{"id":"https://openalex.org/W2928980871","doi":"https://doi.org/10.1097/rlu.0000000000002529","title":"Correlation of 99mTc-TRODAT-1 SPECT Imaging Findings and Clinical Staging of Parkinson Disease","display_name":"Correlation of 99mTc-TRODAT-1 SPECT Imaging Findings and Clinical Staging of Parkinson Disease","publication_year":2019,"publication_date":"2019-03-25","ids":{"openalex":"https://openalex.org/W2928980871","doi":"https://doi.org/10.1097/rlu.0000000000002529","mag":"2928980871","pmid":"https://pubmed.ncbi.nlm.nih.gov/30888997"},"language":"en","primary_location":{"id":"doi:10.1097/rlu.0000000000002529","doi":"https://doi.org/10.1097/rlu.0000000000002529","is_oa":false,"landing_page_url":"https://doi.org/10.1097/rlu.0000000000002529","pdf_url":null,"source":{"id":"https://openalex.org/S1118231","display_name":"Clinical Nuclear Medicine","issn_l":"0363-9762","issn":["0363-9762","1536-0229"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087877858","display_name":"Vanshika Gupta","orcid":"https://orcid.org/0000-0002-8833-4472","observed_orcids":["https://orcid.org/0000-0002-8833-4472"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vanshika Gupta","raw_affiliation_strings":["Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038110123","display_name":"Rajeev Ranjan","orcid":"https://orcid.org/0000-0003-4178-9354","observed_orcids":["https://orcid.org/0000-0003-4178-9354"]},"institutions":[{"id":"https://openalex.org/I4210113434","display_name":"Sir Ganga Ram Hospital","ror":"https://ror.org/01x18vk56","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113434"]},{"id":"https://openalex.org/I4210162682","display_name":"Sir Ganga Ram Hospital","ror":"https://ror.org/01ghxpd93","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210162682"]}],"countries":["IN","PK"],"is_corresponding":false,"raw_author_name":"Rajeev Ranjan","raw_affiliation_strings":["Department of Neurology, Sir Ganga Ram Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sir Ganga Ram Hospital; and","institution_ids":["https://openalex.org/I4210113434","https://openalex.org/I4210162682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103949739","display_name":"Ritu Verma","orcid":"https://orcid.org/0000-0002-4171-6625","observed_orcids":["https://orcid.org/0000-0002-4171-6625"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ritu Verma","raw_affiliation_strings":["Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110580168","display_name":"Ethel Shangne Belho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ethel S. Belho","raw_affiliation_strings":["Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051976392","display_name":"Dharmender Malik","orcid":"https://orcid.org/0000-0003-3080-2330","observed_orcids":["https://orcid.org/0000-0003-3080-2330"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dharmender Malik","raw_affiliation_strings":["Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and PET-CT, Mahajan Imaging Center, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045643702","display_name":"Harsh Mahajan","orcid":"https://orcid.org/0000-0003-3856-6627","observed_orcids":["https://orcid.org/0000-0003-3856-6627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harsh Mahajan","raw_affiliation_strings":["Mahajan Imaging Center, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahajan Imaging Center, New Delhi, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051976392","https://openalex.org/A5087877858","https://openalex.org/A5103949739","https://openalex.org/A5110580168"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6666,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6722889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"44","issue":"5","first_page":"347","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/99mtc-trodat-1","display_name":"99mTc-TRODAT-1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dopamine-transporter-imaging","display_name":"dopamine transporter imaging","score":0.7699999809265137},{"id":"https://openalex.org/keywords/binding-ratio","display_name":"binding ratio","score":0.640999972820282},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6790000200271606},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.8009999990463257},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":1.0},{"id":"https://openalex.org/keywords/hoehn-and-yahr-stage","display_name":"Hoehn and Yahr stage","score":0.7390000224113464},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/postural-instability","display_name":"postural instability","score":0.628000020980835},{"id":"https://openalex.org/keywords/gait-disturbance","display_name":"gait disturbance","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.8343490362167358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7839714884757996},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.698957085609436},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6971679329872131},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5123158693313599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49595698714256287},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.431612491607666},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.4243253469467163},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34862932562828064},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.19520246982574463}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/rlu.0000000000002529","doi":"https://doi.org/10.1097/rlu.0000000000002529","is_oa":false,"landing_page_url":"https://doi.org/10.1097/rlu.0000000000002529","pdf_url":null,"source":{"id":"https://openalex.org/S1118231","display_name":"Clinical Nuclear Medicine","issn_l":"0363-9762","issn":["0363-9762","1536-0229"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:30888997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30888997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nuclear medicine","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1605377341","https://openalex.org/W1896655339","https://openalex.org/W1911098755","https://openalex.org/W1957821163","https://openalex.org/W1999018495","https://openalex.org/W2008560062","https://openalex.org/W2036668200","https://openalex.org/W2039151038","https://openalex.org/W2060588252","https://openalex.org/W2074702633","https://openalex.org/W2091052334","https://openalex.org/W2099967870","https://openalex.org/W2115026925","https://openalex.org/W2147569564"],"related_works":["https://openalex.org/W3139247771","https://openalex.org/W2375933632","https://openalex.org/W2376144621","https://openalex.org/W2555394523","https://openalex.org/W2896666142","https://openalex.org/W2368029811","https://openalex.org/W2382813440","https://openalex.org/W929817119","https://openalex.org/W1911098755","https://openalex.org/W2381735727"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,30,206],"aims":[2],"of":[3,25,60,65,73,103,125,184,209,219],"this":[4],"study":[5,31],"were":[6,48,128],"to":[7,14,156,203],"evaluate":[8],"Tc-TRODAT-1":[9,43,172],"SPECT":[10,173],"imaging":[11],"patterns":[12],"and":[13,54,87,106,119,134,138,150,159,163,179],"assess":[15],"their":[16],"correlation":[17,112],"with":[18,35,76,166,189],"disease":[19,27,40,117,182],"severity":[20,118,183],"in":[21,96,122,153,164,176,180,225],"clinically":[22,36,129],"diagnosed":[23,37],"patients":[24,34,154],"Parkinson":[26,39],"(PD).":[28],"METHODS:":[29],"included":[32],"241":[33],"idiopathic":[38],"who":[41],"underwent":[42],"SPECT/CT":[44],"scan.":[45],"Binding":[46],"ratios":[47],"calculated":[49],"for":[50,69,100],"each":[51],"striatum,":[52],"caudate,":[53],"putamen":[55,99],"individually,":[56],"by":[57,84],"drawing":[58],"region":[59,64],"interest.":[61],"Occipital":[62],"cortex":[63],"interest":[66],"was":[67,80,94,113,145],"taken":[68],"background":[70],"correction.":[71],"Correlation":[72],"binding":[74,92,120,207],"ratio":[75,93,121,208],"increasing":[77,116],"clinical":[78],"stage":[79],"derived,":[81],"as":[82,216],"described":[83],"modified":[85,104],"Hoehn":[86,105],"Yahr":[88],"scale.":[89],"RESULTS:":[90],"Median":[91],"least":[95],"the":[97,148,190,197,210,226],"contralateral":[98,191],"all":[101,123],"stages":[102],"Yahr.":[107],"A":[108,186],"statistically":[109],"significant":[110,143,187],"negative":[111],"found":[114,146],"between":[115,147],"subregions":[124],"striatum.":[126,227],"Patients":[127],"categorized":[130],"into":[131],"postural":[132,157],"instability":[133,158],"gait":[135,160],"disorder":[136,161],"group":[137,162],"tremor-dominant":[139,204],"PD":[140],"group.":[141],"No":[142],"asymmetry":[144,188],"left":[149],"right":[151],"striatum":[152,212],"belonging":[155],"those":[165],"bilateral":[167],"tremors":[168],"without":[169],"lateralization.":[170],"CONCLUSIONS:":[171],"is":[174],"useful":[175,215],"early":[177],"detection":[178],"assessing":[181],"PD.":[185],"side":[192,199],"being":[193],"affected":[194],"more":[195],"than":[196],"ipsilateral":[198,211],"can":[200],"be":[201],"attributed":[202],"patients.":[205],"may":[213],"serve":[214],"a":[217],"marker":[218],"remaining":[220],"functional":[221],"dopaminergic":[222],"neuronal":[223],"reserve":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-11T00:00:00"}