{"id":"https://openalex.org/W2923884331","doi":"https://doi.org/10.6004/jnccn.2018.7264","title":"Oncogenic Addiction to ERBB2 Signaling Predicts Response to Trastuzumab in Urothelial Cancer","display_name":"Oncogenic Addiction to ERBB2 Signaling Predicts Response to Trastuzumab in Urothelial Cancer","publication_year":2019,"publication_date":"2019-03-11","ids":{"openalex":"https://openalex.org/W2923884331","doi":"https://doi.org/10.6004/jnccn.2018.7264","mag":"2923884331","pmid":"https://pubmed.ncbi.nlm.nih.gov/30865916"},"language":"en","primary_location":{"id":"doi:10.6004/jnccn.2018.7264","doi":"https://doi.org/10.6004/jnccn.2018.7264","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2018.7264","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/17/3/article-p194.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnccn.org/downloadpdf/journals/jnccn/17/3/article-p194.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072649014","display_name":"Michael Karass","orcid":"https://orcid.org/0000-0002-3222-5664","observed_orcids":["https://orcid.org/0000-0002-3222-5664"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Karass","raw_affiliation_strings":["aDivision of Internal Medicine, New York Medical College, Westchester Medical Center, Valhalla, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDivision of Internal Medicine, New York Medical College, Westchester Medical Center, Valhalla, New York;","institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028420362","display_name":"Rohan Bareja","orcid":"https://orcid.org/0000-0002-0635-7743","observed_orcids":["https://orcid.org/0000-0002-0635-7743"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohan Bareja","raw_affiliation_strings":["bDepartment of Physiology and Biophysics, and","cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and","institution_ids":[]},{"raw_affiliation_string":"cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075530064","display_name":"Ethan Shelkey","orcid":"https://orcid.org/0000-0001-9816-3593","observed_orcids":["https://orcid.org/0000-0001-9816-3593"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Shelkey","raw_affiliation_strings":["dWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina; and","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020970","display_name":"Panagiotis J. Vlachostergios","orcid":"https://orcid.org/0000-0002-1704-1517","observed_orcids":["https://orcid.org/0000-0002-1704-1517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panagiotis J. Vlachostergios","raw_affiliation_strings":["eDepartment of Medicine, Division of Hematology and Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058816521","display_name":"Brian D. Robinson","orcid":"https://orcid.org/0000-0001-5374-890X","observed_orcids":["https://orcid.org/0000-0001-5374-890X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian D. Robinson","raw_affiliation_strings":["fDepartment of Pathology and Laboratory Medicine,","gEnglander Institute for Precision Medicine,","fDepartment of Pathology and Laboratory Medicine,; gEnglander Institute for Precision Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fDepartment of Pathology and Laboratory Medicine,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"fDepartment of Pathology and Laboratory Medicine,; gEnglander Institute for Precision Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059654230","display_name":"Francesca Khani","orcid":"https://orcid.org/0000-0001-7238-8604","observed_orcids":["https://orcid.org/0000-0001-7238-8604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Khani","raw_affiliation_strings":["fDepartment of Pathology and Laboratory Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fDepartment of Pathology and Laboratory Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264445","display_name":"Juan Miguel Mosquera","orcid":"https://orcid.org/0000-0003-4666-6476","observed_orcids":["https://orcid.org/0000-0003-4666-6476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Miguel Mosquera","raw_affiliation_strings":["fDepartment of Pathology and Laboratory Medicine,","gEnglander Institute for Precision Medicine,","fDepartment of Pathology and Laboratory Medicine,; gEnglander Institute for Precision Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fDepartment of Pathology and Laboratory Medicine,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"fDepartment of Pathology and Laboratory Medicine,; gEnglander Institute for Precision Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053215060","display_name":"Douglas S. Scherr","orcid":"https://orcid.org/0000-0001-5868-5493","observed_orcids":["https://orcid.org/0000-0001-5868-5493","https://orcid.org/0000-0002-0008-0771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas S. Scherr","raw_affiliation_strings":["hDepartment of Urology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"hDepartment of Urology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047395289","display_name":"Andrea Sboner","orcid":"https://orcid.org/0000-0001-6915-3070","observed_orcids":["https://orcid.org/0000-0001-6915-3070"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Sboner","raw_affiliation_strings":["bDepartment of Physiology and Biophysics, and","cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","gEnglander Institute for Precision Medicine,","bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;; gEnglander Institute for Precision Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and","institution_ids":[]},{"raw_affiliation_string":"cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;; gEnglander Institute for Precision Medicine,","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007663088","display_name":"Scott T. Tagawa","orcid":"https://orcid.org/0000-0003-2777-8587","observed_orcids":["https://orcid.org/0000-0003-2777-8587"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Tagawa","raw_affiliation_strings":["eDepartment of Medicine, Division of Hematology and Medical Oncology,","gEnglander Institute for Precision Medicine,","hDepartment of Urology, and","iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"hDepartment of Urology, and","institution_ids":[]},{"raw_affiliation_string":"iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009190675","display_name":"Ana M. Molina","orcid":"https://orcid.org/0000-0003-2025-9418","observed_orcids":["https://orcid.org/0000-0003-2025-9418"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana M. Molina","raw_affiliation_strings":["eDepartment of Medicine, Division of Hematology and Medical Oncology,","gEnglander Institute for Precision Medicine,","hDepartment of Urology, and","iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"hDepartment of Urology, and","institution_ids":[]},{"raw_affiliation_string":"iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061702711","display_name":"Olivier Elemento","orcid":"https://orcid.org/0000-0002-8061-9617","observed_orcids":["https://orcid.org/0000-0002-8061-9617"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Elemento","raw_affiliation_strings":["bDepartment of Physiology and Biophysics, and","cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","gEnglander Institute for Precision Medicine,","iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;; gEnglander Institute for Precision Medicine,; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and","institution_ids":[]},{"raw_affiliation_string":"cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"bDepartment of Physiology and Biophysics, and; cInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, New York;; gEnglander Institute for Precision Medicine,; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028538472","display_name":"David M. Nanus","orcid":"https://orcid.org/0000-0003-3514-2976","observed_orcids":["https://orcid.org/0000-0003-3514-2976"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Nanus","raw_affiliation_strings":["eDepartment of Medicine, Division of Hematology and Medical Oncology,","gEnglander Institute for Precision Medicine,","hDepartment of Urology, and","iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"hDepartment of Urology, and","institution_ids":[]},{"raw_affiliation_string":"iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; hDepartment of Urology, and; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040904315","display_name":"Bishoy M. Faltas","orcid":"https://orcid.org/0000-0002-6432-1693","observed_orcids":["https://orcid.org/0000-0002-6432-1693"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bishoy M. Faltas","raw_affiliation_strings":["eDepartment of Medicine, Division of Hematology and Medical Oncology,","gEnglander Institute for Precision Medicine,","iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"gEnglander Institute for Precision Medicine,","institution_ids":[]},{"raw_affiliation_string":"iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"eDepartment of Medicine, Division of Hematology and Medical Oncology,; gEnglander Institute for Precision Medicine,; iSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9543,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74213472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"3","first_page":"194","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/erbb2-signaling","display_name":"ErbB2 signaling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.925000011920929},{"id":"https://openalex.org/keywords/oncogenic-addiction","display_name":"oncogenic addiction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/metastatic-urothelial-carcinoma","display_name":"metastatic urothelial carcinoma","score":0.8159999847412109},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7160000205039978},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.722000002861023},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.4880000054836273},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/rna-sequencing","display_name":"RNA sequencing","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8034093379974365},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7661720514297485},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5395750999450684},{"id":"https://openalex.org/C2911057145","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Metastatic Urothelial Carcinoma","level":5,"score":0.518013060092926},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5179787874221802},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5038213133811951},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46736809611320496},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4559500813484192},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.4419691264629364},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.41846853494644165},{"id":"https://openalex.org/C3020745361","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial cancer","level":4,"score":0.4114657938480377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33140963315963745},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.3171849846839905},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24510318040847778},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.2369891107082367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22235974669456482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11088714003562927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10015952587127686},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.06764569878578186}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000074723","descriptor_name":"Oncogene Addiction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014523","descriptor_name":"Urethral Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014523","descriptor_name":"Urethral Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014523","descriptor_name":"Urethral Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014523","descriptor_name":"Urethral Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.6004/jnccn.2018.7264","doi":"https://doi.org/10.6004/jnccn.2018.7264","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2018.7264","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/17/3/article-p194.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},{"id":"pmid:30865916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30865916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network : JNCCN","raw_type":"Case Reports"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-2795","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/1913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"case_report"}],"best_oa_location":{"id":"doi:10.6004/jnccn.2018.7264","doi":"https://doi.org/10.6004/jnccn.2018.7264","is_oa":true,"landing_page_url":"https://doi.org/10.6004/jnccn.2018.7264","pdf_url":"https://jnccn.org/downloadpdf/journals/jnccn/17/3/article-p194.pdf","source":{"id":"https://openalex.org/S935620192","display_name":"Journal of the National Comprehensive Cancer Network","issn_l":"1540-1405","issn":["1540-1405","1540-1413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4324004213","host_organization_name":"National Comprehensive Cancer","host_organization_lineage":["https://openalex.org/P4324004213"],"host_organization_lineage_names":["National Comprehensive Cancer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Comprehensive Cancer Network","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4621975981","display_name":null,"funder_award_id":"CA160212","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G6949876057","display_name":null,"funder_award_id":"CA160212","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923884331.pdf","grobid_xml":"https://content.openalex.org/works/W2923884331.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1964321121","https://openalex.org/W1987707833","https://openalex.org/W1997936386","https://openalex.org/W2010457001","https://openalex.org/W2018838463","https://openalex.org/W2049273954","https://openalex.org/W2065855960","https://openalex.org/W2090119371","https://openalex.org/W2100305481","https://openalex.org/W2108234281","https://openalex.org/W2114699723","https://openalex.org/W2124010429","https://openalex.org/W2124913341","https://openalex.org/W2130410032","https://openalex.org/W2134526812","https://openalex.org/W2136561378","https://openalex.org/W2141831115","https://openalex.org/W2147609992","https://openalex.org/W2169456326","https://openalex.org/W2171136968","https://openalex.org/W2179438025","https://openalex.org/W2341548114","https://openalex.org/W2482598544","https://openalex.org/W2588442711"],"related_works":["https://openalex.org/W7116397930","https://openalex.org/W4389397957","https://openalex.org/W4366827348","https://openalex.org/W4389280765","https://openalex.org/W2604920530","https://openalex.org/W4324136243","https://openalex.org/W2597455201","https://openalex.org/W2300072281","https://openalex.org/W2139296232","https://openalex.org/W4389285474"],"abstract_inverted_index":{"Urothelial":[0],"carcinoma":[1],"(UC)":[2],"is":[3],"a":[4,51,58],"common":[5],"and":[6,29,42,47,64],"frequently":[7],"lethal":[8],"cancer.":[9],"Despite":[10],"the":[11,22],"presence":[12],"of":[13,24,40,45,66,82,111],"genomic":[14],"alterations":[15],"creating":[16],"dependency":[17],"on":[18],"particular":[19],"signaling":[20,70,104],"pathways,":[21],"use":[23],"targeted":[25],"therapies":[26],"in":[27,50,71],"advanced":[28],"metastatic":[30,48],"UC":[31,85],"has":[32],"been":[33],"limited.":[34],"We":[35,56],"performed":[36],"an":[37,79,90],"integrated":[38],"analysis":[39],"whole-exome":[41],"RNA":[43],"sequencing":[44],"primary":[46],"tumors":[49,74,77],"patient":[52,88],"with":[53,76,84],"platinum-resistant":[54],"UC.":[55,112],"found":[57],"strikingly":[59],"high":[60],"ERBB2":[61,69,103],"mRNA":[62],"expression":[63],"enrichment":[65],"downstream":[67],"oncogenic":[68,100],"this":[72],"patient's":[73],"compared":[75],"from":[78],"unselected":[80],"group":[81],"patients":[83],"(N=17).":[86],"This":[87],"had":[89],"exceptional":[91],"sustained":[92],"response":[93,107],"to":[94,102,108],"trastuzumab.":[95],"Our":[96],"findings":[97],"show":[98],"that":[99],"addiction":[101],"potentially":[105],"predicts":[106],"ERBB2-directed":[109],"therapy":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-01T00:00:00"}