{"id":"https://openalex.org/W29279755","doi":null,"title":"Cytokine gene polymorphisms in population of ethnic Macedonians.","display_name":"Cytokine gene polymorphisms in population of ethnic Macedonians.","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W29279755","mag":"29279755","pmid":"https://pubmed.ncbi.nlm.nih.gov/16100774"},"language":"en","primary_location":{"id":"pmid:16100774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16100774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Croatian medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112895431","display_name":"\u0414\u0435\u0458\u0430\u043d \u0422\u0440\u0430\u0458\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0003-2710-5710","observed_orcids":["https://orcid.org/0000-0003-2710-5710"]},"institutions":[{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Dejan Trajkov","raw_affiliation_strings":["Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Kiril and Metodij University, 1109 Skopje, PO Box 60, Republic of Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Kiril and Metodij University, 1109 Skopje, PO Box 60, Republic of Macedonia","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005572954","display_name":"Todor Arsov","orcid":"https://orcid.org/0000-0003-4149-752X","observed_orcids":["https://orcid.org/0000-0003-4149-752X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todor Arsov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034963533","display_name":"\u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0430\u0440 \u041f\u0435\u0442\u043b\u0438\u0447\u043a\u043e\u0432\u0441\u043a\u0438","orcid":"https://orcid.org/0000-0002-1956-4063","observed_orcids":["https://orcid.org/0000-0002-1956-4063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandar Petlichkovski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072340485","display_name":"Ana Strezova","orcid":"https://orcid.org/0000-0002-0143-253X","observed_orcids":["https://orcid.org/0000-0002-0143-253X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Strezova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044941021","display_name":"\u041e\u043b\u0438\u0432\u0438\u0458\u0430 \u0415\u0444\u0438\u043d\u0441\u043a\u0430-\u041c\u043b\u0430\u0434\u0435\u043d\u043e\u0432\u0441\u043a\u0430","orcid":"https://orcid.org/0000-0002-2730-0519","observed_orcids":["https://orcid.org/0000-0002-2730-0519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivija Efinska-Mladenovska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086445556","display_name":"Mirko Zhivko Spiroski","orcid":"https://orcid.org/0000-0001-5559-7981","observed_orcids":["https://orcid.org/0000-0001-5559-7981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirko Spiroski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5859,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81336266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"4","first_page":"685","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-gene-polymorphisms","display_name":"cytokine gene polymorphisms","score":0.9610000252723694},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.972000002861023},{"id":"https://openalex.org/keywords/population-genetics","display_name":"population genetics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.7379999756813049},{"id":"https://openalex.org/keywords/balancing-selection","display_name":"balancing selection","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7419999837875366},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.4690000116825104},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.5870000123977661},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.41100001335144043},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.746999979019165},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7369999885559082},{"id":"https://openalex.org/keywords/il12b","display_name":"IL12B","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.620567262172699},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5755772590637207},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5591327548027039},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5575794577598572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4894615411758423},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4436456263065338},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.42977219820022583},{"id":"https://openalex.org/C100882016","wikidata":"https://www.wikidata.org/wiki/Q49974","display_name":"Hardy\u2013Weinberg principle","level":5,"score":0.42917633056640625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38592666387557983},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3575546145439148},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3370477557182312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27962732315063477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23203781247138977},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16100774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16100774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Croatian medical journal","raw_type":"Journal Article"},{"id":"mag:29279755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16100774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W67590150","https://openalex.org/W1801074251","https://openalex.org/W1891283710","https://openalex.org/W1903982198","https://openalex.org/W1966618606","https://openalex.org/W1979979001","https://openalex.org/W2000625134","https://openalex.org/W2007946478","https://openalex.org/W2014545271","https://openalex.org/W2028027160","https://openalex.org/W2029812572","https://openalex.org/W2043319156","https://openalex.org/W2043638204","https://openalex.org/W2057478159","https://openalex.org/W2071468584","https://openalex.org/W2080237200","https://openalex.org/W2087712790","https://openalex.org/W2096392622","https://openalex.org/W2107348873","https://openalex.org/W2142985496","https://openalex.org/W2155616821","https://openalex.org/W2216494795","https://openalex.org/W2333197305","https://openalex.org/W2403923596"],"related_works":["https://openalex.org/W149283663","https://openalex.org/W2183150385","https://openalex.org/W1981316270","https://openalex.org/W4281388600","https://openalex.org/W2101126066","https://openalex.org/W2063361602","https://openalex.org/W2272583195","https://openalex.org/W2069279445","https://openalex.org/W2116379520","https://openalex.org/W4297336879"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"genotype":[2],"cytokine":[3,96,166,405],"polymorphisms":[4,180],"in":[5,84,203,271,307,379,410],"the":[6,13,54,75,80,85,89,138,162,165,207,210,226,302,308,311,333,340,368,371,411,414],"Macedonian":[7,41,90,312,372,415],"population":[8,154,416],"as":[9,100,436,438],"a":[10,253,346,418],"part":[11],"of":[12,24,40,50,53,56,88,164,174,212,250,304,315,325,404,427],"international":[14],"project":[15],"Cytokine":[16,135],"Polymorphism":[17],"Component":[18],"(CPC).":[19],"METHODS:":[20],"The":[21,153,172,289,402],"sample":[22,309,369,412],"consisted":[23],"125":[25],"healthy":[26],"unrelated":[27],"individuals,":[28],"46":[29],"men":[30],"and":[31,43,48,79,131,188,234,242,246,267,276,278,298,358,408,429],"79":[32],"women,":[33],"aged":[34],"20-35":[35],"years.":[36],"All":[37],"individuals":[38],"were":[39,60,82,98,269,295,399],"origin":[42],"nationality,":[44],"Christian":[45],"Orthodox":[46],"religion,":[47],"residents":[49],"different":[51,236,360,443],"regions":[52],"Republic":[55],"Macedonia.":[57],"Blood":[58],"samples":[59,81,140],"collected":[61],"after":[62],"written":[63],"consent":[64],"was":[65,68,141,159,232,284,356,375],"obtained,":[66],"DNA":[67,92],"isolated":[69],"from":[70,183,237,310,361,370,413],"peripheral":[71],"blood":[72],"leukocytes":[73],"by":[74,143],"phenol-chloroform":[76],"extraction":[77],"method,":[78],"stored":[83],"Anthropology":[86],"section":[87],"Human":[91],"Bank":[93],"(hDNAMKD).":[94],"Fourteen":[95],"genes":[97],"identified":[99],"candidates:":[101],"gamma-interferon":[102],"(IFNgamma);":[103],"interleukin":[104],"(IL)":[105],"1":[106,129,378],"alpha":[107,122,133],"(IL-1alpha);":[108],"IL-1":[109,112],"beta":[110,128],"(IL-1beta);":[111],"receptor":[113,121],"(IL-1R);":[114],"IL-1R":[115],"antagonist":[116],"(IL-1RA);":[117],"IL-2;":[118],"IL-4;":[119],"IL-4":[120,341],"(IL-4Ralpha);":[123],"IL-6;":[124],"IL-10;":[125],"IL-12B;":[126],"TGF":[127],"(TGF-beta1);":[130],"TNF":[132],"(TNF-alpha).":[134],"genotyping":[136],"for":[137,161,168,176,185,190,195,217,239,293,320,339,349,363,387,425,433,439],"anthropology":[139],"performed":[142],"polymerase":[144],"chain":[145],"reaction":[146],"with":[147,256,301,382,421,442],"sequence-specific":[148],"priming":[149],"(PCR-SSP)":[150],"(Heidelberg":[151],"kit).":[152],"genetics":[155],"analysis":[156,163,403],"package,":[157],"PyPop,":[158],"used":[160,432],"data":[167],"this":[169],"report.":[170],"RESULTS:":[171],"frequency":[173],"alleles":[175,227],"some":[177],"single":[178],"nucleotide":[179],"(SNP)":[181],"varied":[182],"0.967":[184],"TGF-beta1":[186,243,294],"cdn25/G":[187],"0.920":[189],"TNF-alpha":[191,388],"-238/G,":[192],"to":[193,377],"0.914":[194],"IL-1alpha":[196],"-889/C,":[197],"indicating":[198],"common":[199],"\"wild":[200],"type\"":[201],"allele":[202],"those":[204],"cytokines.":[205],"For":[206],"most":[208,290,426],"SNPs,":[209],"test":[211,324],"neutrality":[213,316],"showed":[214,252,317,345,417],"negative":[215,233,318,357],"value":[216,319,348],"F(nd)":[218,231,321,350,355],"statistic,":[219,351],"which":[220,327,392],"indicated":[221,328,393],"balancing":[222,329],"selection":[223,330],"operating":[224,331],"on":[225,332],"at":[228,335],"that":[229,336,394],"locus.":[230],"significantly":[235,359],"0":[238,362],"IFNgamma":[240],"UTR5644":[241],"cdn10":[244],"(P=0.006":[245],"P=0.007,":[247],"respectively).":[248],"Most":[249],"SNPs":[251,261,428],"good":[254,419],"fit":[255,420],"HWP":[257,272],"expectations.":[258],"A":[259],"few":[260],"(IL-1alpha":[262],"-889,":[263],"IL-1beta":[264],"-511,":[265],"IL-1beta+3962,":[266],"IFNgammaUTR5644)":[268],"not":[270],"(P<":[273,286,389],"or":[274,287,390,396],"=0.005),":[275],"Guo":[277],"Thompson":[279],"Hardy":[280,422],"Weinberg":[281,423],"Output":[282],"(GTHWO)":[283],"significant":[285],"=0.005).":[288],"frequent":[291],"haplotypes":[292,334,365,381,398,409],"TG":[296],"(0.491)":[297],"CG":[299],"(0.476),":[300],"absence":[303],"TGF-beta1/TC":[305],"haplotype":[306],"population.":[313],"Test":[314],"statistic":[322],"(Ewens-Watterson":[323],"neutrality)":[326],"locus,":[337],"except":[338,386],"haplotypes,":[342],"where":[343],"it":[344],"positive":[347],"but":[352],"without":[353],"significance.":[354],"IL-10":[364],"(P=0.002).":[366],"In":[367],"population,":[373],"D'":[374],"equal":[376],"all":[380],"P":[383],"values":[384],"<0.0001,":[385],"=0.012),":[391],"one":[395],"more":[397],"missing.":[400],"CONCLUSION:":[401],"alleles,":[406],"genotypes,":[407],"equilibrium":[424],"can":[430],"be":[431],"anthropological":[434],"comparisons,":[435],"well":[437],"association":[440],"studies":[441],"diseases.":[444]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
