{"id":"https://openalex.org/W2926607289","doi":"https://doi.org/10.1002/jcp.28520","title":"Regulatory networks upon neurogenesis induction in PC12 cell line by small molecules","display_name":"Regulatory networks upon neurogenesis induction in PC12 cell line by small molecules","publication_year":2019,"publication_date":"2019-03-28","ids":{"openalex":"https://openalex.org/W2926607289","doi":"https://doi.org/10.1002/jcp.28520","mag":"2926607289","pmid":"https://pubmed.ncbi.nlm.nih.gov/30919969"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.28520","doi":"https://doi.org/10.1002/jcp.28520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.28520","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002087602","display_name":"Nafiseh Falsafi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nafiseh Falsafi","raw_affiliation_strings":["Department of Biology School of Sciences, Razi University Kermanshah Iran","Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","Falsafi and Soleimani have contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology School of Sciences, Razi University Kermanshah Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Falsafi and Soleimani have contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tahereh Soleimani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Tahereh Soleimani","raw_affiliation_strings":["Department of Biology School of Sciences, Razi University Kermanshah Iran","Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","Falsafi and Soleimani have contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology School of Sciences, Razi University Kermanshah Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Falsafi and Soleimani have contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012898980","display_name":"Hossein Fallahi","orcid":"https://orcid.org/0000-0002-8754-3491","observed_orcids":["https://orcid.org/0000-0002-8754-3491"]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Hossein Fallahi","raw_affiliation_strings":["Department of Biology School of Sciences, Razi University Kermanshah Iran","Department of Biology, School of Sciences, Razi University, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0002-8754-3491","affiliations":[{"raw_affiliation_string":"Department of Biology School of Sciences, Razi University Kermanshah Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026398187","display_name":"Mehri Azadbakht","orcid":"https://orcid.org/0000-0003-3493-7785","observed_orcids":["https://orcid.org/0000-0003-3493-7785"]},"institutions":[{"id":"https://openalex.org/I1187138","display_name":"Razi University","ror":"https://ror.org/02ynb0474","country_code":"IR","type":"education","lineage":["https://openalex.org/I1187138"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehri Azadbakht","raw_affiliation_strings":["Department of Biology School of Sciences, Razi University Kermanshah Iran","Department of Biology, School of Sciences, Razi University, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology School of Sciences, Razi University Kermanshah Iran","institution_ids":["https://openalex.org/I1187138"]},{"raw_affiliation_string":"Department of Biology, School of Sciences, Razi University, Kermanshah, Iran","institution_ids":["https://openalex.org/I1187138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012898980"],"corresponding_institution_ids":["https://openalex.org/I1187138"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.1614,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.41216487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"234","issue":"10","first_page":"18813","last_page":"18824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.8920000195503235},{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.7419999837875366},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-peptide","display_name":"pituitary adenylate cyclase-activating peptide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trimethyltin","display_name":"trimethyltin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7350000143051147},{"id":"https://openalex.org/keywords/neuronal-reprogramming","display_name":"neuronal reprogramming","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.6986321210861206},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6679538488388062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.623529314994812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5555122494697571},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5397447347640991},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47370192408561707},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4485175609588623},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4361932873725891},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3397057056427002},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.161942720413208}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.28520","doi":"https://doi.org/10.1002/jcp.28520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.28520","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:30919969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30919969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1584279734","https://openalex.org/W1862346079","https://openalex.org/W1932303130","https://openalex.org/W1965596654","https://openalex.org/W1968015127","https://openalex.org/W1968581250","https://openalex.org/W1972664118","https://openalex.org/W1984871200","https://openalex.org/W1987052032","https://openalex.org/W1987355743","https://openalex.org/W1988995683","https://openalex.org/W1996725686","https://openalex.org/W2000860171","https://openalex.org/W2005821807","https://openalex.org/W2007071063","https://openalex.org/W2012654383","https://openalex.org/W2016472064","https://openalex.org/W2017955991","https://openalex.org/W2037155998","https://openalex.org/W2047226001","https://openalex.org/W2058045877","https://openalex.org/W2065167751","https://openalex.org/W2067754245","https://openalex.org/W2069198916","https://openalex.org/W2080151785","https://openalex.org/W2084652820","https://openalex.org/W2087367550","https://openalex.org/W2090755410","https://openalex.org/W2094051261","https://openalex.org/W2111431369","https://openalex.org/W2112513984","https://openalex.org/W2121792371","https://openalex.org/W2124910340","https://openalex.org/W2139922386","https://openalex.org/W2140815401","https://openalex.org/W2144929276","https://openalex.org/W2153385508","https://openalex.org/W2153887599","https://openalex.org/W2156364581","https://openalex.org/W2156716434","https://openalex.org/W2156979070","https://openalex.org/W2157593127","https://openalex.org/W2158610627","https://openalex.org/W2164333337","https://openalex.org/W2167962847","https://openalex.org/W2253427860","https://openalex.org/W2313606451","https://openalex.org/W2407632744","https://openalex.org/W2475319420","https://openalex.org/W2487609709","https://openalex.org/W2597332014","https://openalex.org/W4234924759"],"related_works":["https://openalex.org/W2409278910","https://openalex.org/W2377956979","https://openalex.org/W4388014052","https://openalex.org/W2019492885","https://openalex.org/W2004228152","https://openalex.org/W2465219495","https://openalex.org/W1998139797","https://openalex.org/W2045770287","https://openalex.org/W2021057876","https://openalex.org/W2004231989"],"abstract_inverted_index":{"Alteration":[0],"in":[1,40,45,73,98,108,140],"the":[2,11,46,52,55,96,99,104,114,119,128,141],"normal":[3],"regulatory":[4,85],"pathway":[5],"of":[6,13,54,58,70,95,103,143,147],"differentiation":[7,39,59,132],"can":[8],"lead":[9],"to":[10,34,37,78,110,145],"induction":[12,60],"programmed":[14],"cell":[15,48,106],"death.":[16],"Accordingly,":[17],"some":[18],"chemicals":[19,112],"like":[20],"staurosporine,":[21],"nerve":[22],"growth":[23],"factor,":[24],"pituitary":[25],"adenylate":[26],"cyclase":[27],"activating":[28],"peptide,":[29],"and":[30,122,133],"trimethyltin":[31],"are":[32,65],"shown":[33],"be":[35,138],"able":[36],"induce":[38],"vitro,":[41],"via":[42],"different":[43],"mechanisms":[44,57],"PC12":[47,105],"line.":[49],"Hence,":[50],"understanding":[51],"details":[53],"molecular":[56],"by":[61,149],"these":[62,71,80,111],"small":[63,151],"molecules":[64,72,152],"important":[66],"for":[67],"further":[68],"application":[69],"neurogenesis.":[74],"Therefore,":[75],"we":[76,89,125],"sought":[77],"determine":[79],"signaling":[81],"pathways,":[82],"using":[83],"gene":[84,100],"networks":[86],"analysis.":[87],"Then,":[88],"have":[90,126],"conducted":[91],"a":[92],"comparative":[93,120],"analysis":[94,121],"alterations":[97],"expression":[101],"pattern":[102],"lines":[107],"response":[109],"at":[113],"early":[115],"stages.":[116],"Based":[117],"on":[118],"previous":[123],"knowledge,":[124],"proposed":[127],"affected":[129],"pathways":[130],"during":[131],"apoptosis.":[134],"Our":[135],"findings":[136],"could":[137],"useful":[139],"development":[142],"protocols":[144],"reprogramming":[146],"neurons":[148],"such":[150],"with":[153],"high":[154],"efficiency.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}