{"id":"https://openalex.org/W2923866911","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","title":"The Influence of CYP1A2 Genotype on Caffeine Consumption Habits and Athletic Performance Enhancement in Collegiate Distance Runners","display_name":"The Influence of CYP1A2 Genotype on Caffeine Consumption Habits and Athletic Performance Enhancement in Collegiate Distance Runners","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2923866911","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","mag":"2923866911"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.lb738","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069396209","display_name":"Jiayu Jennifer Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiayu Jennifer Ye","raw_affiliation_strings":["Department of Biochemistry, Colby College, Waterville, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Colby College, Waterville, ME","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103297060","display_name":"Erzs\u00e9bet Nagy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195575238","display_name":"Middlebury College","ror":"https://ror.org/0217hb928","country_code":"US","type":"education","lineage":["https://openalex.org/I195575238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erzsebet Emily Nagy","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Middlebury College, Middlebury, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Middlebury College, Middlebury, VT","institution_ids":["https://openalex.org/I195575238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041998517","display_name":"Julie T. Millard","orcid":"https://orcid.org/0000-0001-6825-0207","observed_orcids":["https://orcid.org/0000-0001-6825-0207"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie T. Millard","raw_affiliation_strings":["Department of Biochemistry, Colby College, Waterville, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Colby College, Waterville, ME","institution_ids":["https://openalex.org/I27504731"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1908,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56682185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.20739999413490295,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/caffeine-metabolism","display_name":"caffeine metabolism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/caffeine-intake","display_name":"caffeine consumption","score":0.6740000247955322},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.847000002861023},{"id":"https://openalex.org/keywords/gene-diet-interaction","display_name":"gene-diet interaction","score":0.6349999904632568},{"id":"https://openalex.org/keywords/athletic-performance","display_name":"athletic performance","score":0.6290000081062317},{"id":"https://openalex.org/keywords/long-distance-runners","display_name":"long-distance runners","score":0.8899999856948853},{"id":"https://openalex.org/keywords/intron-1-polymorphism","display_name":"intron 1 polymorphism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/caffeine-supplementation","display_name":"caffeine supplementation","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.8881553411483765},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.8452268838882446},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7793541550636292},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5958724617958069},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.44145360589027405},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4262138605117798},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.4150576889514923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4145127534866333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35562169551849365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35086631774902344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35078030824661255},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34450286626815796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2842468321323395},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.2560509443283081},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.10977903008460999}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.lb738","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.lb738","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4099999964237213}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2673461945","display_name":null,"funder_award_id":"P20 GM0103423","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175105008","https://openalex.org/W4390349520","https://openalex.org/W2619595513","https://openalex.org/W7163256086","https://openalex.org/W2791466980","https://openalex.org/W2805501279","https://openalex.org/W2843105544","https://openalex.org/W1976387836","https://openalex.org/W6887711740","https://openalex.org/W3120747900"],"abstract_inverted_index":{"The":[0],"liver":[1],"enzyme":[2],"CYP1A2,":[3],"which":[4],"is":[5,10,20],"responsible":[6],"for":[7],"metabolizing":[8],"caffeine,":[9],"a":[11],"member":[12],"of":[13,48,79,153,171,194,198,202],"the":[14,49,76,86,137,157,191,199],"cytochrome":[15],"P450":[16],"family.":[17],"CYP1A2":[18,50,104],"activity":[19,64],"highly":[21],"variable":[22],"across":[23],"individuals,":[24],"depending":[25],"on":[26,136],"factors":[27,166],"such":[28],"as":[29],"gender,":[30],"personal":[31],"habits":[32],"(e.g.,":[33],"smoking":[34],"status":[35],"and":[36,38,110,119,151,160],"diet),":[37],"genotype.":[39,131],"A":[40],"single":[41],"nucleotide":[42],"polymorphism":[43],"(A/C)":[44],"in":[45,55,113,146,179],"intron":[46],"1":[47],"gene":[51,56,169],"leads":[52],"to":[53,129],"differences":[54],"inducibility,":[57],"with":[58,85],"AA":[59,87,158],"individuals":[60],"reportedly":[61],"having":[62],"higher":[63],"than":[65,98],"C\u2010allele":[66,99,161],"carriers.":[67,100],"Several":[68],"reports":[69],"have":[70],"suggested":[71],"that":[72,140,164],"genotype":[73,88,105],"can":[74],"modulate":[75,168],"physiological":[77],"effects":[78,112,170],"caffeine.":[80],"For":[81],"example,":[82],"\u201cfast":[83],"metabolizers\u201d":[84],"benefit":[89],"more":[90],"from":[91,123,190],"caffeine":[92,108,149],"supplementation":[93],"before":[94],"cycling":[95],"time":[96],"trials":[97],"We":[101],"investigated":[102],"whether":[103],"influences":[106],"self\u2010reported":[107,147],"consumption":[109,150],"performance":[111,154],"collegiate":[114],"distance":[115],"runners.":[116],"DNA":[117],"samples":[118],"questionnaires":[120,138],"were":[121],"collected":[122],"65":[124],"subjects.":[125],"PRC\u2010RFLP":[126],"was":[127,142,182],"performed":[128],"determine":[130],"Preliminary":[132],"statistical":[133],"analysis":[134],"based":[135],"indicates":[139],"there":[141],"no":[143],"significant":[144],"difference":[145],"daily":[148],"degree":[152],"enhancement":[155],"between":[156],"homozygotes":[159],"carriers,":[162],"suggesting":[163],"environmental":[165],"may":[167],"CYP1A2.":[172],"Support":[173],"or":[174],"Funding":[175],"Information":[176],"Research":[177],"reported":[178],"this":[180],"publication":[181],"supported":[183],"by":[184],"an":[185],"Institutional":[186],"Development":[187],"Award":[188],"(IDeA)":[189],"National":[192,200],"Institute":[193],"General":[195],"Medical":[196],"Sciences":[197],"Institutes":[201],"Health":[203],"under":[204],"grant":[205],"number":[206],"P20GM0103423.":[207]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-04-01T00:00:00"}