{"id":"https://openalex.org/W292519290","doi":null,"title":"Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis.","display_name":"Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W292519290","mag":"292519290","pmid":"https://pubmed.ncbi.nlm.nih.gov/8952540","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865333"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865333","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079986408","display_name":"Peter Bugert","orcid":"https://orcid.org/0000-0002-2001-3904","observed_orcids":["https://orcid.org/0000-0002-2001-3904"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Bugert","raw_affiliation_strings":["Department of Urology, Ruprecht Karls University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Ruprecht Karls University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023486650","display_name":"Gyula Kov\u00e1cs","orcid":"https://orcid.org/0000-0003-2890-3781","observed_orcids":["https://orcid.org/0000-0003-2890-3781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3443,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.96171182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"149","issue":"6","first_page":"2081","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.9390000104904175},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromophobe-renal-cell-carcinoma","display_name":"chromophobe renal cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-oncocytoma","display_name":"renal oncocytoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/chromosome-3p-loss","display_name":"chromosome 3p deletion","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.8782829642295837},{"id":"https://openalex.org/C78795084","wikidata":"https://www.wikidata.org/wiki/Q5113900","display_name":"Chromophobe cell","level":4,"score":0.819774866104126},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6929332613945007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6600345969200134},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.5651471018791199},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.5239855647087097},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5237398147583008},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.48698386549949646},{"id":"https://openalex.org/C2777430276","wikidata":"https://www.wikidata.org/wiki/Q3882418","display_name":"Renal oncocytoma","level":4,"score":0.47614312171936035},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4641863703727722},{"id":"https://openalex.org/C2780674462","wikidata":"https://www.wikidata.org/wiki/Q1760202","display_name":"Oncocytoma","level":3,"score":0.4608357548713684},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.44766661524772644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2061726450920105},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.1923981010913849},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16380107402801514},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.10328778624534607},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06561565399169922}],"mesh":[{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004276","descriptor_name":"DNA, Satellite","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:8952540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8952540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1865333","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1865333/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:292519290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8952540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W24886319","https://openalex.org/W181147267","https://openalex.org/W256880428","https://openalex.org/W1481158683","https://openalex.org/W1511581598","https://openalex.org/W1549171185","https://openalex.org/W1555600027","https://openalex.org/W1576321535","https://openalex.org/W1596875459","https://openalex.org/W1596893076","https://openalex.org/W1603249784","https://openalex.org/W1824107816","https://openalex.org/W1826981476","https://openalex.org/W1944728686","https://openalex.org/W1964382251","https://openalex.org/W1978928328","https://openalex.org/W1981432410","https://openalex.org/W2001258296","https://openalex.org/W2010160635","https://openalex.org/W2016384431","https://openalex.org/W2081919674","https://openalex.org/W2089837140","https://openalex.org/W2123335542","https://openalex.org/W2150954721","https://openalex.org/W2158350288","https://openalex.org/W2164171045","https://openalex.org/W2170582700","https://openalex.org/W2318508214"],"related_works":["https://openalex.org/W1834762587","https://openalex.org/W2040251534","https://openalex.org/W2411284813","https://openalex.org/W2109184910","https://openalex.org/W2055915689","https://openalex.org/W2089837140","https://openalex.org/W1969841042","https://openalex.org/W2026714514","https://openalex.org/W2402442166","https://openalex.org/W2081919674"],"abstract_inverted_index":{"Recent":[0],"application":[1],"of":[2,12,15,22,39,63,90,99,107,109,134,141,163,174],"molecular":[3],"cytogenetic":[4,74],"techniques":[5],"has":[6],"resulted":[7],"in":[8,151],"a":[9,36,45,55,97],"new":[10],"type":[11],"genetic":[13,40],"classification":[14],"renal":[16,82,93,100,136,165,175],"cell":[17,83,94,137,166,176],"tumors.":[18,167],"The":[19],"key":[20],"aspect":[21],"the":[23,69,161,171],"novel":[24],"diagnostic":[25],"concept":[26],"is":[27],"reflected":[28],"by":[29,35,105],"biologically":[30],"distinct":[31],"entities,":[32],"each":[33],"characterized":[34],"specific":[37],"combination":[38],"changes.":[41],"To":[42],"work":[43],"out":[44,181],"diagnostic/prognostic":[46],"approach,":[47,170],"we":[48],"have":[49],"applied":[50],"polymorphic":[51],"microsatellite":[52],"markers":[53],"for":[54],"quick":[56],"analysis,":[57],"based":[58],"on":[59],"polymerase":[60],"chain":[61],"reaction,":[62],"82":[64],"tumor":[65],"specimens.":[66],"We":[67],"compared":[68],"results":[70],"to":[71,153],"previously":[72],"evaluated":[73],"and":[75,80,96,116,125,149,158],"histological":[76],"data.":[77],"All":[78],"nonpapillary":[79,135],"chromophobe":[81,164],"carcinomas,":[84],"which":[85],"make":[86],"up":[87],"approximately":[88],"90%":[89],"all":[91],"malignant":[92],"tumors,":[95],"subset":[98],"oncocytomas":[101],"were":[102],"correctly":[103],"diagnosed":[104],"detection":[106],"loss":[108,140],"heterozygosity":[110,142],"at":[111,120,143,155],"chromosomal":[112,121],"sites":[113],"1,":[114],"2,":[115,159],"3p.":[117],"Allelic":[118],"losses":[119],"regions":[122],"8p,":[123],"9p,":[124],"14q":[126],"are":[127],"associated":[128],"with":[129],"an":[130],"advanced":[131],"pathological":[132],"stage":[133],"carcinomas.":[138],"A":[139],"chromosomes":[144,156],"6,":[145],"10,":[146],"13,":[147],"17,":[148],"21,":[150],"addition":[152],"those":[154],"1":[157,183],"confirm":[160],"diagnosis":[162,173],"Using":[168],"this":[169],"differential":[172],"tumors":[177],"could":[178],"be":[179],"carried":[180],"within":[182],"or":[184],"2":[185],"days.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}