{"id":"https://openalex.org/W2923706752","doi":"https://doi.org/10.18240/ijo.2018.12.10","title":"Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial","display_name":"Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial","publication_year":2018,"publication_date":"2018-12-05","ids":{"openalex":"https://openalex.org/W2923706752","doi":"https://doi.org/10.18240/ijo.2018.12.10","mag":"2923706752","pmid":"https://pubmed.ncbi.nlm.nih.gov/30588426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6288534"},"language":"en","primary_location":{"id":"doi:10.18240/ijo.2018.12.10","doi":"https://doi.org/10.18240/ijo.2018.12.10","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2018.12.10","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.18240/ijo.2018.12.10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108094032","display_name":"Aloisa Librando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aloisa Librando","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108673251","display_name":"Sandra Cinzia Carlesimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandra Cinzia Carlesimo","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067442619","display_name":"Giorgio Albanese","orcid":"https://orcid.org/0000-0002-6610-2654","observed_orcids":["https://orcid.org/0000-0002-6610-2654"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Albanese","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027171373","display_name":"Giuseppe Maria Albanese","orcid":"https://orcid.org/0000-0001-7562-9274","observed_orcids":["https://orcid.org/0000-0001-7562-9274"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Maria Albanese","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091822481","display_name":"Raffaele Migliorini","orcid":"https://orcid.org/0000-0001-8158-2142","observed_orcids":["https://orcid.org/0000-0001-8158-2142"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Migliorini","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064895227","display_name":"Elena Pacella","orcid":"https://orcid.org/0000-0002-5431-6399","observed_orcids":["https://orcid.org/0000-0002-5431-6399"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Pacella","raw_affiliation_strings":["Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":0.2454,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52787046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"12","first_page":"1936","last_page":"1940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-salicylic-acid","display_name":"topical salicylic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blepharoconjunctivitis","display_name":"blepharoconjunctivitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/prostaglandin-analogs","display_name":"prostaglandin analogues","score":0.9179999828338623},{"id":"https://openalex.org/keywords/clobetasone-butyrate","display_name":"clobetasone butyrate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/conjunctival-hyperemia","display_name":"conjunctival hyperemia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tear-film","display_name":"tear film","score":0.734000027179718},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.935589075088501},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6247966885566711},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.563799262046814},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5507345199584961},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5409061312675476},{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.4928169548511505},{"id":"https://openalex.org/C2779578545","wikidata":"https://www.wikidata.org/wiki/Q420054","display_name":"Topical medication","level":3,"score":0.48545318841934204},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.45468708872795105},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42737361788749695},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24366265535354614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2375638484954834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18240/ijo.2018.12.10","doi":"https://doi.org/10.18240/ijo.2018.12.10","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2018.12.10","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5274762","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6288534","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30588426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30588426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6288534","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6288534/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/1276276","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1276276","pdf_url":"http://hdl.handle.net/11573/1276276","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:52cec06bd2c846ccb4ee9ad2d8c9667c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/52cec06bd2c846ccb4ee9ad2d8c9667c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Ophthalmology, Vol 11, Iss 12, Pp 1936-1940 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18240/ijo.2018.12.10","doi":"https://doi.org/10.18240/ijo.2018.12.10","is_oa":true,"landing_page_url":"https://doi.org/10.18240/ijo.2018.12.10","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923706752.pdf","grobid_xml":"https://content.openalex.org/works/W2923706752.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1927080571","https://openalex.org/W1964377771","https://openalex.org/W1969290907","https://openalex.org/W1986328790","https://openalex.org/W2007431853","https://openalex.org/W2013011863","https://openalex.org/W2014557345","https://openalex.org/W2018706730","https://openalex.org/W2080751946","https://openalex.org/W2084959783","https://openalex.org/W2406505528","https://openalex.org/W2424107777","https://openalex.org/W2478352406"],"related_works":["https://openalex.org/W2010027101","https://openalex.org/W1968092649","https://openalex.org/W1988894620","https://openalex.org/W2006214447","https://openalex.org/W7065482764","https://openalex.org/W1557151753","https://openalex.org/W1876746183","https://openalex.org/W2020079268","https://openalex.org/W2605201600","https://openalex.org/W6929330912"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"evaluate":[2],"the":[3,135],"efficacy":[4],"of":[5,43,61,76,119,131,169,183,193],"0.1%":[6,47,51,139,154,159,199],"topical":[7,26,52],"salicylic":[8],"acid":[9],"(TSA)":[10],"to":[11,163,179],"treat":[12],"iatrogenic":[13],"chronic":[14],"blepharoconjunctivitis":[15,170],"in":[16,103,123,134,149],"patients":[17,33,151,173],"with":[18,25,46,138,153,176],"primary":[19],"open":[20],"angle":[21],"glaucoma":[22,172],"(POAG),":[23],"treated":[24,45,105,125,137,152],"prostaglandin":[27],"analogues":[28],"(TPAs).":[29],"METHODS:":[30],"Totally":[31],"60":[32],"were":[34],"randomly":[35],"distributed":[36],"into":[37,67],"3":[38],"equal":[39],"size":[40],"groups,":[41],"two":[42],"which":[44],"TSA":[48,140,160],"(OMKASA\u00ae)":[49],"and":[50,58,72,87,92,128,190],"clobetasone":[53],"butyrate":[54],"(TCB;":[55],"VISUCLOBEN\u00ae)":[56],"respectively,":[57],"one":[59],"consisting":[60],"untreated":[62],"controls.":[63,111],"The":[64,142,158],"parameters":[65],"taken":[66],"account":[68],"at":[69],"baseline":[70],"(T0)":[71],"after":[73],"30d":[74],"(T1)":[75],"therapy":[77,175],"were:":[78],"conjunctival":[79],"hyperemia,":[80],"lacrimal":[81,113],"function":[82,114],"tests":[83,115],"[Schirmer":[84],"I":[85,121],"test":[86,122],"break":[88],"up":[89],"time":[90],"(BUT)]":[91],"intraocular":[93],"pressure":[94],"(IOP).":[95],"RESULTS:":[96],"Conjunctival":[97],"hyperemia":[98],"showed":[99],"a":[100,180],"substantial":[101],"improvement":[102,118,192],"both":[104,124,188],"groups":[106,126],"(P<0.001)":[107],"but":[108],"not":[109,203],"among":[110],"Similarly,":[112],"displayed":[116],"an":[117,129,165],"Schirmer":[120],"(P<0.05)":[127],"extension":[130],"BUT":[132],"only":[133,148],"group":[136],"(P<0.05).":[141],"IOP":[143,207],"increase":[144],"was":[145],"statistically":[146],"significant":[147,206],"those":[150],"TCB":[155],"(P<0.001).":[156],"CONCLUSION:":[157],"has":[161],"proved":[162],"be":[164],"effective":[166],"anti-inflammatory":[167],"treatment":[168],"affecting":[171],"on":[174],"TPAs,":[177],"leading":[178],"sizeable":[181],"decrease":[182],"inflammation":[184],"as":[185,187],"well":[186],"quantitative":[189],"qualitative":[191],"tear":[194],"film.":[195],"Furthermore,":[196],"differently":[197],"from":[198],"TCB,":[200],"it":[201],"does":[202],"induce":[204],"any":[205],"increase.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-04-01T00:00:00"}