{"id":"https://openalex.org/W2923596170","doi":null,"title":"Pengaruh Pemberian Ekstrak Teh Hijau Terhadap Jumlah Sel Epitel Sekretorik Dan Ekspresi Reseptor Estrogen-\u0391 Tuba Fallopi Tikus Wistar Yang Dipapar Monosodium Glutamat","display_name":"Pengaruh Pemberian Ekstrak Teh Hijau Terhadap Jumlah Sel Epitel Sekretorik Dan Ekspresi Reseptor Estrogen-\u0391 Tuba Fallopi Tikus Wistar Yang Dipapar Monosodium Glutamat","publication_year":2017,"publication_date":"2017-08-24","ids":{"openalex":"https://openalex.org/W2923596170","mag":"2923596170"},"language":"id","primary_location":{"id":"mag:2923596170","doi":null,"is_oa":false,"landing_page_url":"http://repository.ub.ac.id/2473/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081987423","display_name":"Ika Suherlin","orcid":"https://orcid.org/0000-0003-3762-1823","observed_orcids":["https://orcid.org/0000-0003-3762-1823"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ika Suherlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081987423"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-tea-extract","display_name":"green tea extract","score":0.996999979019165},{"id":"https://openalex.org/keywords/monosodium-glutamate","display_name":"monosodium glutamate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/fallopian-tube-epithelium","display_name":"fallopian tube epithelium","score":0.8090000152587891},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8309999704360962},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tubal-factor-infertility","display_name":"tubal infertility","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5640000104904175},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.34599998593330383},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.7400000095367432},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.4180000126361847},{"id":"https://openalex.org/keywords/estrogen-levels","display_name":"estrogen levels","score":0.41200000047683716},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/glutathione-s-transferase-a1","display_name":"glutathione S-transferase A1","score":0.6000000238418579},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5756641626358032},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5626078844070435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5565073490142822},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3572094440460205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2929708957672119}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2923596170","doi":null,"is_oa":false,"landing_page_url":"http://repository.ub.ac.id/2473/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4290739139","https://openalex.org/W3017811466","https://openalex.org/W2563159863","https://openalex.org/W2908861786","https://openalex.org/W2979879794","https://openalex.org/W2891659674","https://openalex.org/W1946451674","https://openalex.org/W2796211191","https://openalex.org/W2922387722","https://openalex.org/W2594437336"],"abstract_inverted_index":{"Infertilitas":[0],"merupakan":[1],"masalah":[2],"yang":[3,10,20,33,69,105,118,138,153,184,243,259,284,353,365,389,495,545,569,580,601,650,736],"cukup":[4],"sensitif":[5],"bagi":[6],"pasangan":[7,19],"suami":[8],"istri":[9],"sulit":[11],"mempunyai":[12],"anak,":[13],"prevalensi":[14],"infertilitas":[15,25,54],"mencapai":[16],"15%":[17],"dari":[18,342],"baru":[21],"menikah.":[22],"Penyebab":[23],"utama":[24],"adalah":[26,97],"di":[27,132,245,273,277,288,316,328],"saluran":[28,38],"tuba":[29,208,279,309,317,477,485,530,621,682,713,731],"yaitu":[30,58,291,344],"setiap":[31],"keadaan":[32],"mempengaruhi":[34,220],"fungsi":[35,168],"normal,":[36],"anatomi":[37],"tuba,":[39],"dan":[40,47,62,111,123,134,143,203,215,247,265,302,382,475,492,617,637,646,728],"mencegah":[41],"fertilisasi":[42],"sperma":[43],"dengan":[44,59,90,103,240,394,454,487,497,503,509,518,537,572,604,630,642,671,676,703,708],"sel":[45,200,212,216,222,315,379,482,528,566,614,656,679,725],"telur":[46],"hasil":[48,532,685],"fertilisasi.":[49,233],"Stres":[50],"oksidatif":[51],"dapat":[52,80,563,597,722],"menyebabkan":[53,81,108,128,159,176,197,248,313,324],"melalui":[55],"berbagai":[56,115,551,558,586],"mekanisme,":[57],"ketidakseimbangan":[60],"antioksidan":[61,327,341,358],"radikal":[63,335],"bebas,":[64],"sehingga":[65,149,166,326],"meningkatkan":[66,355,564,598,723],"kerusakan":[67,160],"seluler":[68],"disebabkan":[70],"oleh":[71,211],"Reactive":[72],"oxygen":[73],"species":[74],"(ROS).":[75],"Monosodium":[76],"glutamat":[77,127,131,271,299,308,322],"(MSG)":[78],"diketahui":[79],"peningkatan":[82,135,146],"produksi":[83],"ROS.":[84],"Konsumsi":[85],"MSG":[86,158,192,571,603],"pada":[87,145,161,177,189,193,386,526,547,582,663,695,733],"orang":[88],"dewasa":[89],"dosis":[91,104,552,559,587,593,673,705],"terbesar":[92],"untuk":[93,121,224,230,262,333,371,468],"mendapatkan":[94],"rasa":[95],"enak":[96],"60":[98],"mg/kg":[99],"BB/hr,":[100],"jika":[101],"mengkonsumsi":[102],"lebih":[106],"tinggi":[107],"dampak":[109],"negatif.\r\nGlutamat":[110],"reseptornya":[112],"dilokalisasi":[113],"dalam":[114,329,359],"inti":[116,246,527],"hipotalamus":[117,165,274],"dianggap":[119],"penting":[120],"reproduksi":[122],"neuroendokrin.":[124],"Peningkatan":[125],"konsumsi":[126],"overaktivasi":[129],"reseptor":[130,205,241,249,283,298,307,321,384,619,689,711,729],"tubuh":[133,330,360],"Ca2+":[136],"intraseluler":[137],"secara":[139,408,452],"langsung":[140],"menghasilkan":[141],"ROS":[142,325],"berdampak":[144],"respirasi":[147],"mitokondria":[148,152],"terjadi":[150],"disfungsi":[151],"akhirnya":[154],"mengakibatkan":[155],"kematian":[156,314],"sel.":[157],"sumbu":[162],"arkuata":[163],"nukleus":[164],"menggangu":[167],"Hipothalamic":[169],"Pituitary":[170],"Adrenal":[171],"(HPA)":[172],"axis.":[173],"Hal":[174],"ini":[175,369],"folikulogenesis":[178],"sebagian":[179],"besar":[180],"folikel":[181],"ovarium":[182],"atretik":[183],"berakibat":[185],"penurunan":[186,198],"kadar":[187],"estrogen":[188,237,242,250],"darah.":[190],"Paparan":[191],"tikus":[194,387,405,467,512,734],"wistar":[195,388,406,735],"ternyata":[196],"jumlah":[199,378,481,565,613,655,678,724],"epitel":[201,213,217,254,278,380,483,529,567,615,657,680,726],"sekretorik":[202,255,381,484,568,616,658,681,727],"ekspresi":[204,383,599,618,688,710],"estrogen-\u03b1.":[206],"Epitel":[207],"fallopi":[209,310,478,622,732],"disusun":[210],"bersilia":[214,223],"sekretorik.":[218],"Estrogen":[219],"aktivitas":[221,357],"membantu":[225,231],"mengarahkan":[226],"ovum":[227],"ke":[228,462],"uterus":[229],"proses":[232],"Jumlah":[234],"optimal":[235],"hormon":[236],"akan":[238],"berikatan":[239],"berada":[244],"menjadi":[251,410],"aktif.":[252],"Sel":[253],"berfungsi":[256],"mengeluarkan":[257],"cairan":[258],"bersifat":[260],"nutritif":[261],"sperma,":[263],"embrio":[264,268],"melubrikasi":[266],"jalan":[267],"menuju":[269],"uterus.\r\nReseptor":[270],"selain":[272],"juga":[275,296],"terdapat":[276,295,648],"fallopi.":[280,318,683,714],"Salah":[281],"satu":[282],"memiliki":[285],"distribusi":[286],"luas":[287],"jaringan":[289],"perifer":[290],"NMDAR1.":[292],"Selain":[293],"NMDAR1,":[294],"subtipe":[297],"GluR":[300],"2/3":[301],"Ka":[303],"2.":[304],"Jika":[305],"aktifasi":[306,320],"berlebihan":[311,323],"maka":[312,674,706],"Apabila":[319],"tidak":[331],"mampu":[332,354],"menetralisir":[334],"bebas.":[336],"Oleh":[337],"karena":[338],"itu,":[339],"dibutuhkan":[340],"luar":[343],"ekstrak":[345,374,425,435,445,553,560,588,594,719],"teh":[346,349,375,426,436,446,554,561,589,595,720],"hijau.":[347],"Ekstrak":[348],"hijau":[350,376,427,437,447,562,596,721],"mengandung":[351],"katekin":[352],"regulasi":[356],"seperti":[361],"katalase,":[362],"superoksida":[363],"dismutase":[364],"mengalami":[366],"stres":[367],"oksidatif.\r\nPenelitian":[368],"bertujuan":[370],"mengetahui":[372],"pengaruh":[373,665,670,697,702],"terhadap":[377],"estrogen-\u03b1":[385,620,690,712,730],"dipapar":[390,570,602,737],"MSG.":[391,738],"Penelitian":[392],"eksperimental":[393],"rancangan":[395],"randomized":[396],"post":[397],"test":[398],"control":[399],"group":[400],"design":[401],"menggunakan":[402,455,498,534],"25":[403],"ekor":[404],"dibagi":[407],"acak":[409],"lima":[411],"kelompok.":[412],"Kelompok":[413],"kontrol":[414,416,628,632,640],"negatif,":[415],"positif":[417,633,641,662,694],"(MSG":[418,422,432,442],"saja),":[419],"perlakuan":[420,430,440,451,550,557,585,644],"1":[421],"0,7":[423,428,433,443],"mg/gBB+":[424,434,444],"mg/tks/hr),":[429,439],"2":[431],"1,4":[438],"3":[441,647],"2,8":[448],"mg/tks/hr).":[449],"Diberi":[450],"oral":[453],"sonde":[456],"selama":[457],"30":[458],"hari.":[459],"Pada":[460],"hari":[461],"31":[463],"dilakukan":[464,473,486],"swab":[465],"vagina":[466],"menentukan":[469],"fase":[470],"proestrus":[471],"kemudian":[472],"pembedahan":[474],"organ":[476],"diambil.":[479],"Penghitungan":[480],"pemeriksaan":[488],"histopatologis":[489],"pewarnaan":[490],"Hematoksilin":[491],"Eosin":[493],"(HE)":[494],"diamati":[496],"mikroskop":[499],"olympus":[500],"XC":[501],"10":[502],"pembesaran":[504],"400x.":[505],"Ekspresi":[506,521],"RE-\u03b1":[507,522,600],"dideteksi":[508],"antibodi":[510],"anti":[511],"ER-\u03b1":[513],"bs-0725R":[514],"merk":[515],"Bios":[516],"antibody":[517],"metode":[519],"imunohistokimia.":[520],"tampak":[523],"berwarna":[524],"coklat":[525],"fallopi.\r\nAnalisa":[531],"penelitian":[533],"uji":[535,609,653],"Anova":[536],"tingkat":[538],"kepercayaan":[539],"0,05":[540],"menunjukkan":[541,623,668,700],"bahwa":[542,624,717],"ada":[543,578],"perbedaan":[544,579,611],"bermakna":[546,581],"rerata":[548,583,612],"kelompok":[549,556,584,591,627,631,639,643],"hijau,":[555,590],"nilai":[573,605,661,693],"p=":[574,606],"0,000.":[575,607],"Secara":[576],"statistik":[577],"perlakuan\r\nix\r\nberbagai":[592],"Hasil":[608],"LSD":[610],"antara":[625],"perbandingan":[626,638],"negatif":[629],"didapatkan":[634],"berbeda":[635],"signfikan,":[636],"1,2":[645],"perbedan":[649],"signifikan.\r\nHasil":[651],"analisis":[652,686],"regresi":[654,666,687,698],"diperoleh":[659,691],"besarnya":[660,692],"koefisien":[664,696],"6,509":[667],"adanya":[669,701],"bertambahnya":[672,704],"seiring":[675,707],"pertambahan":[677,709],"Selanjutnya,":[684],"8,942":[699],"Dapat":[715],"disimpulkan":[716],"pemberian":[718]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2019-04-01T00:00:00"}