{"id":"https://openalex.org/W2923224548","doi":"https://doi.org/10.3892/ijo.2019.4762","title":"Tumor\u2011suppressive microRNA\u2011223 targets WDR62 directly in bladder cancer","display_name":"Tumor\u2011suppressive microRNA\u2011223 targets WDR62 directly in bladder cancer","publication_year":2019,"publication_date":"2019-03-22","ids":{"openalex":"https://openalex.org/W2923224548","doi":"https://doi.org/10.3892/ijo.2019.4762","mag":"2923224548","pmid":"https://pubmed.ncbi.nlm.nih.gov/30942440"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2019.4762","doi":"https://doi.org/10.3892/ijo.2019.4762","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2019.4762","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2019.4762/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijo.2019.4762/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102963861","display_name":"Satoshi Sugita","orcid":"https://orcid.org/0009-0002-9191-3165","observed_orcids":["https://orcid.org/0009-0002-9191-3165"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Sugita","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025601550","display_name":"Hirofumi Yoshino","orcid":"https://orcid.org/0000-0002-5470-7445","observed_orcids":["https://orcid.org/0000-0002-5470-7445"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Yoshino","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080245763","display_name":"Masaya Yonemori","orcid":"https://orcid.org/0000-0002-1679-2394","observed_orcids":["https://orcid.org/0000-0002-1679-2394"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Yonemori","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198633","display_name":"Kazutaka Miyamoto","orcid":"https://orcid.org/0009-0005-8220-1205","observed_orcids":["https://orcid.org/0009-0005-8220-1205"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutaka Miyamoto","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112307955","display_name":"Ryosuke Matsushita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Matsushita","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113947515","display_name":"Takashi Sakaguchi","orcid":"https://orcid.org/0000-0002-0187-9948","observed_orcids":["https://orcid.org/0000-0002-0187-9948"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sakaguchi","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100923748","display_name":"Toshihiko Itesako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Itesako","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030624081","display_name":"Shuichi Tatarano","orcid":"https://orcid.org/0000-0003-4224-5084","observed_orcids":["https://orcid.org/0000-0003-4224-5084"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Tatarano","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038105097","display_name":"Masayuki Nakagawa","orcid":"https://orcid.org/0000-0002-6972-9612","observed_orcids":["https://orcid.org/0000-0002-6972-9612"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Nakagawa","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044574879","display_name":"Hideki Enokida","orcid":"https://orcid.org/0000-0002-3050-9700","observed_orcids":["https://orcid.org/0000-0002-3050-9700"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Enokida","raw_affiliation_strings":["Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890\u20118520, Japan","institution_ids":["https://openalex.org/I107139324"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107139324"],"apc_list":null,"apc_paid":null,"fwci":1.4302,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78311407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"54","issue":"6","first_page":"2222","last_page":"2236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-223","display_name":"miR-223","score":0.9810000061988831},{"id":"https://openalex.org/keywords/wdr62","display_name":"WDR62","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microrna-target-identification","display_name":"miRNA target identification","score":0.7360000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/caspase-3-7-activation","display_name":"caspase-3/7 activation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.9629999995231628},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.4729999899864197},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.797587513923645},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7900835275650024},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7546257972717285},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7262439727783203},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6873553991317749},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6596383452415466},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5586444735527039},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.48200908303260803},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.48006734251976013},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4581311345100403},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.45570218563079834},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.446961909532547},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.43563351035118103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20873111486434937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16562935709953308}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015653","descriptor_name":"Cystectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.2019.4762","doi":"https://doi.org/10.3892/ijo.2019.4762","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2019.4762","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2019.4762/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:30942440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30942440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2019.4762","doi":"https://doi.org/10.3892/ijo.2019.4762","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2019.4762","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2019.4762/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1943261201","display_name":"Development of the marker predicting GC primary resistance of the bladder cancer by multifaceted approach","funder_award_id":"19K18615","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2699951444","display_name":"Exploring molecular network of functional nucleic acid and developing therapeutic innovations in drug-resistant renal cell carcinoma","funder_award_id":"16H05464","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3659320413","display_name":"Elucidation of the resistance mechanism to the molecular targeting drug in renal cancer using the genome editing technology","funder_award_id":"17K16799","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5267912379","display_name":"Functional analyses of oncogenic microRNA by genome editing and development of innovative genome-based drug discovery for bladder cancer.","funder_award_id":"17H04332","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6084659622","display_name":"Development of the innovative treatment based on the search of microRNA blocking growth signals in urothelial carcinoma","funder_award_id":"16K11015","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8478797743","display_name":"Targeting the Ubiquitin Proteasome Pathway as a Novel Therapeutic Strategy for Advanced Renal Cell Carcinoma","funder_award_id":"19K07736","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2923224548.pdf","grobid_xml":"https://content.openalex.org/works/W2923224548.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1565224655","https://openalex.org/W1866091572","https://openalex.org/W1965692834","https://openalex.org/W1966622127","https://openalex.org/W1970583256","https://openalex.org/W1974590880","https://openalex.org/W1975787075","https://openalex.org/W1982499214","https://openalex.org/W1987328298","https://openalex.org/W1993475190","https://openalex.org/W1999574084","https://openalex.org/W2002995168","https://openalex.org/W2007991122","https://openalex.org/W2013336814","https://openalex.org/W2013436504","https://openalex.org/W2022010237","https://openalex.org/W2026570544","https://openalex.org/W2036747263","https://openalex.org/W2042563959","https://openalex.org/W2043361100","https://openalex.org/W2048261127","https://openalex.org/W2051762085","https://openalex.org/W2062475603","https://openalex.org/W2074679319","https://openalex.org/W2075696813","https://openalex.org/W2080498539","https://openalex.org/W2083250350","https://openalex.org/W2094074562","https://openalex.org/W2100932663","https://openalex.org/W2101562875","https://openalex.org/W2107277218","https://openalex.org/W2112413055","https://openalex.org/W2122962350","https://openalex.org/W2128635872","https://openalex.org/W2137726406","https://openalex.org/W2148987313","https://openalex.org/W2151325032","https://openalex.org/W2163199119","https://openalex.org/W2167531754","https://openalex.org/W2168083201","https://openalex.org/W2168846224","https://openalex.org/W2169970785","https://openalex.org/W2172207823","https://openalex.org/W2291986393","https://openalex.org/W2416204406","https://openalex.org/W2467808394","https://openalex.org/W2512720780","https://openalex.org/W2520598456","https://openalex.org/W2531926336","https://openalex.org/W2587387416","https://openalex.org/W2589357971","https://openalex.org/W2594432047","https://openalex.org/W2917837889","https://openalex.org/W2964528894","https://openalex.org/W2994956051","https://openalex.org/W6716461336"],"related_works":["https://openalex.org/W2743037086","https://openalex.org/W1514190541","https://openalex.org/W2922164798","https://openalex.org/W1975787075","https://openalex.org/W2589357971","https://openalex.org/W2887247193","https://openalex.org/W2902065272","https://openalex.org/W2017342964","https://openalex.org/W7143918334","https://openalex.org/W3008071576"],"abstract_inverted_index":{"miRNA\u2011223":[0],"(miR\u2011223)":[1],"has":[2,32,165],"been":[3,34,166],"reported":[4],"to":[5,36,40,87,95,126,161,169],"function":[6],"not":[7,33],"only":[8],"as":[9,15,74],"a":[10,75,155,171,197,229],"tumor":[11,76,139,199,211],"suppressor,":[12],"but":[13],"also":[14],"an":[16],"oncogenic":[17,233],"microRNA":[18],"(miRNA":[19],"or":[20],"miR)":[21],"in":[22,68,79,99,109,147,162,173,203],"various":[23],"cancer":[24,56],"cells.":[25,149,219],"Therefore,":[26],"the":[27,41,49,89,215,221,223,239],"functional":[28,90],"role":[29,172],"of":[30,43,53,83,92,104,134,158,207,217,225,241],"miR\u2011223":[31,63,72,93,105,122,135,159,180,231],"elucidated":[35],"date,":[37],"at":[38],"least":[39],"best":[42],"our":[44,110],"knowledge.":[45],"We":[46],"previously":[47,167],"performed":[48],"deep":[50],"sequencing":[51],"analysis":[52],"clinical":[54,111],"bladder":[55],"(BC)":[57],"specimens.":[58,113],"It":[59],"was":[60,65,86,124,181],"revealed":[61,189],"that":[62,71,121],"expression":[64,102,123,136,195],"significantly":[66,107,137,209],"downregulated":[67],"BC,":[69],"suggesting":[70],"functions":[73],"suppressor":[77],"miRNA":[78],"BC.":[80,100,204,242],"The":[81,101,114,132,186,205],"aim":[82],"this":[84,226],"study":[85,227],"investigate":[88],"roles":[91],"and":[94,129,141,179,196,201,213,235],"identify":[96],"its":[97],"targets":[98],"levels":[103],"were":[106],"decreased":[108],"BC":[112,148,218],"Cancer":[115],"Genome":[116],"Atlas":[117],"(TCGA)":[118],"database":[119,188],"indicated":[120],"related":[125],"lymphovascular":[127],"invasion":[128],"distant":[130],"metastasis.":[131],"restoration":[133],"inhibited":[138,210],"aggressiveness":[140,212],"induced":[142,214],"apoptosis":[143,216],"via":[144],"caspase\u20113/7":[145],"activation":[146],"WD":[150],"repeat":[151],"domain":[152],"62":[153],"(WDR62),":[154],"candidate":[156],"target":[157],"according":[160],"silico":[163],"analyses,":[164],"proposed":[168],"play":[170],"neurodevelopment.":[174],"Direct":[175],"binding":[176],"between":[177,192],"WDR62":[178,193,208],"confirmed":[182],"by":[183],"luciferase":[184],"assay.":[185],"TCGA":[187],"positive":[190],"associations":[191],"mRNA":[194],"higher":[198],"grade":[200],"stage":[202],"knockdown":[206],"On":[220],"whole,":[222],"findings":[224],"reveal":[228],"novel":[230],"target,":[232],"WDR62,":[234],"provided":[236],"insight":[237],"into":[238],"oncogenesis":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-01T00:00:00"}
