{"id":"https://openalex.org/W2929329501","doi":"https://doi.org/10.3390/ijms20071647","title":"AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway","display_name":"AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway","publication_year":2019,"publication_date":"2019-04-03","ids":{"openalex":"https://openalex.org/W2929329501","doi":"https://doi.org/10.3390/ijms20071647","mag":"2929329501","pmid":"https://pubmed.ncbi.nlm.nih.gov/30987073","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6480054"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20071647","doi":"https://doi.org/10.3390/ijms20071647","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20071647","pdf_url":"https://www.mdpi.com/1422-0067/20/7/1647/pdf?version=1554254002","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/7/1647/pdf?version=1554254002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110731751","display_name":"Chia\u2010Cheng Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]},{"id":"https://openalex.org/I56019348","display_name":"Chia Nan University of Pharmacy and Science","ror":"https://ror.org/02834m470","country_code":"TW","type":"education","lineage":["https://openalex.org/I56019348"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Cheng Su","raw_affiliation_strings":["Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan","Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","institution_ids":["https://openalex.org/I4210136334"]},{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102999086","display_name":"Kun-Lin Hsieh","orcid":"https://orcid.org/0000-0002-2492-9717","observed_orcids":["https://orcid.org/0000-0002-2492-9717"]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kun-Lin Hsieh","raw_affiliation_strings":["Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126682325","display_name":"Shu-Chi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Chi Wang","raw_affiliation_strings":["Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005629084","display_name":"Hsin\u2010Chih Yeh","orcid":"https://orcid.org/0000-0003-4113-629X","observed_orcids":["https://orcid.org/0000-0003-4113-629X"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]},{"id":"https://openalex.org/I4210144252","display_name":"Kaohsiung Municipal Ta-Tung Hospital","ror":"https://ror.org/03db90279","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210144252"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Chih Yeh","raw_affiliation_strings":["Department of Urology, Kaohsiung Medical University Hospital and Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan","Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kaohsiung Medical University Hospital and Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan","institution_ids":["https://openalex.org/I4210144252"]},{"raw_affiliation_string":"Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054033654","display_name":"Shu\u2010Pin Huang","orcid":"https://orcid.org/0000-0003-2968-6125","observed_orcids":["https://orcid.org/0000-0003-2968-6125"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Pin Huang","raw_affiliation_strings":["Department of Urology, Kaohsiung Medical University Hospital and Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kaohsiung Medical University Hospital and Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080150681","display_name":"Po\u2010Len Liu","orcid":"https://orcid.org/0000-0003-2896-1666","observed_orcids":["https://orcid.org/0000-0003-2896-1666"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210148575","display_name":"National Taiwan University of Sport","ror":"https://ror.org/04mwjpk69","country_code":"TW","type":"education","lineage":["https://openalex.org/I4210148575"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Len Liu","raw_affiliation_strings":["Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Institute of Athletics, National Taiwan University of Sport, Taichung 40404, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Institute of Athletics, National Taiwan University of Sport, Taichung 40404, Taiwan","institution_ids":["https://openalex.org/I4210148575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527145","display_name":"Shih-Hua Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210148575","display_name":"National Taiwan University of Sport","ror":"https://ror.org/04mwjpk69","country_code":"TW","type":"education","lineage":["https://openalex.org/I4210148575"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Hua Fang","raw_affiliation_strings":["Institute of Athletics, National Taiwan University of Sport, Taichung 40404, Taiwan","Graduate Institute of Biomedical Sciences, and Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Athletics, National Taiwan University of Sport, Taichung 40404, Taiwan","institution_ids":["https://openalex.org/I4210148575"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, and Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125355850","display_name":"Wei-Chung Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Chung Cheng","raw_affiliation_strings":["Graduate Institute of Biomedical Sciences, and Research Center for Tumor Medical Science, and Drug development center, China Medical University, Taichung 40402, Taiwan","Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, and Research Center for Tumor Medical Science, and Drug development center, China Medical University, Taichung 40402, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144935241","display_name":"Kuan-Hua Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Hua Huang","raw_affiliation_strings":["Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan","institution_ids":["https://openalex.org/I4210136334"]},{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051699095","display_name":"Fang\u2010Yen Chiu","orcid":"https://orcid.org/0000-0002-0174-3047","observed_orcids":["https://orcid.org/0000-0002-0174-3047"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fang-Yen Chiu","raw_affiliation_strings":["Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053152591","display_name":"I\u2010Ling Lin","orcid":"https://orcid.org/0000-0001-7022-4315","observed_orcids":["https://orcid.org/0000-0001-7022-4315"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Ling Lin","raw_affiliation_strings":["Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Radiation Oncology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Radiation Oncology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan","institution_ids":["https://openalex.org/I2802587341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113531435","display_name":"Ming-Yii Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ming-Yii Huang","raw_affiliation_strings":["Department of Radiation Oncology, College of Medicine, and Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan","Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, College of Medicine, and Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan","institution_ids":["https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039476669","display_name":"Chia\u2010Yang Li","orcid":"https://orcid.org/0000-0001-5689-9850","observed_orcids":["https://orcid.org/0000-0001-5689-9850"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Yang Li","raw_affiliation_strings":["Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5039476669","https://openalex.org/A5113531435"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":2.7102,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.91855221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"20","issue":"7","first_page":"1647","last_page":"1647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6019999980926514},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.8360000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5529999732971191},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8739205598831177},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8195198774337769},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7635973691940308},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6253900527954102},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5983914732933044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.419575959444046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4164160490036011},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4133923053741455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3165079355239868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3029293119907379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30086010694503784},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.20942530035972595},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.20196902751922607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07844346761703491}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms20071647","doi":"https://doi.org/10.3390/ijms20071647","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20071647","pdf_url":"https://www.mdpi.com/1422-0067/20/7/1647/pdf?version=1554254002","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/474197","doi":"https://doi.org/10.1101/474197","is_oa":true,"landing_page_url":"https://doi.org/10.1101/474197","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/11/19/474197.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:6480054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6480054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:30987073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30987073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:42ffa697ce5142d488ccd4a6b4381b90","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42ffa697ce5142d488ccd4a6b4381b90","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 7, p 1647 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms20071647","doi":"https://doi.org/10.3390/ijms20071647","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20071647","pdf_url":"https://www.mdpi.com/1422-0067/20/7/1647/pdf?version=1554254002","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3216290202","display_name":"Integrative Bioinformatics Analysis of Multidimensional Genomics Data in Cancer Research","funder_award_id":"MOST106-2221-E039-011-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4396036305","display_name":null,"funder_award_id":"KMU-M102001","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G4444831932","display_name":"To Investigate the Physiological Effect of Corylin on the Activation of Nlrp3 Inflammasome and the Change of Tumor Microenvironment in Prostate Cancer and Explore Its Mechanism of Action (2nd Year and 3rd Year).","funder_award_id":"MOST107-2320-B037-019","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G497937365","display_name":null,"funder_award_id":"MOST 107?","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5563719332","display_name":null,"funder_award_id":"106-2221-E-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5985008850","display_name":"To Explore the Dna Damage Related Mechanism of Bardoxolone and Its Derivatives on Chemoradiotherapeutic Effects in Colorectal Cancer","funder_award_id":"MOST107-2314-B037-047","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6011834614","display_name":null,"funder_award_id":"CMU106\u2010N\u201005","funder_id":"https://openalex.org/F4320324301","funder_display_name":"China Medical University"},{"id":"https://openalex.org/G6324573598","display_name":null,"funder_award_id":"KMU-M106023","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"},{"id":"https://openalex.org/G7323760484","display_name":null,"funder_award_id":"KMUH 107-7R73","funder_id":"https://openalex.org/F4320327176","funder_display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital"},{"id":"https://openalex.org/G939887807","display_name":null,"funder_award_id":"MOST 106","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322811","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"},{"id":"https://openalex.org/F4320327176","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2929329501.pdf","grobid_xml":"https://content.openalex.org/works/W2929329501.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W990115821","https://openalex.org/W1841767566","https://openalex.org/W1966706887","https://openalex.org/W1975577875","https://openalex.org/W1987960087","https://openalex.org/W1994869118","https://openalex.org/W2004592773","https://openalex.org/W2006966606","https://openalex.org/W2011185738","https://openalex.org/W2017134992","https://openalex.org/W2017219924","https://openalex.org/W2022101765","https://openalex.org/W2033077175","https://openalex.org/W2041559415","https://openalex.org/W2046843522","https://openalex.org/W2058785803","https://openalex.org/W2064111108","https://openalex.org/W2076572520","https://openalex.org/W2080439368","https://openalex.org/W2080680563","https://openalex.org/W2104216849","https://openalex.org/W2108552422","https://openalex.org/W2114825009","https://openalex.org/W2116508133","https://openalex.org/W2120292596","https://openalex.org/W2128058282","https://openalex.org/W2158906397","https://openalex.org/W2159664830","https://openalex.org/W2215222410","https://openalex.org/W2253836736","https://openalex.org/W2277240911","https://openalex.org/W2336582847","https://openalex.org/W2339722892","https://openalex.org/W2408632899","https://openalex.org/W2520343687","https://openalex.org/W2567743670","https://openalex.org/W2587210054","https://openalex.org/W2727380696","https://openalex.org/W2753718912","https://openalex.org/W2767344670","https://openalex.org/W2781525129","https://openalex.org/W2792922126","https://openalex.org/W6654640476","https://openalex.org/W6714409477"],"related_works":["https://openalex.org/W2339722892","https://openalex.org/W4395114615","https://openalex.org/W4393092761","https://openalex.org/W2017134992","https://openalex.org/W2114147584","https://openalex.org/W2140805825","https://openalex.org/W2165662050","https://openalex.org/W4365813120","https://openalex.org/W2018734911","https://openalex.org/W4391655208"],"abstract_inverted_index":{"Current":[0],"clinical":[1],"challenges":[2],"of":[3,30,35,43,56,64,133,209],"prostate":[4,44,65,152,159,189,210],"cancer":[5,45,66,153,190],"management":[6],"are":[7],"to":[8,138,186],"restrict":[9],"tumor":[10],"growth":[11,40,61,69,150,172],"and":[12,41,62,75,89,101,108,117,178,182],"prohibit":[13],"metastasis.":[14],"AICAR":[15,36,57,134,147,167,200],"(5-aminoimidazole-4-carbox-amide-1-\u03b2-d-ribofuranoside),":[16],"an":[17],"AMP-activated":[18],"protein":[19,115,180],"kinase":[20],"(AMPK)":[21],"agonist,":[22],"has":[23,46],"demonstrated":[24,165],"antitumor":[25],"activities":[26],"for":[27,206],"several":[28],"types":[29],"cancers.":[31],"However,":[32],"the":[33,38,54,59,131,136,184,194,207],"activity":[34],"on":[37,58,135],"cell":[39,60,79,99,149,175],"metastasis":[42,63],"not":[47,156],"been":[48],"extensively":[49],"studied.":[50],"Herein":[51],"we":[52,128],"examine":[53],"effects":[55],"cells.":[67,160],"Cell":[68],"was":[70,81],"performed":[71],"by":[72,83,105,123],"MTT":[73,141],"assay":[74,107,110],"soft":[76],"agar":[77],"assay;":[78],"apoptosis":[80],"examined":[82],"Annexin":[84],"V/propidium":[85],"iodide":[86],"(PI)":[87],"staining":[88],"poly":[90],"ADP":[91],"ribose":[92],"polymerase":[93],"(PARP)":[94],"cleavage":[95],"western":[96,124],"blot,":[97],"while":[98],"migration":[100],"invasion":[102,177],"were":[103,121],"evaluated":[104],"wound-healing":[106],"transwell":[109],"respectively.":[111],"Epithelial-mesenchymal":[112],"transition":[113],"(EMT)-related":[114],"expression":[116],"AMPK/mTOR-dependent":[118,195],"signaling":[119],"axis":[120],"analyzed":[122],"blot.":[125],"In":[126,161],"addition,":[127,162],"also":[129],"tested":[130],"effect":[132],"chemosensitivity":[137,185],"docetaxel":[139,187],"using":[140],"assay.":[142],"Our":[143],"results":[144,164],"indicated":[145],"that":[146,166],"inhibits":[148],"in":[151,157,188],"cells,":[154],"but":[155],"non-cancerous":[158],"our":[163],"induces":[168],"apoptosis,":[169],"attenuates":[170],"transforming":[171],"factor":[173],"(TGF)-\u03b2-induced":[174],"migration,":[176],"EMT-related":[179],"expression,":[181],"enhances":[183],"cells":[191],"through":[192],"regulating":[193],"pathway.":[196],"These":[197],"findings":[198],"support":[199],"as":[201],"a":[202],"potential":[203],"therapeutic":[204],"agent":[205],"treatment":[208],"cancer.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2019-04-11T00:00:00"}