{"id":"https://openalex.org/W2925613754","doi":"https://doi.org/10.1111/cns.13123","title":"Astrocyte morphology: Diversity, plasticity, and role in neurological diseases","display_name":"Astrocyte morphology: Diversity, plasticity, and role in neurological diseases","publication_year":2019,"publication_date":"2019-03-30","ids":{"openalex":"https://openalex.org/W2925613754","doi":"https://doi.org/10.1111/cns.13123","mag":"2925613754","pmid":"https://pubmed.ncbi.nlm.nih.gov/30929313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6515705"},"language":"en","primary_location":{"id":"doi:10.1111/cns.13123","doi":"https://doi.org/10.1111/cns.13123","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.13123","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/cns.13123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022395038","display_name":"Bin Zhou","orcid":"https://orcid.org/0000-0001-9858-9471","observed_orcids":["https://orcid.org/0000-0001-9858-9471"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Zhou","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066018922","display_name":"Yunxia Zuo","orcid":"https://orcid.org/0000-0002-3539-5706","observed_orcids":["https://orcid.org/0000-0002-3539-5706","https://orcid.org/0000-0003-1743-078X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun\u2010Xia Zuo","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101406277","display_name":"Ruotian Jiang","orcid":"https://orcid.org/0000-0001-5322-6802","observed_orcids":["https://orcid.org/0000-0001-5322-6802"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruo\u2010Tian Jiang","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-5322-6802","affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101406277"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":3.1121,"has_fulltext":false,"cited_by_count":442,"citation_normalized_percentile":{"value":0.95466491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"6","first_page":"665","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte-morphology","display_name":"astrocyte morphology","score":0.8999999761581421},{"id":"https://openalex.org/keywords/protoplasmic-astrocyte","display_name":"protoplasmic astrocyte","score":0.9210000038146973},{"id":"https://openalex.org/keywords/astrocyte-heterogeneity","display_name":"astrocyte heterogeneity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neuron-astrocyte-interactions","display_name":"astrocyte-neuron interaction","score":0.7369999885559082},{"id":"https://openalex.org/keywords/reactive-astrogliosis","display_name":"reactive astrogliosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.5809999704360962},{"id":"https://openalex.org/keywords/astrocyte-dysfunction","display_name":"astrocyte dysfunction","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.8633316159248352},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8058395385742188},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8037793040275574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5753259062767029},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4401454031467438}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cns.13123","doi":"https://doi.org/10.1111/cns.13123","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.13123","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5560062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6515705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6515705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6515705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:30929313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30929313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cns.13123","doi":"https://doi.org/10.1111/cns.13123","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.13123","pdf_url":null,"source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1155091906","display_name":null,"funder_award_id":"8187051920","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6536227272","display_name":null,"funder_award_id":"31600832","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W768574866","https://openalex.org/W1495250009","https://openalex.org/W1552543129","https://openalex.org/W1594747697","https://openalex.org/W1968201904","https://openalex.org/W1969305530","https://openalex.org/W1971125401","https://openalex.org/W1975372045","https://openalex.org/W1976225114","https://openalex.org/W1983823915","https://openalex.org/W1985084268","https://openalex.org/W1988216749","https://openalex.org/W1992603070","https://openalex.org/W1993415479","https://openalex.org/W1994610525","https://openalex.org/W1995219764","https://openalex.org/W2002247284","https://openalex.org/W2002293846","https://openalex.org/W2022900933","https://openalex.org/W2025498751","https://openalex.org/W2029343038","https://openalex.org/W2032730787","https://openalex.org/W2033868363","https://openalex.org/W2034675173","https://openalex.org/W2035471044","https://openalex.org/W2035891650","https://openalex.org/W2036572142","https://openalex.org/W2036838450","https://openalex.org/W2037159639","https://openalex.org/W2037904566","https://openalex.org/W2039067152","https://openalex.org/W2040490831","https://openalex.org/W2046207649","https://openalex.org/W2047585900","https://openalex.org/W2048173148","https://openalex.org/W2050245491","https://openalex.org/W2051046645","https://openalex.org/W2055474933","https://openalex.org/W2058409428","https://openalex.org/W2060319077","https://openalex.org/W2064119008","https://openalex.org/W2069264323","https://openalex.org/W2073432906","https://openalex.org/W2073748140","https://openalex.org/W2078880746","https://openalex.org/W2079477479","https://openalex.org/W2089954323","https://openalex.org/W2092030050","https://openalex.org/W2092276546","https://openalex.org/W2093352806","https://openalex.org/W2106495485","https://openalex.org/W2112227347","https://openalex.org/W2115565454","https://openalex.org/W2119747492","https://openalex.org/W2120741241","https://openalex.org/W2121540976","https://openalex.org/W2124940469","https://openalex.org/W2128327517","https://openalex.org/W2129082075","https://openalex.org/W2129567809","https://openalex.org/W2141351251","https://openalex.org/W2143000970","https://openalex.org/W2147324040","https://openalex.org/W2151122745","https://openalex.org/W2152460583","https://openalex.org/W2152797586","https://openalex.org/W2157414926","https://openalex.org/W2163225965","https://openalex.org/W2166959857","https://openalex.org/W2180489978","https://openalex.org/W2284538027","https://openalex.org/W2307837122","https://openalex.org/W2336812220","https://openalex.org/W2343186916","https://openalex.org/W2344367297","https://openalex.org/W2345444307","https://openalex.org/W2530810650","https://openalex.org/W2571065439","https://openalex.org/W2610865917","https://openalex.org/W2611326560","https://openalex.org/W2613550486","https://openalex.org/W2616733389","https://openalex.org/W2621213207","https://openalex.org/W2735769265","https://openalex.org/W2737379596","https://openalex.org/W2749560933","https://openalex.org/W2767022103","https://openalex.org/W2767960938","https://openalex.org/W2787343838","https://openalex.org/W2793948158","https://openalex.org/W2794585550","https://openalex.org/W2795520491","https://openalex.org/W2799543599","https://openalex.org/W2804479495","https://openalex.org/W2886586689","https://openalex.org/W2896089133","https://openalex.org/W2897601491","https://openalex.org/W2910780660","https://openalex.org/W2950684508","https://openalex.org/W4235774781"],"related_works":["https://openalex.org/W4401304736","https://openalex.org/W4229335295","https://openalex.org/W7202120378","https://openalex.org/W7117319593","https://openalex.org/W4400054247","https://openalex.org/W2888094777","https://openalex.org/W3183857833","https://openalex.org/W4387026881","https://openalex.org/W4280500951","https://openalex.org/W3123491320"],"abstract_inverted_index":{"Astrocytes":[0],"are":[1,94,136],"the":[2,8,52,62,89,98,112,122,174],"most":[3],"abundant":[4],"glial":[5,83],"cells":[6],"in":[7,15,75,117,166,190],"central":[9],"nervous":[10],"system":[11],"(CNS)":[12],"and":[13,18,67,81,104,133,195],"participate":[14],"synaptic,":[16],"circuit,":[17],"behavioral":[19],"functions.":[20,147],"The":[21,148],"well-developed":[22],"protoplasmic":[23],"astrocytes":[24,93,126],"contain":[25],"numerous":[26],"processes":[27,58],"forming":[28],"well-delineated":[29],"bushy":[30],"territories":[31],"that":[32,92,108],"overlap":[33],"by":[34,56],"as":[35,37,155],"little":[36],"5%":[38],"at":[39],"their":[40],"boundaries.":[41],"This":[42,185],"highly":[43,131],"complex":[44],"morphology,":[45,152],"with":[46,59,77],"up":[47],"to":[48,71,111,129,138,145],"approximately":[49],"80%":[50],"of":[51,64,125,150],"cell's":[53],"membrane":[54],"constituted":[55],"fine":[57,123,175],"dimensions":[60],"on":[61],"tens":[63],"nanometer":[65],"scale":[66],"high":[68],"surface":[69],"area":[70],"volume":[72],"ratios,":[73],"comes":[74],"contact":[76],"synapses,":[78],"blood":[79],"vessels,":[80],"other":[82],"cells.":[84],"Recent":[85],"progress":[86],"is":[87,127,161],"challenging":[88],"conventional":[90],"view":[91],"morphologically":[95],"homogeneous":[96],"throughout":[97],"brain;":[99],"instead,":[100],"they":[101],"display":[102],"circuit-":[103],"region-specific":[105],"morphological":[106,192],"diversity":[107],"may":[109,181],"contribute":[110],"heterogeneous":[113],"astrocyte-neuron":[114],"spatiotemporal":[115],"interplay":[116],"different":[118],"brain":[119,146],"areas.":[120],"Further,":[121],"structure":[124],"found":[128],"be":[130],"plastic":[132],"activity-dependent.":[134],"We":[135],"beginning":[137],"understand":[139],"how":[140],"astrocyte":[141,151,191],"structural":[142,176],"plasticity":[143],"contributes":[144],"change/loss":[149],"traditionally":[153],"known":[154],"a":[156,162],"hallmark":[157],"for":[158],"reactive":[159,179],"astrogliosis,":[160],"common":[163],"pathological":[164],"feature":[165],"many":[167],"neurological":[168],"disorders.":[169],"However,":[170],"recent":[171,188],"data":[172],"suggest":[173],"deficits":[177],"preceding":[178],"astrogliosis":[180],"drive":[182],"disease":[183],"progression.":[184],"review":[186],"summarizes":[187],"advances":[189],"diversity,":[193],"plasticity,":[194],"disease-related":[196],"deficits.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":56},{"year":2025,"cited_by_count":91},{"year":2024,"cited_by_count":88},{"year":2023,"cited_by_count":85},{"year":2022,"cited_by_count":63},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-11T00:00:00"}
