{"id":"https://openalex.org/W29266343","doi":null,"title":"The immunomodulatory molecule pidotimod induces the expression of the NOD-like receptor NLRP12 and attenuates TLR-induced inflammation.","display_name":"The immunomodulatory molecule pidotimod induces the expression of the NOD-like receptor NLRP12 and attenuates TLR-induced inflammation.","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W29266343","mag":"29266343","pmid":"https://pubmed.ncbi.nlm.nih.gov/25620184"},"language":"en","primary_location":{"id":"pmid:25620184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25620184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083653590","display_name":"Manuela Fogli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Fogli","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002324379","display_name":"Francesca Caccuri","orcid":"https://orcid.org/0000-0002-1923-9033","observed_orcids":["https://orcid.org/0000-0002-1923-9033"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Caccuri","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077415550","display_name":"Maria Luisa Iaria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M L Iaria","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083294917","display_name":"Cinzia Giagulli","orcid":"https://orcid.org/0000-0002-4461-9353","observed_orcids":["https://orcid.org/0000-0002-4461-9353"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Giagulli","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022047823","display_name":"Silvia Corbellini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Corbellini","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076601168","display_name":"Federica Campilongo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Campilongo","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047949241","display_name":"Arnaldo Caruso","orcid":"https://orcid.org/0000-0001-5178-566X","observed_orcids":["https://orcid.org/0000-0001-5178-566X"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Caruso","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015268079","display_name":"Simona Fiorentini","orcid":"https://orcid.org/0000-0002-1866-314X","observed_orcids":["https://orcid.org/0000-0002-1866-314X"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Fiorentini","raw_affiliation_strings":["Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79940851"],"apc_list":null,"apc_paid":null,"fwci":0.5492,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.61949945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"4","first_page":"753","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pidotimod","display_name":"pidotimod","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nlrp12","display_name":"NLRP12","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nod-like-receptors","display_name":"NOD-like receptors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/immunomodulatory-peptides","display_name":"immunomodulatory peptides","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pro-inflammatory-mediators","display_name":"pro-inflammatory mediators","score":0.8140000104904175},{"id":"https://openalex.org/keywords/monocytic-cells","display_name":"monocytic cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/anti-inflammatory-mechanism","display_name":"anti-inflammatory mechanism","score":0.4860000014305115},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8522477746009827},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.663267970085144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6399098634719849},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6035557985305786},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5434924960136414},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.4710806608200073},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4644012749195099},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4383273124694824},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42649000883102417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42314934730529785},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4219413995742798},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.41798636317253113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4016300439834595},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3934774398803711},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35374948382377625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34026163816452026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30426716804504395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15926069021224976},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053778","descriptor_name":"Thiazolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:25620184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25620184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibs.it:11379/457832","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/457832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:29266343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25620184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2948008166","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/25612594","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1874151292","https://openalex.org/W1907149689","https://openalex.org/W1968777410","https://openalex.org/W1982479612","https://openalex.org/W2017821807","https://openalex.org/W2031200896","https://openalex.org/W2038752330","https://openalex.org/W2045817362","https://openalex.org/W2058585881","https://openalex.org/W2067844969","https://openalex.org/W2068345774","https://openalex.org/W2076654662","https://openalex.org/W2086919865","https://openalex.org/W2090357739","https://openalex.org/W2099439401","https://openalex.org/W2105560808","https://openalex.org/W2135596527","https://openalex.org/W2159819650","https://openalex.org/W2268559917","https://openalex.org/W2300011769","https://openalex.org/W2347049117","https://openalex.org/W2464932009","https://openalex.org/W2501725114","https://openalex.org/W2502279078","https://openalex.org/W2530520240","https://openalex.org/W2546493736","https://openalex.org/W2562044150","https://openalex.org/W2572554549","https://openalex.org/W2584789564","https://openalex.org/W2594703707","https://openalex.org/W2610334250"],"related_works":["https://openalex.org/W2149537676","https://openalex.org/W2360714284","https://openalex.org/W4299538929","https://openalex.org/W2163314509","https://openalex.org/W2030871777","https://openalex.org/W2047699377","https://openalex.org/W4400735950","https://openalex.org/W2366622617","https://openalex.org/W54888041","https://openalex.org/W2179163565"],"abstract_inverted_index":{"Pidotimod":[0],"(3-L-pyroglutamyl-L-thiaziolidine-4-carboxylic":[1],"acid)":[2],"(PDT)":[3],"is":[4,17,46,249,264],"a":[5,71,79,114,125,198,313],"synthetic":[6],"dipeptide":[7],"with":[8,70,113,148,183,247,251],"in":[9,12,26,128,135,141,170,180,201,210,242],"vitro":[10],"and":[11,22,28,44,193,308],"vivo":[13],"immunomodulatory":[14,270],"properties":[15],"that":[16,61,144,158,215,235,272],"largely":[18],"used":[19],"for":[20,289],"treatment":[21,217],"prevention":[23],"of":[24,34,52,54,82,116,131,164,173,178,204,237,255,268,292],"infections":[25],"paediatric":[27],"disease-prone":[29],"patients.":[30],"However,":[31],"the":[32,50,68,83,98,129,138,162,165,171,202,219,227,238,252,265,280,287,290],"effects":[33],"PDT":[35,62,95,110,159,184,216],"on":[36,49],"cellular":[37],"immune":[38,84,99],"responses":[39],"are":[40],"still":[41],"poorly":[42],"characterized":[43],"there":[45],"little":[47],"information":[48],"mechanism":[51],"action":[53,63],"this":[55,263,277],"compound.":[56],"It":[57],"has":[58],"been":[59],"speculated":[60],"may":[64],"be":[65],"exerted":[66],"through":[67,276],"interaction":[69,246],"Pattern":[72],"Recognition":[73],"Receptor":[74],"(PRR).":[75],"Therefore,":[76],"to":[77,92,109,137],"gain":[78],"further":[80,175],"understanding":[81],"pathways":[85],"involved":[86],"by":[87,102,223,258],"PDT,":[88],"we":[89,123,155,213],"first":[90,266],"decided":[91],"investigate":[93],"whether":[94],"could":[96],"modify":[97],"response":[100],"triggered":[101],"TLR":[103,117,224],"ligands.":[104],"Monocytic":[105],"cells":[106,143,181,212,233,244],"were":[107,145],"exposed":[108],"then":[111],"stimulated":[112],"panel":[115],"agonists.":[118,225],"Under":[119],"these":[120],"experimental":[121],"conditions,":[122],"observed":[124,140,157],"significant":[126],"decrease":[127],"synthesis":[130],"key":[132],"proinflammatory":[133,239],"mediators":[134],"comparison":[136],"production":[139],"TLR-stimulated":[142],"not":[146],"treated":[147,182],"PDT.":[149,259],"Using":[150],"RT\u00b2":[151],"Profiler":[152],"PCR":[153,192],"Array":[154],"have":[156],"specifically":[160,188],"up-regulates":[161],"expression":[163],"NOD-like":[166],"receptor":[167],"NLRP12":[168,179,205,220,231,256,274,311],"mRNA":[169],"absence":[172],"any":[174],"costimulation.":[176],"Increase":[177],"was":[185,207],"confirmed":[186],"using":[187,230],"designed":[189],"real-time":[190],"quantitative":[191],"western":[194],"blotting":[195],"assays":[196],"where":[197,310],"clear":[199],"increase":[200],"amount":[203],"protein":[206],"detected.":[208],"Furthermore,":[209],"myeloid/monocytic":[211],"demonstrated":[214],"counteracts":[218],"reduction":[221],"induced":[222,257],"Finally,":[226],"results":[228,285],"obtained":[229],"silenced":[232],"showed":[234],"down-regulation":[236],"function":[240],"occurring":[241],"PDT-treated":[243],"upon":[245],"TLRs":[248],"associated":[250],"increased":[253],"levels":[254],"To":[260],"our":[261],"knowledge":[262],"evidence":[267],"an":[269],"peptide":[271],"upregulates":[273],"and,":[275],"molecule,":[278],"antagonizes":[279],"TLR-induced":[281],"inflammatory":[282,306],"response.":[283],"These":[284],"pave":[286],"way":[288],"development":[291],"innovative":[293],"therapeutic":[294],"approaches":[295],"aimed":[296],"at":[297],"controlling":[298],"different":[299],"pathological":[300],"settings":[301],"such":[302],"as":[303],"tumorigenesis,":[304],"systemic":[305],"processes":[307],"autoimmunity,":[309],"plays":[312],"crucial":[314],"role.":[315]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}