{"id":"https://openalex.org/W2924349331","doi":"https://doi.org/10.1002/acn3.736","title":"Cognitive deficits in adult m.3243A>G\u2010 and m.8344A>G\u2010related mitochondrial disease: importance of correcting for baseline intellectual ability","display_name":"Cognitive deficits in adult m.3243A>G\u2010 and m.8344A>G\u2010related mitochondrial disease: importance of correcting for baseline intellectual ability","publication_year":2019,"publication_date":"2019-03-27","ids":{"openalex":"https://openalex.org/W2924349331","doi":"https://doi.org/10.1002/acn3.736","mag":"2924349331","pmid":"https://pubmed.ncbi.nlm.nih.gov/31139680","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6529924"},"language":"en","primary_location":{"id":"doi:10.1002/acn3.736","doi":"https://doi.org/10.1002/acn3.736","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.736","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.736","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064950496","display_name":"Heather L. Moore","orcid":"https://orcid.org/0000-0002-2999-8332","observed_orcids":["https://orcid.org/0000-0002-2999-8332"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather L. Moore","raw_affiliation_strings":["Institute of Health & Society, Newcastle University, 3rd Floor, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP United Kingdom","Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health & Society, Newcastle University, 3rd Floor, Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP United Kingdom","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I84884186"]},{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112257861","display_name":"Thomas P. Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Kelly","raw_affiliation_strings":["Department of Neuropsychology, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 4LP United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychology, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 4LP United Kingdom","institution_ids":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077284838","display_name":"Alexandra Bright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandra Bright","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010057939","display_name":"Robert H. Field","orcid":"https://orcid.org/0000-0002-2202-2126","observed_orcids":["https://orcid.org/0000-0002-2202-2126"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert H. Field","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067436636","display_name":"Andrew M. Schaefer","orcid":"https://orcid.org/0000-0001-8212-7635","observed_orcids":["https://orcid.org/0000-0001-8212-7635"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. Schaefer","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102797504","display_name":"Alasdair P. Blain","orcid":"https://orcid.org/0000-0002-3712-5283","observed_orcids":["https://orcid.org/0000-0002-3712-5283"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair P. Blain","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636153","display_name":"Robert William Taylor","orcid":"https://orcid.org/0000-0002-7768-8873","observed_orcids":["https://orcid.org/0000-0002-7768-8873"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert W. Taylor","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053767923","display_name":"Robert McFarland","orcid":"https://orcid.org/0000-0002-8833-2688","observed_orcids":["https://orcid.org/0000-0002-8833-2688"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert McFarland","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050697713","display_name":"Douglass M. Turnbull","orcid":"https://orcid.org/0000-0002-8878-9901","observed_orcids":["https://orcid.org/0000-0002-8878-9901"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Doug M. Turnbull","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006400472","display_name":"Gr\u00e1inne S. Gorman","orcid":"https://orcid.org/0000-0002-7585-3409","observed_orcids":["https://orcid.org/0000-0002-7585-3409"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gr\u00e1inne S. Gorman","raw_affiliation_strings":["Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH United Kingdom","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006400472"],"corresponding_institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":2656,"currency":"EUR","value_usd":2864},"fwci":0.58,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.58636083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"5","first_page":"826","last_page":"836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/m-3243a-g-mutation","display_name":"m.3243A>G mutation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8259999752044678},{"id":"https://openalex.org/keywords/premorbid-intelligence","display_name":"premorbid intelligence","score":0.7799999713897705},{"id":"https://openalex.org/keywords/executive-dysfunction","display_name":"executive dysfunction","score":0.6890000104904175},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7820000052452087},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.8939999938011169},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/compensatory-strategies","display_name":"compensatory strategies","score":0.8069999814033508},{"id":"https://openalex.org/keywords/neuropsychological-assessment","display_name":"neuropsychological assessment","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.8030601143836975},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.6186755895614624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5835132598876953},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.5402320623397827},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4999356269836426},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.4963536858558655},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4230799674987793},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4102455675601959},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3791182041168213},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3220571279525757},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25323110818862915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21287453174591064},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.18687298893928528}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1002/acn3.736","doi":"https://doi.org/10.1002/acn3.736","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.736","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.736","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},{"id":"pmid:31139680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31139680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and translational neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6529924","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6529924/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Clin Transl Neurol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f867092267ad45ff9f7263569a957034","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f867092267ad45ff9f7263569a957034","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of Clinical and Translational Neurology, Vol 6, Iss 5, Pp 826-836 (2019)","raw_type":"article"},{"id":"doi:10.25405/ncl.34382808","doi":"https://doi.org/10.25405/ncl.34382808","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34382808","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34382808.v1","doi":"https://doi.org/10.25405/ncl.34382808.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34382808.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1002/acn3.736","doi":"https://doi.org/10.1002/acn3.736","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.736","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.736","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1683062455","display_name":"MICA: MRC Centre for Neuromuscular Diseases","funder_award_id":"MR/K000608/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3252469178","display_name":null,"funder_award_id":"13/NE/0326","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5022481816","display_name":null,"funder_award_id":"L016354","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5961236553","display_name":"Wellcome Centre for Mitochondrial Research","funder_award_id":"203105","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8065043414","display_name":null,"funder_award_id":"L016354","funder_id":"https://openalex.org/F4320320295","funder_display_name":"Newcastle University"},{"id":"https://openalex.org/G8206191503","display_name":"Centre for Ageing and Vitality","funder_award_id":"MR/L016354/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8827204909","display_name":null,"funder_award_id":"L016354","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320295","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70"},{"id":"https://openalex.org/F4320320332","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90"},{"id":"https://openalex.org/F4320322155","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847"},{"id":"https://openalex.org/F4320329087","display_name":"Centre for Cognitive Ageing and Cognitive Epidemiology","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2924349331.pdf","grobid_xml":"https://content.openalex.org/works/W2924349331.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1521947818","https://openalex.org/W1577606010","https://openalex.org/W1964507575","https://openalex.org/W1978062616","https://openalex.org/W1978895645","https://openalex.org/W2013114094","https://openalex.org/W2020599485","https://openalex.org/W2022215047","https://openalex.org/W2030754119","https://openalex.org/W2034369826","https://openalex.org/W2038617129","https://openalex.org/W2048576001","https://openalex.org/W2056101303","https://openalex.org/W2065789205","https://openalex.org/W2072923531","https://openalex.org/W2084875295","https://openalex.org/W2096656403","https://openalex.org/W2100637353","https://openalex.org/W2108594039","https://openalex.org/W2121044470","https://openalex.org/W2128919439","https://openalex.org/W2129642619","https://openalex.org/W2149983419","https://openalex.org/W2154658384","https://openalex.org/W2160284652","https://openalex.org/W2165292147","https://openalex.org/W2167499282","https://openalex.org/W2777944691","https://openalex.org/W2786198454","https://openalex.org/W2910972539","https://openalex.org/W4234801520","https://openalex.org/W4248039115","https://openalex.org/W4255759911","https://openalex.org/W4316087831"],"related_works":["https://openalex.org/W2229529372","https://openalex.org/W2970886671","https://openalex.org/W4414824329","https://openalex.org/W4412807796","https://openalex.org/W7127337263","https://openalex.org/W2058340972","https://openalex.org/W2079946576","https://openalex.org/W2100637353","https://openalex.org/W7002352770","https://openalex.org/W3003550050"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,13,137],"cognitive":[4,66,129,159,176],"profile":[5,157],"of":[6,15,45,57,124,154,158,175,193,197,208],"adult":[7],"patients":[8],"with":[9,163],"mitochondrial":[10],"disease,":[11],"and":[12,25,33,52,75,87,118,133,161,204,206],"effect":[14],"disease":[16,119,165],"severity":[17,120],"on":[18,104],"cognition.":[19],"METHODS:":[20],"=":[21],"13)":[22],"mtDNA":[23],"mutations":[24],"32":[26],"controls,":[27,102],"matched":[28],"by":[29,95],"age":[30],"(\u00b15":[31],"years)":[32],"premorbid":[34,65,111],"cognition":[35,47,58,74,112,117,125],"(\u00b110":[36],"WTAR":[37],"FSIQ":[38],"points),":[39],"participated.":[40],"Participants":[41],"completed":[42],"neuropsychological":[43],"assessments":[44],"general":[46,73],"(WAIS-IV),":[48],"executive":[49],"function":[50],"(D-KEFS),":[51],"memory":[53,88,105,209],"(WMS-IV).":[54],"Potential":[55],"predictors":[56,123],"were":[59,121],"explored.":[60],"RESULTS:":[61],"Patients":[62,98,146],"show":[63],"mild-to-moderate":[64],"impairment,":[67],"but":[68],"substantial":[69],"impairment":[70],"in":[71,126,136],"current":[72],"distinct":[76],"domains,":[77],"including":[78],"verbal":[79],"comprehension,":[80],"perceptual":[81],"reasoning,":[82],"working":[83],"memory,":[84,109],"processing":[85],"speed,":[86],"retrieval.":[89],"Executive":[90],"dysfunction":[91],"may":[92,211],"be":[93,148,168,182],"caused":[94],"slower":[96,191],"decision-making.":[97],"performed":[99],"worse":[100],"than":[101],"except":[103],"tasks,":[106],"indicating":[107],"intact":[108],"when":[110,139],"is":[113,134],"controlled":[114],"for.":[115],"Premorbid":[116],"consistent":[122],"patients;":[127],"however,":[128],"decline":[130],"appears":[131],"slow":[132],"unlikely":[135],"short-term,":[138],"other":[140],"disease-specific":[141],"factors":[142],"remain":[143],"stable.":[144],"INTERPRETATION:":[145],"should":[147,167,181],"monitored":[149],"to":[150,201],"facilitate":[151],"early":[152],"identification":[153],"a":[155],"complex":[156],"deficits":[160],"individuals":[162],"higher":[164],"burden":[166],"followed":[169],"up":[170],"more":[171],"closely.":[172],"On":[173],"development":[174],"difficulties,":[177],"appropriate":[178],"compensatory":[179],"strategies":[180,188],"determined":[183],"through":[184],"in-depth":[185],"assessment.":[186],"Using":[187],"such":[189],"as":[190],"presentation":[192],"information,":[194],"multiple":[195],"modes":[196],"presentation,":[198],"active":[199],"discussion":[200],"aid":[202],"understanding":[203],"decision-making,":[205],"use":[207],"aids,":[210],"ameliorate":[212],"difficulties.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-01T00:00:00"}
