[110],"These":[111],"models":[112],"offer":[113],"opportunities":[114],"mix":[116],"compare":[118],"mesenchymal":[119],"(donor":[120],"derived)":[121],"hematopoietic":[123],"elements":[124],"(host":[125],"derived).":[126],"Multiple":[127],"implants":[128],"placed":[131],"one":[133],"mouse":[134],"facilitate":[136],"various":[137],"outcome":[138],"analyses,":[139],"such":[140,152,172],"as":[141,153,173],"histomorphometry,":[142],"micro-CT,":[143],"gene":[144],"expression":[145],"studies,":[146],"tracking":[149],"using":[150],"markers":[151],"luciferase,":[154],"response":[156],"pharma":[158],"cological":[159],"genetic":[161],"manipulation.":[162],"Implants":[163],"also":[165],"combined":[167],"with":[168],"other":[169],"types,":[171],"cancer":[174],"cells":[175],"evaluate":[177],"bone-tumor":[179],"microenvironment.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}