{"id":"https://openalex.org/W2923171978","doi":"https://doi.org/10.1145/3314074.3314095","title":"Meta-analysis for a therapeutic target involved in the activation of the genes associated with C3 glomerulopathy","display_name":"Meta-analysis for a therapeutic target involved in the activation of the genes associated with C3 glomerulopathy","publication_year":2019,"publication_date":"2019-03-26","ids":{"openalex":"https://openalex.org/W2923171978","doi":"https://doi.org/10.1145/3314074.3314095","mag":"2923171978"},"language":"en","primary_location":{"id":"doi:10.1145/3314074.3314095","doi":"https://doi.org/10.1145/3314074.3314095","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3314074.3314095","pdf_url":null,"source":{"id":"https://openalex.org/S7407119857","display_name":"Conference of the Moroccan Classification Society: New Challenges in Data Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the New Challenges in Data Sciences: Acts of the Second Conference of the Moroccan Classification Society","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040276303","display_name":"Boutaina Ettetuani","orcid":"https://orcid.org/0000-0002-6630-6382","observed_orcids":["https://orcid.org/0000-0002-6630-6382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boutaina Ettetuani","raw_affiliation_strings":["Research Team in Data and Systems Engineering, National School of Applied Sciences, Tangier, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Team in Data and Systems Engineering, National School of Applied Sciences, Tangier, Morocco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074793043","display_name":"Rajaa Chahboune","orcid":"https://orcid.org/0009-0003-6063-4048","observed_orcids":["https://orcid.org/0009-0003-6063-4048"]},"institutions":[{"id":"https://openalex.org/I240042149","display_name":"Abdelmalek Essa\u00e2di University","ror":"https://ror.org/03c4shz64","country_code":"MA","type":"education","lineage":["https://openalex.org/I240042149"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Rajaa Chahboune","raw_affiliation_strings":["Faculty of Medicine and Pharmacy Tangier, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy Tangier, Morocco","institution_ids":["https://openalex.org/I240042149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039717493","display_name":"Ahmed Moussa","orcid":"https://orcid.org/0000-0003-1628-8179","observed_orcids":["https://orcid.org/0000-0003-1628-8179"]},"institutions":[{"id":"https://openalex.org/I240042149","display_name":"Abdelmalek Essa\u00e2di University","ror":"https://ror.org/03c4shz64","country_code":"MA","type":"education","lineage":["https://openalex.org/I240042149"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ahmed Moussa","raw_affiliation_strings":["National School of Applied Sciences, Systems and Data Enginneering Team, Abdelmalek Essaadi University, Tangier, Morrocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National School of Applied Sciences, Systems and Data Enginneering Team, Abdelmalek Essaadi University, Tangier, Morrocco","institution_ids":["https://openalex.org/I240042149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4872,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.96060606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3-glomerulopathy","display_name":"C3 glomerulopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dense-deposit-disease","display_name":"dense deposit disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/c3-glomerulonephritis","display_name":"C3 glomerulonephritis","score":1.0},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7390000224113464},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/gene-ontology-terms","display_name":"Gene Ontology terms","score":0.8690000176429749},{"id":"https://openalex.org/keywords/microarray-gene-expression","display_name":"microarray gene expression","score":0.9409999847412109},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7319999933242798},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.9044893980026245},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.6745807528495789},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.6054555177688599},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6005597114562988},{"id":"https://openalex.org/C2778415529","wikidata":"https://www.wikidata.org/wiki/Q1435223","display_name":"Focal segmental glomerulosclerosis","level":4,"score":0.5472887754440308},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5143038034439087},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4727132022380829},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4669457674026489},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.42398712038993835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4010874629020691},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.372070848941803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36747288703918457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3369525074958801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3086509704589844},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2596646547317505},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.1852215826511383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14388492703437805}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3314074.3314095","doi":"https://doi.org/10.1145/3314074.3314095","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3314074.3314095","pdf_url":null,"source":{"id":"https://openalex.org/S7407119857","display_name":"Conference of the Moroccan Classification Society: New Challenges in Data Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the New Challenges in Data Sciences: Acts of the Second Conference of the Moroccan Classification Society","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1629202041","https://openalex.org/W1964904043","https://openalex.org/W1967053372","https://openalex.org/W1982003857","https://openalex.org/W2032912400","https://openalex.org/W2035667239","https://openalex.org/W2094121461","https://openalex.org/W2108858161","https://openalex.org/W2118510193","https://openalex.org/W2150267510","https://openalex.org/W2154998360","https://openalex.org/W2156246479","https://openalex.org/W2167821466","https://openalex.org/W2172215633","https://openalex.org/W2172557341","https://openalex.org/W2178353191","https://openalex.org/W2293164280","https://openalex.org/W2333082097","https://openalex.org/W2429117898","https://openalex.org/W2727134083","https://openalex.org/W4238793777"],"related_works":["https://openalex.org/W2151241196","https://openalex.org/W2116085004","https://openalex.org/W4413236712","https://openalex.org/W2772845867","https://openalex.org/W2914604561","https://openalex.org/W2982401918","https://openalex.org/W4212845999","https://openalex.org/W2069258445","https://openalex.org/W4397040187","https://openalex.org/W2792935006"],"abstract_inverted_index":{"The":[0,195],"term":[1],"C3":[2,25,44,52,209],"glomerulopathy":[3,45,210],"is":[4,117],"a":[5,63,79],"group":[6],"of":[7,20,24,29,32,37,43,62,81,121,161,169,180,193],"related":[8],"conditions":[9,77],"that":[10,133,154],"cause":[11],"the":[12,18,27,35,41,71,118,159,178,191,201],"kidneys":[13,139],"to":[14,107,138,157,176],"malfunction,":[15],"characterized":[16],"by":[17,129,141],"presence":[19],"glomerular":[21],"deposits":[22],"composed":[23],"in":[26,70,203,211],"absence":[28],"significant":[30],"amounts":[31],"Ig.":[33],"On":[34],"basis":[36],"electron":[38],"microscopy":[39],"appearance,":[40],"subsets":[42],"include":[46,75],"dense":[47],"deposit":[48],"disease":[49,114,213],"(DDD)":[50],"and":[51,83,94,98,189],"glomerulonephritis":[53,97],"(C3GN).":[54],"Affected":[55],"individuals":[56],"may":[57],"have":[58,100,134],"particularly":[59],"low":[60],"levels":[61],"protein":[64],"called":[65,111],"complement":[66],"component":[67],"3":[68],"(C3)":[69],"blood.":[72],"Glomerular":[73],"diseases":[74],"many":[76],"with":[78,208],"variety":[80],"genetic":[82],"environmental":[84],"causes,":[85,102],"but":[86],"they":[87,103],"fall":[88],"into":[89],"two":[90,212],"major":[91],"categories;":[92],"Glomerulonephritis":[93],"Glomerulosclerosis.":[95],"Although":[96],"glomerulosclerosis":[99],"different":[101],"can":[104,126],"both":[105],"lead":[106],"kidney":[108,123],"failure,":[109],"also":[110],"end-stage":[112],"renal":[113],"(ESRD);":[115],"it":[116],"final":[119],"stage":[120],"chronic":[122],"disease.":[124],"It":[125],"be":[127],"caused":[128],"other":[130],"health":[131],"problems":[132],"done":[135],"permanent":[136],"damage":[137],"little":[140],"little,":[142],"over":[143],"time.":[144],"In":[145],"this":[146],"study":[147],"we":[148,165],"examined":[149],"Gene":[150],"Ontology":[151],"(GO)":[152],"terms,":[153,175],"are":[155],"used":[156],"assess":[158],"results":[160],"microarray":[162,204],"experiments.":[163],"However,":[164],"propose":[166],"testing":[167],"groups":[168],"GO":[170],"terms":[171],"rather":[172],"than":[173],"individual":[174],"improve":[177,190],"interpretation":[179,192],"gene":[181,205],"set":[182],"enrichment":[183],"reduce":[184],"dependence":[185],"between":[186],"statistical":[187],"tests":[188],"results.":[194],"data":[196],"analyzed":[197],"here":[198],"focus":[199],"on":[200],"differences":[202],"expression":[206],"associated":[207],"subtypes.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-04-01T00:00:00"}