{"id":"https://openalex.org/W292708047","doi":null,"title":"Development of Targeted Nanogels for the Sirna-Mediated Antiangiogenesis Treatment of Breast Cancer","display_name":"Development of Targeted Nanogels for the Sirna-Mediated Antiangiogenesis Treatment of Breast Cancer","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W292708047","mag":"292708047"},"language":"en","primary_location":{"id":"pmh:ADA484225","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA484225","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091267298","display_name":"Joseph A. Vetro","orcid":"https://orcid.org/0000-0003-2446-9797","observed_orcids":["https://orcid.org/0000-0003-2446-9797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vetro, Joseph A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Vinogradov, Serguei V.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinogradov, Serguei V.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060794463","display_name":"Rakesh K. Singh","orcid":"https://orcid.org/0000-0002-1124-9202","observed_orcids":["https://orcid.org/0000-0002-1124-9202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Singh, Rakesh K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02813165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanogels","display_name":"nanogels","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9660000205039978},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7329999804496765},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.8109999895095825},{"id":"https://openalex.org/keywords/polyethylenimine","display_name":"polyethyleneimine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.722000002861023},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.756627082824707},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.7545688152313232},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6518856883049011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5915278196334839},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5324870944023132},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4805648624897003},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.457976758480072},{"id":"https://openalex.org/C2775925850","wikidata":"https://www.wikidata.org/wiki/Q418697","display_name":"Polyethylenimine","level":4,"score":0.4429699182510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43294960260391235},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4150685667991638},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39596301317214966},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29112866520881653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26569515466690063},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.18567869067192078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13343247771263123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09007874131202698},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:ADA484225","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA484225","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804508967","https://openalex.org/W2590483119","https://openalex.org/W3208971891","https://openalex.org/W2148508697","https://openalex.org/W1824209751","https://openalex.org/W1969596428","https://openalex.org/W2081552594","https://openalex.org/W2047036303","https://openalex.org/W4302082843","https://openalex.org/W4256501288"],"abstract_inverted_index":{"The":[0],"inhibition":[1],"of":[2,15,34,57,66,100,151],"tumor":[3,38],"angiogenesis":[4,39],"has":[5],"significant":[6],"potential":[7,150],"as":[8,155,161],"a":[9,156,162],"therapeutic":[10],"modality":[11],"in":[12,94,136],"the":[13,32,55,149],"treatment":[14],"breast":[16,25,48,81,88],"cancer.":[17],"Delivering":[18],"small,":[19],"interfering":[20],"RNA":[21],"(siRNA)":[22],"to":[23,42,79,116],"activated":[24,80,86],"microvascular":[26],"endothelial":[27],"cells":[28,138],"(MVEC)":[29],"can":[30],"decrease":[31],"expression":[33],"proteins":[35],"required":[36],"during":[37],"and":[40,45,70,91,107,121],"lead":[41],"less":[43],"toxic":[44],"more":[46],"effective":[47],"cancer":[49],"treatments":[50],"but":[51],"is":[52],"limited":[53],"by":[54,112],"absence":[56],"efficient":[58],"targeted":[59,76,108,163],"drug":[60],"delivery":[61,78,165],"vehicles.":[62],"Nanogels":[63],"(NG)":[64],"composed":[65],"cross-linked":[67],"polyethylene":[68],"glycol":[69],"polyethylenimine":[71],"(PEG-cl-PEI)":[72],"were":[73,139],"investigated":[74],"for":[75,128,158],"siRNA":[77,117,129,164],"MVEC.":[82],"Targeted":[83],"NG":[84,109,125,154],"inhibited":[85],"murine":[87],"MVEC":[89,111],"growth":[90],"vessel-like":[92],"formation":[93],"vitro":[95],"with":[96,141],"little":[97],"cytotoxicity":[98,120],"irrespective":[99],"loaded":[101],"siRNA.":[102],"This":[103],"indicates":[104],"that":[105,122],"unmodified":[106],"inhibit":[110],"some":[113],"mechanism":[114],"unrelated":[115],"or":[118],"detectable":[119],"first":[123],"generation":[124],"are":[126,146],"insufficient":[127],"delivery.":[130],"Similar":[131],"observations":[132],"delivering":[133],"nucleoside":[134],"analogs":[135],"other":[137],"overcome":[140],"biodegradable":[142,153],"NG.":[143],"Therefore,":[144],"we":[145],"now":[147],"assessing":[148],"using":[152],"platform":[157],"further":[159],"development":[160],"vehicle.":[166]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}