{"id":"https://openalex.org/W2924635338","doi":null,"title":"Piezo ion channels in cancer cell mechanotransduction","display_name":"Piezo ion channels in cancer cell mechanotransduction","publication_year":2018,"publication_date":"2018-01-24","ids":{"openalex":"https://openalex.org/W2924635338","mag":"2924635338"},"language":"es","primary_location":{"id":"pmh:oai:dnet:tdr_________::8243f85e449b26ec63cedb99d19a2dab","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/664209","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/664209","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002992380","display_name":"Pardo Pastor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pardo Pastor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Carlos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piezo1","display_name":"Piezo1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/piezo2","display_name":"Piezo2","score":1.0},{"id":"https://openalex.org/keywords/mechanosensitive-channels","display_name":"mechanosensitive ion channels","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-confinement","display_name":"cell confinement","score":0.6769999861717224},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pde1","display_name":"PDE1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.734000027179718},{"id":"https://openalex.org/keywords/myosin-ii","display_name":"myosin II","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-stiffness","display_name":"cell stiffness","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7549999952316284},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.7519999742507935},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.8090000152587891},{"id":"https://openalex.org/keywords/invadopodia","display_name":"invadopodia","score":0.8180000185966492},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-2","display_name":"plasminogen activator inhibitor-2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6552494168281555},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5943489074707031},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42680540680885315},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3880021274089813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16770651936531067}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::8243f85e449b26ec63cedb99d19a2dab","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/664209","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositori-api.upf.edu:10230/36047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/664209","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/664209","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/664209","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2924635338","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/tesis?codigo=228418","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:tdr_________::8243f85e449b26ec63cedb99d19a2dab","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/664209","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3040485407","https://openalex.org/W7130939599","https://openalex.org/W3207547404","https://openalex.org/W7152096269","https://openalex.org/W2940729606","https://openalex.org/W7162691762","https://openalex.org/W2793563162","https://openalex.org/W1996711923","https://openalex.org/W7219193463","https://openalex.org/W7153637511"],"abstract_inverted_index":{"The":[0,258],"mechanical":[1,40,160,275],"dependence":[2],"of":[3,14,39,88,158,170,190,215,244,274,295,300],"transformation":[4],"and":[5,34,99,120,187,196,222,242,291],"metastasis":[6],"is":[7,198],"an":[8,150],"emerging":[9],"field,":[10],"but":[11],"the":[12,25,29,37,122,145,167,191,293],"role":[13,152],"mechanosensitive":[15,30],"channels":[16,32,269,297],"has":[17],"been":[18],"largely":[19],"omitted.":[20],"This":[21,64],"thesis":[22,263],"focuses":[23],"on":[24],"roles":[26,266],"played":[27],"by":[28,49,91,200,210],"ion":[31,296],"Piezo1":[33,114],"Piezo2":[35,154,177,228],"in":[36,108,125,261,278],"transduction":[38],"stimuli":[41],"(confinement,":[42],"adhesion,":[43],"substrate":[44],"rigidity,":[45],"adhesive":[46],"ligand":[47],"concentration)":[48],"cancer":[50,175,289],"cells.":[51,132,176,280],"In":[52,144,226],"a":[53,84,94,134,156,246,271],"first":[54,272],"chapter,":[55,147],"we":[56,148],"show":[57,138],"that":[58],"confinement":[59],"triggers":[60],"Piezo1-mediated":[61],"calcium":[62,118,202],"entry.":[63],"activates":[65],"phosphodiesterase":[66],"1,":[67],"reducing":[68],"cAMP":[69],"levels":[70],"and,":[71],"consequently,":[72],"PKA\uf0e0Rac1":[73],"activity,":[74],"relieving":[75],"Myosin":[76,89],"II":[77,90],"from":[78,253],"its":[79],"inhibition.":[80],"We":[81],"also":[82],"find":[83],"parallel,":[85],"direct":[86],"activation":[87,164],"confinement.":[92,143],"As":[93,133],"combined":[95],"result,":[96,135],"cells":[97,137,252],"stiffen":[98],"optimize":[100],"their":[101],"adhesion-free":[102],"migration":[103,110],"mode,":[104],"usually":[105],"responsible":[106],"for":[107,153,249,267,285],"vivo":[109],"during":[111],"metastatic":[112,173],"invasion.":[113],"knockdown":[115,178,229],"supresses":[116],"confinement-induced":[117],"entry":[119],"impairs":[121],"underlying":[123],"circuitry":[124],"ovarian":[126],"epithelial":[127],"(CHO)":[128],"or":[129,209,217],"melanoma":[130],"(A375)":[131],"siPiezo1":[136],"reduced":[139],"migratory":[140],"capacity":[141],"under":[142],"second":[146],"discover":[149],"essential":[151],"as":[155,270,298],"transducer":[157],"environmental":[159,301],"cues":[161],"into":[162],"RhoA":[163],"to":[165],"modulate":[166],"mechanobiological":[168],"responses":[169],"MDA-MB-231-BrM2":[171],"brain":[172,254],"breast":[174],"disturbs":[179],"stress":[180,220],"fibre":[181],"formation,":[182,238],"adhesion":[183],"orientation,":[184],"force":[185],"transmission":[186],"nuclear":[188,223],"accumulation":[189],"malignant":[192],"co-transcriptional":[193],"activator":[194],"YAP,":[195],"this":[197,262],"phenocopied":[199],"extracellular":[201,239],"suppression.":[203],"Promoting":[204],"Actin":[205],"polymerization":[206],"with":[207],"jasplakinolide":[208],"over-expressing":[211],"constitutively":[212],"active":[213],"forms":[214],"Rho":[216],"mDia1":[218],"restores":[219],"fibres":[221],"YAP":[224],"accumulation.":[225],"addition,":[227],"disrupts":[230],"several":[231,286],"pro-metastatic":[232],"functions:":[233],"cell":[234],"proliferation,":[235],"migration,":[236],"invadopodia":[237],"matrix":[240],"degradation,":[241],"secretion":[243],"SERPINB2,":[245],"protein":[247],"needed":[248],"protecting":[250],"invasive":[251],"parenchymal":[255],"defence":[256],"mechanisms.":[257],"works":[259],"presented":[260],"unveil":[264],"important":[265],"Piezo":[268],"line":[273],"input":[276],"detectors":[277],"distinct":[279],"These":[281],"discoveries":[282],"are":[283],"relevant":[284],"fields,":[287],"e.g.":[288],"research,":[290],"highlight":[292],"importance":[294],"transducers":[299],"stimuli.":[302]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-04-01T00:00:00"}