{"id":"https://openalex.org/W2926094652","doi":"https://doi.org/10.1021/acsinfecdis.9b00003","title":"Detecting Vertical Zika Transmission: Emerging Diagnostic Approaches for an Emerged Flavivirus","display_name":"Detecting Vertical Zika Transmission: Emerging Diagnostic Approaches for an Emerged Flavivirus","publication_year":2019,"publication_date":"2019-04-05","ids":{"openalex":"https://openalex.org/W2926094652","doi":"https://doi.org/10.1021/acsinfecdis.9b00003","mag":"2926094652","pmid":"https://pubmed.ncbi.nlm.nih.gov/30951637"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.9b00003","doi":"https://doi.org/10.1021/acsinfecdis.9b00003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.9b00003","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039276250","display_name":"Matthew H. Collins","orcid":"https://orcid.org/0000-0001-7974-1933","observed_orcids":["https://orcid.org/0000-0001-7974-1933"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew H. Collins","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, United States"],"raw_orcid":"https://orcid.org/0000-0001-7974-1933","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088151911","display_name":"Jesse J. Waggoner","orcid":"https://orcid.org/0000-0002-0244-5957","observed_orcids":["https://orcid.org/0000-0002-0244-5957"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse J. Waggoner","raw_affiliation_strings":["Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States","Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039276250"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.2865,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.33755943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"7","first_page":"1055","last_page":"1069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/congenital-zika-syndrome","display_name":"congenital Zika syndrome","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.8119999766349792},{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.5820000171661377},{"id":"https://openalex.org/keywords/serologic-testing","display_name":"serologic testing","score":0.6919999718666077},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.6520000100135803},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/flavivirus-cross-reactivity","display_name":"flavivirus cross-reactivity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/passive-immunity","display_name":"passive immunity","score":0.5090000033378601},{"id":"https://openalex.org/keywords/microcephaly","display_name":"microcephaly","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fetal-malformations","display_name":"fetal malformations","score":0.609000027179718},{"id":"https://openalex.org/keywords/diagnostic-testing-guidelines","display_name":"diagnostic testing guidelines","score":0.38199999928474426},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8314375877380371},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.7348774075508118},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6056355237960815},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.5907801389694214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3983694314956665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21918714046478271},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.1414317786693573},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.09984079003334045}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":false},{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsinfecdis.9b00003","doi":"https://doi.org/10.1021/acsinfecdis.9b00003","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.9b00003","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:30951637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30951637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/9","score":0.4300000071525574,"display_name":"Industry, innovation and infrastructure"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W176669131","https://openalex.org/W1493838725","https://openalex.org/W1869004733","https://openalex.org/W1906136187","https://openalex.org/W1968281114","https://openalex.org/W1975120587","https://openalex.org/W1989929122","https://openalex.org/W2032330669","https://openalex.org/W2036265216","https://openalex.org/W2039415249","https://openalex.org/W2043352558","https://openalex.org/W2046685467","https://openalex.org/W2048715901","https://openalex.org/W2050832075","https://openalex.org/W2081356962","https://openalex.org/W2082066129","https://openalex.org/W2093630275","https://openalex.org/W2101419987","https://openalex.org/W2104989660","https://openalex.org/W2108821947","https://openalex.org/W2122349387","https://openalex.org/W2122645657","https://openalex.org/W2125205431","https://openalex.org/W2144932456","https://openalex.org/W2148758435","https://openalex.org/W2164613060","https://openalex.org/W2170619342","https://openalex.org/W2255907993","https://openalex.org/W2285713692","https://openalex.org/W2292422784","https://openalex.org/W2294138400","https://openalex.org/W2295245778","https://openalex.org/W2296488263","https://openalex.org/W2297369703","https://openalex.org/W2311770845","https://openalex.org/W2317185636","https://openalex.org/W2319900810","https://openalex.org/W2322900261","https://openalex.org/W2333018296","https://openalex.org/W2334999650","https://openalex.org/W2337135418","https://openalex.org/W2342696065","https://openalex.org/W2344277836","https://openalex.org/W2346028445","https://openalex.org/W2356757232","https://openalex.org/W2376146183","https://openalex.org/W2400827254","https://openalex.org/W2406009021","https://openalex.org/W2409032752","https://openalex.org/W2420917578","https://openalex.org/W2423421007","https://openalex.org/W2461605911","https://openalex.org/W2464595900","https://openalex.org/W2465533376","https://openalex.org/W2472922462","https://openalex.org/W2475982166","https://openalex.org/W2480435167","https://openalex.org/W2482354067","https://openalex.org/W2491333701","https://openalex.org/W2495290366","https://openalex.org/W2501714377","https://openalex.org/W2509643246","https://openalex.org/W2511376151","https://openalex.org/W2512647517","https://openalex.org/W2515345207","https://openalex.org/W2515664676","https://openalex.org/W2515741006","https://openalex.org/W2516880050","https://openalex.org/W2517093811","https://openalex.org/W2518728671","https://openalex.org/W2524063359","https://openalex.org/W2528733278","https://openalex.org/W2529317297","https://openalex.org/W2539130992","https://openalex.org/W2546845633","https://openalex.org/W2546889486","https://openalex.org/W2559769259","https://openalex.org/W2559954089","https://openalex.org/W2562513421","https://openalex.org/W2563585436","https://openalex.org/W2564382896","https://openalex.org/W2571121293","https://openalex.org/W2577798709","https://openalex.org/W2580629663","https://openalex.org/W2580915045","https://openalex.org/W2586860795","https://openalex.org/W2587380109","https://openalex.org/W2592026062","https://openalex.org/W2592799286","https://openalex.org/W2593486131","https://openalex.org/W2595707583","https://openalex.org/W2597777251","https://openalex.org/W2602125518","https://openalex.org/W2606591457","https://openalex.org/W2606996549","https://openalex.org/W2610800247","https://openalex.org/W2611308758","https://openalex.org/W2612496103","https://openalex.org/W2617923816","https://openalex.org/W2618036915","https://openalex.org/W2619889792","https://openalex.org/W2622967054","https://openalex.org/W2655748067","https://openalex.org/W2709838691","https://openalex.org/W2714911268","https://openalex.org/W2730227941","https://openalex.org/W2735191646","https://openalex.org/W2736041148","https://openalex.org/W2738362228","https://openalex.org/W2738468401","https://openalex.org/W2740301920","https://openalex.org/W2741005213","https://openalex.org/W2741337198","https://openalex.org/W2741608607","https://openalex.org/W2747500164","https://openalex.org/W2755048196","https://openalex.org/W2755194545","https://openalex.org/W2758691957","https://openalex.org/W2761760850","https://openalex.org/W2762780024","https://openalex.org/W2764065813","https://openalex.org/W2765250428","https://openalex.org/W2765261100","https://openalex.org/W2767037689","https://openalex.org/W2767265855","https://openalex.org/W2771735634","https://openalex.org/W2774183802","https://openalex.org/W2775838290","https://openalex.org/W2778260327","https://openalex.org/W2784037629","https://openalex.org/W2786242561","https://openalex.org/W2788848251","https://openalex.org/W2789967317","https://openalex.org/W2790200468","https://openalex.org/W2791927440","https://openalex.org/W2791976124","https://openalex.org/W2792390442","https://openalex.org/W2793055876","https://openalex.org/W2794704627","https://openalex.org/W2795427963","https://openalex.org/W2795840126","https://openalex.org/W2796081518","https://openalex.org/W2796225404","https://openalex.org/W2796800715","https://openalex.org/W2799884628","https://openalex.org/W2800770916","https://openalex.org/W2805927998","https://openalex.org/W2806475749","https://openalex.org/W2807522427","https://openalex.org/W2807936073","https://openalex.org/W2808421820","https://openalex.org/W2810451218","https://openalex.org/W2811449746","https://openalex.org/W2874999101","https://openalex.org/W2876236341","https://openalex.org/W2883198349","https://openalex.org/W2884839496","https://openalex.org/W2884962666","https://openalex.org/W2887901062","https://openalex.org/W2899044014","https://openalex.org/W2902128651","https://openalex.org/W2907164577","https://openalex.org/W2949788040","https://openalex.org/W2952711002","https://openalex.org/W3022354856","https://openalex.org/W4246743966"],"related_works":["https://openalex.org/W2470011254","https://openalex.org/W2579971229","https://openalex.org/W2911733585","https://openalex.org/W2766036349","https://openalex.org/W2979456591","https://openalex.org/W2970637931","https://openalex.org/W2592833503","https://openalex.org/W2781962683","https://openalex.org/W2771221560","https://openalex.org/W3002422169"],"abstract_inverted_index":{"Zika":[0,18,28,70,97,108,113,124,133,178,271,289,321],"virus":[1,134],"(Zika)":[2],"was":[3],"recently":[4],"responsible":[5],"for":[6,130,155,172,265,269,300,310],"a":[7,62,78,95,116],"massive":[8],"epidemic":[9],"that":[10,296],"spread":[11],"throughout":[12],"Latin":[13],"America":[14,52],"and":[15,42,50,84,187,219,229,243,261,276,313],"beyond.":[16],"Though":[17,147],"is":[19,75,126,153],"typically":[20],"asymptomatic":[21,203],"or":[22,59,115,138,144],"self-limiting,":[23],"the":[24,32,68,91,142,148,208,294,315],"sheer":[25],"numbers":[26],"of":[27,34,45,61,64,80,105,132,177,245,287],"infections":[29],"led":[30],"to":[31,111,159,167,183,189,225,239,291,305,319],"identification":[33],"unexpected":[35],"phenotypes":[36],"including":[37],"sexual":[38],"transmission,":[39],"Guillain-Barr\u00e9":[40],"syndrome,":[41],"teratogenicity.":[43],"Thousands":[44],"infants":[46],"in":[47,120,135,141,169,241,248,252,259,302],"South,":[48],"Central,":[49],"North":[51],"have":[53],"now":[54],"been":[55],"born":[56],"with":[57,122,202,283],"microcephaly":[58],"one":[60],"number":[63],"fetal":[65],"anomalies":[66],"constituting":[67],"congenital":[69,107,123,270,288,320],"syndrome":[71],"(CZS).":[72],"Diagnosing":[73],"CZS":[74],"based":[76],"on":[77],"combination":[79],"clinical":[81,285],"risk":[82],"assessment":[83],"laboratory":[85,297],"testing":[86,171,298],"(which":[87],"includes":[88],"determining":[89],"whether":[90],"mother":[92,224,304],"has":[93],"experienced":[94],"possible":[96],"infection":[98,109,114,290],"during":[99],"her":[100],"pregnancy).":[101],"A":[102],"newborn":[103],"suspected":[104],"having":[106],"(due":[110],"maternal":[112],"birth":[117],"defect":[118],"described":[119],"association":[121],"infection)":[125],"then":[127],"specifically":[128],"tested":[129],"presence":[131],"neonatal":[136],"tissue":[137],"anti-Zika":[139],"IgM":[140],"blood":[143],"cerebrospinal":[145],"fluid.":[146],"guidelines":[149],"are":[150,193,212],"clear,":[151],"there":[152],"room":[154],"considerable":[156],"practice":[157],"variation":[158],"emerge":[160],"from":[161,223],"individualized":[162],"patient\u2013provider":[163],"encounters,":[164],"largely":[165],"due":[166,238,318],"limitations":[168,240],"diagnostic":[170,209,231,267,274],"Zika.":[173],"The":[174,273],"natural":[175],"history":[176],"further":[179],"obscures":[180],"our":[181],"ability":[182],"know":[184],"who,":[185],"when,":[186],"how":[188],"test.":[190],"Molecular":[191],"diagnostics":[192],"highly":[194],"specific":[195],"but":[196,211,308],"may":[197,233],"not":[198,234],"serve":[199],"well":[200,256],"those":[201],"infection.":[204,272,322],"Serologic":[205],"assays":[206],"expand":[207],"window":[210],"complicated":[213],"by":[214],"cross-reactivity":[215],"among":[216],"related":[217],"flaviviruses":[218],"passive":[220],"immunity":[221],"transferred":[222],"baby.":[226],"Furthermore,":[227],"existing":[228],"emerging":[230],"tools":[232,275],"be":[235,281],"widely":[236],"available":[237],"resources":[242],"infrastructure":[244],"health":[246,316],"systems":[247],"affected":[249],"areas.":[250],"Improvements":[251],"assay":[253],"parameters":[254],"as":[255,257],"advances":[258],"platforms":[260],"deployability":[262],"hold":[263],"promise":[264],"optimizing":[266],"approaches":[268],"technologies":[277],"under":[278],"development":[279],"must":[280],"integrated":[282],"forthcoming":[284],"knowledge":[286],"fully":[292],"realize":[293],"value":[295],"holds":[299],"diagnosing":[301],"utero":[303],"child":[306],"transmission":[307],"also":[309],"understanding,":[311],"predicting,":[312],"managing":[314],"outcomes":[317]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-11T00:00:00"}
