{"id":"https://openalex.org/W2923917067","doi":null,"title":"The metabolic microenvironment regulates myogenic fate decisions through altered histone acetylation","display_name":"The metabolic microenvironment regulates myogenic fate decisions through altered histone acetylation","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2923917067","mag":"2923917067"},"language":"en","primary_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/221693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/221693","pdf_url":"http://hdl.handle.net/11343/221693","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11343/221693","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110014895","display_name":"Chi Ly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chi Ly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110014895"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0812000036239624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.5389999747276306},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7101016640663147},{"id":"https://openalex.org/C2778106681","wikidata":"https://www.wikidata.org/wiki/Q416095","display_name":"MyoD","level":4,"score":0.661881685256958},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6564414501190186},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6138606667518616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5645655393600464},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.41964054107666016},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.23067784309387207},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.22866138815879822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07168447971343994},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/221693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/221693","pdf_url":"http://hdl.handle.net/11343/221693","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},{"id":"mag:2923917067","doi":null,"is_oa":false,"landing_page_url":"https://minerva-access.unimelb.edu.au/bitstream/handle/11343/221693/HTLY Thesis Final 387757.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/221693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/221693","pdf_url":"http://hdl.handle.net/11343/221693","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923917067.pdf","grobid_xml":"https://content.openalex.org/works/W2923917067.grobid-xml"},"referenced_works_count":218,"referenced_works":["https://openalex.org/W58326483","https://openalex.org/W69776591","https://openalex.org/W79291003","https://openalex.org/W1479673257","https://openalex.org/W1541248931","https://openalex.org/W1547610032","https://openalex.org/W1547854630","https://openalex.org/W1617847244","https://openalex.org/W1881681712","https://openalex.org/W1893330971","https://openalex.org/W1894632965","https://openalex.org/W1938282147","https://openalex.org/W1964204876","https://openalex.org/W1965754626","https://openalex.org/W1966174134","https://openalex.org/W1966909881","https://openalex.org/W1970461933","https://openalex.org/W1971407164","https://openalex.org/W1972525015","https://openalex.org/W1972806358","https://openalex.org/W1972984824","https://openalex.org/W1973483073","https://openalex.org/W1974543599","https://openalex.org/W1977622464","https://openalex.org/W1977745244","https://openalex.org/W1978003151","https://openalex.org/W1978159913","https://openalex.org/W1980073120","https://openalex.org/W1981180583","https://openalex.org/W1982245720","https://openalex.org/W1982260012","https://openalex.org/W1987761030","https://openalex.org/W1988060154","https://openalex.org/W1988393390","https://openalex.org/W1991231222","https://openalex.org/W1991440852","https://openalex.org/W1991988594","https://openalex.org/W1993755388","https://openalex.org/W1995091371","https://openalex.org/W2004396725","https://openalex.org/W2004602258","https://openalex.org/W2005856601","https://openalex.org/W2006938530","https://openalex.org/W2007398635","https://openalex.org/W2010110230","https://openalex.org/W2011009219","https://openalex.org/W2011189226","https://openalex.org/W2011367132","https://openalex.org/W2013621644","https://openalex.org/W2014058353","https://openalex.org/W2014639769","https://openalex.org/W2015207840","https://openalex.org/W2016957645","https://openalex.org/W2017043267","https://openalex.org/W2017075649","https://openalex.org/W2017429680","https://openalex.org/W2019673480","https://openalex.org/W2020072016","https://openalex.org/W2021110291","https://openalex.org/W2021405394","https://openalex.org/W2023200943","https://openalex.org/W2023424615","https://openalex.org/W2024382317","https://openalex.org/W2025957803","https://openalex.org/W2026170688","https://openalex.org/W2028835848","https://openalex.org/W2028897202","https://openalex.org/W2029054948","https://openalex.org/W2029914169","https://openalex.org/W2030137409","https://openalex.org/W2030509917","https://openalex.org/W2031495223","https://openalex.org/W2033607377","https://openalex.org/W2035010201","https://openalex.org/W2036024484","https://openalex.org/W2036799174","https://openalex.org/W2037209340","https://openalex.org/W2037334278","https://openalex.org/W2037844862","https://openalex.org/W2039350499","https://openalex.org/W2041622114","https://openalex.org/W2043317882","https://openalex.org/W2043457504","https://openalex.org/W2046079276","https://openalex.org/W2048741905","https://openalex.org/W2049016912","https://openalex.org/W2049279804","https://openalex.org/W2049311574","https://openalex.org/W2050853454","https://openalex.org/W2051181260","https://openalex.org/W2051393353","https://openalex.org/W2052543023","https://openalex.org/W2053213876","https://openalex.org/W2057289143","https://openalex.org/W2058191248","https://openalex.org/W2061266080","https://openalex.org/W2061434701","https://openalex.org/W2067657178","https://openalex.org/W2067906234","https://openalex.org/W2069564414","https://openalex.org/W2069752613","https://openalex.org/W2070151086","https://openalex.org/W2071918153","https://openalex.org/W2072451938","https://openalex.org/W2072809212","https://openalex.org/W2073403442","https://openalex.org/W2074516296","https://openalex.org/W2076208069","https://openalex.org/W2078718449","https://openalex.org/W2080130289","https://openalex.org/W2080592158","https://openalex.org/W2083145525","https://openalex.org/W2083405476","https://openalex.org/W2085205835","https://openalex.org/W2086441678","https://openalex.org/W2086756183","https://openalex.org/W2087803244","https://openalex.org/W2087814592","https://openalex.org/W2088043742","https://openalex.org/W2089050750","https://openalex.org/W2089551665","https://openalex.org/W2091154312","https://openalex.org/W2091545998","https://openalex.org/W2091757969","https://openalex.org/W2092077225","https://openalex.org/W2092152920","https://openalex.org/W2093882821","https://openalex.org/W2094807296","https://openalex.org/W2096083625","https://openalex.org/W2099466631","https://openalex.org/W2099547258","https://openalex.org/W2101967659","https://openalex.org/W2102188028","https://openalex.org/W2104135721","https://openalex.org/W2106220546","https://openalex.org/W2106562809","https://openalex.org/W2107270084","https://openalex.org/W2109487240","https://openalex.org/W2109627278","https://openalex.org/W2110905563","https://openalex.org/W2112468384","https://openalex.org/W2112513572","https://openalex.org/W2113539953","https://openalex.org/W2114104545","https://openalex.org/W2117692326","https://openalex.org/W2118942329","https://openalex.org/W2119406072","https://openalex.org/W2122059149","https://openalex.org/W2122795085","https://openalex.org/W2126997806","https://openalex.org/W2130202974","https://openalex.org/W2130410032","https://openalex.org/W2134614924","https://openalex.org/W2134846845","https://openalex.org/W2134847995","https://openalex.org/W2135518377","https://openalex.org/W2136615863","https://openalex.org/W2138041459","https://openalex.org/W2138233516","https://openalex.org/W2139581284","https://openalex.org/W2139754605","https://openalex.org/W2140254135","https://openalex.org/W2140729960","https://openalex.org/W2143025255","https://openalex.org/W2144575277","https://openalex.org/W2146138975","https://openalex.org/W2146512944","https://openalex.org/W2147494386","https://openalex.org/W2149544198","https://openalex.org/W2152240130","https://openalex.org/W2154507552","https://openalex.org/W2154861644","https://openalex.org/W2158217645","https://openalex.org/W2160463657","https://openalex.org/W2161789547","https://openalex.org/W2162142628","https://openalex.org/W2163748946","https://openalex.org/W2165105249","https://openalex.org/W2168757635","https://openalex.org/W2171370093","https://openalex.org/W2184324819","https://openalex.org/W2187913346","https://openalex.org/W2188212395","https://openalex.org/W2194012442","https://openalex.org/W2197722206","https://openalex.org/W2223742570","https://openalex.org/W2224270925","https://openalex.org/W2294143173","https://openalex.org/W2314203155","https://openalex.org/W2328227932","https://openalex.org/W2336439489","https://openalex.org/W2342297429","https://openalex.org/W2343956310","https://openalex.org/W2346143774","https://openalex.org/W2408077393","https://openalex.org/W2417386614","https://openalex.org/W2418696384","https://openalex.org/W2467481365","https://openalex.org/W2504379340","https://openalex.org/W2531264048","https://openalex.org/W2605810679","https://openalex.org/W2606946599","https://openalex.org/W2611841948","https://openalex.org/W2615913297","https://openalex.org/W2752202814","https://openalex.org/W2762997208","https://openalex.org/W2769123411","https://openalex.org/W2773791718","https://openalex.org/W2774294488","https://openalex.org/W2791038745","https://openalex.org/W2883070801","https://openalex.org/W2890631306","https://openalex.org/W2895137021","https://openalex.org/W2923948921","https://openalex.org/W2950801021","https://openalex.org/W2951538476","https://openalex.org/W2982815105","https://openalex.org/W7099684798"],"related_works":["https://openalex.org/W3201506834","https://openalex.org/W2955111823","https://openalex.org/W3094891898","https://openalex.org/W2067961761","https://openalex.org/W2894128335","https://openalex.org/W3149044824","https://openalex.org/W4389479217","https://openalex.org/W3110433355","https://openalex.org/W2516110596","https://openalex.org/W1452894599"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,20,295,475],"has":[2,127],"an":[3,54,554],"extensive":[4],"capacity":[5],"for":[6,108,203,247],"regeneration,":[7],"a":[8,15,41,60,89,133,187,415,447,544,551],"property":[9],"conferred":[10],"on":[11,234,333],"this":[12,26,67,156,161],"tissue":[13],"by":[14,45,362],"resident":[16],"population":[17,27,550],"of":[18,28,62,83,91,102,149,155,168,190,207,284,337,357,408,412,418,452,464,466,492,496,512,546,553,557,569],"skeletal":[19,294],"stem":[21,29,104,124,141],"cells":[22,30,273,302,453,493],"(MuSCs).Any":[23],"impairment":[24],"to":[25,33,53,72,85,95,99,110,159,176,375,378,380,435,446,509,530,543,565],"can":[31,562],"lead":[32],"increased":[34,510,555],"morbidity":[35],"and":[36,64,79,121,123,146,151,165,170,175,209,224,347,370,398,404,428,478,481,515,536],"mortality.MuSCs":[37],"normally":[38],"exist":[39],"in":[40,119,136,173,288,305,382,421,449,494],"quiescent":[42],"state":[43],"marked":[44,272],"the":[46,74,81,86,103,147,153,166,204,218,282,285,330,450,484,490,520,524,547,567],"paired":[47],"box":[48],"transcription":[49],"factor":[50,77],"Pax7.In":[51],"response":[52],"activating":[55],"signal,":[56],"MuSCs":[57,70,92,109,174,192,208,238,240,257,262,299],"rapidly":[58],"undergo":[59,112],"process":[61,82],"activation":[63],"cell-cycle":[65],"re-entry.At":[66],"early":[68,473],"stage,":[69],"begin":[71],"express":[73],"myogenic":[75,87,171,276,359,455],"determination":[76],"MyoD":[78],"initiate":[80],"commitment":[84,113,172,277,535],"lineage.Importantly,":[88],"sub-population":[90],"will":[93],"return":[94],"quiescence":[96],"so":[97],"as":[98,131],"prevent":[100],"depletion":[101],"cell":[105,125,142,215,222,228,372],"pool.This":[106],"decision":[107],"either":[111,235,274],"or":[114,239,278,300,323],"self-renewal":[115,169,537],"remains":[116],"ill":[117],"defined.Studies":[118],"cancer,":[120],"developmental":[122],"biology":[126],"identified":[128],"cellular":[129,348,396],"metabolism":[130,164,179,223,379,397,413,420],"playing":[132],"key":[134,342,358],"role":[135,283,417],"directing":[137],"changes":[138,381],"associated":[139],"with":[140,266,441,538],"selfrenewal,":[143],"lineage":[144,291,438,534],"specification":[145,292,352],"processes":[148,167],"proliferation":[150],"differentiation.Therefore,":[152],"aim":[154],"study":[157],"was":[158,232,350,353,388,433,507],"investigate":[160],"link":[162,219,376],"between":[163,220],"identify":[177],"how":[178],"may":[180],"regulate":[181],"these":[182,497],"processes.":[183],"2.To":[184],"efficiently":[185],"isolate":[186],"large":[188],"number":[189],"primary":[191,298],"I":[193],"utilized":[194],"Pax7creER":[195],"T2":[196],"xROSA26e":[197],"YFP":[198],"transgenic":[199],"mice":[200],"which":[201],"allows":[202],"fluorescent":[205],"labelling":[206],"subsequent":[210],"isolation":[211],"via":[212,355,401],"fluorescence":[213],"activated":[214],"sorting.To":[216],"examine":[217,281],"innate":[221,395],"MuSC":[225,290,533,549,570],"heterogeneity,":[226],"single":[227,371,499],"RNA":[229],"sequencing":[230,369,373,427],"(scRNAseq)":[231],"performed":[233],"freshly":[236,255],"isolated":[237,256,297],"that":[241,253,483,503,523],"had":[242],"been":[243],"cultured":[244,261,304],"ex":[245],"vivo":[246],"96":[248],"hrs.The":[249],"scRNAseq":[250,457],"results":[251,518],"revealed":[252],"while":[254],"are":[258],"largely":[259],"homogeneous,":[260],"exhibited":[263],"significant":[264],"heterogeneity":[265],"divergent":[267],"metabolic":[268,270,286,486,526,560],"signatures.These":[269],"signatures":[271],"undergoing":[275,454],"self-renewal.3.":[279],"To":[280],"microenvironment":[287,527],"regulating":[289],"whole":[293,367,425],"fibres,":[296],"C2C12":[301],"were":[303],"media":[306],"containing":[307],"different":[308],"carbohydrate":[309,390,419,431,443,505,540],"conditions;":[310],"high":[311],"glucose":[312,318],"(25":[313],"mM":[314,320,326],"glucose,":[315,321],"HG),":[316],"low":[317],"(5":[319],"LG)":[322],"galactose":[324],"(10":[325],"galactose,":[327],"GAL).Following":[328],"culture,":[329],"downstream":[331],"effects":[332],"metabolism,":[334],"including":[335,468],"measurements":[336],"mitochondrial":[338,340],"DNA,":[339],"abundance,":[341],"electron":[343],"transport":[344],"chain":[345],"proteins":[346],"bioenergetics":[349],"assessed.Myogenic":[351],"assessed":[354],"examination":[356],"regulatory":[360],"factors":[361],"PCR,":[363],"western":[364],"immunoblotting,":[365],"immunofluorescence,":[366],"transcriptome":[368,426],"(scRNAseq).Finally,":[374],"alterations":[377],"gene":[383,399],"transcription,":[384],"global":[385],"histone":[386,405,422],"acetylation":[387],"examined.Extracellular":[389],"availability":[391,403,432,444,506,541],"directly":[392,436,488,531],"regulates":[393],"both":[394,424],"expression":[400],"acetyl-CoA":[402],"acetylation.Importantly,":[406],"use":[407],"several":[409],"pharmacological":[410],"modulators":[411],"confirm":[414],"central":[416],"acetylation.Combining":[423],"scRNAseq,":[429],"extracellular":[430,485,525],"shown":[434],"influence":[437],"fate":[439],"decisions,":[440],"reduced":[442,504,539],"linked":[445,508],"reduction":[448],"proportion":[451,491],"commitment.The":[456],"dataset":[458],"presented":[459],"provides":[460],"entirely":[461],"new":[462],"information":[463],"subpopulations":[465],"cells;":[467],"true":[469,548],"MuSCs,":[470,472],"primed":[471],"committed":[474],"progenitors":[476],"(CMPs)":[477],"late":[479],"CMPs":[480],"show":[482],"environment":[487],"influences":[489],"each":[495],"subpopulations.Finally,":[498],"fibre":[500],"experiments":[501],"showed":[502],"rates":[511],"asymmetric":[513,558],"division":[514],"self-renewal.4.":[516],"These":[517],"provide":[519],"first":[521],"evidence":[522],"is":[528],"able":[529],"alter":[532],"leading":[542],"maintenance":[545],"result":[552],"proportions":[556],"divisions.Finally,":[559],"remodelling":[561],"be":[563],"used":[564],"enhance":[566],"efficiency":[568],"transplantation.":[571]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-01T00:00:00"}
