{"id":"https://openalex.org/W2923645507","doi":"https://doi.org/10.1371/journal.ppat.1007659","title":"Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes","display_name":"Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes","publication_year":2019,"publication_date":"2019-03-21","ids":{"openalex":"https://openalex.org/W2923645507","doi":"https://doi.org/10.1371/journal.ppat.1007659","mag":"2923645507","pmid":"https://pubmed.ncbi.nlm.nih.gov/30897158","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6445466"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1007659","doi":"https://doi.org/10.1371/journal.ppat.1007659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007659","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007659&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007659&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025477993","display_name":"Jialei Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jialei Xie","raw_affiliation_strings":["Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069249471","display_name":"Hui Zhi","orcid":"https://orcid.org/0000-0001-6008-1541","observed_orcids":["https://orcid.org/0000-0001-6008-1541"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Zhi","raw_affiliation_strings":["Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6008-1541","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079208816","display_name":"Ryan J. Garrigues","orcid":"https://orcid.org/0000-0002-5923-3250","observed_orcids":["https://orcid.org/0000-0002-5923-3250"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Garrigues","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5923-3250","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013305909","display_name":"Andrew Keightley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Keightley","raw_affiliation_strings":["Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, United States of America","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014066546","display_name":"Brandon L. Garcia","orcid":"https://orcid.org/0000-0002-6724-8700","observed_orcids":["https://orcid.org/0000-0002-6724-8700"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon L. Garcia","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6724-8700","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067154316","display_name":"Jon T. Skare","orcid":"https://orcid.org/0000-0001-8378-7862","observed_orcids":["https://orcid.org/0000-0001-8378-7862"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jon T. Skare","raw_affiliation_strings":["Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8378-7862","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Sciences Center, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014066546","https://openalex.org/A5067154316"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I186335123","https://openalex.org/I91045830"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":5.0152,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.96477397,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"3","first_page":"e1007659","last_page":"e1007659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.37619999051094055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.9539999961853027},{"id":"https://openalex.org/keywords/complement-evasion","display_name":"complement evasion","score":0.6679999828338623},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.9789999723434448},{"id":"https://openalex.org/keywords/c1-complex","display_name":"C1 complex","score":0.8180000185966492},{"id":"https://openalex.org/keywords/borrelia-afzelii","display_name":"Borrelia afzelii","score":0.7839999794960022},{"id":"https://openalex.org/keywords/borrelia-garinii","display_name":"Borrelia garinii","score":1.0},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6919999718666077},{"id":"https://openalex.org/keywords/four-helix-bundle","display_name":"four-helix bundle","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.8209999799728394},{"id":"https://openalex.org/keywords/serum-resistance","display_name":"serum resistance","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.7683514356613159},{"id":"https://openalex.org/C2781232936","wikidata":"https://www.wikidata.org/wiki/Q2911330","display_name":"Borrelia afzelii","level":5,"score":0.6926330327987671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6536648869514465},{"id":"https://openalex.org/C2778852094","wikidata":"https://www.wikidata.org/wiki/Q2911332","display_name":"Borrelia garinii","level":5,"score":0.5925491452217102},{"id":"https://openalex.org/C2780508971","wikidata":"https://www.wikidata.org/wiki/Q115528","display_name":"Borrelia","level":4,"score":0.5659803152084351},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5362322926521301},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3220485746860504},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27243572473526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20259642601013184}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003171","descriptor_name":"Complement Pathway, Classical","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003171","descriptor_name":"Complement Pathway, Classical","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015748","descriptor_name":"Borrelia burgdorferi Group","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015923","descriptor_name":"Complement C1r","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.ppat.1007659","doi":"https://doi.org/10.1371/journal.ppat.1007659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007659","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007659&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6445466","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6445466","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:30897158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30897158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/8334","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/8334","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:00894cf20d844732a71ee2b0c2f1dda7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/00894cf20d844732a71ee2b0c2f1dda7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 15, Iss 3, p e1007659 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7877309","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structural_determination_of_the_complement_inhibitory_domain_of_i_Borrelia_burgdorferi_i_BBK32_provides_insight_into_classical_pathway_complement_evasion_by_lyme_disease_spirochetes/7877309","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1007659","doi":"https://doi.org/10.1371/journal.ppat.1007659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007659","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007659&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2993454340","display_name":null,"funder_award_id":"AI119821","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G302878262","display_name":"Classical Complement Pathway Evasion Mechanisms of Lyme Disease Spirochetes","funder_award_id":"R21AI133367","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5888245624","display_name":null,"funder_award_id":"AI133367","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923645507.pdf","grobid_xml":"https://content.openalex.org/works/W2923645507.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W149417510","https://openalex.org/W782553196","https://openalex.org/W1486365785","https://openalex.org/W1499593166","https://openalex.org/W1539796472","https://openalex.org/W1902402699","https://openalex.org/W1908771231","https://openalex.org/W1926303070","https://openalex.org/W1928157229","https://openalex.org/W1955410713","https://openalex.org/W1956624115","https://openalex.org/W1971447551","https://openalex.org/W1973675012","https://openalex.org/W1973876528","https://openalex.org/W1979214371","https://openalex.org/W1982891627","https://openalex.org/W1985750892","https://openalex.org/W1989844444","https://openalex.org/W1992322744","https://openalex.org/W1995507202","https://openalex.org/W1996734830","https://openalex.org/W2005425772","https://openalex.org/W2010717419","https://openalex.org/W2013636685","https://openalex.org/W2022013307","https://openalex.org/W2029582401","https://openalex.org/W2043321476","https://openalex.org/W2049370749","https://openalex.org/W2054115369","https://openalex.org/W2056797634","https://openalex.org/W2075100038","https://openalex.org/W2076368535","https://openalex.org/W2087694422","https://openalex.org/W2095593044","https://openalex.org/W2097306531","https://openalex.org/W2099118431","https://openalex.org/W2105632527","https://openalex.org/W2106200480","https://openalex.org/W2108710265","https://openalex.org/W2109184569","https://openalex.org/W2114622716","https://openalex.org/W2116073343","https://openalex.org/W2116673560","https://openalex.org/W2117018536","https://openalex.org/W2117677427","https://openalex.org/W2122003767","https://openalex.org/W2124026197","https://openalex.org/W2124475162","https://openalex.org/W2124479213","https://openalex.org/W2134406068","https://openalex.org/W2136648677","https://openalex.org/W2139871036","https://openalex.org/W2143679420","https://openalex.org/W2145318669","https://openalex.org/W2152200583","https://openalex.org/W2153545178","https://openalex.org/W2155785635","https://openalex.org/W2158427762","https://openalex.org/W2158820430","https://openalex.org/W2159614853","https://openalex.org/W2159626137","https://openalex.org/W2162083336","https://openalex.org/W2163003258","https://openalex.org/W2163239436","https://openalex.org/W2163713360","https://openalex.org/W2169788329","https://openalex.org/W2180229411","https://openalex.org/W2223099905","https://openalex.org/W2267745420","https://openalex.org/W2345914382","https://openalex.org/W2483224239","https://openalex.org/W2507589390","https://openalex.org/W2514394561","https://openalex.org/W2523773452","https://openalex.org/W2582530596","https://openalex.org/W2588853073","https://openalex.org/W2607213148","https://openalex.org/W2610959354","https://openalex.org/W2748098899","https://openalex.org/W2751961291","https://openalex.org/W2763454568","https://openalex.org/W2770722600","https://openalex.org/W2774178591","https://openalex.org/W2782825321","https://openalex.org/W2785721281","https://openalex.org/W2794314089","https://openalex.org/W2801643542","https://openalex.org/W2804822363","https://openalex.org/W2806148815"],"related_works":["https://openalex.org/W2267745420","https://openalex.org/W7099100985","https://openalex.org/W3213333529","https://openalex.org/W4412624841","https://openalex.org/W4399464953","https://openalex.org/W7066689185","https://openalex.org/W4382045134","https://openalex.org/W4323032263","https://openalex.org/W3196082718","https://openalex.org/W2071543117"],"abstract_inverted_index":{"The":[0,167,221,260],"carboxy-terminal":[1],"domain":[2],"of":[3,21,35,38,87,191,197,268,283,286],"the":[4,17,22,33,39,88,179,186,194,218,225,230,256,287],"BBK32":[5,36,126,160,192,270],"protein":[6,170],"from":[7,48,55,139,217],"Borrelia":[8,41],"burgdorferi":[9,42,289],"sensu":[10,43,290],"stricto,":[11],"termed":[12],"BBK32-C,":[13],"binds":[14],"and":[15,53,81,84,99,127,161,174,243,272,275],"inhibits":[16,273],"initiating":[18],"serine":[19,257],"protease":[20,80,258],"human":[23],"classical":[24,89],"complement":[25,90,109,188,280],"pathway,":[26],"C1r.":[27],"In":[28],"this":[29,175],"study":[30],"we":[31],"investigated":[32],"function":[34],"orthologues":[37],"Lyme-associated":[40,284],"lato":[44,291],"complex,":[45,83],"designated":[46,172],"BAD16":[47,128,162],"B.":[49,56,64,93,288],"afzelii":[50,65],"strain":[51,58],"PGau":[52],"BGD19":[54,120,133],"garinii":[57,94],"IP90.":[59],"Our":[60],"data":[61],"show":[62],"that":[63,156,224,249],"BAD16-C":[66],"exhibits":[67],"BBK32-C-like":[68],"activities":[69,111,190],"in":[70,107,165,229,240],"all":[71],"assays":[72,247],"tested,":[73],"including":[74],"high-affinity":[75,102],"binding":[76,242,246],"to":[77,113,125,146,149,201],"purified":[78],"C1r":[79,100,123,241,253,274],"C1":[82,98],"potent":[85],"inhibition":[86],"pathway.":[91],"Recombinant":[92],"BGD19-C":[95,151],"also":[96],"bound":[97],"with":[101,212],"yet":[103],"exhibited":[104],"significantly":[105],"reduced":[106],"vitro":[108],"inhibitory":[110,189],"relative":[112,124],"BBK32-C":[114,148,176,198,205,250],"or":[115],"BAD16-C.":[116],"Interestingly,":[117],"natively":[118],"produced":[119],"weakly":[121],"recognized":[122,252],"and,":[129],"unlike":[130],"these":[131],"proteins,":[132],"did":[134],"not":[135],"confer":[136],"significant":[137],"protection":[138],"serum":[140],"killing.":[141],"Site-directed":[142],"mutagenesis":[143],"was":[144,171,199],"performed":[145],"convert":[147],"resemble":[150],"at":[152],"three":[153,226],"residue":[154],"positions":[155],"are":[157,233],"identical":[158],"between":[159],"but":[163],"different":[164],"BGD19.":[166],"resulting":[168],"chimeric":[169],"BXK32-C":[173,231],"variant":[177],"mimicked":[178],"properties":[180],"observed":[181],"for":[182],"BGD19-C.":[183],"To":[184],"query":[185],"disparate":[187],"orthologues,":[193],"crystal":[195],"structure":[196,222],"solved":[200],"1.7\u00c5":[202],"limiting":[203],"resolution.":[204],"adopts":[206],"an":[207],"anti-parallel":[208],"four-helix":[209],"bundle":[210],"fold":[211],"a":[213],"fifth":[214],"alpha-helix":[215],"protruding":[216],"helical":[219],"core.":[220],"revealed":[223],"residues":[227],"targeted":[228],"chimera":[232],"surface-exposed,":[234],"further":[235],"supporting":[236],"their":[237],"potential":[238],"relevance":[239],"inhibition.":[244],"Additional":[245],"showed":[248],"only":[251],"fragments":[254],"containing":[255],"domain.":[259],"structure-function":[261],"studies":[262],"reported":[263],"here":[264],"improve":[265],"our":[266],"understanding":[267],"how":[269],"recognizes":[271],"provide":[276],"new":[277],"insight":[278],"into":[279],"evasion":[281],"mechanisms":[282],"spirochetes":[285],"complex.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-01T00:00:00"}
