{"id":"https://openalex.org/W2923264377","doi":null,"title":"Comparative Identification and Characterization of Myosin Heavy Chain Isoforms in Avian Skeletal Muscle","display_name":"Comparative Identification and Characterization of Myosin Heavy Chain Isoforms in Avian Skeletal Muscle","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2923264377","mag":"2923264377"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/82514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82514","pdf_url":"https://utoronto.scholaris.ca/bitstreams/52472e87-9315-4a57-815a-47f77c4d2955/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/52472e87-9315-4a57-815a-47f77c4d2955/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067940516","display_name":"Brandy P. Velten","orcid":"https://orcid.org/0000-0003-0424-7978","observed_orcids":["https://orcid.org/0000-0003-0424-7978"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brandy P. Velten","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0424-7978","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067940516"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/avian-skeletal-muscle","display_name":"avian skeletal muscle","score":0.9909999966621399},{"id":"https://openalex.org/keywords/flight-muscle","display_name":"flight muscle","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pectoral-muscle","display_name":"pectoralis muscle","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hummingbirds","display_name":"hummingbirds","score":0.7289999723434448},{"id":"https://openalex.org/keywords/bird-migration","display_name":"bird migration","score":0.7889999747276306},{"id":"https://openalex.org/keywords/passerine-birds","display_name":"Passeriformes","score":0.6850000023841858},{"id":"https://openalex.org/keywords/white-crowned-sparrow","display_name":"white-crowned sparrow","score":0.949999988079071},{"id":"https://openalex.org/keywords/life-stages","display_name":"life stages","score":0.5799999833106995},{"id":"https://openalex.org/keywords/muscle-contractile-properties","display_name":"muscle contractile properties","score":0.6510000228881836},{"id":"https://openalex.org/keywords/locomotion","display_name":"locomotion","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7928541898727417},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6858271956443787},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.675652801990509},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5166835784912109},{"id":"https://openalex.org/C84613547","wikidata":"https://www.wikidata.org/wiki/Q17037912","display_name":"Heavy chain","level":3,"score":0.44699394702911377},{"id":"https://openalex.org/C74581901","wikidata":"https://www.wikidata.org/wiki/Q14876107","display_name":"MYH7","level":4,"score":0.44020721316337585},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3861251175403595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36823198199272156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35807639360427856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34693294763565063},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.2980530261993408},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25526314973831177},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09235724806785583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08636850118637085}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/82514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82514","pdf_url":"https://utoronto.scholaris.ca/bitstreams/52472e87-9315-4a57-815a-47f77c4d2955/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2923264377","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/82514?mode=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/82514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/82514","pdf_url":"https://utoronto.scholaris.ca/bitstreams/52472e87-9315-4a57-815a-47f77c4d2955/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923264377.pdf","grobid_xml":"https://content.openalex.org/works/W2923264377.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W1410674031","https://openalex.org/W1486851320","https://openalex.org/W1508733727","https://openalex.org/W1526273052","https://openalex.org/W1540720871","https://openalex.org/W1556101864","https://openalex.org/W1573366176","https://openalex.org/W1848683662","https://openalex.org/W1913743281","https://openalex.org/W1925502003","https://openalex.org/W1963590825","https://openalex.org/W1964404638","https://openalex.org/W1964906652","https://openalex.org/W1968874454","https://openalex.org/W1971532772","https://openalex.org/W1972240739","https://openalex.org/W1972506441","https://openalex.org/W1978032840","https://openalex.org/W1979613163","https://openalex.org/W1979650561","https://openalex.org/W1979765668","https://openalex.org/W1982238379","https://openalex.org/W1983509368","https://openalex.org/W1992036272","https://openalex.org/W1993069853","https://openalex.org/W1994263589","https://openalex.org/W1995319149","https://openalex.org/W1995417214","https://openalex.org/W1996247660","https://openalex.org/W2001813010","https://openalex.org/W2002308187","https://openalex.org/W2002440775","https://openalex.org/W2003385162","https://openalex.org/W2004098052","https://openalex.org/W2006640683","https://openalex.org/W2009078468","https://openalex.org/W2009699195","https://openalex.org/W2015016910","https://openalex.org/W2016073677","https://openalex.org/W2018581055","https://openalex.org/W2020358612","https://openalex.org/W2022996140","https://openalex.org/W2023069776","https://openalex.org/W2028049528","https://openalex.org/W2031570395","https://openalex.org/W2037002952","https://openalex.org/W2037234162","https://openalex.org/W2042053845","https://openalex.org/W2045333877","https://openalex.org/W2045443808","https://openalex.org/W2046377871","https://openalex.org/W2048546609","https://openalex.org/W2055285260","https://openalex.org/W2056351771","https://openalex.org/W2061200435","https://openalex.org/W2062381888","https://openalex.org/W2067925860","https://openalex.org/W2071642479","https://openalex.org/W2074069675","https://openalex.org/W2076697713","https://openalex.org/W2078660921","https://openalex.org/W2086061329","https://openalex.org/W2088179831","https://openalex.org/W2088772436","https://openalex.org/W2090074298","https://openalex.org/W2090836895","https://openalex.org/W2093347399","https://openalex.org/W2094375469","https://openalex.org/W2094604030","https://openalex.org/W2095480857","https://openalex.org/W2098827594","https://openalex.org/W2100849288","https://openalex.org/W2103421559","https://openalex.org/W2104004860","https://openalex.org/W2104158244","https://openalex.org/W2105262063","https://openalex.org/W2105856665","https://openalex.org/W2106770401","https://openalex.org/W2106995983","https://openalex.org/W2110732649","https://openalex.org/W2112165239","https://openalex.org/W2119782418","https://openalex.org/W2122139344","https://openalex.org/W2122333710","https://openalex.org/W2123825820","https://openalex.org/W2124199270","https://openalex.org/W2126040686","https://openalex.org/W2127098394","https://openalex.org/W2127779696","https://openalex.org/W2130025116","https://openalex.org/W2130452373","https://openalex.org/W2131489959","https://openalex.org/W2136138816","https://openalex.org/W2136246488","https://openalex.org/W2136887992","https://openalex.org/W2137128469","https://openalex.org/W2139736670","https://openalex.org/W2140896864","https://openalex.org/W2140945864","https://openalex.org/W2140994672","https://openalex.org/W2141528332","https://openalex.org/W2145260877","https://openalex.org/W2145455882","https://openalex.org/W2146414580","https://openalex.org/W2148881731","https://openalex.org/W2150584970","https://openalex.org/W2151986066","https://openalex.org/W2153612098","https://openalex.org/W2153947402","https://openalex.org/W2154780708","https://openalex.org/W2155253185","https://openalex.org/W2156021648","https://openalex.org/W2156719734","https://openalex.org/W2157099360","https://openalex.org/W2160969036","https://openalex.org/W2162208582","https://openalex.org/W2168285135","https://openalex.org/W2168454062","https://openalex.org/W2168518330","https://openalex.org/W2169365599","https://openalex.org/W2176715668","https://openalex.org/W2179494850","https://openalex.org/W2183985856","https://openalex.org/W2199937920","https://openalex.org/W2200247547","https://openalex.org/W2215036374","https://openalex.org/W2215460973","https://openalex.org/W2240950819","https://openalex.org/W2269135633","https://openalex.org/W2275082952","https://openalex.org/W2316176061","https://openalex.org/W2317203154","https://openalex.org/W2317574385","https://openalex.org/W2328655713","https://openalex.org/W2411288085","https://openalex.org/W2468128326","https://openalex.org/W2525290762","https://openalex.org/W2946780078"],"related_works":["https://openalex.org/W2105262063","https://openalex.org/W2557245552","https://openalex.org/W6929949966","https://openalex.org/W2127098394","https://openalex.org/W2122139344","https://openalex.org/W1979224160","https://openalex.org/W2551991155","https://openalex.org/W2018246442","https://openalex.org/W1983665620","https://openalex.org/W2331572228"],"abstract_inverted_index":{"Organisms":[0],"require":[1],"muscles":[2,67],"capable":[3],"of":[4,9,12,16,24,36,54,68,77,90,108,116,153,204,212,220,227,239,255,273,282,290,325,332,338],"meeting":[5,306],"the":[6,13,22,32,65,87,105,125,159,189,193,218,236,251,260,274,279,283,286,307,319,333],"functional":[7,336],"demands":[8,309],"locomotion.":[10],"Many":[11],"contractile":[14,78,127],"properties":[15],"muscle":[17,111,122,165,168,181,195,276],"are":[18],"tightly":[19],"correlated":[20],"to":[21,99,119,142,157,178,293],"expression":[23,89,107,146,161,176,233,245,254,272,301,321],"specific":[25],"myosin":[26],"heavy":[27],"chain":[28],"(MHC)":[29],"isoforms.":[30,92,225],"While":[31,174],"identification":[33],"and":[34,57,133,149,170,322,335],"characteristics":[35,228],"mammalian":[37],"MHC":[38,50,91,106,144,160,175,190,206,232,244,253,271,288,320],"isoforms":[39],"have":[40],"been":[41],"well":[42],"documented,":[43],"comparatively":[44],"little":[45],"is":[46],"known":[47],"about":[48],"avian":[49,138,163,224,287,326],"expression.":[51],"The":[52,151],"diversity":[53],"locomotor":[55,66,132,187],"styles":[56],"life":[58,134,171,267],"histories":[59],"observed":[60,340],"in":[61,84,162,208,246,303,313],"birds":[62],"suggests":[63],"that":[64,80,115,229,235,270],"these":[69],"species":[70,118,139,213,241,327],"must":[71],"operate":[72],"over":[73],"a":[74,209,240],"wide":[75],"range":[76],"conditions":[79],"may":[81,230],"be":[82],"achieved,":[83],"part,":[85,304],"by":[86,192],"differential":[88],"Specifically,":[93],"it":[94],"was":[95,156],"hypothesized":[96],"that,":[97],"due":[98],"their":[100],"very":[101],"rapid":[102,121],"wingbeat":[103],"frequencies,":[104],"hummingbird":[109],"flight":[110,194,275],"would":[112,140],"differ":[113],"from":[114],"larger-bodied":[117],"enable":[120],"shortening.":[123],"Further,":[124],"unique":[126],"requirements":[128],"associated":[129,310],"with":[130,184,243,278,300,305,311],"different":[131,186],"history":[135,172],"strategies":[136],"across":[137,166,180,200,265],"lead":[141],"varying":[143],"isoform":[145],"both":[147],"intra-":[148],"interspecifically.":[150],"aim":[152],"this":[154,339],"thesis":[155],"explore":[158],"skeletal":[164],"species,":[167,259],"groups,":[169],"stages.":[173],"appeared":[177,197],"vary":[179],"groups":[182],"tasked":[183],"performing":[185],"activities,":[188],"expressed":[191],"initially":[196],"relatively":[198],"conserved":[199],"species.":[201,249,284,315],"However,":[202],"analysis":[203],"pectoral":[205,252],"isoform(s)":[207],"larger":[210],"array":[211],"revealed":[214,234],"greater":[215],"diversity,":[216],"including":[217],"presence":[219],"several":[221],"characteristically":[222],"distinct":[223],"Analysis":[226],"influence":[231],"migratory":[237,257,280],"predisposition":[238],"corresponded":[242],"small-bodied":[247],"passerine":[248,258],"Examining":[250],"one":[256],"white-crowned":[261],"sparrow":[262],"(Zonotrichia":[263],"leucophrys),":[264],"three":[266],"stages":[268],"demonstrated":[269],"altered":[277],"status":[281],"Thus,":[285],"family":[289],"proteins":[291],"appears":[292],"much":[294],"more":[295],"diverse":[296],"than":[297],"previously":[298],"anticipated,":[299],"associated,":[302],"mechanical":[308],"migration":[312],"some":[314],"Continued":[316],"research":[317],"into":[318],"gene":[323],"families":[324],"will":[328],"further":[329],"our":[330],"understanding":[331],"evolutionary":[334],"implications":[337],"diversity.":[341]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-04-01T00:00:00"}